Field training is the backbone of the teacher-preparation process.Its importance stems from the goals that colleges of education aim to achieve,which include bridging the gap between theory and practice and aligning w...Field training is the backbone of the teacher-preparation process.Its importance stems from the goals that colleges of education aim to achieve,which include bridging the gap between theory and practice and aligning with contemporary educational trends during teacher training.Currently,trainee students attendance in field training is recordedmanually through signatures on attendance sheets.However,thismethod is prone to impersonation,time wastage,and misplacement.Additionally,traditional methods of evaluating trainee students are often susceptible to human errors during the evaluation and scoring processes.Field training also lacks modern technology that the supervisor can use in case of his absence from school to monitor the trainee students’implementation of the required activities and tasks.These shortcomings do not meet the needs of the digital era that universities are currently experiencing.As a result,this paper presents a smart management system for field training based on Internet of Things(IoT)and mobile technology.It includes three subsystems:attendance,monitoring,and evaluation.The attendance subsystem uses an R307 fingerprint sensor to record trainee students’attendance.The Arduino Nano microcontroller transmits attendance data to the proposed Android application via an ESP-12F Wi-Fi module,which then forwards it to the Firebase database for storage.The monitoring subsystem utilizes Global Positioning System(GPS)technology to continually track trainee students’locations,ensuring they remain at the school during training.It also enables remote communication between trainee students and supervisors via audio,video,or text by integrating video call and chat technologies.The evaluation subsystem is based on three items:an online exam,attendance,and implementation of required activities and tasks.Experimental results have demonstrated the accuracy and efficiency of the proposed management system in recording attendance,as well as in monitoring and evaluating trainee students during field traiing.展开更多
App reviews are crucial in influencing user decisions and providing essential feedback for developers to improve their products.Automating the analysis of these reviews is vital for efficient review management.While t...App reviews are crucial in influencing user decisions and providing essential feedback for developers to improve their products.Automating the analysis of these reviews is vital for efficient review management.While traditional machine learning(ML)models rely on basic word-based feature extraction,deep learning(DL)methods,enhanced with advanced word embeddings,have shown superior performance.This research introduces a novel aspectbased sentiment analysis(ABSA)framework to classify app reviews based on key non-functional requirements,focusing on usability factors:effectiveness,efficiency,and satisfaction.We propose a hybrid DL model,combining BERT(Bidirectional Encoder Representations from Transformers)with BiLSTM(Bidirectional Long Short-Term Memory)and CNN(Convolutional Neural Networks)layers,to enhance classification accuracy.Comparative analysis against state-of-the-art models demonstrates that our BERT-BiLSTM-CNN model achieves exceptional performance,with precision,recall,F1-score,and accuracy of 96%,87%,91%,and 94%,respectively.Thesignificant contributions of this work include a refined ABSA-based relabeling framework,the development of a highperformance classifier,and the comprehensive relabeling of the Instagram App Reviews dataset.These advancements provide valuable insights for software developers to enhance usability and drive user-centric application development.展开更多
Wearable sensing systems have been designed to monitor health conditions in real-time by detecting analytes in human biofluids.Wound diagnosis remains challenging,necessitating suitable materials for high-performance ...Wearable sensing systems have been designed to monitor health conditions in real-time by detecting analytes in human biofluids.Wound diagnosis remains challenging,necessitating suitable materials for high-performance wearable sensors to offer prompt feedback.Existing devices have limitations in measuring pH and the concentration of pH-dependent electroactive species simultaneously,which is crucial for obtaining a comprehensive understanding of wound status and optimizing biosensors.Therefore,improving materials and analysis system accuracy is essential.This article introduces the first example of a flexible array capable of detecting pyocyanin,a bacterial virulence factor,while correcting dynamic pH fluctuations.We demonstrate that this combined sensor enhances accuracy by mitigating the impact of pH variability on pyocyanin sensor response.Customized screen-printable inks were developed to enhance analytical performance.The analytical performances of two sensitive sensor systems(i.e.,fully-printed porous graphene/multiwalled carbon nanotube(CNT)and polyaniline/CNT composites for pyocyanin and pH sensors)are evaluated.Partial least square regression is employed to analyze nonzero-order data arrays from square wave voltammetric and potentiometric measurements of pyocyanin and pH sensors to establish a predictive model for pyocyanin concentration in complex fluids.This sensitive and effective strategy shows potential for personalized applications due to its affordability,ease of use,and ability to adjust for dynamic pH changes.展开更多
Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic nerve.Still,it is unknown whether olfactory enshea...Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic nerve.Still,it is unknown whether olfactory ensheathing glia also have neuroprotective properties.Olfactory ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion cells.Therefore,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve crush.Olfactory ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive treatments.Anatomical and gene expression analyses were performed.Olfactory bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡmolecules.Allogeneically and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an epimembrane.In axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 days.In these retinas,microglial anatomical activation was higher than after optic nerve crush alone.In intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or immunosuppression.However,neuroprotection of axotomized retinal ganglion cells did not improve with these treatments.The different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.展开更多
Lifestyle and demographics of the world's population are causing serious health problems impacting the brain,increasing the incidence of Alzheimer's disease(AD)and other types of dementia.Although we have gain...Lifestyle and demographics of the world's population are causing serious health problems impacting the brain,increasing the incidence of Alzheimer's disease(AD)and other types of dementia.Although we have gained important insights into the pathogenic mechanisms of AD,only palliative care is available to patients.AD is characterized by the abnormal deposition of protein aggregates in the brain formed by amyloid β and hyper-phosphorylated,Tau in addition to neuroinflammation.展开更多
Aqueous zinc-halogen batteries are promising candidates for large-scale energy storage due to their abundant resources,intrinsic safety,and high theoretical capacity.Nevertheless,the uncontrollable zinc dendrite growt...Aqueous zinc-halogen batteries are promising candidates for large-scale energy storage due to their abundant resources,intrinsic safety,and high theoretical capacity.Nevertheless,the uncontrollable zinc dendrite growth and spontaneous shuttle effect of active species have prohibited their practical implementation.Herein,a double-layered protective film based on zinc-ethylenediamine tetramethylene phosphonic acid(ZEA)artificial film and ZnF2-rich solid electrolyte interphase(SEI)layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic optimization.The ZEA-based artificial film shows strong affinity for the ZnF2-rich SEI layer,therefore effectively suppressing the SEI breakage and facilitating the construction of double-layered protective film on the zinc metal anode.Such double-layered architecture not only modulates Zn2+flux and suppresses the zinc dendrite growth,but also blocks the direct contact between the metal anode and electrolyte,thus mitigating the corrosion from the active species.When employing optimized metal anodes and electrolytes,the as-developed zinc-(dual)halogen batteries present high areal capacity and satisfactory cycling stability.This work provides a new avenue for developing aqueous zinc-(dual)halogen batteries.展开更多
