摘要
Gout is an independent risk factor for hypertension,diabetes mellitus,hyperlipidemia,coronary heart disease and cerebral infarction.At present,the studies on the mechanism of gout at home and abroad have mainly focused on immune inflammation,gene polymorphism and related studies.Uric acid deposition or crystal precipitation activates phagocytes,fibroblasts and mast cells in synovium,produces IL-1β,TNF and chemokine IL-8(CXCL8),thereby activating neutrophils,urate crystal polyanion surface can be coated with immunoglobulins and other serum proteins as substrates for complement activation,complement substitution pathways and classical complement pathways to activate complements.Uric acid crystals activate inflammation-related signal transduction pathways including the activation of inflammation-related signal transduction pathway by uric acid crystals and TLRS/MyD88 signal transduction pathways.Gene polymorphism is related to inflammation and signaling pathway,EGF gene is closely related to gout inflammation,which may be involved in the regulation of gout inflammation,among which NLRP3 inflammatory signaling pathway and gene polymorphism have been deeply studied in the pathogenesis of gout,which is the main therapeutic target of anti-inflammatory and uric acid lowering.
Gout is an independent risk factor for hypertension, diabetes mellitus, hyperlipidemia, coronary heart disease and cerebral infarction. At present, the studies on the mechanism of gout at home and abroad have mainly focused on immune inflammation, gene polymorphism and related studies. Uric acid deposition or crystal precipitation activates phagocytes, fibroblasts and mast cells in synovium, produces IL-1β, TNF and chemokine IL-8(CXCL8), thereby activating neutrophils, urate crystal polyanion surface can be coated with immunoglobulins and other serum proteins as substrates for complement activation, complement substitution pathways and classical complement pathways to activate complements. Uric acid crystals activate inflammation-related signal transduction pathways including the activation of inflammation-related signal transduction pathway by uric acid crystals and TLRS/MyD88 signal transduction pathways. Gene polymorphism is related to inflammation and signaling pathway, EGF gene is closely related to gout inflammation, which may be involved in the regulation of gout inflammation, among which NLRP3 inflammatory signaling pathway and gene polymorphism have been deeply studied in the pathogenesis of gout, which is the main therapeutic target of anti-inflammatory and uric acid lowering.
基金
Supported by Six Peak Talents Projects in Jiangsu Province on Clinical Application of HuRAT1 Combined with ABCG2 Gene Detection in Predicting Hyperuricemia/Gout Susceptibility(2015-WSN-089)
Research Projects of Traditional Chinese Medicine of Wuxi Municipal Health Commission on Mechanisms of Bixie Drink on Neutrophils and Inflammatory Signal Transduction Pathway of NLRP3 in Gout Model Rats(ZYZL201803).
