摘要
目的观察补肾化瘀法治疗老年性痴呆的疗效,并探索其对脂蛋白E血浆浓度的影响。方法选择我院60例住院及门诊的老年性痴呆患者,随机分成两组,分别采用中药与西药治疗。检测两组治疗前后简明精神状态检查表(MMSE)、功能活动量表(FAQ)的变化及载脂蛋白E血浆浓度的变化。结果治疗组总有效率为83.3%,对照组总有效率为70.0%,两组差别有显著统计学意义(P<0.05)。两组治疗前MMSE和FAQ评分并无明显差别,治疗后与治疗前比较,治疗组差异具有统计学意义(P<0.05),对照组治疗前后自身比较差别不大(P>0.05);组间比较,治疗后治疗组MMSE评分高于对照组(P<0.05),而FAQ评分低于对照组(P<0.05)。两组Apo E血浆浓度治疗后较治疗前自身比较均有下降(P<0.05);治疗后,治疗组ApoE血浆浓度与对照组比较,变化无统计学意义(P>0.05)。结论中西医治疗老年性痴呆均有一定疗效,但中医药治疗更值得在临床推广应用。
Objective To observe the effect of kidney-tonifying and stasis-removing on senile dementia,and explore its effect on plasma concentration of apolipoprotein E(Apo E).Methods 60 cases of patients with senile dementia were randomly divided into two groups.The changes of Mini-Mental State Examination(MMSE),FAQ scale and apolipoprotein E plasma concentration before and after treatment were detected.Results The total effective rate was 83.3%in treatment group and 70.0%in control group,with significant difference between the two groups(P<0.05);there was no significant difference in MMSE and FAQ scores between the two groups before and after treatment,compared with before treatment,the difference of treatment group was statistically significant(P<0.05),while the difference of control group was not significant(P>0.05).After treatment,MMSE score of treatment group was higher than that of control group(P<0.05),while FAQ score was lower than that of control group(P<0.05);the plasma concentration of Apo E in treatment group was lower than that in control group(P<0.05),compared with control group,there was no statistical difference in treatment group(P>0.05).Conclusion Integrated Chinese-western therapy has curative effect on senile dementia,but it has good effect of Chinese medicine to treat Alzheimer’s disease,and can be widely used in clinic.
作者
何俊华
龚文蕾
梅建勇
夏雄
肖潇
刘红华
李迁
章茜
HE Junhua;GONG Wenlei;MEI Jianyong;XIA Xiong;XIAO Xiao;LIU Honghua;LI Qian;ZHANG Qian(Wuhan Huangpi District Hospital of Traditional Chinese Medicine,Wuhan 430300;Hubei Provincial Hospital of Traditional Chinese Medicine,Wuhan 430061;Hubei University of Chinese Medicine,Wuhan 430061)
出处
《湖北中医药大学学报》
2020年第3期30-32,共3页
Journal of Hubei University of Chinese Medicine
基金
武汉市卫计委科研项目(项目编号:WZ16D10)
关键词
老年性痴呆
补肾化瘀
载脂蛋白E
senile dementia
kidney-tonifying and stasis-removing
ApoE