BACKGROUND In the absence of effective antimicrobials,transplant surgery is not viable,and antirejection immunosuppressants cannot be administered,as resistant infections compromise the life-saving goal of organ trans...BACKGROUND In the absence of effective antimicrobials,transplant surgery is not viable,and antirejection immunosuppressants cannot be administered,as resistant infections compromise the life-saving goal of organ transplantation.AIM To evaluate the efficacy of antimicrobials in preventing resistance in solid organ transplant recipients.METHODS A systematic review was conducted using a search methodology consistent with the preferred reporting items for systematic reviews and meta-analyses.This review included randomized clinical trials that evaluated the efficacy of antimicrobial agents(prophylactic or therapeutic)aimed at preventing antimicrobial resistance.The search strategy involved analyzing multiple databases,including PubMed/MEDLINE,Web of Science,Embase,Scopus,and SciELO,as well as examining gray literature sources on Google Scholar.A comprehensive electronic database search was conducted from the databases’inception until May 2024,with no language restrictions.RESULTS After the final phase of the eligibility assessment,this systematic review ultimate-ly included 7 articles.A total of 2318 patients were studied.The most studied microorganisms were cytomegalovirus,although vancomycinresistant enterococci,Clostridioides difficile,and multidrug-resistant Enterobacterales were also analyzed.The antimicrobials used in the interventions were mainly maribavir,valganciclovir,gancic-lovir,and colistin-neomycin.Of concern,all clinical trials showed significant proportions of resistant microorga-nisms after the interventions,with no statistically significant differences between the groups(mean resistance 13.47%vs 14.39%),except for two studies that demonstrated greater efficacy of maribavir and valganciclovir(mean resistance 22.2%vs 41.1%in the control group;P<0.05).The total reported deaths in three clinical trials were 75,and there were 24 graft rejections in two studies.CONCLUSION All clinical trials reported significant proportions of antimicrobial-resistant microorganisms following interventions.More high-quality randomized clinical trials are needed to corroborate these results.展开更多
Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent bioc...Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic stroke.However,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery efficiency.By utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly improved.Furthermore,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic stroke.Small extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke therapy.In this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification methodologies.Given the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment process.Moreover,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.展开更多
Objective: The importance of culture in nursing lies in its influence on patients’ health perceptions, behaviors, and responses to care. Despite the challenges posed by the complexity of studying culture, there remai...Objective: The importance of culture in nursing lies in its influence on patients’ health perceptions, behaviors, and responses to care. Despite the challenges posed by the complexity of studying culture, there remains a critical need to develop cultural competence in nursing. This study investigated how nursing students in rural Indonesia enhance their cultural competence through education and practice. Methods: This study employed a qualitative descriptive phenomenological approach. It conducted face-to-face interviews with 32 students across 6 regions, selected purposively. Thematic analysis was employed to evaluate the results. Results: Five themes emerge in this research: perceptions of cultural competence, learning cultural competence in the classroom, practical experience, learning expectations related to cultural competence, and cultural learning barriers. Conclusions: Enhancing cultural competence necessitates enriched curricula, adept clinical mentors, and continual student evaluation. This iterative assessment informs tailored strategies for nurturing cultural proficiency.展开更多
BACKGROUND Ovarian hyperstimulation syndrome(OHSS)is a life-threatening complication that can occur in the luteal phase or early pregnancy after controlled ovarian stimulation.This case report highlights a unique mani...BACKGROUND Ovarian hyperstimulation syndrome(OHSS)is a life-threatening complication that can occur in the luteal phase or early pregnancy after controlled ovarian stimulation.This case report highlights a unique manifestation of OHSS involving pleural effusion(PE)in a patient without identifiable risk factors.CASE SUMMARY A 39-year-old woman who underwent controlled ovarian hyperstimulation for an in vitro fertilization(IVF)cycle experienced dyspnea on the eleventh day of post oocyte retrieval.The diagnosis was severe OHSS with a unique manifestation of PE without ascites.Clinical management involved fluid balance and treatment with albumin,furosemide,thromboembolic prophylaxis,and thoracentesis.A continued drainage of the pleural cavity was performed.The patient had a favo-rable outcome,and a dichorionic diamniotic gestation passed without incident.CONCLUSION OHSS and its potential complications can include respiratory distress and PE,as well as thromboembolic disorders.展开更多
Objective:To evaluate the antioxidant activity of Kaempferia(K.)parviflora rhizome extract and study its protective effect against male reproductive impairment induced by fenitrothion.Methods:The phytochemicals and an...Objective:To evaluate the antioxidant activity of Kaempferia(K.)parviflora rhizome extract and study its protective effect against male reproductive impairment induced by fenitrothion.Methods:The phytochemicals and antioxidant properties of K.parviflora ethanolic extract were assessed.Twenty-four male mice aged 4-weeks-old were assigned into four groups.Groups 1 to 4 respectively received extra virgin olive oil(served as the vehicle control),20 mg/kg body weight(bw)of fenitrothion,50 mg/kg bw of K.parviflora ethanolic extract,and 50 mg/kg bw of K.parviflora ethanolic extract plus 20 mg/kg bw of fenitrothion.Upon completion of 28 days of continuous feeding treatment,the mice were subjected to mating evaluation and the assessment of epididymal sperm quality,lipid peroxidation,testosterone level and histological evaluation.Results:Eight phytochemical compounds were detected in the ethanolic extract of K.parviflora via GC-MS.The extract exhibited a DPPH radical scavenging activity with an EC50 value of(0.870±0.007)mg/mL.Mice fed with fenitrothion in group 2 displayed an increase in relative testis weight,lipid peroxidation levels and a significant reduction in all sperm parameters(sperm concentration,progressive motility,and viability),as well as serum testosterone levels compared to the control mice in group 1(P<0.05).On the other hand,mice fed with K.parviflora ethanolic extract in group 3 showed a significant increase in serum testosterone levels compared to group 1.Mice co-administered with K.parviflora ethanolic extract and fenitrothion in group 4 exhibited a significant improvement in testosterone levels,sperm concentration,motility,and viability compared to the mice administered only with fenitrothion in group 2(P<0.05).Histological analysis of testicular tissue from group 4 further revealed improved testicular morphology in comparison to fenitrothion-treated mice.Conclusions:Eight bioactive compounds were identified in K.parviflora ethanolic extract and the extract exhibited antioxidative properties.Fenitrothion administration impairs testicular function,reducing sperm parameters and testosterone while increasing lipid peroxidation.However,K.parviflora ethanolic extract coadministration alleviates oxidative stress,improves sperm parameters and testosterone levels,and enhances testicular morphology.These findings suggest that K.parviflora ethanolic extract has the therapeutic potential in mitigating male reproductive adverse effects induced by fenitrothion.展开更多
