摘要
目的:对比2%碳酸氢钠溶液和复方氯己定含漱液分别联合氟康唑治疗口腔念珠菌病的疗效。方法:选取114例口腔念珠菌感染患者,将其随机分为氟康唑联合2%碳酸氢钠溶液含漱治疗(A组),氟康唑联合复方氯己定含漱液治疗(B组),氟康唑联合生理盐水含漱治疗(C组),每组各38例。比较3组患者治疗后疼痛、口干、黏膜红斑或假膜等指标以及病损区念珠菌培养数量。结果:3组疗效对比,红斑假膜总有效率分别为92.11%,73.68%,71.05%,差异具有统计学意义(P<0.05);疼痛总有效率均为100%,差异不具有统计学意义(P>0.05);口干总有效率分别为94.74%,76.32%,73.68%,差异具有统计学意义(P<0.05);菌检总有效率分别为97.3%,81.58%,78.95%,差异具有统计学意义(P<0.05)。结论:氟康唑联合2%碳酸氢钠溶液治疗口腔念珠菌病效果优于氟康唑联合复方氯己定含漱液治疗效果。
Objective:To compare the efficacy of fluconazole combined with 2%sodium bicarbonate solution and compound chlorhexidine gargle respectively for oral candidosis treatment.Methods:Totally 114 patients with oral candida infection were randomly divided into group A of fluconazole combined with 2%sodium bicarbonate solution gargle,group B of fluconazole combined with compound chlorhexidine gargle and group C of fluconazole combined with physiological saline solution,with 38 cases in each group.The reduction of pain,dry mouth,mucous erythema or pseudomembrane and the number of candida in lesion area after treatment were compared.Results:By comparing group A,B and C,the total effective rate of mucous erythema pseudomembrane was 92.11%,73.68%and 71.05%(P<0.05).The total effective rate of pain was 100%respectively(P>0.05).The total effective rate of dry mouth was 94.74%,76.32%and 73.68%(P<0.05).The total effective rate was 97.3%,81.58%and 78.95%(P<0.05).Conclusion:Fluconazole combined with 2%sodium bicarbonate solution is better than fluconazole combined with compound chlorhexidine gargle in the treatment of oral candidosis.
作者
徐健
XU Jian(Aviation General Hospital,Department of Stomatology,Beijing 100012,China.)
出处
《临床口腔医学杂志》
2020年第3期171-174,共4页
Journal of Clinical Stomatology
