摘要
目的比较经导管肝动脉灌注化疗(hepatic arterial perfusion chemotherapy,HAIC)与全身化疗在肝继发性恶性肿瘤(secondary malignant tumor of liver,LSM)治疗中的生存率。方法选取2021年1月至2022年9月国药东风总医院收治的49例LSM患者作为研究对象,按照治疗方法不同分为HAIC组(n=25)和全身化疗组(n=24)。以首次HAIC或全身化疗为起点,以患者死亡或截至随访时间为终点,随访截止时间为2022年11月14日。采用Kaplan-Meier法进行生存分析,Log-rank检验结果的组间差异;采用Cox回归模型进行多因素分析。结果HAIC组肿瘤客观缓解率为28.00%,肿瘤控制率为84.00%,全身化疗组分别为16.67%、50.00%,两组肿瘤客观缓解率比较,差异无统计学意义(P>0.05),两组肿瘤控制率比较,差异有统计学意义(P<0.05)。HAIC组3个月、6个月、1年的总生存率(overall survival rate,OS)分别为100.00%、68.00%、32.00%,全身化疗组分别为66.67%、33.33%、4.17%,两组OS的差异有统计学意义(P=0.034);HAIC组3个月、6个月、1年无进展生存率(progression-free survival,PFS)分别为96.00%、68.00%、32.00%,全身化疗组分别为45.83%、29.17%、4.17%,两组PFS的差异有统计学意义(P<0.05)。Cox回归分析显示,治疗方法是OS、PFS的独立预后因素。结论HAIC化疗可显著延长LSM患者的生存时间。
Objective To compare the survival rates of hepatic arterial perfusion chemotherapy(HAIC)and systemic chemotherapy in the treatment of secondary malignant tumors of the liver(LSM).Methods Forty-nine patients with LSM who were admitted to the Sinopharm Dongfeng General Hospital from January 2021 to September 2022 were selected and divided into HAIC(n=25)and systemic chemotherapy groups(n=24).The first HAIC or systemic chemotherapy administration was designated as the starting point and patient death or the last follow-up evaluation was designated as the endpoint.The follow-up deadline was 14 November 2022.The Kaplan-Meier method and log-rank test results were used to compare differences between the groups.Multivariate analysis was performed using a Cox regression model.Results Objective response rate(ORR)and tumor control rate(TCR)of HAIC group were 28.00%and 84.00%,respectively,those of systemic chemotherapy group were 16.67%and 50.00%,respectively,the ORR between the two groups was no significantly different(P>0.05),the TCR between the two groups was significantly different(P<0.05).The HAIC and systemic chemotherapy group overall survival(OS)rates in 3 months,6 months,and after 1 year were 100.00%,68.00%,32.00%,and 66.67%,33.33%,4.17%,respectively.The OS rates between the two groups were significantly different(P<0.05).The HAIC and systemic chemotherapy group progression-free survival(PFS)rates at 3 months,6 months,and after 1 year were 96.00%,68.00%,32.00%,and 45.83%,29.17%,and 4.17%,respectively.The PFS rates between the two groups were significantly different(P<0.05).Cox regression model showed therapeutic method was independent prognosis factor for OS and PFS.Conclusions HAIC can significantly prolong the survival time of patients with LSMs compared to systemic chemotherapy.
作者
聂今
郭俊
NIE Jin;GUO Jun(Jinzhou Medical University Sinopharm Dongfeng General Hospital Graduate Training Base,Shiyan,Hubei 442001,China;不详)
出处
《慢性病学杂志》
2023年第5期653-658,664,共7页
Chronic Pathematology Journal
关键词
经导管肝动脉灌注化疗
肝继发性恶性肿瘤
生存分析
Hepatic arterial perfusion chemotherapy
Secondary malignancies of the liver
Survival analysis