Oxidized cholesterol(OXC)is a harmful dietary substance.Although the consumption of OXC has been associated with colonic inflammation,related underlying mechanisms are still limited.We evaluated the influence of dieta...Oxidized cholesterol(OXC)is a harmful dietary substance.Although the consumption of OXC has been associated with colonic inflammation,related underlying mechanisms are still limited.We evaluated the influence of dietary OXC on gut health and ecology by applying the murine model.Results showed that the thickness of the mucus layer was significantly reduced in healthy mice treated with OXC.Short-term intake of OXC did not influence the expression of pro-inflammatory factors in healthy mice but it induced the decrease of Muc2 expression in the proximal colon,accompanied by an increase in the abundance of 2 mucusdegrading bacteria,namely Akkermansia muciniphila and Bacteroides acidifaciens.Consistently,oral exposure of OXC promoted mucus barrier erosion in dextran sulfate sodium(DSS)-induced colitis mice and facilitated bacteria infiltration in the colon.The adverse effect of OXC on mucus layer disappeared in antibiotics-treated healthy mice,suggesting that the damaging effect of OXC on the gut mucus layer was not direct and instead was mediated by causing microbiota dysbiosis.Finally,the impact of OXC on the mucus layer and colitis was partly alleviated by green tea catechins.These studies demonstrated that the OXC-induced mucus barrier damage was mainly induced by the dysregulation of gut microbiota at least in this mouse model.展开更多
Natural rubber(NR)foams are widely used.However,further studies are required for preparing eco-friendly NR foam and determining the optimum physical properties appropriate for application.This study aims to create an ...Natural rubber(NR)foams are widely used.However,further studies are required for preparing eco-friendly NR foam and determining the optimum physical properties appropriate for application.This study aims to create an NR foam from rubber reinforced with sugarcane bagasse ash(SCBA)and sodium alginate.The results showed that the SCBA was primarily composed of silica or silicon dioxide(87.52%by weight)and carbon(11.41%by weight).This study investigated the influence of the amount of sodium alginate(0-5 phr)used in the NR foam formation.The addition of SCBA on the NR foam affected the density,swelling behavior,and crosslink density of the foam.The results identified an optimal loading level that improved the density and morphology of the foam.The hardness and modulus of the NR foam increased with increasing amounts of SCBA,suggesting insufficient reinforcement.The NR exhibited the highest compressive stress at the SCBA concentration of 5 phr.This study facilitates the development of NR as green material and other support materials.展开更多
The fusion excitation functions for 12 colliding systems with 96≤Z_(1)Z_(2)≤608 are analyzed using coupled-channel(CC)calculations based on the M3Y double-folding(DF)potential supplemented with a repulsive potential...The fusion excitation functions for 12 colliding systems with 96≤Z_(1)Z_(2)≤608 are analyzed using coupled-channel(CC)calculations based on the M3Y double-folding(DF)potential supplemented with a repulsive potential that takes into account the incompressibility of the nuclear matter.We also applied the polarization effects of hot nuclear matter(PEHNM)on the calculations of the bare nucleus-nucleus interaction potential within the framework of the modified density-dependent Seyler-Blanchard(SB)approach in the T^(2)approximation.Our results reveal that we obtain a nice description of the experimental data of different fusion systems when we use the present theoretical approach to calculate the energy-dependent values of the fusion cross sections.In this paper,the influence of the PEHNM on the surface diffuseness parameter of the Woods-Saxon(WS)potential is also studied.In order to reach this goal,we extract the corresponding values of this parameter based on the modified form of the DF potential(M3Y+Repulsion+polarization).We find that the extracted values are located in a range between a=0.61 and 0.80 fm at different incident energies.It seems that the polarization effects of hot nuclear matter play a key role in describing the abnormally large values of the nuclear potential diffusenesses in the heavy-ion fusion reactions.Additionally,the regular decreasing trend for the diffuseness parameter of the nucleus-nucleus potential with the increase in the bombarding energies is also observed.展开更多
Objectives Patient education while hospitalized enhances patients’ability to manage chronic diseases,including mental disorders,promoting adherence to treatment plans.This study aimed to evaluate the effectiveness of...Objectives Patient education while hospitalized enhances patients’ability to manage chronic diseases,including mental disorders,promoting adherence to treatment plans.This study aimed to evaluate the effectiveness of gamification as an instructional approach for nurse-led inpatient education.Methods A quasi-experimental study was conducted.A total of 112 participants were recruited from the Geha Mental Health Center,a tertiary mental health center in Israel,from September 2022 to June 2023 and randomly allocated to the intervention group or control group.Nurses provided health education to patients in the intervention group using gamification techniques based on traditional health education methods.Responsibilities,rights,and relevant information for hospitalized patients were written on different cards.Patients were divided into groups of 3–4,and health education was delivered through memory card games and quartet card games.Each type of game was played twice,each lasting 30 min,occurring once every two weeks.In the control group of patients,traditional health education methods were utilized.A self-developed questionnaire assessing knowledge,self-efficacy,and adherence was used to investigate the two patient groups before and after the intervention,allowing for a comparison of the results.Results Overall,90 patients completed the study:45 in the intervention group and 45 in the control group.Both groups improved knowledge,self-efficacy,and adherence after the intervention(P<0.01).Furthermore,health education based on gamification methods was more effective than conventional health education in enhancing all three aspects of patient outcomes(P<0.01).Conclusion Gamification is preferable to routine education for fostering patient engagement in therapeutic sessions by enhancing self-efficacy and knowledge.The findings may contribute to developing gamified educational interventions to improve the effectiveness of inpatient education.展开更多
Terrestrial invasive alien weed plants are known to infest cultivated land, potentially releasing allelochemicals into the rhizosphere during decomposition, negatively impacting crop growth. This study aimed to evalua...Terrestrial invasive alien weed plants are known to infest cultivated land, potentially releasing allelochemicals into the rhizosphere during decomposition, negatively impacting crop growth. This study aimed to evaluate: (1) the allelopathic activity of five invasive weed species (Ageratum conyzoides, Bidens pilosa, Cecropia peltata, Tithonia diversifolia, and Chromolaena odorata) on Lactuca sativa and Phaseolus vulgaris growth;and (2) the effects of A. conyzoides rhizospheric soil on P. vulgaris seed germination. Bioassays of aqueous and leachate extracts were prepared from fresh leaves of the invasive species at concentrations of 0%, 25%, 50%, 75%, and 100% to assess allelopathic effects on L. sativa and P. vulgaris seed germination. Additionally, rhizospheric soil from A. conyzoides stands was collected, processed, and applied at varied weights (0.5 - 7 kg) to P. vulgaris seeds, with germination observed over nine days. Polynomial regression analysis was applied to model the data. High-concentration extracts (75% and 100%) significantly inhibited germination, root, and shoot growth in both L. sativa and P. vulgaris (P 2 − 80.294922x3 + 41.541115x4 − 11.747532x5 + 1.8501702x6 − 0.1519795x7 + 0.0050631x8. Allelopathic effects were concentration-dependent, with roots more sensitive than shoots to the invasive extracts. L. sativa was the most susceptible, while P. vulgaris showed greater tolerance. Modelling the allelopathic impact of A. conyzoides rhizospheric soil offers valuable insight into the allelochemical dosage necessary to affect seed germination, informing potential agricultural management strategies for invasive plant control.展开更多
