Purpose–The deformation of the roadbed is easily influenced by the external environment to improve the accuracy of high-speed railway subgrade settlement prediction.Design/methodology/approach–A high-speed railway s...Purpose–The deformation of the roadbed is easily influenced by the external environment to improve the accuracy of high-speed railway subgrade settlement prediction.Design/methodology/approach–A high-speed railway subgrade settlement interval prediction method using the secretary bird optimization(SBOA)algorithm to optimize the BP neural network under the premise of gray relational analysis is proposed.Findings–Using the SBOA algorithm to optimize the BP neural network,the optimal weights and thresholds are obtained,and the best parameter prediction model is combined.The data were collected from the sensors deployed through the subgrade settlement monitoring system,and the gray relational analysis is used to verify that all four influencing factors had a great correlation to the subgrade settlement,and the collected data are verified using the model.Originality/value–The experimental results show that the SBOA-BP model has higher prediction accuracy than the BP model,and the SBOA-BP model has a wider range of prediction intervals for a given confidence level,which can provide higher guiding value for practical engineering applications.展开更多
Surface-enhanced Raman spectroscopy(SERS)microfluidic system,which enables rapid detection of chemical and biological analytes,offers an effective platform to monitor various food contaminants and disease diagnoses.Th...Surface-enhanced Raman spectroscopy(SERS)microfluidic system,which enables rapid detection of chemical and biological analytes,offers an effective platform to monitor various food contaminants and disease diagnoses.The efficacy of SERS microfluidic systems is greatly dependent on the sensitivity and reusability of SERS detection substrates to ensure repeated use for prolonged periods.This study proposed a novel process of femtosecond laser nanoparticle array(NPA)implantation to achieve homogeneous forward transfer of gold NPA on a flexible polymer film and accurately integrated it within microfluidic chips for SERS detection.The implanted Au-NPA strips show a remarkable electromagnetic field enhancement with the factor of 9×108 during SERS detection of malachite green(MG)solution,achieving a detection limit lower than 10 ppt,far better than most laser-prepared SERS substrates.Furthermore,Au-NPA strips show excellent reusability after several physical and chemical cleaning,because of the robust embedment of laser-implanted NPA in flexible substrates.To demonstrate the performance of Au-NPA,a SERS microfluidic system is built to monitor the online oxidation reaction between MG/NaClO reactants,which helps infer the reaction path.The proposed method of nanoparticle implantation is more effective than the direct laser structuring technique.It provides better performance for SERS detection,robustness of detection,and substrate flexibility and has a wider range of applications for microfluidic systems without any negative impact.展开更多
The structure of liquid water is primarily composed of three-dimensional networks of water clusters formed by hydrogen bonds,and dis-solved oxygen is one of the most important indicators for assessing water qual-ity.I...The structure of liquid water is primarily composed of three-dimensional networks of water clusters formed by hydrogen bonds,and dis-solved oxygen is one of the most important indicators for assessing water qual-ity.In this work,distilled water with different concentration of dissolved oxygen were prepared,and a clear negative correlation between the size of water clus-ters and dissolved oxygen concentration was observed.Besides,a phenomenon of rapid absorption and release of oxygen at the water interfaces was unveiled,suggesting that oxygen molecules predominantly exist at the interfaces of water clusters.Oxygen molecules can move rapidly through the interfaces among water clusters,allowing dissolved oxygen to quickly reach a saturation level at certain partial pressure of oxygen and temperature.Further exploration into the mechanism by molecular dynamics simulations of oxygen and water clusters found that oxygen molecules can only exist stably at the interfaces among water clusters.A semi-empirical formula relating the average number of water molecules in a cluster(n)to ^(17)O NMR half-peak width(W)was summarized:n=0.1 W+0.85.These findings provide a foundation for exploring the structure and properties of water.展开更多
Piezoelectric ultrasonic transducers have shown great potential in biomedical applications due to their high acoustic-to-electric conversion efficiency and large power capacity.The focusing technique enables the trans...Piezoelectric ultrasonic transducers have shown great potential in biomedical applications due to their high acoustic-to-electric conversion efficiency and large power capacity.The focusing technique enables the transducer to produce an extremely narrow beam,greatly improving the resolution and sensitivity.In this work,we summarize the fundamental properties and biological effects of the ultrasound field,aiming to establish a correlation between device design and application.Focusing techniques for piezoelectric transducers are highlighted,including material selection and fabrication methods,which determine the final performance of piezoelectric transducers.Numerous examples,from ultrasound imaging,neuromodulation,tumor ablation to ultrasonic wireless energy transfer,are summarized to highlight the great promise of biomedical applications.Finally,the challenges and opportunities of focused ultrasound transducers are presented.The aim of this review is to bridge the gap between focused ultrasound systems and biomedical applications.展开更多
User-interactive electronic skin(e-skin) that could convert mechanical stimuli into distinguishable outputs displays tremendous potential for wearable devices and health care applications. However, the existing device...User-interactive electronic skin(e-skin) that could convert mechanical stimuli into distinguishable outputs displays tremendous potential for wearable devices and health care applications. However, the existing devices have the disadvantages such as complex integration procedure and lack of the intuitive signal display function. Here, we present a bioinspired user-interactive e-skin, which is simple in structure and can synchronously achieve digital electrical response and optical visualization upon external mechanical stimulus. The e-skin comprises a conductive layer with a carbon nanotubes/cellulose nanofibers/MXene nanohybrid network featuring remarkable electromechanical behaviors, and a stretchable elastomer layer, which is composed of silicone rubber and thermochromic pigments. Furthermore, the conductive nanohybrid network with outstanding Joule heating performance can generate controllable thermal energy under voltage input and then achieve the dynamic coloration of silicone-based elastomer. Especially, such an innovative fusion strategy of digital data and visual images enables the e-skin to monitor human activities with evermore intuition and accuracy. The simple design philosophy and reliable operation of the demonstrated e-skin are expected to provide an ideal platform for next-generation flexible electronics.展开更多
