Background A flame burn is an injury of body tissues,including respiratory tract damage,due to exposure to a flame or its dense smoke.Flame burns cause some of the most physically and psychologically devastating forms...Background A flame burn is an injury of body tissues,including respiratory tract damage,due to exposure to a flame or its dense smoke.Flame burns cause some of the most physically and psychologically devastating forms of trauma.Compared to scald burns,flame burn patients have a higher mortality rate and a higher frequency of multiorgan failure.The purpose of this research was to investigate the trends,complications,and mortality risk factors of flame burns at the Department of Plastic and Burn Surgery(DPBS)of the People’s Hospital of China Three Gorges University(PHCTGU).Methods A retrospective analysis of 48 flame burn patients—accounting for 8.3%of the 576 burn victims admitted for burns at the PHCTGU from February 1,2010,to September 30,2019—was performed after collecting information from the Burns Registry of the said hospital.Results The proportion of patients with flame burns was 8.3%(n=48).The mean total body surface area(TBSA)affected was 27.6%.The mean duration of hospitalization was 32.5 days.The etiologies of the flame burns were as follows:gas explosions(21,43.8%),ethanol(8,16.7%),charcoal fire(7,14.6%),petrol explosions(4,8.3%),wooden houses(4,8.3%),and others,including dust,cigarette lighter,and burning incense,accounting for 8.3%of cases(4).Finally,42(87.5%)patients were treated and discharged,and 6(12.5%)patients died.Complications included scarring in 38(90.5%)patients,severe scar contractures on different parts of the body in 25(60.0%)patients,scar ulcer in 6(14.3%)patients,keloids in 3(7.1%)patients,and scar cancer in 1(2.4%)patient.Multiple complications occurred in the same patient.The only risk factor for mortality that was identified was TBSA(P=0.043).Conclusions Our study revealed that a small population(8.3%)was injured by flame burns,but 6 deaths were recorded.Society must continually enhance safeguard procedures to flames and strengthen education to protect life and avoid severe complications.展开更多
Image technology is applied more and more to help doctors to improve the accuracy of tumor diagnosis as well as researchers to study tumor characteristics. Image segmentation technology is an important part of image t...Image technology is applied more and more to help doctors to improve the accuracy of tumor diagnosis as well as researchers to study tumor characteristics. Image segmentation technology is an important part of image treatment. This paper summarizes the advances of image segmentation by using artificial neural network including mainly the BP network and convolutional neural network (CNN). Many CNN models with different structures have been built and successfully used in segmentation of tumor images such as supervised and unsupervised learning CNN. It is shown that the application of artificial network can improve the efficiency and accuracy of segmentation of tumor image. However, some deficiencies of image segmentation by using artificial neural network still exist. For example, new methods should be found to reduce the cost of building the marked data set. New artificial networks with higher efficiency should be built.展开更多
Breast tumor is the most common tumor in the world. The most important method to reduce the mortality due to breast tumor is diagnosed and found as early as possible. Imaging technology is one of the most important me...Breast tumor is the most common tumor in the world. The most important method to reduce the mortality due to breast tumor is diagnosed and found as early as possible. Imaging technology is one of the most important means to help doctors diagnose tumor early. This paper first simply introduces the common imaging technology. Then the mechanism and application of the ultrasonic elastic imaging technology in the diagnosis of breast tumor are summarized and discussed detailly. The methods for image treatment are introduced also. At last the development trend is analyzed. It is shown that the ultrasonic imaging technology is the most convenient and the cheapest relative to other imaging technologies such as nuclear magnetic imaging (NMI) and computer tomography (CT). Especially the ultrasonic elastic imaging technology can provide not only imaging information but also mechanism parameters, which helps to improve the accuracy of diagnosis obviously. Therefore, the ultrasonic elastic imaging technology is worthy of being studied further. More effective image analysis method is required.展开更多
Deep vein thrombosis (DVT) is the second reason of death due to tumor. In order to find more effective methods for prevention of DVT due to gynecologic tumor, the advances of study and practice in this aspect should b...Deep vein thrombosis (DVT) is the second reason of death due to tumor. In order to find more effective methods for prevention of DVT due to gynecologic tumor, the advances of study and practice in this aspect should be summarized. As an important and effective measure for prevention of DVT, the comprehensive nursing is to be analyzed carefully. Lots of practices show that proper nursing measures can prevent effectively the occurrence of postoperative DVT. Virchow thought that DVT is caused by three factors: injury of venous wall, slowed blood flow and hypercoagulability. Thus, the prevention measures are presented on the factors such as application of sequential decompression elastic socks, intraoperative intervention etc. Clinical nursing pathway is shown to be very effective method recently. More effective measures and related facilities for prevention of DVT should be built in the future. Physical and psychological methods should be combined in the nursing of DVT.展开更多
