摘要
目的观察定频振动、正弦振动、随机振动等对大鼠失血性休克时生理功能的影响,为伤员转运、医疗后送中载具减振设计研究奠定基础。方法将32只大鼠通过横断脾实质复制非控制性失血性休克大鼠模型,随机分成4组:对照组(CG)、定频振动组(FG)、正弦振动组(SG)和随机振动组(RG)。将创伤休克大鼠模型分组置于振动平台,分别施加定频振动(8、16、32 Hz)、正弦振动(5~50 Hz)和随机振动(10~500 Hz),于实验0、15、30、45、60 min监测大鼠的平均动脉压、心率、呼吸频率、体温等生理指标,对照组观测相应时间点的上述指标,并在60 min实验结束时活杀大鼠,统计出血量。结果与对照组相比,特定固定频率振动使休克大鼠平均动脉压(45 min后)、心率(30 min后)显著下降,对呼吸频率的影响不显著;各振动条件均使创伤休克大鼠出血量增加。结论特定全身振动可引起创伤休克大鼠心率下降,出血量增多,对大鼠平均动脉压、呼吸频率、体温调节能力产生影响不确切;不同振动条件对创伤休克大鼠生理指标的影响不同。
Objective To observe the effects of vibration conditions(constant frequency vibration,sinusoidal vibration,and random vibration)on the physiological functions of rats with hemorrhagic shock.Methods A total of 32 rats with uncontrolled hemorrhagic shock(UHS)were randomly divided into 4 groups:control group(CG),constant frequency vibration group(FG),sinusoidal vibration group(SG)and random vibration group(RG).All the rat models of traumatic shock were used on the vibration platform,and were respectively subjected to constant frequency vibration(8,16,and 32 Hz),sinusoidal vibration(5-50 Hz)and random vibration(10-500 Hz).The mean arterial pressure(MAP),heart rate,respiratory rate,body temperature and other physiological indexes of the rats were recorded at 0(T0),15(T15),30(T30),45(T45)and 60 min(T60)after the test.The same physiological indexes of the control group were also recorded at the corresponding time.At the end of the experiment,the rats were sacrificed and the bleeding volume was counted.Results The constant frequency vibration significantly decreased the MAP(T45)and heart rate(T30)of the shock rats,but had no significant effect on respiratory frequency.Each of the vibration conditions increased the blood loss of rats with traumatic shock.Conclusion Specific whole-body vibration can lead to the decrease in heart rate and increase in blood loss in rats with trauma shock,which might affect the MAP,respiratory rate and thermoregulation ability of rats.Different types of vibration can bring about different effects on physiological indexes of rats with UHS.
作者
徐乾
周邦富
贺丽
肖南
XU Qian;ZHOU Bang⁃fu;HE Li;XIAO Nan(Institute of Surgery Research,Daping Hospital,Army Medical University(Third Military Medical University),Chongqing 400042,China)
出处
《军事医学》
CAS
北大核心
2020年第6期401-405,共5页
Military Medical Sciences
基金
国家重点实验室专项课题(SKLZZ201701)
关键词
振动
休克
生理功能
出血
vibration
shock
physiological function
hemorrhage
