摘要
目的分析血清γ-谷氨酰转移酶(GGT)水平与急性ST段抬高型心肌梗死(STEMI)患者近期临床预后的相关性。方法纳入经皮冠状动脉介入治疗(PCI)的STEMI患者143例为研究对象,收集患者基本临床资料,检测常规生化指标及血清GGT水平。随访6个月,记录随访期间主要心脏不良事件发生情况,分析患者临床相关指标与主要心脏不良事件发生率的关系。结果143例患者中,经6个月随访,共发生心脏不良事件40例,其中心绞痛19例,非致死性心肌梗死12例,继发性心力衰竭7例,心源性休克2例。随访6个月ROC曲线下面积(AUC)为0.719(95%CI:0.673~0.861,P<0.05),截断点为29.03U/L。随访1、3、6个月时心脏不良事件发生率GGT≥29.03U/L组(24.56%,43.86%,47.37%)均明显高于GGT<29.03U/L组(8.14%,10.47%,15.12%),差异均有统计学意义(χ~2=7.379、21.094、17.698,P值均<0.05)。多因素logistic回归分析结果显示,随访1个月时,性别、Killi分级≥Ⅱ级与心脏不良事件发生有统计学关联(P值均<0.05),随访3个月和6个月时,Killi分级≥Ⅱ级和GGT均与心脏不良事件发生有统计学关联(P值均<0.05)。结论血清GGT水平与STEMI患者近期临床预后有关,可能对患者预后具有一定的预测价值。
Objective To analyze the correlation between serum gamma-glutamyltransferase(GGT)level and short-term clinical prognosis of patients with acute ST-segment elevation myocardial infarction(STEMI).Methods A total of 143 STEMI patients treated by percutaneous coronary intervention(PCI)in our hospital were included as study subjects.The basic clinical data of the patients were collected and the routine biochemical indexes and serum GGT levels were measured.During the follow-up period of 6 months,the major adverse cardiac events were recorded and the relationship between the clinical indicators and the incidence of major adverse cardiac events was analyzed.Results Among the 143 patients,40 had adverse cardiac events,19 had central colic,12 had non-fatal myocardial infarction,7 had secondary heart failure and 2 had cardiogenic shock in the 6-month follow-up period.The ROC curve analysis showed that AUC area under ROC curve was 0.719 in 6 months(95%CI:0.673-0.861,P<0.05),and the cut-off point was 29.03 U/L.At 1,3 and 6 month follow-up period,the incidences of adverse cardiac events in GGT≥29.03 U/L group(24.56%,43.86%and 47.37%,respectively)were significantly higher than those in GGT<29.03 U/L group(8.14%,10.47%and 15.12%,respectively),the differences were statistically significant(χ~2=7.379,21.094,17.698,all P<0.05).The results of multivariate logistic regression analysis showed that at 1 month follow-up,there was a statistical correlation between the incidence of adverse cardiac events and gender or Killi grade≥II(all P<0.05).At 3 and 6 months follow-up,Killi grade≥II and GGT were statistically correlated with the incidence of adverse cardiac events(all P<0.05).Conclusion Serum GGT level is related to the short-term clinical prognosis of STEMI patients,which has certain predictive value for the prognosis of STEMI patients.
作者
张超伟
王娟
赵争明
ZHANG Chao-wei;WANG Juan;ZHAO Zhe-ming(He′nan Provincial Hospital,He′nan Zhengzhou 450000,China)
出处
《江苏预防医学》
CAS
2020年第2期152-155,共4页
Jiangsu Journal of Preventive Medicine
关键词
谷氨酰转移酶
急性ST段抬高型心肌梗死
临床预后
相关性
Gamma-glutamyltransferase
Acute ST-segment elevation myocardial infarction
Prognosis
Correlation