Objective:To construct a novel nanoplatform GNS@CaCO3/Ce6-NK by loading the CaCO3-coated gold nanostars(GNSs)with Chlorin e6 molecules(Ce6)into human peripheral blood mononuclear cells(PBMCs)-derived NK cells for tumo...Objective:To construct a novel nanoplatform GNS@CaCO3/Ce6-NK by loading the CaCO3-coated gold nanostars(GNSs)with Chlorin e6 molecules(Ce6)into human peripheral blood mononuclear cells(PBMCs)-derived NK cells for tumor targeted therapy.Methods:GNS@CaCO3/Ce6 nanoparticles were prepared and characterized by TEM and UV-vis.The cell surface markers and cytokines secretion of NK cells before and after loading the GNS@CaCO3/Ce6 nanoparticles were detected by Flow Cytometry(FCM)and ELISA.Effects of the GNS@CaCO3/Ce6-NK cells on A549 cancer cells was determined by FCM and CCK-8.Intracellular fluorescent signals of GNS@CaCO3/Ce6-NK cells were detected via Confocal laser scanning microscopic(CLSM)and FCM at different time points.Intracellular ROS generation of GNS@CaCO3/Ce6-NK cells under laser irradiation were examined by FCM.The distribution of GNS@CaCO3/Ce6-NK in A549 tumor-bearing mice were observed by fluorescence imaging and PA imaging.The combination therapy of GNS@CaCO3/Ce6-NK under laser irradiation were investigated on tumor-bearing mice.Results:The coated CaC03 shell on the surface of GNSs exhibited prominent delivery and protection effect of Ce6 during the cellular uptake process.The as-prepared multifunctional GNS@CaCO3/Ce6-NK cells possessed bimodal functions of fluorescence imaging and photoacoustic imaging.The as-prepared multifunctional GNS@CaCO3/Ce6-NK cells could actively target tumor tissues with the enhanced photothermal/photodynamic therapy and immunotherapy.Conclusions:The GNS@CaCO3/Ce6-NK shows effective tumor-targeting ability and prominent therapeutic efficacy toward lung cancer A549 tumor-bearing mice.Through fully utilizing the features of GNSs and NK cells,this new nanoplatform provides a new synergistic strategy for enhanced photothermal/photodynamic therapy and immunotherapy in the field of anticancer development in the near future.展开更多
Circulating tumor cells(CTCs) are the cancer cells that circulate in the peripheral blood after escaping from the original or metastatic tumors. CTCs could be used as non-invasive source of clinical information in ear...Circulating tumor cells(CTCs) are the cancer cells that circulate in the peripheral blood after escaping from the original or metastatic tumors. CTCs could be used as non-invasive source of clinical information in early diagnosis of cancer and evaluation of cancer development. In recent years, CTC research has become a hotspot field wherein many novel CTC detection technologies based on microfluidics have been developed. Great advances have been made that exhibit obvious technical advantages, but cannot yet satisfy the current clinical requirements. In this study, we review the main advances in isolation and detection methods of CTC based on microfluidics research over several years, propose five technical indicators for evaluating these methods, and explore the application prospects. We also discuss the concepts, issues, approaches, advantages, limitations, and challenges with an aim of stimulating a broader interest in developing microfluidics-based CTC detection technology.展开更多
A mathematical model describing the flow field, heat transfer and the electromagnetic phenomenon in a DC electric arc furnace has been developed. First the governing equations in the arc plasma region are solved and t...A mathematical model describing the flow field, heat transfer and the electromagnetic phenomenon in a DC electric arc furnace has been developed. First the governing equations in the arc plasma region are solved and the calculated results of heat transfer, current density and shear stresses on the anode surface are used as boundary conditions in a model of molten bath. Then a two-dimensional time-dependent model is used to describe the flow field and electromagnetic phenomenon in the molten bath. Moreover, the effect of bottom electrode diameter on the circulation of molten bath is studied.展开更多
The rate performance and cycle stability of graphitized needle coke(GNC)as anode are still limited by the sluggish kinetics and volume expansion during the Li ions intercalation and de-intercalation process.Especially...The rate performance and cycle stability of graphitized needle coke(GNC)as anode are still limited by the sluggish kinetics and volume expansion during the Li ions intercalation and de-intercalation process.Especially,the output of energy density for lithium ion batteries(LIBs)is directly affected by the delithiation capacity below 0.5 V.Here,the mildly expanded graphitized needle coke(MEGNC)with the enlarged interlayer spacing from 0.346 to 0.352 nm is obtained by the two-step mild oxidation intercalation modification.The voltage plateau of MEGNC anode below 0.5 V is obviously broadened as compared to the initial GNC anode,contributing to the enhancement of Li storage below the low voltage plateau.Moreover,the coin full cell and pouch full cell configured with MEGNC anode exhibit much enhanced Li storage ability,energy density and better cycling stability than those full cells configured with GNC and commercial graphite anodes,demonstrating the practical application value of MEGNC.The superior anode behaviors of MEGNC including the increased effective capacity at low voltage and superior cyclic stability are mainly benefited from the enlarged interlayer spacing,which not only accelerates the Li ions diffusion rate,but also effectively alleviates the volume expansion and fragmentation during the Li ions intercalation process.In addition,the above result is further confirmed by the density functional theory simulation.This work provides an effective modification strategy for the NC-based graphite to enhance the delithiation capacity at a low voltage plateau,dedicated to improving the energy density and durability of LIBs.展开更多
