摘要
目的:探讨凉血活血法改善溃疡性肠炎患者肠道菌群状态及黏膜修复的效果。方法:选取2018年1月~2019年6月我院收治的72例溃疡性肠炎患者为研究对象,将接受活血凉血法治疗方案治疗的患者纳入观察组(36例),将接受常规西药治疗方案的患者纳入对照组(36例)。比较两组临床疗效及治疗前后肠道菌群变化、肠黏膜功能改善情况、Mayo评分和Baron内镜评分、血清炎症因子水平变化。结果:观察组临床有效率(94.44%)显著高于对照组(72.22%),差异具有统计学意义(P<0.05)。经过治疗后,两组患者的Mayo评分和Baron内镜评分较治疗前均显著降低,粪便中的双歧杆菌、乳酸杆菌的含量显著升高,大肠杆菌含量显著降低,血清TNF-α、IL-6、IL-8、内毒素、D-乳酸、降钙素原水平较治疗前均显著降低,差异均具有统计学意义(P<0.05)。经过治疗后,观察组患者的Mayo评分和Baron内镜评分均显著低于对照组,患者粪便中的双歧杆菌、乳酸杆菌的含量显著高于对照组,大肠杆菌含量显著低于对照组,患者血清TNF-α、IL-6、IL-8、内毒素、D-乳酸、降钙素原水平均显著低于对照组,差异均具有统计学意义(P<0.05)。结论:凉血活血法治疗溃疡性肠炎疗效显著,能够调节患者肠道菌群状态,减轻炎症反应,修复肠道黏膜功能,值得临床推广。
Objective:To explore the effect of cooling blood and activating blood circulation method on improving intestinal flora status and mucosal repair for patients with ulcerative colitis.Methods:72 patients with ulcerative colitis admitted to our hospital from January 2018 to June 2019 were selected.Patients who received treatment regimen of cooling blood and activating blood circulation were assigned to the observation group(36 cases),and patients who received treatment regimen of conventional western medicine were assigned to the controlled group(36 cases).The clinical efficacy,changes of intestinal flora,improvement of intestinal mucosal function,Mayo and Baron endoscopy scores,changes in serum inflammatory factors before and after treatment were compared between the two groups.Results:The clinical effective rate in the observation group(94.44%)was significantly higher than that in the controlled group(72.22%),above had statistical difference(P<0.05).After treatment,the Mayo and Baron endoscopy scores in two groups significantly decreased,the contents of Bifidobacteria and Lactobacillus in feces were significantly increased,the contents of Escherichia coli were significantly decreased,and the serum levels of TNF-α,IL-6,IL-8,endotoxin,D-lactic acid and procalcitonin were significantly decreased,all above had statistical difference(P<0.05).After treatment,the Mayo and Baron endoscopy scores in the observation group were significantly lower than those in the controlled group,the contents of Bifidobacteria and Lactobacillus in feces were significantly higher than those in the controlled group,the contents of Escherichia coli was significantly lower than that in the controlled group,the serum levels of TNF-α,IL-6,IL-8,endotoxin,D-lactic acid and procalcitonin were significantly lower than those in the controlled group,all above had statistical difference(P<0.05).Conclusion:The method of cooling blood and activating blood circulation is effective in the treatment of ulcerative colitis,which could regulate the status of intestinal flora,reduce inflammation,and repair intestinal mucosa function.It is worthy of clinical promotion.
作者
沈青
冯敏晓
SHEN Qing;FENG Minxiao(Suining Municipal Hospital of Traditional Chinese Medicine,Suining Sichuan 629000,China;Department of Spleen and Stomach,Zhangjiagang Hospital of Traditional Chinese Medicine,Zhangjiagang Jiangsu 215600,China)
出处
《四川中医》
2023年第2期111-115,共5页
Journal of Sichuan of Traditional Chinese Medicine
基金
苏州市科技发展计划项目(编号:SYSD2017007)
关键词
溃疡性肠炎
凉血活血法
肠道菌群
肠黏膜功能
炎症反应
Ulcerative colitis
Cooling blood and activating blood circulation method
Intestinal flora
Intestinal mucosa function
Inflammation
