摘要
目的探讨三维准连续动脉自旋标记(3D-pCASL)与动态增强磁共振成像(DCE-MRI)在鼻咽癌不同临床分期中的应用价值及相关性。方法回顾性分析45例经病理确诊的鼻咽癌首诊患者资料,分成高、低分期组。所有患者治疗前均行鼻咽部MRI平扫、3D-pCASL及DCE-MRI扫描,用后处理软件得到肿瘤血流量(TBF)与药代动力学参数容积转运常数(Ktrans)、速率常数(Kep)、血管外细胞外间隙容积分数(Ve)值。鼻咽癌高、低分期组间各参数差异采用独立样本t检验;TBF值与DCE参数间行Pearson相关分析;TBF值、DCE参数与鼻咽癌不同分期行采用Spearman相关分析;TBF值、DCE参数对不同分期的诊断效能行受试者工作特征(ROC)曲线分析。结果在鼻咽癌不同分期中高、低分期组TBF、Ktrans、Kep差异具有统计学意义(P<0.05),Ve值无统计学意义;TBF、Ktrans、Kep与不同分期间具有很好的相关性,Ve无相关性;TBF与Ktrans、Kep显著正相关,与Ve无相关性;TBF、Ktrans对不同分期具有很好的诊断效能,Ktrans略优于TBF。结论3D-pCASL与DCE-MRI均能很好地评估鼻咽癌灌注,并用于临床分期的预测,两者间具有显著的一致性,3D-pCASL是一种可供选择的无创评价鼻咽癌灌注水平的有效替代手段。
Objective To explore the application value and correlation of three-dimensional quasi-continuous arterial spin labeling(3 D pCASL)imaging and dynamic enhanced magnetic resonance imaging(DCE-MRI)in different clinical stages of nasopharyngeal carcinoma.Methods A retrospective analysis of 45 patients with nasopharyngeal carcinoma diagnosed by pathology was divided into high and low staging groups.All patients underwent MRI scans of the nasopharynx,3 D pCASL and DCE scans before treatment.Tumor blood flow(TBF)and pharmacokinetic parameters Ktrans,Kep,Ve values were obtained using post-processing software.The difference of each parameter between high and low stage nasopharyngeal carcinoma was analyzed by independent sample t test;Pearson correlation analysis between TBF value and DCE parameter;Spearman correlation analysis between TBF value,DCE parameter and different stage of nasopharyngeal carcinoma;the parameters were used to analyze the diagnostic efficacy of different stages by ROC curve analysis.Results The differences in TBF,Ktrans,and Kep in the high and low stage groups of nasopharyngeal carcinoma were statistically significant(P<0.05),and the Ve value was not statistically significant.TBF,Ktrans,and Kep had good correlations with different stages.There is no correlation between Ve and TBF.TBF is significantly positively correlated with Ktrans and Kep,and there is no correlation with Ve.TBF and Ktrans have good diagnostic efficacy for different stages,and Ktrans is slightly better than TBF.Conclusion Both 3 DpCASL and DCE-MRI can optimally evaluate nasopharyngeal carcinoma perfusion and are used to predict the clinical stage.There is significant consistency between the two.3 DpCASL is an alternative noninvasive method for evaluating the perfusion level of nasopharyngeal carcinoma.
作者
刘骏
钱银锋
朱娟
汪飞
杨擎
张泳
LIU Jun;QIAN Yinfeng;ZHU Juan(Department of Radiology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui Province 230022,P.R.China)
出处
《临床放射学杂志》
CSCD
北大核心
2020年第3期466-471,共6页
Journal of Clinical Radiology
基金
安徽省卫生和计划生育委员会科研计划项目(编号:2016QK094)
关键词
三维准连续动脉自旋标记
动态增强磁共振成像
鼻咽癌
肿瘤分期
Three-dimensional pseudo continuous arterial spin labeling
Dynamic contrast enhanced magnetic resonanceimaging
Nasopharyngeal carcinoma
Neoplasm staging