This mini-review highlights selectively the recent research progress in the composites of Li Fe PO4 and graphene. In particularly, the different fabrication protocols, and the electrochemical performance of the compos...This mini-review highlights selectively the recent research progress in the composites of Li Fe PO4 and graphene. In particularly, the different fabrication protocols, and the electrochemical performance of the composites are summarized in detail. The structural and morphology characters of graphene sheets that may affect the property of the composites are discussed briefly. The possible ongoing researches in area are speculated upon.展开更多
Biosynthesis of gold nanostructures has drawn increasing concerns because of its green and sustainable synthetic process. However, biosynthesis of gold nanoplates is still a challenge because of the expensive source a...Biosynthesis of gold nanostructures has drawn increasing concerns because of its green and sustainable synthetic process. However, biosynthesis of gold nanoplates is still a challenge because of the expensive source and difficulties of controllable formation of morphology and size. Herein, one-pot biosynthesis of gold nanoplates is proposed, in which cheap yeast was extracted as a green precursor. The morphologies and sizes of the gold nanostructures can be controlled via varying the pH value of the biomedium. In acid condition, gold nanoplates with side length from 1300 ± 200 to 300 ± 100 nm and height from 18 to 15 nm were obtained by increasing the pH value. Whereas, in neutral or basic condition, only gold nanoflowers and nanoparticles were obtained. It was determined that organic molecules, such as succinic acid, lactic acid, malic acid, and glutathione, which are generated in metabolism process, played important role in the reduction of gold ions. Besides, it was found that the gold nanoplates exhibited plasmonic property with prominent dipole infrared resonance in near-infrared region, indicating their potential in surface plasmon-enhanced applications, such as bioimaging and photothermal therapy.展开更多
Inter-regional and transnational grid interconnection is necessary for energy development. Xinjiang, which is rich in renewable energy resources, is adjacent to countries in Central Asia and has great potential for in...Inter-regional and transnational grid interconnection is necessary for energy development. Xinjiang, which is rich in renewable energy resources, is adjacent to countries in Central Asia and has great potential for interconnection with its neighbors. This paper outlines China's relevant policies for transnational power interconnection, and introduces the energy structure, load demand endowments, and power supply status of Xinjiang, Pakistan, and five Central Asian countries. Further, it analyzes the advantages of the multinational power interconnection from the aspects of power supply and load complementation. Finally, from the perspective of technical support and practical basis, the feasibility of interconnection between Xinjiang, Pakistan, and five Central Asian countries have been analyzed. This paper provides a theoretical basis for promoting and implementing China's "Belt and Road" power transnational interconnected development strategy.展开更多
In order to promote the development of the Internet of Things(IoT),there has been an increase in the coverage of the customer electric information acquisition system(CEIAS).The traditional fault location method for th...In order to promote the development of the Internet of Things(IoT),there has been an increase in the coverage of the customer electric information acquisition system(CEIAS).The traditional fault location method for the distribution network only considers the information reported by the Feeder Terminal Unit(FTU)and the fault tolerance rate is low when the information is omitted or misreported.Therefore,this study considers the influence of the distributed generations(DGs)for the distribution network.This takes the CEIAS as a redundant information source and solves the model by applying a binary particle swarm optimization algorithm(BPSO).The improved Dempster/S-hafer evidence theory(D-S evidence theory)is used for evidence fusion to achieve the fault section location for the distribution network.An example is provided to verify that the proposed method can achieve single or multiple fault locations with a higher fault tolerance.展开更多
In order to calibrate electrical instruments and generate a constant magnetic field, a novel design method for square Helmholtz coil is proposed. According to the superposition principle in electromagnetics, the theor...In order to calibrate electrical instruments and generate a constant magnetic field, a novel design method for square Helmholtz coil is proposed. According to the superposition principle in electromagnetics, the theory of the square Helmholtz coil is established, and the design method is verified by Matlab calculation. Compared with conventional circular Helmholtz coil, the novel square one is with a larger uniform region. Simulation work is conducted in Maxwell, and the distribution of the magnetic field is obtained. The results demonstrate the validation of the applied calculation method of the proposed Helmholtz model. The space utilization rate η is used to make a comparison between the square and circular coils for the uniform region. The square Helmholtz coil is fabricated, the length of a single square coil is 1.5 m, and the amplitude of the magnetic field is controlled by the current. The GSM-19 T proton magnetometer is used to measure the amplitude of the magnetic field generated by the square Helmholtz coil. Experimental results indicate that a wide-range variable uniform magnetic field from 0 to 120 μT is generated in the center of Helmholtz coils.展开更多
The green production of hydrogen from electrocatalytic water splitting is an important base and promising direction for the future of the large-scale application of hydrogen energy.The key of green hydrogen evolution ...The green production of hydrogen from electrocatalytic water splitting is an important base and promising direction for the future of the large-scale application of hydrogen energy.The key of green hydrogen evolution depends on the development of low-cost and highly active electrocatalysts.Molybdenum carbides(MoxC),as a typical of earth-abundant transition-metal material,have accumulated great attention due to their low cost,earth abundance,electrical conductivity,similar d-band state to Pt,and regulated morphology/electronic structures.In this paper,recent researches focusing on MoxC for efficient HER in a wide pH range are summarized from respects of modulation of unique morphology,electronic structure,and electrode interface step by step.Briefly,modulation of morphology influence the apparent activity of catalyst,modulation of electronic structure of active sites by heteroatom doping and designing heterointerface boost intrinsic HER kinetics,and modulation of electrode interface via hybridization of MoxC structures with carbon materials can ensure the fast electron transfer and boost the activity.Besides the above methods discussed,perspective and challenges of designing MoxC as the substitute of Pt-based electrocatalyst for practical hydrogen generation in a wide pH range are pointed out.展开更多
