摘要
中西药联合使用在临床上是常见的。环丙沙星是治疗感染性疾病最常用的氟喹诺酮类药物之一,为提高感染性疾病的治疗效果或应对同时患多种疾病的患者,环丙沙星与一种或多种中药合并使用的现象较为普遍。中药与环丙沙星联用产生的中药-药物相互作用(herb-drug interaction,HDI)可能起到增效减毒的积极作用,也可能导致治疗失败或者发生不良反应。环丙沙星在体内的吸收(absorption,A)、分布(distribution,D)、代谢(metabolism,M)、排泄(excretion,E)等过程,是发生HDI的主要环节。药物代谢酶和转运体对环丙沙星ADME过程的影响近年来备受关注。因此,分别从药物代谢酶、转运体角度对常用中药与环丙沙星之间的直接/潜在相互作用及其作用机制进行综述,以期从药动学方面为环丙沙星与中药的临床合理使用提供依据。
The combination of Chinese and Western medicine is common in clinical practice.Ciprofloxacin is one of the most commonly used fluoroquinolones for the treatment of infectious diseases.In order to improve the therapeutic effect of infectious diseases or cope with patients with multiple diseases at the same time,the combination of ciprofloxacin with one or more traditional Chinese medicines is more common.The herb-drug interactions produced by the combination of Chinese materia medica and ciprofloxacin may play an active role in increasing efficacy and reducing toxicity,and may also lead to treatment failure or adverse reactions.The herb-drug interaction mechanisms will occur in the course of absorption(A),distribution(D),metabolism(M),and excretion(E).The effects of drug-metabolizing enzymes and transporters on the ADME process of ciprofloxacin have received much attention in recent years.Therefore,this paper reviews the potential interaction between common Chinese medicine and ciprofloxacin from the perspective of drug-metabolizing enzymes and transporters.It is expected to provide the basis on the rational use of ciprofloxacin and Chinese materia medica.
作者
张小莉
李自强
黄宇虹
刘昌孝
ZHANG Xiao-li;LI Zi-qiang;HUANG Yu-hong;LIU Chang-xiao(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300150,China;Tianjin Institute of Pharmaceutical Research,Tianjin 300462,China)
出处
《中草药》
CAS
CSCD
北大核心
2020年第5期1324-1335,共12页
Chinese Traditional and Herbal Drugs
基金
天津市科技计划项目(17ZXXYSY00060)
天津市自然科学基金项目(18JCQNJC83800)
天津市卫计委项目(2017144)
国家科技部“十三五”重大新药创制项目(2018ZX09734-002)
国家自然科学基金资助项目(81703861).
关键词
代谢酶
转运体
中药
环丙沙星
药物相互作用
metabolic enzymes
transporters
Chinese materia medica
ciprofloxacin
drug interaction
