摘要
目的观察连续性血液净化对治疗肝衰竭合并肝性脑病患者的临床效果。方法选取我院2018年6月-2020年6月60例肝衰竭合并肝性脑病患者作为研究对象,按照随机数字表法分为观察组(血浆置换+连续性血液净化)与对照组(血浆置换),每组各30例。比较两组患者治疗前后肝功能指标,比较治疗效果及不良反应发生率。结果两组患者ALT、TBIL、INR值治疗后均低于治疗前,PTA高于治疗前,差异有统计学意义(P<0.05),两组间治疗后比较观察组ALT、TBIL、INR低于对照组,PTA高于对照组,差异有统计学意义(P<0.05);两组患者总有效率比较观察组高于对照组(93.3%vs 70.0%),差异有统计学意义(P<0.05);观察组不良反应的6.7%(2/30)低于对照组的26.7%(8/30),差异有统计学意义(P<0.05)。结论连续性血液净化应用于肝衰竭合并肝性脑病,在提升患者肝功能方面有着突出效果,不良反应少,疗效确切。
Objective This paper aims to observe the clinical effect of continuous blood purification treatment on the patients with liver failure combined with hepatic encephalopathy.Methods From June 2018 to June 2020,60 patients with liver failure and hepatic encephalopathy in our hospital were selected as the research objects.According to the random number table method,the patients were divided into two groups,observation group(plasma exchange+continuous blood purification)and control group(plasma replacement),30 cases in each group.The liver function indexes before and after treatment were compared between the two groups,the treatment effect and the incidence of adverse reactions were compared.Results The ALT,TBIL,and INR values of the two groups of patients after treatment were lower than that before treatment,and the PTA was higher than that before treatment.The difference was statistically significant(P<0.05).After treatment,the ALT,TBIL and INR of the observation group were low.In the control group,PTA was higher than that of the control group,the difference was statistically significant(P<0.05);the total effective rate of the two groups was higher than that of the control group(93.3%vs 70.0%),which was statistically significant(P<0.05);6.7%(2/30)of adverse reactions in the observation group were lower than 26.7%(8/30)in the control group,the difference was statistically significant(P<0.05).Conclusion Continuous blood purification applied to liver failure and hepatic encephalopathy has outstanding effects in improving the liver function of patients,with few adverse reactions and definite curative effects,which can be promoted.
作者
张志成
谭荣兴
熊述
ZHANG Zhi-cheng;TAN Rong-xing;XIONG Shu(Department of Critical Care,the Ninth Hospital of Nanchang,Nanchang Jiangxi 330002,China)
出处
《透析与人工器官》
2021年第1期18-20,24,共4页
Chinese Journal of Dialysis and Artificial Organs
基金
江西省卫生计生委科技计划(No.20167056)
关键词
连续性血液净化
肝衰竭
肝性脑病
肝功能
不良反应
continuous blood purification
liver failure
hepatic encephalopathy
liver function
adverse reactions