Heavy-load transfer robots are widely used in automobile production and machinery manufacturing to improve production efficiency.In order to meet the needs of large billet transfer,a 4-DOF transfer robot is designed i...Heavy-load transfer robots are widely used in automobile production and machinery manufacturing to improve production efficiency.In order to meet the needs of large billet transfer,a 4-DOF transfer robot is designed in this paper,which consists of parallel four-bar mechanisms.The Jacobian matrix referring to the mapping matrix from the joint velocity to the operating space velocity of the transfer robot can be solved by the differential-vector method.The mean value of the Jacobian matrix condition number in the workspace is used as the global performance index of the robot velocity and the optimization goal.The constraint condition is established based on the actual working condition.Then the linkage length optimization is carried out to decrease the length of the linkage and to increase the global performance index of velocity.The total length of robot rods is reduced by 6.12%.The global performance index of velocity is improved by 45.15%.Taking the optimized rod length as the mechanism parameter,the distribution of the motion space of the transfer robot is obtained.Finally,the results show that the proposed method for establishing the Jacobian matrix of the lower-mobility robot and for the optimization of the rods based on the velocity global performance index is accurate and effective.The workspace distribution of the robot meets the design requirements.展开更多
Motivated by 5th generation wireless systems(5G),a large number of emerging applications appear,which put forward higher requirements for the task’s transmission determinacy,which refers to the delay and jitter.To sa...Motivated by 5th generation wireless systems(5G),a large number of emerging applications appear,which put forward higher requirements for the task’s transmission determinacy,which refers to the delay and jitter.To satisfy the deterministic requirement,mobile edge computing(MEC)is envisioned as a promising technique for reducing the end-to-end delay significantly.In this paper,we consider delaysensitive task and jitter-sensitive task,and then formulate the joint communications and computing optimization problem under the latency,the total bandwidth,the total transmission power of base station(BS)and the computing ability of the MEC server constraints to minimize the delay and jitter in a multiuser MEC system.Because of the problems are nonconvex,we decouple them into some subproblems and propose the corresponding algorithms to obtain a suboptimal solution.Finally,numerical results show that the proposed algorithms have a significant performance gain over the traditional solution in terms of the delay and the jitter.展开更多
Stimulated Raman scattering(SRS)in a longitudinal magnetized plasma is studied by theoretical analysis and kinetic simulation.The linear growth rate derived via one-dimensional fluid theory shows the dependence on the...Stimulated Raman scattering(SRS)in a longitudinal magnetized plasma is studied by theoretical analysis and kinetic simulation.The linear growth rate derived via one-dimensional fluid theory shows the dependence on the plasma density,electron temperature,and magnetic field intensity.One-dimensional particle-in-cell simulations are carried out to examine the kinetic evolution of SRS under low magnetic intensity of w_c/w_0<0.01.There are two density regions distinguished in which the absolute growth of enveloped electrostatic waves and spectrum present quite different characteristics.In a relatively low-density plasma(ne~0.20 nc),the plasma wave presents typical absolute growth and the magnetic field alleviates linear SRS.While in the plasma whose density is near the cut-off point(ne~0.23 nc),the magnetic field induces a spectral splitting of the backscattering and forward-scattering waves.It has been observed in simulations and verified by theoretical analysis.Due to this effect,the onset of reflectivity delays,and the plasma waves form high-frequency oscillation and periodic envelope structure.The split wavenumber Dk/k0 is proportional to the magnetic field intensity and plasma density.These studies provide novel insight into the kinetic behavior of SRS in magnetized plasmas.展开更多
Faults in rotating machine are difficult to detect and identify,especially when the system is complex and nonlinear.In order to solve this problem,a novel performance monitoring and fault diagnosis method based on ker...Faults in rotating machine are difficult to detect and identify,especially when the system is complex and nonlinear.In order to solve this problem,a novel performance monitoring and fault diagnosis method based on kernel generalized discriminant analysis(kernel GDA,KGDA)was proposed.Through KGDA,the data were mapped from the original space to the high-dimensional feature space.Then the statistic distance between normal data and test data was constructed to detect whether a fault was occurring.If a fault had occurred,similar analysis was used to identify the type of faults.The effectiveness of the proposed method was evaluated by simulation results of vibration signal fault dataset in the rotating machinery,which was scalable to different rotating machinery.展开更多
文摘Purpose–The deformation of the roadbed is easily influenced by the external environment to improve the accuracy of high-speed railway subgrade settlement prediction.Design/methodology/approach–A high-speed railway subgrade settlement interval prediction method using the secretary bird optimization(SBOA)algorithm to optimize the BP neural network under the premise of gray relational analysis is proposed.Findings–Using the SBOA algorithm to optimize the BP neural network,the optimal weights and thresholds are obtained,and the best parameter prediction model is combined.The data were collected from the sensors deployed through the subgrade settlement monitoring system,and the gray relational analysis is used to verify that all four influencing factors had a great correlation to the subgrade settlement,and the collected data are verified using the model.Originality/value–The experimental results show that the SBOA-BP model has higher prediction accuracy than the BP model,and the SBOA-BP model has a wider range of prediction intervals for a given confidence level,which can provide higher guiding value for practical engineering applications.
