BACKGROUND The role of primary-level medical pharmacists in medical institutions in China is limited;therefore,it is necessary to explore the role of pharmacists in the process of drug treatment.CASE SUMMARY A Chinese...BACKGROUND The role of primary-level medical pharmacists in medical institutions in China is limited;therefore,it is necessary to explore the role of pharmacists in the process of drug treatment.CASE SUMMARY A Chinese pharmacist participated in the complete treatment of a patient with a duodenal ulcer.The rationale for drug treatment was evaluated,and adjustments were made to the antacid and anti-infective regimen,as well as the dose and frequency of administration.Body temperature,routine blood examination,and adverse drug reactions were strictly monitored.During treatment,the pharmacist recommended anti-infective therapy with ampicillin-sulbactam,which effectively controlled the infection.Additionally,the pharmacist suggested changing famotidine to lansoprazole for acid suppression and gastroprotective treatment,combined with Chinese patent medicine such as Kangfuxin Liquid.This is the first case report of a pharmacist in primary-level medical institutions adjusting drug use for patients with duodenal ulcer and pulmonary infection.CONCLUSION A pharmacist participated in the treatment process,provided individualized medication adjustment,and achieved good clinical results.展开更多
The Chinese drug agency has issued the Urgently Needed Overseas Drug(UNOD)lists since 2018,which allows drugs to be approved based on overseas trial data,to address drug delays.We aimed to evaluate the effects of the ...The Chinese drug agency has issued the Urgently Needed Overseas Drug(UNOD)lists since 2018,which allows drugs to be approved based on overseas trial data,to address drug delays.We aimed to evaluate the effects of the UNOD on the drug launch delay in China.We collected the new molecular entities and biologics approved in the United States from 2012 to 2019,and measured the launch delay of these drugs in China.An instrumental variables(IV)strategy of the causal exposure effect in Cox model was established to examine the effects of the UNOD on the time from the approval in the United States to the approval in China.A total of 278 new drugs were approved in the United States from 2012 to 2019,of which 15.1%were designated as UNOD by the Chinese drug agency.Among all the drugs,only 34.9%reached the Chinese market before July 1,2024,with a mean of launch delay of 2397.2 days(standard deviation(SD)=1037.0).The IV estimator found that,after accounting for the endogeneity concerns,the UNOD did not have a significant effect on the launch delay(coefficient=-2.52 and robust standard error=1.73).The main reason may be that there are other policies delivering similar benefits to non-UNOD drugs,which undermines the priority of the UNOD-designated drugs in the drug approval process.The UNOD designation did not attract more applications for the urgently needed oversea drugs.Our findings highlight the need of prioritizing the drugs with substantial clinical benefits in the drug regulatory process.展开更多
Background:Primary healthcare doctors in China often experience problems with occupational burnout,a condition known to relate to high job stress and low wages.In China,many medical alliances have recently been establ...Background:Primary healthcare doctors in China often experience problems with occupational burnout,a condition known to relate to high job stress and low wages.In China,many medical alliances have recently been established in rural areas,where village physicians work as healthcare gatekeepers.However,burnout in village physicians in the context of medical alliances remains underresearched.Methods:This cross-sectional survey was conducted among 100 village physicians practicing at village clinics in Qiandongnan prefecture,Guizhou province,China.An online questionnaire was distributed to assess physicians'demographic characteristics and work situations.Burnout was measured using the Oldenburg Burnout Inventory(validated Chinese version).A multivariate linear model with stepwise procedure was used to estimate the effects of factors of interest on burnout,focusing particularly on actions within the medical alliance that involved respondents'clinics,such as training and support for village physicians provided by higher-level facilities.Results:The overall response rate was 79%.The mean burnout score was 38.09(standard deviation,4.55;range,25–47).The multivariate analysis showed that fewer working years and too much farming work were significantly related to exacerbation of burnout.Greater medical services in the total workload and greater support from higher-level facilities were associated with burnout alleviation.Conclusion:Close connections and interactions across medical alliance member facilities could facilitate reduction in burnout for village physicians practicing as primary care gatekeepers.展开更多
文摘BACKGROUND The role of primary-level medical pharmacists in medical institutions in China is limited;therefore,it is necessary to explore the role of pharmacists in the process of drug treatment.CASE SUMMARY A Chinese pharmacist participated in the complete treatment of a patient with a duodenal ulcer.The rationale for drug treatment was evaluated,and adjustments were made to the antacid and anti-infective regimen,as well as the dose and frequency of administration.Body temperature,routine blood examination,and adverse drug reactions were strictly monitored.During treatment,the pharmacist recommended anti-infective therapy with ampicillin-sulbactam,which effectively controlled the infection.Additionally,the pharmacist suggested changing famotidine to lansoprazole for acid suppression and gastroprotective treatment,combined with Chinese patent medicine such as Kangfuxin Liquid.This is the first case report of a pharmacist in primary-level medical institutions adjusting drug use for patients with duodenal ulcer and pulmonary infection.CONCLUSION A pharmacist participated in the treatment process,provided individualized medication adjustment,and achieved good clinical results.
文摘The Chinese drug agency has issued the Urgently Needed Overseas Drug(UNOD)lists since 2018,which allows drugs to be approved based on overseas trial data,to address drug delays.We aimed to evaluate the effects of the UNOD on the drug launch delay in China.We collected the new molecular entities and biologics approved in the United States from 2012 to 2019,and measured the launch delay of these drugs in China.An instrumental variables(IV)strategy of the causal exposure effect in Cox model was established to examine the effects of the UNOD on the time from the approval in the United States to the approval in China.A total of 278 new drugs were approved in the United States from 2012 to 2019,of which 15.1%were designated as UNOD by the Chinese drug agency.Among all the drugs,only 34.9%reached the Chinese market before July 1,2024,with a mean of launch delay of 2397.2 days(standard deviation(SD)=1037.0).The IV estimator found that,after accounting for the endogeneity concerns,the UNOD did not have a significant effect on the launch delay(coefficient=-2.52 and robust standard error=1.73).The main reason may be that there are other policies delivering similar benefits to non-UNOD drugs,which undermines the priority of the UNOD-designated drugs in the drug approval process.The UNOD designation did not attract more applications for the urgently needed oversea drugs.Our findings highlight the need of prioritizing the drugs with substantial clinical benefits in the drug regulatory process.
文摘Background:Primary healthcare doctors in China often experience problems with occupational burnout,a condition known to relate to high job stress and low wages.In China,many medical alliances have recently been established in rural areas,where village physicians work as healthcare gatekeepers.However,burnout in village physicians in the context of medical alliances remains underresearched.Methods:This cross-sectional survey was conducted among 100 village physicians practicing at village clinics in Qiandongnan prefecture,Guizhou province,China.An online questionnaire was distributed to assess physicians'demographic characteristics and work situations.Burnout was measured using the Oldenburg Burnout Inventory(validated Chinese version).A multivariate linear model with stepwise procedure was used to estimate the effects of factors of interest on burnout,focusing particularly on actions within the medical alliance that involved respondents'clinics,such as training and support for village physicians provided by higher-level facilities.Results:The overall response rate was 79%.The mean burnout score was 38.09(standard deviation,4.55;range,25–47).The multivariate analysis showed that fewer working years and too much farming work were significantly related to exacerbation of burnout.Greater medical services in the total workload and greater support from higher-level facilities were associated with burnout alleviation.Conclusion:Close connections and interactions across medical alliance member facilities could facilitate reduction in burnout for village physicians practicing as primary care gatekeepers.
