摘要
目的探讨电针治疗对职业性噪声聋(ONID)并发抑郁症状患者皮质醇与炎性因子水平的影响。方法采用随机数表法将78例ONID伴发抑郁症状患者分为对照组(40例)和电针组(38例)。对照组患者予常规治疗,治疗组患者在对照组基础上加用电针治疗,隔天1次,每周治疗3次,连续治疗4周。比较2组患者治疗前后唾液皮质醇水平及血清中皮质醇、白细胞介素(IL)-6、肿瘤坏死因子-α(TNF-α)及C反应蛋白(CRP)的水平。结果治疗前,2组患者早晨、晚间唾液皮质醇水平和血清的皮质醇、IL-6、TNF-α、CRP的水平分别比较,差异均无统计学意义(P>0.05)。电针组患者治疗后血清皮质醇水平较同组治疗前下降(P<0.01);对照组和电针组患者治疗后早晨、晚间唾液皮质醇及血清皮质醇水平分别与同组治疗前比较,差异均无统计学意义(P>0.05)。电针组患者治疗后血清中IL-6和TNF-α水平均低于同组治疗前及对照组治疗后(P<0.01)。结论电针治疗可降低ONID伴发抑郁症状患者血清TNF-α和IL-6水平;电针对炎性因子的调节可能是治疗ONID并发的抑郁症状的作用机制之一。
Objective To explore the effect of electroacupuncture treatment on the levels of cortisol and immune factors in patients with occupational noise-induced deafness(ONID)combined with depressive symptoms.Methods A total of 78 ONID patients combined with depressive symptoms were randomly divided into control group(40 cases)and electroacupuncture group(38 cases)by a random number table method.The control group received routine therapy,while the electroacupuncture group was treated with routine therapy plus electroacupuncture on alternate days,3 times a week for 4 consecutive weeks.The levels of salivary cortisol,as well as the serum levels of cortisol,tumor necrosis factor alpha(TNF-α),interleukin-6(IL-6)and C-reactive protein(CRP)of the two groups were observed and compared before and after treatment.Results Before treatment,the levels of saliva cortisol in the morning and night,and the serum levels of cortisol,IL-6,TNF-αand CRP in the two groups were compared,and the differences were not statistically significant(P>0.05).After treatment,the serum cortisol level of patients in electroacupuncture group reduced than that before treatment in the same group(P<0.05).However,there was no significant difference in the levels of salivary cortisol in the morning and night,and serum cortisol before and after treatment both in control group and electroacupuncture group(P>0.05).After treatment,the serum levels of IL-6 and TNF-αdecreased in electroacupuncture group as compared with those before treatment and those after treatment in control group(P<0.01).Conclusion Electroacupuncture treatment could reduce the levels of TNF-αand IL-6 in serum of ONID patients combined with depressive symptoms.The regulation of electroacupuncture on the inflammatory cytokines may be one of the mechanisms in treating ONID combined with depressive symptoms.
作者
邓小峰
罗巧
赖丽丽
郑莹
康滢
徐琳
杨爱初
DENG Xiaofeng;LUO Qiao;LAI Lili;ZHENG Yin;KANG Yin;XU Ling;YANG Aichu(Guangdong Province Hospital for Occupational Disease Prevention and Treatment,Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment,Guangzhou,Guangdong 510300,China)
出处
《中国职业医学》
CAS
北大核心
2020年第3期324-328,共5页
China Occupational Medicine
基金
国家临床重点专科建设项目(2011-09)
广东省中医药局面上科研项目(20191048)
广东省医学科学技术研究基金(B2018211)
广东省职业病防治重点实验室(2017B030314152)
关键词
电针
职业性噪声聋
抑郁
合并症
皮质醇
白细胞介素-6
肿瘤坏死因子-α
C反应蛋白
炎性因子
Electroacupuncture
Occupational noise-induced deafness
Depression
Cortisol
Interleukin-6
Tumor necrosis factor-α
C-reactive protein
Inflammatory cytokine