基金The National Natural Science Foundation of China(Grant Numbers:U21A20135 and 52205488)‘Shuguang Program’supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commission(Grant Number:20SG12)Shanghai Jiao Tong University(Grant Number:2020QY11).
文摘Surface-enhanced Raman spectroscopy(SERS)microfluidic system,which enables rapid detection of chemical and biological analytes,offers an effective platform to monitor various food contaminants and disease diagnoses.The efficacy of SERS microfluidic systems is greatly dependent on the sensitivity and reusability of SERS detection substrates to ensure repeated use for prolonged periods.This study proposed a novel process of femtosecond laser nanoparticle array(NPA)implantation to achieve homogeneous forward transfer of gold NPA on a flexible polymer film and accurately integrated it within microfluidic chips for SERS detection.The implanted Au-NPA strips show a remarkable electromagnetic field enhancement with the factor of 9×108 during SERS detection of malachite green(MG)solution,achieving a detection limit lower than 10 ppt,far better than most laser-prepared SERS substrates.Furthermore,Au-NPA strips show excellent reusability after several physical and chemical cleaning,because of the robust embedment of laser-implanted NPA in flexible substrates.To demonstrate the performance of Au-NPA,a SERS microfluidic system is built to monitor the online oxidation reaction between MG/NaClO reactants,which helps infer the reaction path.The proposed method of nanoparticle implantation is more effective than the direct laser structuring technique.It provides better performance for SERS detection,robustness of detection,and substrate flexibility and has a wider range of applications for microfluidic systems without any negative impact.
基金funding support from National Natural Science Foundation of China(Project No.61574091)Wuxi River and Lake Management and Water Resources Management Center(Project No.JSXXCG2022-004).
文摘The structure of liquid water is primarily composed of three-dimensional networks of water clusters formed by hydrogen bonds,and dis-solved oxygen is one of the most important indicators for assessing water qual-ity.In this work,distilled water with different concentration of dissolved oxygen were prepared,and a clear negative correlation between the size of water clus-ters and dissolved oxygen concentration was observed.Besides,a phenomenon of rapid absorption and release of oxygen at the water interfaces was unveiled,suggesting that oxygen molecules predominantly exist at the interfaces of water clusters.Oxygen molecules can move rapidly through the interfaces among water clusters,allowing dissolved oxygen to quickly reach a saturation level at certain partial pressure of oxygen and temperature.Further exploration into the mechanism by molecular dynamics simulations of oxygen and water clusters found that oxygen molecules can only exist stably at the interfaces among water clusters.A semi-empirical formula relating the average number of water molecules in a cluster(n)to ^(17)O NMR half-peak width(W)was summarized:n=0.1 W+0.85.These findings provide a foundation for exploring the structure and properties of water.
基金National Natural Science Foundation of China(12072189,82171011)Shanghai Jiao Tong University‘Deep Blue Program’Fund(Grant No.SL2103)+1 种基金Project of Biobank(No.YBKB202117)from Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of Medicine and Science Foundation of National Key Laboratory of Science and Technology on Advanced Composites in Special Environments(No.6142905223704)。
文摘Piezoelectric ultrasonic transducers have shown great potential in biomedical applications due to their high acoustic-to-electric conversion efficiency and large power capacity.The focusing technique enables the transducer to produce an extremely narrow beam,greatly improving the resolution and sensitivity.In this work,we summarize the fundamental properties and biological effects of the ultrasound field,aiming to establish a correlation between device design and application.Focusing techniques for piezoelectric transducers are highlighted,including material selection and fabrication methods,which determine the final performance of piezoelectric transducers.Numerous examples,from ultrasound imaging,neuromodulation,tumor ablation to ultrasonic wireless energy transfer,are summarized to highlight the great promise of biomedical applications.Finally,the challenges and opportunities of focused ultrasound transducers are presented.The aim of this review is to bridge the gap between focused ultrasound systems and biomedical applications.
基金supported by National Key Basic Research Program of China(No.2017YFA0205301)Natural Science Foundation of China(31771081,81921002,and 8202010801)+2 种基金S&T Innovation 2025 Major Special Program of Ningbo(2018B10040)the Fundamental Research Funds for the Central Universities(22120210582)China Postdoctoral Science Foundation(2021TQ0247)。
文摘User-interactive electronic skin(e-skin) that could convert mechanical stimuli into distinguishable outputs displays tremendous potential for wearable devices and health care applications. However, the existing devices have the disadvantages such as complex integration procedure and lack of the intuitive signal display function. Here, we present a bioinspired user-interactive e-skin, which is simple in structure and can synchronously achieve digital electrical response and optical visualization upon external mechanical stimulus. The e-skin comprises a conductive layer with a carbon nanotubes/cellulose nanofibers/MXene nanohybrid network featuring remarkable electromechanical behaviors, and a stretchable elastomer layer, which is composed of silicone rubber and thermochromic pigments. Furthermore, the conductive nanohybrid network with outstanding Joule heating performance can generate controllable thermal energy under voltage input and then achieve the dynamic coloration of silicone-based elastomer. Especially, such an innovative fusion strategy of digital data and visual images enables the e-skin to monitor human activities with evermore intuition and accuracy. The simple design philosophy and reliable operation of the demonstrated e-skin are expected to provide an ideal platform for next-generation flexible electronics.