This study provides a systematic investigation into the influence of feature selection methods on cryptocurrency price forecasting models employing technical indicators.In this work,over 130 technical indicators—cove...This study provides a systematic investigation into the influence of feature selection methods on cryptocurrency price forecasting models employing technical indicators.In this work,over 130 technical indicators—covering momentum,volatility,volume,and trend-related technical indicators—are subjected to three distinct feature selection approaches.Specifically,mutual information(MI),recursive feature elimination(RFE),and random forest importance(RFI).By extracting an optimal set of 20 predictors,the proposed framework aims to mitigate redundancy and overfitting while enhancing interpretability.These feature subsets are integrated into support vector regression(SVR),Huber regressors,and k-nearest neighbors(KNN)models to forecast the prices of three leading cryptocurrencies—Bitcoin(BTC/USDT),Ethereum(ETH/USDT),and Binance Coin(BNB/USDT)—across horizons ranging from 1 to 20 days.Model evaluation employs the coefficient of determination(R2)and the root mean squared logarithmic error(RMSLE),alongside a walk-forward validation scheme to approximate real-world trading contexts.Empirical results indicate that incorporating momentum and volatility measures substantially improves predictive accuracy,with particularly pronounced effects observed at longer forecast windows.Moreover,indicators related to volume and trend provide incremental benefits in select market conditions.Notably,an 80%–85% reduction in the original feature set frequently maintains or enhances model performance relative to the complete indicator set.These findings highlight the critical role of targeted feature selection in addressing high-dimensional financial data challenges while preserving model robustness.This research advances the field of cryptocurrency forecasting by offering a rigorous comparison of feature selection methods and their effects on multiple digital assets and prediction horizons.The outcomes highlight the importance of dimension-reduction strategies in developing more efficient and resilient forecasting algorithms.Future efforts should incorporate high-frequency data and explore alternative selection techniques to further refine predictive accuracy in this highly volatile domain.展开更多
Recently,photodynamic therapy(PDT)has gained considerable attention as a promising therapeutic approach for the treatment of psoriasis.Unfortunately,the activation of high mobility group box 1 protein(HMGB1)by PDT tri...Recently,photodynamic therapy(PDT)has gained considerable attention as a promising therapeutic approach for the treatment of psoriasis.Unfortunately,the activation of high mobility group box 1 protein(HMGB1)by PDT triggers innate and adaptive immune responses,which exacerbate skin inflammation.Herein,we combined glycyrrhizic acid(GA),a natural anti-inflammatory compound and immunomodulator derived from the herb Glycyrrhiza uralensis Fisch.,with PDT actuated by the photosensitizer chlorin e6(Ce6)by co-loading them in GA-based lipid nanoparticles coated with a catechol-modified quaternary chitosan salt(GC NPs/QCS-C).GC NPs/QCS-C exhibited high drug loading efficacy,uniform size distribution,an ideal topical adhesive property,enhanced skin retention and penetration in psoriasis-like lesions,and high intracellular uptake in epidermal cells compared with the counterparts.Subsequently,the transdermal administration of GC NPs/QCS-C followed by near-infrared laser radiation in an imiquimod-induced psoriasis-like mouse model significantly ameliorated psoriasis symptoms,promoted the apoptosis of hyperproliferative epidermal cells,and alleviated the inflammatory cascade.The significant therapeutic outcomes of GC NPs/QCS-C were attributed to the synergistic effects of GA and PDT on modulating immune cell recruitment and inhibiting dendritic cell maturation.Our results demonstrated that the topical bio-adhesive nanosystem that combines GA and Ce6 offers a synergistic chemo-phototherapeutic strategy for psoriasis treatment.展开更多
BACKGROUND Type 2 diabetes mellitus(T2DM)is a chronic metabolic disease characterized by combinations of insulin resistance and insulin deficiency.Non-alcoholic fatty liver disease(NAFLD)is emerging as a public health...BACKGROUND Type 2 diabetes mellitus(T2DM)is a chronic metabolic disease characterized by combinations of insulin resistance and insulin deficiency.Non-alcoholic fatty liver disease(NAFLD)is emerging as a public health problem worldwide and affects up to 70%of patients with T2DM.Although patients with T2DM have an increased risk of developing advanced liver disease compared to healthy individuals,varying prevalence rates of NAFLD among patients with T2DM,ranging from 34%to 94%,have been reported.AIM To determine prevalence and identify associated factors of NAFLD among Limbe patients with T2DM and evaluate correlation with glycemic control.METHODS A cross-sectional study was carried out from February to June 2024 among patients with T2DM.Gamma-glutamyl transferase(GGT)activity and serum triglycerides(TGs)were measured by spectrophotometry.NAFLD was diagnosed using the fatty liver index score.Data were analyzed using SPSS version 26.0 for Windows.Student’s t-test was used to compare the means of two groups.The χ^(2) test was applied to determine the association of NAFLD and T2DM.Logistic regression analysis was performed to identify predictors of NAFLD.P<0.05 was considered statistically significant.RESULTS Of the 150 patients with T2DM recruited for this study,63(58%)were females and the majority(84.7%)had good glycemic control(glycated hemoglobin<7%).Prevalence of NAFLD among patients with T2DM was 19%.Patients with NAFLD had significantly elevated levels of TGs,GGT,and increased body mass index and waist circumference compared to those without NAFLD.There was a significant association between NAFLD and glycemic control.Predictive factors of NAFLD among patients with T2DM were vegetable intake of less than three times per week[adjusted odds ratio(aOR):0.131,95%CI:0.020-0.839;P=0.032],central obesity(aOR:0.167,95%CI:0.037-0.748;P=0.019),and metformin treatment for T2DM(aOR:0.167,95%CI:0.037-0.718;P<0.001).CONCLUSION The prevalence of NAFLD in patients with T2DM in Limbe Regional Hospital was 19%.Age,central obesity,metformin use,and infrequent consumption of vegetables were important predictors of NAFLD.展开更多
Tropidacris spp. represent the largest known group among acridoids. Their presence ranges from southeastern Mexico and has so far been confirmed only in tropical habitats. This publication seeks to highlight the curre...Tropidacris spp. represent the largest known group among acridoids. Their presence ranges from southeastern Mexico and has so far been confirmed only in tropical habitats. This publication seeks to highlight the current and potential challenges associated with their presence. For decades, the use of chemical insecticides has been the primary method for controlling locust populations, though these substances pose significant risks to human health and the environment. Recent research efforts are directed toward developing control methods that are less detrimental to both ecological and human health, such as biopesticides derived from pathogenic fungi, plant extracts, and strategically prescribed burns. Satellite surveillance enables the monitoring of the origination and progression of outbreaks to inform control strategy selection.展开更多
文摘Field training is the backbone of the teacher-preparation process.Its importance stems from the goals that colleges of education aim to achieve,which include bridging the gap between theory and practice and aligning with contemporary educational trends during teacher training.Currently,trainee students attendance in field training is recordedmanually through signatures on attendance sheets.However,thismethod is prone to impersonation,time wastage,and misplacement.Additionally,traditional methods of evaluating trainee students are often susceptible to human errors during the evaluation and scoring processes.Field training also lacks modern technology that the supervisor can use in case of his absence from school to monitor the trainee students’implementation of the required activities and tasks.These shortcomings do not meet the needs of the digital era that universities are currently experiencing.As a result,this paper presents a smart management system for field training based on Internet of Things(IoT)and mobile technology.It includes three subsystems:attendance,monitoring,and evaluation.The attendance subsystem uses an R307 fingerprint sensor to record trainee students’attendance.The Arduino Nano microcontroller transmits attendance data to the proposed Android application via an ESP-12F Wi-Fi module,which then forwards it to the Firebase database for storage.The monitoring subsystem utilizes Global Positioning System(GPS)technology to continually track trainee students’locations,ensuring they remain at the school during training.It also enables remote communication between trainee students and supervisors via audio,video,or text by integrating video call and chat technologies.The evaluation subsystem is based on three items:an online exam,attendance,and implementation of required activities and tasks.Experimental results have demonstrated the accuracy and efficiency of the proposed management system in recording attendance,as well as in monitoring and evaluating trainee students during field traiing.
