摘要
目的:了解直接抗人球蛋白实验(DAT)阳性输血患者临床分布特征和血清学特征,探讨DAT凝集度与输血前Hb、LDH的关系,评价输血疗效。方法:根据714例输血患者DAT结果,按科室、疾病、DAT分型、DAT凝集强度进行归类,并检测74例DAT阳性患者输血前后Hb、LDH,对输注效果进行判断。结果:714例输血患者中,DAT阳性74例,阳性率10.36%,患者主要集中在血液科、风湿免疫科、感染科,主要病种为AIHA、尿毒症、淋巴瘤。DAT分型结果显示IgG+C3d阳性46例,占比62.16%,单独IgG阳性19例,占比25.68%,单独C3d阳性9例,占比12.16%。DAT凝集强度4+组患者输血前Hb低于凝集强度≤1+组,输注后各组患者Hb均高于输注前,差异有统计学意义,LDH输注前后差异无统计学意义。74例DAT阳性患者,RBC输注有效67例,有效率90.54%,DAT不同凝集强度组输血有效率差异无统计学意义。结论:DAT分型有助于对疾病初步诊断,DAT凝集强度与输血前Hb有一定相关性,DAT凝集强度越强,Hb水平越低。
Objective To understand the clinical distribution and serological characteristics of patients with DAT positive blood transfusion,to explore the relationship between DAT agglutination and Hb,LDH before blood transfusion,and to evaluate the effect of blood transfusion.Methods According to the DAT results of 714 blood transfusion patients,according to the Department,disease,DAT classification,DAT agglutination intensity,74 patients with DAT positive before and after blood transfusion were tested for HB and LDH,and the infusion effect was judged.Results Among 714 blood transfusion patients,DAT was positive in 74 cases,with a positive rate of 10.36%.The patients were mainly concentrated in hematology,rheumatology and immunology,and infection.The main diseases were AIHA,uremia and lymphoma.The results of DAT typing showed that 46 cases were IgG+C3d positive,accounting for 62.16%,19 cases were IgG positive alone,accounting for 25.68%,9 cases were C3d positive alone,accounting for 12.16%.The Hb of patients in DAT 4+group before transfusion was lower than that in DAT≤1+group,and the Hb of patients in each group after transfusion was higher than that before transfusion,the difference was statistically significant,and the difference before and after LDH transfusion was not statistically significant.Among 74 DAT positive patients,67 were effective in RBC transfusion,with an effective rate of 90.54%.There was no significant difference in blood transfusion efficiency among DAT groups with different agglutination strength.Conclusion DAT typing is helpful for the initial diagnosis of the disease.There is a certain correlation between DAT agglutination intensity and Hb before blood transfusion.The stronger DAT agglutination intensity is,the lower Hb level is.
作者
周朝霞
杨小红
Zhou Zhao-xia;Yang Xiao-hong(Affiliated Hospital of Changsha in Hunan Normal University,The Fourth Hospital of Changsha,Changsha 410006,China;Medical College,Hunan Normal University,Changsha 410013,China)
出处
《晓庄学院学报（医学版）》
2020年第3期60-63,共4页
Journal of Hunan Normal University(Medical Sciences)