基金supported from 973 Project (Grant No. 2015CB931802 and 2017YFA0205301)Chinese National Natural Scientific Fund (Grant No.81327002 and 81803094)+1 种基金China Postdoctoral Science Foundation (Grant No. 2017M621486)Funding from Shanghai Engineering Research Center for Intelligent diagnosis and treatment instrument (Grant No.15DZ2252000)
文摘Objective:To construct a novel nanoplatform GNS@CaCO3/Ce6-NK by loading the CaCO3-coated gold nanostars(GNSs)with Chlorin e6 molecules(Ce6)into human peripheral blood mononuclear cells(PBMCs)-derived NK cells for tumor targeted therapy.Methods:GNS@CaCO3/Ce6 nanoparticles were prepared and characterized by TEM and UV-vis.The cell surface markers and cytokines secretion of NK cells before and after loading the GNS@CaCO3/Ce6 nanoparticles were detected by Flow Cytometry(FCM)and ELISA.Effects of the GNS@CaCO3/Ce6-NK cells on A549 cancer cells was determined by FCM and CCK-8.Intracellular fluorescent signals of GNS@CaCO3/Ce6-NK cells were detected via Confocal laser scanning microscopic(CLSM)and FCM at different time points.Intracellular ROS generation of GNS@CaCO3/Ce6-NK cells under laser irradiation were examined by FCM.The distribution of GNS@CaCO3/Ce6-NK in A549 tumor-bearing mice were observed by fluorescence imaging and PA imaging.The combination therapy of GNS@CaCO3/Ce6-NK under laser irradiation were investigated on tumor-bearing mice.Results:The coated CaC03 shell on the surface of GNSs exhibited prominent delivery and protection effect of Ce6 during the cellular uptake process.The as-prepared multifunctional GNS@CaCO3/Ce6-NK cells possessed bimodal functions of fluorescence imaging and photoacoustic imaging.The as-prepared multifunctional GNS@CaCO3/Ce6-NK cells could actively target tumor tissues with the enhanced photothermal/photodynamic therapy and immunotherapy.Conclusions:The GNS@CaCO3/Ce6-NK shows effective tumor-targeting ability and prominent therapeutic efficacy toward lung cancer A549 tumor-bearing mice.Through fully utilizing the features of GNSs and NK cells,this new nanoplatform provides a new synergistic strategy for enhanced photothermal/photodynamic therapy and immunotherapy in the field of anticancer development in the near future.
基金supported by National Key Basic Research Program of China (Grant No.2017FYA0205300 and No.2015 CB931802)National Natural Scientific Foundation of China (No. 81571835)
文摘Circulating tumor cells(CTCs) are the cancer cells that circulate in the peripheral blood after escaping from the original or metastatic tumors. CTCs could be used as non-invasive source of clinical information in early diagnosis of cancer and evaluation of cancer development. In recent years, CTC research has become a hotspot field wherein many novel CTC detection technologies based on microfluidics have been developed. Great advances have been made that exhibit obvious technical advantages, but cannot yet satisfy the current clinical requirements. In this study, we review the main advances in isolation and detection methods of CTC based on microfluidics research over several years, propose five technical indicators for evaluating these methods, and explore the application prospects. We also discuss the concepts, issues, approaches, advantages, limitations, and challenges with an aim of stimulating a broader interest in developing microfluidics-based CTC detection technology.
文摘A mathematical model describing the flow field, heat transfer and the electromagnetic phenomenon in a DC electric arc furnace has been developed. First the governing equations in the arc plasma region are solved and the calculated results of heat transfer, current density and shear stresses on the anode surface are used as boundary conditions in a model of molten bath. Then a two-dimensional time-dependent model is used to describe the flow field and electromagnetic phenomenon in the molten bath. Moreover, the effect of bottom electrode diameter on the circulation of molten bath is studied.
基金Supported by National Basic Research Program of China （973 Program） （2010CB731800）, National Natural Science Foundation of China （60934003, 61074065）, Key Project for Natural Science Research of Hebei Education Department （ZD200908）, and the Doctor Foundation of Northeastern University at Qinhuangdao（XNB201507）
基金supported by the National Natural Science Foundation of China(21776309,22122807 and 21706283)。
文摘The rate performance and cycle stability of graphitized needle coke(GNC)as anode are still limited by the sluggish kinetics and volume expansion during the Li ions intercalation and de-intercalation process.Especially,the output of energy density for lithium ion batteries(LIBs)is directly affected by the delithiation capacity below 0.5 V.Here,the mildly expanded graphitized needle coke(MEGNC)with the enlarged interlayer spacing from 0.346 to 0.352 nm is obtained by the two-step mild oxidation intercalation modification.The voltage plateau of MEGNC anode below 0.5 V is obviously broadened as compared to the initial GNC anode,contributing to the enhancement of Li storage below the low voltage plateau.Moreover,the coin full cell and pouch full cell configured with MEGNC anode exhibit much enhanced Li storage ability,energy density and better cycling stability than those full cells configured with GNC and commercial graphite anodes,demonstrating the practical application value of MEGNC.The superior anode behaviors of MEGNC including the increased effective capacity at low voltage and superior cyclic stability are mainly benefited from the enlarged interlayer spacing,which not only accelerates the Li ions diffusion rate,but also effectively alleviates the volume expansion and fragmentation during the Li ions intercalation process.In addition,the above result is further confirmed by the density functional theory simulation.This work provides an effective modification strategy for the NC-based graphite to enhance the delithiation capacity at a low voltage plateau,dedicated to improving the energy density and durability of LIBs.