基金supported by the Deanship of Scientific Research(DSR)at King Abdulaziz University,Jeddah,under grant no.(GPIP:13-612-2024).
文摘App reviews are crucial in influencing user decisions and providing essential feedback for developers to improve their products.Automating the analysis of these reviews is vital for efficient review management.While traditional machine learning(ML)models rely on basic word-based feature extraction,deep learning(DL)methods,enhanced with advanced word embeddings,have shown superior performance.This research introduces a novel aspectbased sentiment analysis(ABSA)framework to classify app reviews based on key non-functional requirements,focusing on usability factors:effectiveness,efficiency,and satisfaction.We propose a hybrid DL model,combining BERT(Bidirectional Encoder Representations from Transformers)with BiLSTM(Bidirectional Long Short-Term Memory)and CNN(Convolutional Neural Networks)layers,to enhance classification accuracy.Comparative analysis against state-of-the-art models demonstrates that our BERT-BiLSTM-CNN model achieves exceptional performance,with precision,recall,F1-score,and accuracy of 96%,87%,91%,and 94%,respectively.Thesignificant contributions of this work include a refined ABSA-based relabeling framework,the development of a highperformance classifier,and the comprehensive relabeling of the Instagram App Reviews dataset.These advancements provide valuable insights for software developers to enhance usability and drive user-centric application development.
基金the Talent Management Project of Prince of Songkla University
文摘Wearable sensing systems have been designed to monitor health conditions in real-time by detecting analytes in human biofluids.Wound diagnosis remains challenging,necessitating suitable materials for high-performance wearable sensors to offer prompt feedback.Existing devices have limitations in measuring pH and the concentration of pH-dependent electroactive species simultaneously,which is crucial for obtaining a comprehensive understanding of wound status and optimizing biosensors.Therefore,improving materials and analysis system accuracy is essential.This article introduces the first example of a flexible array capable of detecting pyocyanin,a bacterial virulence factor,while correcting dynamic pH fluctuations.We demonstrate that this combined sensor enhances accuracy by mitigating the impact of pH variability on pyocyanin sensor response.Customized screen-printable inks were developed to enhance analytical performance.The analytical performances of two sensitive sensor systems(i.e.,fully-printed porous graphene/multiwalled carbon nanotube(CNT)and polyaniline/CNT composites for pyocyanin and pH sensors)are evaluated.Partial least square regression is employed to analyze nonzero-order data arrays from square wave voltammetric and potentiometric measurements of pyocyanin and pH sensors to establish a predictive model for pyocyanin concentration in complex fluids.This sensitive and effective strategy shows potential for personalized applications due to its affordability,ease of use,and ability to adjust for dynamic pH changes.
基金supported by the Spanish Ministry of Economy and Competitiveness,No.PID2019-106498GB-I00(to MVS)the Instituto de Salud CarlosⅢ,Fondo Europeo de Desarrollo Regional“Una manera de hacer Europa”,No.PI19/00071(to MAB)+1 种基金Ministerio de Ciencia e Innovación Project,No.SAF2017-82736-C2-1-R(to MTMF)in Universidad Autónoma de MadridFundación Universidad Francisco de Vitoria(to JS)。
文摘Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic nerve.Still,it is unknown whether olfactory ensheathing glia also have neuroprotective properties.Olfactory ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion cells.Therefore,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve crush.Olfactory ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive treatments.Anatomical and gene expression analyses were performed.Olfactory bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡmolecules.Allogeneically and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an epimembrane.In axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 days.In these retinas,microglial anatomical activation was higher than after optic nerve crush alone.In intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or immunosuppression.However,neuroprotection of axotomized retinal ganglion cells did not improve with these treatments.The different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.
基金funded by U.S.Air Force Office of Scientific Research FA9550-21-1-0096,FONDAP program 15150012,ANID/FONDEF ID1ID22I10120,FONDECY/ANID 1220573the US Army Medical Research Acquisition Activity(USAMRAA)project number AL2201415DoD Award HT9425-23-1-0990,AL220141(to CH)。
文摘Lifestyle and demographics of the world's population are causing serious health problems impacting the brain,increasing the incidence of Alzheimer's disease(AD)and other types of dementia.Although we have gained important insights into the pathogenic mechanisms of AD,only palliative care is available to patients.AD is characterized by the abnormal deposition of protein aggregates in the brain formed by amyloid β and hyper-phosphorylated,Tau in addition to neuroinflammation.
基金support from the National Natural Science Foundation of China(22209089,22178187)Natural Science Foundation of Shandong Province(ZR2022QB048,ZR2021MB006)+2 种基金Excellent Youth Science Foundation of Shandong Province(Overseas)(2023HWYQ-089)the Taishan Scholars Program of Shandong Province(tsqn201909091)Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University.
