摘要
从临床试用“7505”治疗血吸虫病以来,已证实该药疗效较高,疗程较短,且较其它类型抗血吸虫病药物安全。为了进一步了解药物的副作用机理,不少单位进行了大量研究工作[1~3]。目前,正在为进一步降低其毒性,提高疗效,并探讨其代谢机理而开展多种实验研究,以期及早对该药作出全面鉴定后在临床推广应用。
We have studied the distribution of^(3)H-labelled schistosomicidal drug in mice by autoradiography.The^(3)H-labelled substances were found in quantities in liver and kidney and in successively decreasing amounts in brain,lung,heart,fat,testis,pancreas and spleen.In various cells the silver granules were present mainly in the cytoplasma but a few in the nucleus.After administration of this labelled schistosomicidal drug,the mice were killed and studied in groups successively at 4,8,24 hrs.No difference in the distribution of silver granules were observed.This fact indicated that,this drug was rapidly absorbed and highly concentrated with a long duration of reservation in liver.All of these favours the schistosomicidal effect of the drug.As this drug was so highly concentrated in the cytoplasm of liver cells,that might provide a pathophysiologic basis for the explanation of jaundice in the clinical practice.Moreover,the appearence of toxic reaction in nervous system may be related to the relatively high concentration of the drug distributed in the brain.
作者
汤灏
田鸿生
刘铭球
尹尧举
胡建民
周德贤
邹祖玉
Tang Hao;Tian Hongsheng;Liu Mingqiu;Yin Yaoju;Hu Jianmin;Zhou Dexian;Zou Zuyu(Department of Nuclear Medicine,Department of Pathology,Hubei Medical College)
出处
《解剖学报》
CAS
1981年第4期432-435,458,共5页
Acta Anatomica Sinica