基金the Science and Technology Commission of Shanghai Municipality (No. 12nm0503500)the National Science Foundation of China (Nos. 21376148, 11374205)
文摘This mini-review highlights selectively the recent research progress in the composites of Li Fe PO4 and graphene. In particularly, the different fabrication protocols, and the electrochemical performance of the composites are summarized in detail. The structural and morphology characters of graphene sheets that may affect the property of the composites are discussed briefly. The possible ongoing researches in area are speculated upon.
基金supported by the National Key Research and Development Program of China(2016YFC0102700)National Natural Science Foundation of China(21171117,21271181,21473240,and 81270209)+1 种基金Medical-Engineering Crossover Fund of Shanghai Jiao Tong University(YG2015MS51 and YG2014MS66)the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning
文摘Biosynthesis of gold nanostructures has drawn increasing concerns because of its green and sustainable synthetic process. However, biosynthesis of gold nanoplates is still a challenge because of the expensive source and difficulties of controllable formation of morphology and size. Herein, one-pot biosynthesis of gold nanoplates is proposed, in which cheap yeast was extracted as a green precursor. The morphologies and sizes of the gold nanostructures can be controlled via varying the pH value of the biomedium. In acid condition, gold nanoplates with side length from 1300 ± 200 to 300 ± 100 nm and height from 18 to 15 nm were obtained by increasing the pH value. Whereas, in neutral or basic condition, only gold nanoflowers and nanoparticles were obtained. It was determined that organic molecules, such as succinic acid, lactic acid, malic acid, and glutathione, which are generated in metabolism process, played important role in the reduction of gold ions. Besides, it was found that the gold nanoplates exhibited plasmonic property with prominent dipole infrared resonance in near-infrared region, indicating their potential in surface plasmon-enhanced applications, such as bioimaging and photothermal therapy.
基金Supported by the State Grid Scientific and Technological Project (Title: Research on the Development and Integration Mode of Renewable Energy in Xinjiang Power Grid under the Background of Multinational Interconnection, NY71-17-008)
文摘Inter-regional and transnational grid interconnection is necessary for energy development. Xinjiang, which is rich in renewable energy resources, is adjacent to countries in Central Asia and has great potential for interconnection with its neighbors. This paper outlines China's relevant policies for transnational power interconnection, and introduces the energy structure, load demand endowments, and power supply status of Xinjiang, Pakistan, and five Central Asian countries. Further, it analyzes the advantages of the multinational power interconnection from the aspects of power supply and load complementation. Finally, from the perspective of technical support and practical basis, the feasibility of interconnection between Xinjiang, Pakistan, and five Central Asian countries have been analyzed. This paper provides a theoretical basis for promoting and implementing China's "Belt and Road" power transnational interconnected development strategy.
基金supported by the Science and Technology Project of State Grid Shandong Electric Power Company?“Research on the Data-Driven Method for Energy Internet”?(Project No.2018A-100)。
文摘In order to promote the development of the Internet of Things(IoT),there has been an increase in the coverage of the customer electric information acquisition system(CEIAS).The traditional fault location method for the distribution network only considers the information reported by the Feeder Terminal Unit(FTU)and the fault tolerance rate is low when the information is omitted or misreported.Therefore,this study considers the influence of the distributed generations(DGs)for the distribution network.This takes the CEIAS as a redundant information source and solves the model by applying a binary particle swarm optimization algorithm(BPSO).The improved Dempster/S-hafer evidence theory(D-S evidence theory)is used for evidence fusion to achieve the fault section location for the distribution network.An example is provided to verify that the proposed method can achieve single or multiple fault locations with a higher fault tolerance.
基金The National Natural Science Foundation of China(No.61327803)
文摘In order to calibrate electrical instruments and generate a constant magnetic field, a novel design method for square Helmholtz coil is proposed. According to the superposition principle in electromagnetics, the theory of the square Helmholtz coil is established, and the design method is verified by Matlab calculation. Compared with conventional circular Helmholtz coil, the novel square one is with a larger uniform region. Simulation work is conducted in Maxwell, and the distribution of the magnetic field is obtained. The results demonstrate the validation of the applied calculation method of the proposed Helmholtz model. The space utilization rate η is used to make a comparison between the square and circular coils for the uniform region. The square Helmholtz coil is fabricated, the length of a single square coil is 1.5 m, and the amplitude of the magnetic field is controlled by the current. The GSM-19 T proton magnetometer is used to measure the amplitude of the magnetic field generated by the square Helmholtz coil. Experimental results indicate that a wide-range variable uniform magnetic field from 0 to 120 μT is generated in the center of Helmholtz coils.