Background: Alzheimer’s disease (AD), commonly known as senile dementia, is a neurodegenerative disease with clinical manifestations of memory impairment, personality and behavior changes. The pathogenesis of AD is c...Background: Alzheimer’s disease (AD), commonly known as senile dementia, is a neurodegenerative disease with clinical manifestations of memory impairment, personality and behavior changes. The pathogenesis of AD is complex and inconclusive in the point of view of western medicine, which is the fundamental reason for the lack of drugs that can reverse the course of the disease. People have gradually shifted from simple amyloid hypothesis to new pathogenesis theories, such as gamma oscillation, prion like transmission, and so on. As an effective means to treat AD, traditional Chinese medicine has made some research progress in recent years. This article mainly reviews the etiology, pathogenesis and treatment of AD, so as to provide reference for the prevention and treatment of AD. Methods: Through systematic literature research, comparison and analysis, the main pathogenesis, influencing factors, progress and development tendency of traditional Chinese medicine and Western medicine in the treatment of AD are presented. Results: Alzheimer’s disease is a kind of multiple neurodegenerative diseases. The pathogenesis and related targets of AD still need to be further explored. The main pathological phenomenon of AD is senile plaques formed by intracellular neurofibrillary tangles and extracellular amyloid protein aggregation. Existing possible pathogenesis includes β-amyloid cascade hypothesis, tau protein hypothesis, cholinergic hypothesis and so on. As the pathogenesis of AD has not been clarified, so far no effective therapeutic drugs or means have been found. The traditional drugs used to treat AD mainly include acetylcholinesterase inhibitor kabbalatin, galantamine, donepezil, and N-methyl-D-aspartate receptor antagonist memantine. However, although these marketed drugs can slow down the course of the disease and alleviate symptoms, they cannot totally cure the disease. Traditional Chinese medicine has the characteristics of personalized differentiation and treatment. The Western medicine can accurately determine the lesion location and target. Conclusions: Integrated traditional Chinese medicine and West medicine is the most promising direction in the treatment of Alzheimer’s disease.展开更多
Background: Obsessive-compulsive, anxiety disorder, and depression are the most common negative emotions. The incidence rate is high and spread across all age groups. With the rapid development of the world economy an...Background: Obsessive-compulsive, anxiety disorder, and depression are the most common negative emotions. The incidence rate is high and spread across all age groups. With the rapid development of the world economy and the increasing competition in social life, the incidence rate has also increased rapidly, more and more young suffer from these three kinds of mental illnesses. Many studies have been carried out to investigate the pathogenesis and therapeutic method. It is necessary to summarize the progress for references to further research and treatment. Method: Based on a series of literature, the studies on the pathogenesis and therapeutic method of the three kinds of illnesses are summarized and analyzed. The points and results either of West medicine (WM) or traditional Chinese medicine (TCM) are collected and compared to find the best tendency of study and the best therapeutic method. Results: Obsessive-compulsive disorder, anxiety disorder and depression are common in recent years and severely affect people’s lives. In view of WM. These three kinds of illnesses are all related to the changes or damage of part of brain and nervous system. While TCM thinks that they are due to Qi stagnation or deficiency of heart Yin. Many methods of treatment have been presented and used clinically, but the effect is limited. Conclusion: The most promising and effective methods are those combining WM and TCM.展开更多
The incidence rate of venous thromboembolism (VTE) of patients after operation is very high. Many studies on VTE have been processed. The pathogenesis, dangerous factors and assessment method of VTE are summarized in ...The incidence rate of venous thromboembolism (VTE) of patients after operation is very high. Many studies on VTE have been processed. The pathogenesis, dangerous factors and assessment method of VTE are summarized in this paper. Two theories of pathogenesis, theory of Virchow’s triad and theory of anoxia at the tip of venous valve, are introduced first. The main dangerous factors of VTE such as tumor, perioperative period are discussed then. The main assessment methods of VTE are introduced also. At last, some problems required to be studied deeper have been presented.展开更多