文摘Aqueous zinc-halogen batteries are promising candidates for large-scale energy storage due to their abundant resources,intrinsic safety,and high theoretical capacity.Nevertheless,the uncontrollable zinc dendrite growth and spontaneous shuttle effect of active species have prohibited their practical implementation.Herein,a double-layered protective film based on zinc-ethylenediamine tetramethylene phosphonic acid(ZEA)artificial film and ZnF2-rich solid electrolyte interphase(SEI)layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic optimization.The ZEA-based artificial film shows strong affinity for the ZnF2-rich SEI layer,therefore effectively suppressing the SEI breakage and facilitating the construction of double-layered protective film on the zinc metal anode.Such double-layered architecture not only modulates Zn2+flux and suppresses the zinc dendrite growth,but also blocks the direct contact between the metal anode and electrolyte,thus mitigating the corrosion from the active species.When employing optimized metal anodes and electrolytes,the as-developed zinc-(dual)halogen batteries present high areal capacity and satisfactory cycling stability.This work provides a new avenue for developing aqueous zinc-(dual)halogen batteries.
文摘BACKGROUND In the absence of effective antimicrobials,transplant surgery is not viable,and antirejection immunosuppressants cannot be administered,as resistant infections compromise the life-saving goal of organ transplantation.AIM To evaluate the efficacy of antimicrobials in preventing resistance in solid organ transplant recipients.METHODS A systematic review was conducted using a search methodology consistent with the preferred reporting items for systematic reviews and meta-analyses.This review included randomized clinical trials that evaluated the efficacy of antimicrobial agents(prophylactic or therapeutic)aimed at preventing antimicrobial resistance.The search strategy involved analyzing multiple databases,including PubMed/MEDLINE,Web of Science,Embase,Scopus,and SciELO,as well as examining gray literature sources on Google Scholar.A comprehensive electronic database search was conducted from the databases’inception until May 2024,with no language restrictions.RESULTS After the final phase of the eligibility assessment,this systematic review ultimate-ly included 7 articles.A total of 2318 patients were studied.The most studied microorganisms were cytomegalovirus,although vancomycinresistant enterococci,Clostridioides difficile,and multidrug-resistant Enterobacterales were also analyzed.The antimicrobials used in the interventions were mainly maribavir,valganciclovir,gancic-lovir,and colistin-neomycin.Of concern,all clinical trials showed significant proportions of resistant microorga-nisms after the interventions,with no statistically significant differences between the groups(mean resistance 13.47%vs 14.39%),except for two studies that demonstrated greater efficacy of maribavir and valganciclovir(mean resistance 22.2%vs 41.1%in the control group;P<0.05).The total reported deaths in three clinical trials were 75,and there were 24 graft rejections in two studies.CONCLUSION All clinical trials reported significant proportions of antimicrobial-resistant microorganisms following interventions.More high-quality randomized clinical trials are needed to corroborate these results.
基金supported by the grants from University of Macao,China,Nos.MYRG2022-00221-ICMS(to YZ)and MYRG-CRG2022-00011-ICMS(to RW)the Natural Science Foundation of Guangdong Province,No.2023A1515010034(to YZ)。
文摘Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic stroke.However,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery efficiency.By utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly improved.Furthermore,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic stroke.Small extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke therapy.In this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification methodologies.Given the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment process.Moreover,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.
基金supported by an internal grant from Universitas Citra Bangsa(Number 6/VI/LP3M/UCB/22).
文摘Objective: The importance of culture in nursing lies in its influence on patients’ health perceptions, behaviors, and responses to care. Despite the challenges posed by the complexity of studying culture, there remains a critical need to develop cultural competence in nursing. This study investigated how nursing students in rural Indonesia enhance their cultural competence through education and practice. Methods: This study employed a qualitative descriptive phenomenological approach. It conducted face-to-face interviews with 32 students across 6 regions, selected purposively. Thematic analysis was employed to evaluate the results. Results: Five themes emerge in this research: perceptions of cultural competence, learning cultural competence in the classroom, practical experience, learning expectations related to cultural competence, and cultural learning barriers. Conclusions: Enhancing cultural competence necessitates enriched curricula, adept clinical mentors, and continual student evaluation. This iterative assessment informs tailored strategies for nurturing cultural proficiency.
文摘BACKGROUND Ovarian hyperstimulation syndrome(OHSS)is a life-threatening complication that can occur in the luteal phase or early pregnancy after controlled ovarian stimulation.This case report highlights a unique manifestation of OHSS involving pleural effusion(PE)in a patient without identifiable risk factors.CASE SUMMARY A 39-year-old woman who underwent controlled ovarian hyperstimulation for an in vitro fertilization(IVF)cycle experienced dyspnea on the eleventh day of post oocyte retrieval.The diagnosis was severe OHSS with a unique manifestation of PE without ascites.Clinical management involved fluid balance and treatment with albumin,furosemide,thromboembolic prophylaxis,and thoracentesis.A continued drainage of the pleural cavity was performed.The patient had a favo-rable outcome,and a dichorionic diamniotic gestation passed without incident.CONCLUSION OHSS and its potential complications can include respiratory distress and PE,as well as thromboembolic disorders.
基金supported by Universiti Tunku Abdul Rahman(UTAR)Research Fund(IPSR/RMC/UTARRF 2021-C2/40).
文摘Objective:To evaluate the antioxidant activity of Kaempferia(K.)parviflora rhizome extract and study its protective effect against male reproductive impairment induced by fenitrothion.Methods:The phytochemicals and antioxidant properties of K.parviflora ethanolic extract were assessed.Twenty-four male mice aged 4-weeks-old were assigned into four groups.Groups 1 to 4 respectively received extra virgin olive oil(served as the vehicle control),20 mg/kg body weight(bw)of fenitrothion,50 mg/kg bw of K.parviflora ethanolic extract,and 50 mg/kg bw of K.parviflora ethanolic extract plus 20 mg/kg bw of fenitrothion.Upon completion of 28 days of continuous feeding treatment,the mice were subjected to mating evaluation and the assessment of epididymal sperm quality,lipid peroxidation,testosterone level and histological evaluation.Results:Eight phytochemical compounds were detected in the ethanolic extract of K.parviflora via GC-MS.The extract exhibited a DPPH radical scavenging activity with an EC50 value of(0.870±0.007)mg/mL.Mice fed with fenitrothion in group 2 displayed an increase in relative testis weight,lipid peroxidation levels and a significant reduction in all sperm parameters(sperm concentration,progressive motility,and viability),as well as serum testosterone levels compared to the control mice in group 1(P<0.05).On the other hand,mice fed with K.parviflora ethanolic extract in group 3 showed a significant increase in serum testosterone levels compared to group 1.Mice co-administered with K.parviflora ethanolic extract and fenitrothion in group 4 exhibited a significant improvement in testosterone levels,sperm concentration,motility,and viability compared to the mice administered only with fenitrothion in group 2(P<0.05).Histological analysis of testicular tissue from group 4 further revealed improved testicular morphology in comparison to fenitrothion-treated mice.Conclusions:Eight bioactive compounds were identified in K.parviflora ethanolic extract and the extract exhibited antioxidative properties.Fenitrothion administration impairs testicular function,reducing sperm parameters and testosterone while increasing lipid peroxidation.However,K.parviflora ethanolic extract coadministration alleviates oxidative stress,improves sperm parameters and testosterone levels,and enhances testicular morphology.These findings suggest that K.parviflora ethanolic extract has the therapeutic potential in mitigating male reproductive adverse effects induced by fenitrothion.