基金financial support from Shandong Provincial Natural Science Foundation(ZR2017MB059)the National Natural Science Foundation of China(21776314)the Fundamental Research Funds for the Central Universities(18CX05016A)。
文摘The green production of hydrogen from electrocatalytic water splitting is an important base and promising direction for the future of the large-scale application of hydrogen energy.The key of green hydrogen evolution depends on the development of low-cost and highly active electrocatalysts.Molybdenum carbides(MoxC),as a typical of earth-abundant transition-metal material,have accumulated great attention due to their low cost,earth abundance,electrical conductivity,similar d-band state to Pt,and regulated morphology/electronic structures.In this paper,recent researches focusing on MoxC for efficient HER in a wide pH range are summarized from respects of modulation of unique morphology,electronic structure,and electrode interface step by step.Briefly,modulation of morphology influence the apparent activity of catalyst,modulation of electronic structure of active sites by heteroatom doping and designing heterointerface boost intrinsic HER kinetics,and modulation of electrode interface via hybridization of MoxC structures with carbon materials can ensure the fast electron transfer and boost the activity.Besides the above methods discussed,perspective and challenges of designing MoxC as the substitute of Pt-based electrocatalyst for practical hydrogen generation in a wide pH range are pointed out.
基金supported by the National Key R&D Program of China(No.2018YFB1307900)the Natural Science Foundation of Shanxi Province(Nos.201901D211009,201901D211010)the Technology In⁃novation Foundation of Shanxi University(No.2019L 0177).
文摘Heavy-load transfer robots are widely used in automobile production and machinery manufacturing to improve production efficiency.In order to meet the needs of large billet transfer,a 4-DOF transfer robot is designed in this paper,which consists of parallel four-bar mechanisms.The Jacobian matrix referring to the mapping matrix from the joint velocity to the operating space velocity of the transfer robot can be solved by the differential-vector method.The mean value of the Jacobian matrix condition number in the workspace is used as the global performance index of the robot velocity and the optimization goal.The constraint condition is established based on the actual working condition.Then the linkage length optimization is carried out to decrease the length of the linkage and to increase the global performance index of velocity.The total length of robot rods is reduced by 6.12%.The global performance index of velocity is improved by 45.15%.Taking the optimized rod length as the mechanism parameter,the distribution of the motion space of the transfer robot is obtained.Finally,the results show that the proposed method for establishing the Jacobian matrix of the lower-mobility robot and for the optimization of the rods based on the velocity global performance index is accurate and effective.The workspace distribution of the robot meets the design requirements.
基金This work is supported by the Ministry of Education of China(MOE)-China Mobile Communication Corpo-ration(CMCC)Science Joint Foundation under grant MCM20180102.
文摘Motivated by 5th generation wireless systems(5G),a large number of emerging applications appear,which put forward higher requirements for the task’s transmission determinacy,which refers to the delay and jitter.To satisfy the deterministic requirement,mobile edge computing(MEC)is envisioned as a promising technique for reducing the end-to-end delay significantly.In this paper,we consider delaysensitive task and jitter-sensitive task,and then formulate the joint communications and computing optimization problem under the latency,the total bandwidth,the total transmission power of base station(BS)and the computing ability of the MEC server constraints to minimize the delay and jitter in a multiuser MEC system.Because of the problems are nonconvex,we decouple them into some subproblems and propose the corresponding algorithms to obtain a suboptimal solution.Finally,numerical results show that the proposed algorithms have a significant performance gain over the traditional solution in terms of the delay and the jitter.
基金supported by the National Key Research and Development Program of China (No. 2016YFA0401100)the Strategic Priority Re-search Program of Chinese Academy of Sciences (No. XDA25050700)+1 种基金the Scientific Research Foundation of Hunan Provincial Education Department (No. 20A042)National Natural Science Foundation of China (Nos. 11805062, 11675264, 11774430)
文摘Stimulated Raman scattering(SRS)in a longitudinal magnetized plasma is studied by theoretical analysis and kinetic simulation.The linear growth rate derived via one-dimensional fluid theory shows the dependence on the plasma density,electron temperature,and magnetic field intensity.One-dimensional particle-in-cell simulations are carried out to examine the kinetic evolution of SRS under low magnetic intensity of w_c/w_0<0.01.There are two density regions distinguished in which the absolute growth of enveloped electrostatic waves and spectrum present quite different characteristics.In a relatively low-density plasma(ne~0.20 nc),the plasma wave presents typical absolute growth and the magnetic field alleviates linear SRS.While in the plasma whose density is near the cut-off point(ne~0.23 nc),the magnetic field induces a spectral splitting of the backscattering and forward-scattering waves.It has been observed in simulations and verified by theoretical analysis.Due to this effect,the onset of reflectivity delays,and the plasma waves form high-frequency oscillation and periodic envelope structure.The split wavenumber Dk/k0 is proportional to the magnetic field intensity and plasma density.These studies provide novel insight into the kinetic behavior of SRS in magnetized plasmas.
基金National Natural Science Foundation of China(No.60504033)
文摘Faults in rotating machine are difficult to detect and identify,especially when the system is complex and nonlinear.In order to solve this problem,a novel performance monitoring and fault diagnosis method based on kernel generalized discriminant analysis(kernel GDA,KGDA)was proposed.Through KGDA,the data were mapped from the original space to the high-dimensional feature space.Then the statistic distance between normal data and test data was constructed to detect whether a fault was occurring.If a fault had occurred,similar analysis was used to identify the type of faults.The effectiveness of the proposed method was evaluated by simulation results of vibration signal fault dataset in the rotating machinery,which was scalable to different rotating machinery.