Infertility is one of the difficult complicated diseases. Many couples suffer from it. The pathogenesis is very complicated. The imbalance or lesson of any link of the reproductive system can cause infertility. This p...Infertility is one of the difficult complicated diseases. Many couples suffer from it. The pathogenesis is very complicated. The imbalance or lesson of any link of the reproductive system can cause infertility. This paper summarizes the treatment of female infertility by integrated Traditional Chinese Medicine (TCM) and Western Medicine (WM) which can not only improve the ovulation rate and pregnancy rate, but also decrease the complications. The effects are better than that by TCM or WM only. Therefore, the coupling method is worth to be used widely in clinical practice.展开更多
Background: Hemodynamics is a practical and complicated theoretical problem. The aim of this paper is to analyze the characteristics of blood pressure in the cardiovascular system changing with the mechanical paramete...Background: Hemodynamics is a practical and complicated theoretical problem. The aim of this paper is to analyze the characteristics of blood pressure in the cardiovascular system changing with the mechanical parameters of blood vessels and the storage of some visceral organs. Method: The fluid network model was used for the study. The cardiovascular system was modeled as a system consisting of 20 segments of vessels. The main controlling parameters were determined first by using dimensional analysis. Then the responses of blood pressure of each segment of vessels were analyzed by changing the controlling parameters. Results: The parameters of the blood vessel of brain have the least influence on the pressures of other parts. The pressures of the system of blood vessels will decrease if some blood is stored in the liver or the abdominal vein system. Vice versa. The effects of regulation of blood on the variation of blood pressure are larger than the other controlling parameters. Conclusions: The controlling parameters of the abdominal aorta and ascending aorta affect greatly the blood pressure of each vessel.展开更多
Background:The 2019 novel coronavirus(2019-nCoV)causing an outbreak of pneumonia in Wuhan,Hubei province of China was isolated in January 2020.This study aims to investigate its epidemiologic history,and analyze the c...Background:The 2019 novel coronavirus(2019-nCoV)causing an outbreak of pneumonia in Wuhan,Hubei province of China was isolated in January 2020.This study aims to investigate its epidemiologic history,and analyze the clinical characteristics,treatment regimens,and prognosis of patients infected with 2019-nCoV during this outbreak.Methods:Clinical data from 1372019-nCoV-infected patients admitted to the respiratory departments of nine tertiary hospitals in Hubei province from December 30,2019 to January 24,2020 were retrospectively collected,including general status,clinical manifestations,laboratory test results,imaging characteristics,and treatment regimens.Results:None of the 137 patients(61 males,76 females,aged 20-83 years,median age 57 years)had a definite history of exposure to Huanan Seafood Wholesale Market.Major initial symptoms included fever(112/137,81.8%),coughing(66/137,48.2%),and muscle pain or fatigue(44/137,32.1%),with other,less typical initial symptoms observed at low frequency,including heart palpitations,diarrhea,and headache.Nearly 80%of the patients had normal or decreased white blood cell counts,and 72.3%(99/137)had lymphocytopenia.Lung involvement was present in all cases,with most chest computed tomography scans showing lesions in multiple lung lobes,some of which were dense;ground-glass opacity co-existed with consolidation shadows or cord-like shadows.Given the lack of effective drugs,treatment focused on symptomatic and respiratory support.Immunoglobulin G was delivered to some critically ill patients according to their conditions.Systemic corticosteroid treatment did not show significant benefits.Notably,early respiratory support facilitated disease recovery and improved prognosis.The risk of death was primarily associated with age,underlying chronic diseases,and median interval from the appearance of initial symptoms to dyspnea.Conclusions:The majority of patients with 2019-nCoV pneumonia present with fever as the first symptom,and most of them still showed typical manifestations of viral pneumonia on chest imaging.Middle-aged and elderly patients with underlying comorbidities are susceptible to respiratory failure and may have a poorer prognosis.展开更多