基金supported by Hong Kong Research Grants Council General Research Fund(CUHK 14102321,14103722 and 14104923)。
文摘Oxidized cholesterol(OXC)is a harmful dietary substance.Although the consumption of OXC has been associated with colonic inflammation,related underlying mechanisms are still limited.We evaluated the influence of dietary OXC on gut health and ecology by applying the murine model.Results showed that the thickness of the mucus layer was significantly reduced in healthy mice treated with OXC.Short-term intake of OXC did not influence the expression of pro-inflammatory factors in healthy mice but it induced the decrease of Muc2 expression in the proximal colon,accompanied by an increase in the abundance of 2 mucusdegrading bacteria,namely Akkermansia muciniphila and Bacteroides acidifaciens.Consistently,oral exposure of OXC promoted mucus barrier erosion in dextran sulfate sodium(DSS)-induced colitis mice and facilitated bacteria infiltration in the colon.The adverse effect of OXC on mucus layer disappeared in antibiotics-treated healthy mice,suggesting that the damaging effect of OXC on the gut mucus layer was not direct and instead was mediated by causing microbiota dysbiosis.Finally,the impact of OXC on the mucus layer and colitis was partly alleviated by green tea catechins.These studies demonstrated that the OXC-induced mucus barrier damage was mainly induced by the dysregulation of gut microbiota at least in this mouse model.
基金supported by the Thailand Science Research and Innovation,National Science Research and Innovation Fund and the Fundamental Fund(FF 2023).
文摘Natural rubber(NR)foams are widely used.However,further studies are required for preparing eco-friendly NR foam and determining the optimum physical properties appropriate for application.This study aims to create an NR foam from rubber reinforced with sugarcane bagasse ash(SCBA)and sodium alginate.The results showed that the SCBA was primarily composed of silica or silicon dioxide(87.52%by weight)and carbon(11.41%by weight).This study investigated the influence of the amount of sodium alginate(0-5 phr)used in the NR foam formation.The addition of SCBA on the NR foam affected the density,swelling behavior,and crosslink density of the foam.The results identified an optimal loading level that improved the density and morphology of the foam.The hardness and modulus of the NR foam increased with increasing amounts of SCBA,suggesting insufficient reinforcement.The NR exhibited the highest compressive stress at the SCBA concentration of 5 phr.This study facilitates the development of NR as green material and other support materials.
文摘The fusion excitation functions for 12 colliding systems with 96≤Z_(1)Z_(2)≤608 are analyzed using coupled-channel(CC)calculations based on the M3Y double-folding(DF)potential supplemented with a repulsive potential that takes into account the incompressibility of the nuclear matter.We also applied the polarization effects of hot nuclear matter(PEHNM)on the calculations of the bare nucleus-nucleus interaction potential within the framework of the modified density-dependent Seyler-Blanchard(SB)approach in the T^(2)approximation.Our results reveal that we obtain a nice description of the experimental data of different fusion systems when we use the present theoretical approach to calculate the energy-dependent values of the fusion cross sections.In this paper,the influence of the PEHNM on the surface diffuseness parameter of the Woods-Saxon(WS)potential is also studied.In order to reach this goal,we extract the corresponding values of this parameter based on the modified form of the DF potential(M3Y+Repulsion+polarization).We find that the extracted values are located in a range between a=0.61 and 0.80 fm at different incident energies.It seems that the polarization effects of hot nuclear matter play a key role in describing the abnormally large values of the nuclear potential diffusenesses in the heavy-ion fusion reactions.Additionally,the regular decreasing trend for the diffuseness parameter of the nucleus-nucleus potential with the increase in the bombarding energies is also observed.
文摘Objectives Patient education while hospitalized enhances patients’ability to manage chronic diseases,including mental disorders,promoting adherence to treatment plans.This study aimed to evaluate the effectiveness of gamification as an instructional approach for nurse-led inpatient education.Methods A quasi-experimental study was conducted.A total of 112 participants were recruited from the Geha Mental Health Center,a tertiary mental health center in Israel,from September 2022 to June 2023 and randomly allocated to the intervention group or control group.Nurses provided health education to patients in the intervention group using gamification techniques based on traditional health education methods.Responsibilities,rights,and relevant information for hospitalized patients were written on different cards.Patients were divided into groups of 3–4,and health education was delivered through memory card games and quartet card games.Each type of game was played twice,each lasting 30 min,occurring once every two weeks.In the control group of patients,traditional health education methods were utilized.A self-developed questionnaire assessing knowledge,self-efficacy,and adherence was used to investigate the two patient groups before and after the intervention,allowing for a comparison of the results.Results Overall,90 patients completed the study:45 in the intervention group and 45 in the control group.Both groups improved knowledge,self-efficacy,and adherence after the intervention(P<0.01).Furthermore,health education based on gamification methods was more effective than conventional health education in enhancing all three aspects of patient outcomes(P<0.01).Conclusion Gamification is preferable to routine education for fostering patient engagement in therapeutic sessions by enhancing self-efficacy and knowledge.The findings may contribute to developing gamified educational interventions to improve the effectiveness of inpatient education.
文摘Terrestrial invasive alien weed plants are known to infest cultivated land, potentially releasing allelochemicals into the rhizosphere during decomposition, negatively impacting crop growth. This study aimed to evaluate: (1) the allelopathic activity of five invasive weed species (Ageratum conyzoides, Bidens pilosa, Cecropia peltata, Tithonia diversifolia, and Chromolaena odorata) on Lactuca sativa and Phaseolus vulgaris growth;and (2) the effects of A. conyzoides rhizospheric soil on P. vulgaris seed germination. Bioassays of aqueous and leachate extracts were prepared from fresh leaves of the invasive species at concentrations of 0%, 25%, 50%, 75%, and 100% to assess allelopathic effects on L. sativa and P. vulgaris seed germination. Additionally, rhizospheric soil from A. conyzoides stands was collected, processed, and applied at varied weights (0.5 - 7 kg) to P. vulgaris seeds, with germination observed over nine days. Polynomial regression analysis was applied to model the data. High-concentration extracts (75% and 100%) significantly inhibited germination, root, and shoot growth in both L. sativa and P. vulgaris (P 2 − 80.294922x3 + 41.541115x4 − 11.747532x5 + 1.8501702x6 − 0.1519795x7 + 0.0050631x8. Allelopathic effects were concentration-dependent, with roots more sensitive than shoots to the invasive extracts. L. sativa was the most susceptible, while P. vulgaris showed greater tolerance. Modelling the allelopathic impact of A. conyzoides rhizospheric soil offers valuable insight into the allelochemical dosage necessary to affect seed germination, informing potential agricultural management strategies for invasive plant control.