Background:Although a variety of risk factors of pneumonia after clipping or coiling of the aneurysm(post-operative pneumonia[POP])in patients with aneurysmal subarachnoid hemorrhage(aSAH)have been studied,the predict...Background:Although a variety of risk factors of pneumonia after clipping or coiling of the aneurysm(post-operative pneumonia[POP])in patients with aneurysmal subarachnoid hemorrhage(aSAH)have been studied,the predictive model of POP after aSAH has still not been well established.Thus,the aim of this study was to assess the feasibility of using admission neutrophil to lymphocyte ratio(NLR)to predict the occurrence of POP in aSAH patients.Methods:We evaluated 711 aSAH patients who were enrolled in a prospective observational study and collected admission blood cell counts data.We analyzed available demographics and baseline variables for these patients and analyzed the correlation of these factors with POP using Cox regression.After screening out the prognosis-related factors,the predictive value of these factors for POP was further assessed.Results:POP occurred in 219 patients(30.4%)in this cohort.Patients with POP had significantly higher NLR than those without(14.11±8.90vs.8.80±5.82,P<0.001).Multivariate analysis revealed that NLR remained a significant factor independently associated with POP following aSAH after adjusting for possible confounding factors,including the age,World Federation of Neurosurgical Societies(WFNS)grade,endovascular treatment,and ventilator use.And the predictive value of NLR was significantly increased after WFNS grade was combined with NLR(NLRvs.WFNS grade×NLR,P=0.011).Conclusions:Regardless of good or poor WNFS grade,patients having NLR>10 had significantly worse POP survival rate than patients having NLR≤10.NLR at admission might be helpful as a predictor of POP in aSAH patients.展开更多
文摘Background A flame burn is an injury of body tissues,including respiratory tract damage,due to exposure to a flame or its dense smoke.Flame burns cause some of the most physically and psychologically devastating forms of trauma.Compared to scald burns,flame burn patients have a higher mortality rate and a higher frequency of multiorgan failure.The purpose of this research was to investigate the trends,complications,and mortality risk factors of flame burns at the Department of Plastic and Burn Surgery(DPBS)of the People’s Hospital of China Three Gorges University(PHCTGU).Methods A retrospective analysis of 48 flame burn patients—accounting for 8.3%of the 576 burn victims admitted for burns at the PHCTGU from February 1,2010,to September 30,2019—was performed after collecting information from the Burns Registry of the said hospital.Results The proportion of patients with flame burns was 8.3%(n=48).The mean total body surface area(TBSA)affected was 27.6%.The mean duration of hospitalization was 32.5 days.The etiologies of the flame burns were as follows:gas explosions(21,43.8%),ethanol(8,16.7%),charcoal fire(7,14.6%),petrol explosions(4,8.3%),wooden houses(4,8.3%),and others,including dust,cigarette lighter,and burning incense,accounting for 8.3%of cases(4).Finally,42(87.5%)patients were treated and discharged,and 6(12.5%)patients died.Complications included scarring in 38(90.5%)patients,severe scar contractures on different parts of the body in 25(60.0%)patients,scar ulcer in 6(14.3%)patients,keloids in 3(7.1%)patients,and scar cancer in 1(2.4%)patient.Multiple complications occurred in the same patient.The only risk factor for mortality that was identified was TBSA(P=0.043).Conclusions Our study revealed that a small population(8.3%)was injured by flame burns,but 6 deaths were recorded.Society must continually enhance safeguard procedures to flames and strengthen education to protect life and avoid severe complications.
文摘Image technology is applied more and more to help doctors to improve the accuracy of tumor diagnosis as well as researchers to study tumor characteristics. Image segmentation technology is an important part of image treatment. This paper summarizes the advances of image segmentation by using artificial neural network including mainly the BP network and convolutional neural network (CNN). Many CNN models with different structures have been built and successfully used in segmentation of tumor images such as supervised and unsupervised learning CNN. It is shown that the application of artificial network can improve the efficiency and accuracy of segmentation of tumor image. However, some deficiencies of image segmentation by using artificial neural network still exist. For example, new methods should be found to reduce the cost of building the marked data set. New artificial networks with higher efficiency should be built.
文摘Breast tumor is the most common tumor in the world. The most important method to reduce the mortality due to breast tumor is diagnosed and found as early as possible. Imaging technology is one of the most important means to help doctors diagnose tumor early. This paper first simply introduces the common imaging technology. Then the mechanism and application of the ultrasonic elastic imaging technology in the diagnosis of breast tumor are summarized and discussed detailly. The methods for image treatment are introduced also. At last the development trend is analyzed. It is shown that the ultrasonic imaging technology is the most convenient and the cheapest relative to other imaging technologies such as nuclear magnetic imaging (NMI) and computer tomography (CT). Especially the ultrasonic elastic imaging technology can provide not only imaging information but also mechanism parameters, which helps to improve the accuracy of diagnosis obviously. Therefore, the ultrasonic elastic imaging technology is worthy of being studied further. More effective image analysis method is required.