文摘This study provides a systematic investigation into the influence of feature selection methods on cryptocurrency price forecasting models employing technical indicators.In this work,over 130 technical indicators—covering momentum,volatility,volume,and trend-related technical indicators—are subjected to three distinct feature selection approaches.Specifically,mutual information(MI),recursive feature elimination(RFE),and random forest importance(RFI).By extracting an optimal set of 20 predictors,the proposed framework aims to mitigate redundancy and overfitting while enhancing interpretability.These feature subsets are integrated into support vector regression(SVR),Huber regressors,and k-nearest neighbors(KNN)models to forecast the prices of three leading cryptocurrencies—Bitcoin(BTC/USDT),Ethereum(ETH/USDT),and Binance Coin(BNB/USDT)—across horizons ranging from 1 to 20 days.Model evaluation employs the coefficient of determination(R2)and the root mean squared logarithmic error(RMSLE),alongside a walk-forward validation scheme to approximate real-world trading contexts.Empirical results indicate that incorporating momentum and volatility measures substantially improves predictive accuracy,with particularly pronounced effects observed at longer forecast windows.Moreover,indicators related to volume and trend provide incremental benefits in select market conditions.Notably,an 80%–85% reduction in the original feature set frequently maintains or enhances model performance relative to the complete indicator set.These findings highlight the critical role of targeted feature selection in addressing high-dimensional financial data challenges while preserving model robustness.This research advances the field of cryptocurrency forecasting by offering a rigorous comparison of feature selection methods and their effects on multiple digital assets and prediction horizons.The outcomes highlight the importance of dimension-reduction strategies in developing more efficient and resilient forecasting algorithms.Future efforts should incorporate high-frequency data and explore alternative selection techniques to further refine predictive accuracy in this highly volatile domain.
基金supported by funding from the China Postdoctoral Science Foundation(Nos.2023T160071 and 2021M690488)Natural Science Foundation of Sichuan Province of China for Youths(No.2023NSFSC1768,China)+3 种基金The Science and Technology Development Fund(SKL-QRCM(UM)2023-2025,China)The State Key Laboratory of Quality Research in Chinese Medicine,University of Macao(No.SKL-QRCM-OP23020,China)The Central Guidance on Local Science and Technology Development Fund of Sichuan(23ZYZYTS0420,China)Multidisciplinary Evaluation of Southwest Characteristic TCM Resources Multidisciplinary Interdisciplinary Innovation Team(No.ZYYCXTD-D-202209,China).
文摘Recently,photodynamic therapy(PDT)has gained considerable attention as a promising therapeutic approach for the treatment of psoriasis.Unfortunately,the activation of high mobility group box 1 protein(HMGB1)by PDT triggers innate and adaptive immune responses,which exacerbate skin inflammation.Herein,we combined glycyrrhizic acid(GA),a natural anti-inflammatory compound and immunomodulator derived from the herb Glycyrrhiza uralensis Fisch.,with PDT actuated by the photosensitizer chlorin e6(Ce6)by co-loading them in GA-based lipid nanoparticles coated with a catechol-modified quaternary chitosan salt(GC NPs/QCS-C).GC NPs/QCS-C exhibited high drug loading efficacy,uniform size distribution,an ideal topical adhesive property,enhanced skin retention and penetration in psoriasis-like lesions,and high intracellular uptake in epidermal cells compared with the counterparts.Subsequently,the transdermal administration of GC NPs/QCS-C followed by near-infrared laser radiation in an imiquimod-induced psoriasis-like mouse model significantly ameliorated psoriasis symptoms,promoted the apoptosis of hyperproliferative epidermal cells,and alleviated the inflammatory cascade.The significant therapeutic outcomes of GC NPs/QCS-C were attributed to the synergistic effects of GA and PDT on modulating immune cell recruitment and inhibiting dendritic cell maturation.Our results demonstrated that the topical bio-adhesive nanosystem that combines GA and Ce6 offers a synergistic chemo-phototherapeutic strategy for psoriasis treatment.
文摘BACKGROUND Type 2 diabetes mellitus(T2DM)is a chronic metabolic disease characterized by combinations of insulin resistance and insulin deficiency.Non-alcoholic fatty liver disease(NAFLD)is emerging as a public health problem worldwide and affects up to 70%of patients with T2DM.Although patients with T2DM have an increased risk of developing advanced liver disease compared to healthy individuals,varying prevalence rates of NAFLD among patients with T2DM,ranging from 34%to 94%,have been reported.AIM To determine prevalence and identify associated factors of NAFLD among Limbe patients with T2DM and evaluate correlation with glycemic control.METHODS A cross-sectional study was carried out from February to June 2024 among patients with T2DM.Gamma-glutamyl transferase(GGT)activity and serum triglycerides(TGs)were measured by spectrophotometry.NAFLD was diagnosed using the fatty liver index score.Data were analyzed using SPSS version 26.0 for Windows.Student’s t-test was used to compare the means of two groups.The χ^(2) test was applied to determine the association of NAFLD and T2DM.Logistic regression analysis was performed to identify predictors of NAFLD.P<0.05 was considered statistically significant.RESULTS Of the 150 patients with T2DM recruited for this study,63(58%)were females and the majority(84.7%)had good glycemic control(glycated hemoglobin<7%).Prevalence of NAFLD among patients with T2DM was 19%.Patients with NAFLD had significantly elevated levels of TGs,GGT,and increased body mass index and waist circumference compared to those without NAFLD.There was a significant association between NAFLD and glycemic control.Predictive factors of NAFLD among patients with T2DM were vegetable intake of less than three times per week[adjusted odds ratio(aOR):0.131,95%CI:0.020-0.839;P=0.032],central obesity(aOR:0.167,95%CI:0.037-0.748;P=0.019),and metformin treatment for T2DM(aOR:0.167,95%CI:0.037-0.718;P<0.001).CONCLUSION The prevalence of NAFLD in patients with T2DM in Limbe Regional Hospital was 19%.Age,central obesity,metformin use,and infrequent consumption of vegetables were important predictors of NAFLD.
文摘Tropidacris spp. represent the largest known group among acridoids. Their presence ranges from southeastern Mexico and has so far been confirmed only in tropical habitats. This publication seeks to highlight the current and potential challenges associated with their presence. For decades, the use of chemical insecticides has been the primary method for controlling locust populations, though these substances pose significant risks to human health and the environment. Recent research efforts are directed toward developing control methods that are less detrimental to both ecological and human health, such as biopesticides derived from pathogenic fungi, plant extracts, and strategically prescribed burns. Satellite surveillance enables the monitoring of the origination and progression of outbreaks to inform control strategy selection.