文摘Deep vein thrombosis (DVT) is the second reason of death due to tumor. In order to find more effective methods for prevention of DVT due to gynecologic tumor, the advances of study and practice in this aspect should be summarized. As an important and effective measure for prevention of DVT, the comprehensive nursing is to be analyzed carefully. Lots of practices show that proper nursing measures can prevent effectively the occurrence of postoperative DVT. Virchow thought that DVT is caused by three factors: injury of venous wall, slowed blood flow and hypercoagulability. Thus, the prevention measures are presented on the factors such as application of sequential decompression elastic socks, intraoperative intervention etc. Clinical nursing pathway is shown to be very effective method recently. More effective measures and related facilities for prevention of DVT should be built in the future. Physical and psychological methods should be combined in the nursing of DVT.
文摘Background: Alzheimer’s disease (AD), commonly known as senile dementia, is a neurodegenerative disease with clinical manifestations of memory impairment, personality and behavior changes. The pathogenesis of AD is complex and inconclusive in the point of view of western medicine, which is the fundamental reason for the lack of drugs that can reverse the course of the disease. People have gradually shifted from simple amyloid hypothesis to new pathogenesis theories, such as gamma oscillation, prion like transmission, and so on. As an effective means to treat AD, traditional Chinese medicine has made some research progress in recent years. This article mainly reviews the etiology, pathogenesis and treatment of AD, so as to provide reference for the prevention and treatment of AD. Methods: Through systematic literature research, comparison and analysis, the main pathogenesis, influencing factors, progress and development tendency of traditional Chinese medicine and Western medicine in the treatment of AD are presented. Results: Alzheimer’s disease is a kind of multiple neurodegenerative diseases. The pathogenesis and related targets of AD still need to be further explored. The main pathological phenomenon of AD is senile plaques formed by intracellular neurofibrillary tangles and extracellular amyloid protein aggregation. Existing possible pathogenesis includes β-amyloid cascade hypothesis, tau protein hypothesis, cholinergic hypothesis and so on. As the pathogenesis of AD has not been clarified, so far no effective therapeutic drugs or means have been found. The traditional drugs used to treat AD mainly include acetylcholinesterase inhibitor kabbalatin, galantamine, donepezil, and N-methyl-D-aspartate receptor antagonist memantine. However, although these marketed drugs can slow down the course of the disease and alleviate symptoms, they cannot totally cure the disease. Traditional Chinese medicine has the characteristics of personalized differentiation and treatment. The Western medicine can accurately determine the lesion location and target. Conclusions: Integrated traditional Chinese medicine and West medicine is the most promising direction in the treatment of Alzheimer’s disease.
文摘Background: Obsessive-compulsive, anxiety disorder, and depression are the most common negative emotions. The incidence rate is high and spread across all age groups. With the rapid development of the world economy and the increasing competition in social life, the incidence rate has also increased rapidly, more and more young suffer from these three kinds of mental illnesses. Many studies have been carried out to investigate the pathogenesis and therapeutic method. It is necessary to summarize the progress for references to further research and treatment. Method: Based on a series of literature, the studies on the pathogenesis and therapeutic method of the three kinds of illnesses are summarized and analyzed. The points and results either of West medicine (WM) or traditional Chinese medicine (TCM) are collected and compared to find the best tendency of study and the best therapeutic method. Results: Obsessive-compulsive disorder, anxiety disorder and depression are common in recent years and severely affect people’s lives. In view of WM. These three kinds of illnesses are all related to the changes or damage of part of brain and nervous system. While TCM thinks that they are due to Qi stagnation or deficiency of heart Yin. Many methods of treatment have been presented and used clinically, but the effect is limited. Conclusion: The most promising and effective methods are those combining WM and TCM.
文摘The incidence rate of venous thromboembolism (VTE) of patients after operation is very high. Many studies on VTE have been processed. The pathogenesis, dangerous factors and assessment method of VTE are summarized in this paper. Two theories of pathogenesis, theory of Virchow’s triad and theory of anoxia at the tip of venous valve, are introduced first. The main dangerous factors of VTE such as tumor, perioperative period are discussed then. The main assessment methods of VTE are introduced also. At last, some problems required to be studied deeper have been presented.
文摘Infertility is one of the difficult complicated diseases. Many couples suffer from it. The pathogenesis is very complicated. The imbalance or lesson of any link of the reproductive system can cause infertility. This paper summarizes the treatment of female infertility by integrated Traditional Chinese Medicine (TCM) and Western Medicine (WM) which can not only improve the ovulation rate and pregnancy rate, but also decrease the complications. The effects are better than that by TCM or WM only. Therefore, the coupling method is worth to be used widely in clinical practice.
文摘Background: Hemodynamics is a practical and complicated theoretical problem. The aim of this paper is to analyze the characteristics of blood pressure in the cardiovascular system changing with the mechanical parameters of blood vessels and the storage of some visceral organs. Method: The fluid network model was used for the study. The cardiovascular system was modeled as a system consisting of 20 segments of vessels. The main controlling parameters were determined first by using dimensional analysis. Then the responses of blood pressure of each segment of vessels were analyzed by changing the controlling parameters. Results: The parameters of the blood vessel of brain have the least influence on the pressures of other parts. The pressures of the system of blood vessels will decrease if some blood is stored in the liver or the abdominal vein system. Vice versa. The effects of regulation of blood on the variation of blood pressure are larger than the other controlling parameters. Conclusions: The controlling parameters of the abdominal aorta and ascending aorta affect greatly the blood pressure of each vessel.
文摘Background:The 2019 novel coronavirus(2019-nCoV)causing an outbreak of pneumonia in Wuhan,Hubei province of China was isolated in January 2020.This study aims to investigate its epidemiologic history,and analyze the clinical characteristics,treatment regimens,and prognosis of patients infected with 2019-nCoV during this outbreak.Methods:Clinical data from 1372019-nCoV-infected patients admitted to the respiratory departments of nine tertiary hospitals in Hubei province from December 30,2019 to January 24,2020 were retrospectively collected,including general status,clinical manifestations,laboratory test results,imaging characteristics,and treatment regimens.Results:None of the 137 patients(61 males,76 females,aged 20-83 years,median age 57 years)had a definite history of exposure to Huanan Seafood Wholesale Market.Major initial symptoms included fever(112/137,81.8%),coughing(66/137,48.2%),and muscle pain or fatigue(44/137,32.1%),with other,less typical initial symptoms observed at low frequency,including heart palpitations,diarrhea,and headache.Nearly 80%of the patients had normal or decreased white blood cell counts,and 72.3%(99/137)had lymphocytopenia.Lung involvement was present in all cases,with most chest computed tomography scans showing lesions in multiple lung lobes,some of which were dense;ground-glass opacity co-existed with consolidation shadows or cord-like shadows.Given the lack of effective drugs,treatment focused on symptomatic and respiratory support.Immunoglobulin G was delivered to some critically ill patients according to their conditions.Systemic corticosteroid treatment did not show significant benefits.Notably,early respiratory support facilitated disease recovery and improved prognosis.The risk of death was primarily associated with age,underlying chronic diseases,and median interval from the appearance of initial symptoms to dyspnea.Conclusions:The majority of patients with 2019-nCoV pneumonia present with fever as the first symptom,and most of them still showed typical manifestations of viral pneumonia on chest imaging.Middle-aged and elderly patients with underlying comorbidities are susceptible to respiratory failure and may have a poorer prognosis.
基金Key Clinical Specialty Discipline Construction Program of Fujian Province,the Major Project of Fujian Provincial Department of Science and Technology(No.2014YZ0003)Qihan Foundation of Fujian Medical University(No.2018QH1049)National Natural Science Foundation of China(No.81901395)。
文摘Background:Although a variety of risk factors of pneumonia after clipping or coiling of the aneurysm(post-operative pneumonia[POP])in patients with aneurysmal subarachnoid hemorrhage(aSAH)have been studied,the predictive model of POP after aSAH has still not been well established.Thus,the aim of this study was to assess the feasibility of using admission neutrophil to lymphocyte ratio(NLR)to predict the occurrence of POP in aSAH patients.Methods:We evaluated 711 aSAH patients who were enrolled in a prospective observational study and collected admission blood cell counts data.We analyzed available demographics and baseline variables for these patients and analyzed the correlation of these factors with POP using Cox regression.After screening out the prognosis-related factors,the predictive value of these factors for POP was further assessed.Results:POP occurred in 219 patients(30.4%)in this cohort.Patients with POP had significantly higher NLR than those without(14.11±8.90vs.8.80±5.82,P<0.001).Multivariate analysis revealed that NLR remained a significant factor independently associated with POP following aSAH after adjusting for possible confounding factors,including the age,World Federation of Neurosurgical Societies(WFNS)grade,endovascular treatment,and ventilator use.And the predictive value of NLR was significantly increased after WFNS grade was combined with NLR(NLRvs.WFNS grade×NLR,P=0.011).Conclusions:Regardless of good or poor WNFS grade,patients having NLR>10 had significantly worse POP survival rate than patients having NLR≤10.NLR at admission might be helpful as a predictor of POP in aSAH patients.
