Precise,efficient copolymerizations of ethylene with cyclic olefins[norbornene(NBE),cyclopentene(CPE)]using nonbridged half-titanocenes of type,Cp TiCl_2(L)(Cp =cyclopentadienyl group,L=aryloxo,ketimide)-MAO catalyst ...Precise,efficient copolymerizations of ethylene with cyclic olefins[norbornene(NBE),cyclopentene(CPE)]using nonbridged half-titanocenes of type,Cp TiCl_2(L)(Cp =cyclopentadienyl group,L=aryloxo,ketimide)-MAO catalyst systems have been summarized.CpTiCl_2(N=C Bu_2)exhibited both remarkable catalytic activity and efficient NBE incorporation for ethylene/NBE copolymerization:the NBE incorporation by Cp TiCl_2(X)(X=N=C Bu_2,O-2,6- Pr_2C_6H_3; Cp =Cp,C_5Me_5,indenyl)was related to the calculated coordination ene...展开更多
In this paper, we report the design and moleculardocking study of analogues of antimycin A3 as inhibitors of anti-apoptotic Bcl-2 of breast cancer. Twenty designed compounds and the original antimycin A3 were docked b...In this paper, we report the design and moleculardocking study of analogues of antimycin A3 as inhibitors of anti-apoptotic Bcl-2 of breast cancer. Twenty designed compounds and the original antimycin A3 were docked based on their interaction with breast tumor receptor binding target Bcl-2. The docking resulted in the five top-ranked compounds, namely, compounds 11, 14, 15, 16, and 20, which have a lower G binding energy, better affinity and stronger hydrogen bonding interactions to the active site of Bcl-2 than antimycin A3. Among those five top-ranked compounds, analogue compounds 11 and 14, which have an 18-membered tetralactone core and 18-membered tetraol core, respectively, exhibited the strongest hydrogen bond interaction, formed high stability conformation, and demonstrated the greatest inhibitory activity on the catalytic site of Bcl-2.展开更多
Cell rotation is one of the most important techniques for cell manipulation in modern bioscience,as it not only permits cell observation from any arbitrary angle,but also simplifies the procedures for analyzing the me...Cell rotation is one of the most important techniques for cell manipulation in modern bioscience,as it not only permits cell observation from any arbitrary angle,but also simplifies the procedures for analyzing the mechanical properties of cells,characterizing cell physiology,and performing microsurgery.Numerous approaches have been reported for rotating cells in a wide range of academic and industrial applications.Among them,the most popular are micro-robot-based direct contact manipulation and field-based non-contact methods(e.g.,optical,magnetic,electric,acoustic,and hydrodynamic methods).This review first summarizes the fundamental mechanisms,merits,and demerits of these six main groups of approaches,and then discusses their differences and limitations in detail.We aim to bridge the gap between each method and illustrate the development progress,current advances,and prospects in the field of cell rotation.展开更多
Equipment used in underwater sensing and exploration typically relies on cables or batteries for energy supply,resulting in a limited and inconvenient energy supply and marine environmental pollution that hinder the s...Equipment used in underwater sensing and exploration typically relies on cables or batteries for energy supply,resulting in a limited and inconvenient energy supply and marine environmental pollution that hinder the sustainable development of distributed ocean sensing networks.Here,we design a deep-sea differential-pressure triboelectric nanogenerator(DP-TENG)based on a spiral shaft drive using modified polymer materials to harness the hydrostatic pressure gradient energy at varying ocean depths to power underwater equipment.The spiral shaft structure converts a single compression into multiple rotations of the TENG rotor,achieving efficient conversion of differential pressure energy.The multi-pair electrode design enables the DP-TENG to generate a peak current of 61.7μA,the instantaneous current density can reach 0.69μA cm^(-2),and the output performance can be improved by optimizing the spiral angle of the shaft.The DP-TENG can charge a 33μF capacitor to 17.5 V within five working cycles.It can also power a digital calculator and light up 116 commercial power light-emitting diodes,demonstrating excellent output capability.With its simple structure,low production cost,and small form factor,the DP-TENG can be seamlessly integrated with underwater vehicles.The results hold broad prospects for underwater blue energy harvesting and are expected to contribute to the development of self-powered equipment toward emerging“smart ocean”and blue economy applications.展开更多
Improved photovoltaic performance of perovskite solar cells is demonstrated through the synergistic effect of electrodeposited ZnO nanorods and rubrene：P3HT bilayer as electron and hole-transporting layers,respective...Improved photovoltaic performance of perovskite solar cells is demonstrated through the synergistic effect of electrodeposited ZnO nanorods and rubrene：P3HT bilayer as electron and hole-transporting layers,respectively. Highly crystalline ZnO nanorods were obtained by electrochemical deposition in a chloride medium. Additionally, rubrene interlayer was able to passivate or cover the grain boundaries of perovskite film effectively that led to reduced leakage current. A perovskite solar cell optimized with ZnO nanorods and rubrene：P3HT bilayer achieved a maximum efficiency of 4.9% showing reduced hysteresis behavior compared with the device having P3HT as the only hole-transporting layer. The application of longer nanorods led to better perovskite infiltration and shorter charge carrier path length. These results highlight the potential of electrodeposited ZnO nanorods and rubrene：P3HT bilayer as charge selective layers for efficient perovskite solar cells.展开更多
Parkinson’s disease (PD) is a slowly progressive neurodegenerative disorder with motor and non-motorsigns, which begins long before the diagnosis can be made. Pharmacotherapy with dopaminergic drugsis the mainstay of...Parkinson’s disease (PD) is a slowly progressive neurodegenerative disorder with motor and non-motorsigns, which begins long before the diagnosis can be made. Pharmacotherapy with dopaminergic drugsis the mainstay of PD therapy. There is no currently available cure or disease-modifying treatment. Dietand various foods have been proposed as possible risk factors for PD. Nutritional supplementation withomega-3 fatty acids, vitamin D, B vitamins, and coenzyme Q may have potential in the management ofPD. In addition, several strategies could possibly lead to the development of medical foods in PD. Forexample, ketogenic diets may have effects complementary to pharmacotherapy. Gut microbial dysbiosisand altered microbial metabolites found in PD may lead to chronic low-grade inflammation in gut andbrain. Interventions targeting gut microbiota, such as the supplementation of probiotics, may providenovel approaches to PD in regard to both symptomatic treatment and disease modification. High qualityrandomized controlled trials need to be conducted in order to evaluate whether these food-basedstrategies have symptomatic efficacy or the potential to delay the progression of PD.展开更多
Potential therapeutic benefits of seaweed consumption have been reported in the management of body weight and obesity.In vitro and in vivo animal studies provide the majority of data available at present.The majority ...Potential therapeutic benefits of seaweed consumption have been reported in the management of body weight and obesity.In vitro and in vivo animal studies provide the majority of data available at present.The majority of studies assessing the short-term effects of alginate consumption indicate that alginate may increase satiety,reduce energy intake and support weight reduction.Mechanisms suggested for these effects include delayed gastric clearance,stimulation of gastric stretch receptors and attenuated nutrient absorption.Long-term studies in humans are required in order to allow firm conclusions.Animal studies have investigated potential anti-obesity effects of seaweeds on adipogenesis and the inhibition of major lipid hydrolyzing and metabolizing enzymes.The results of these studies suggest beneficial effects of seaweed components such as fucoxanthin on body weight and the percentage of abdominal white adipose tissue.It is premature to extrapolate these findings to humans since consistent findings are still lacking.There is at present no solid evidence indicating that seaweeds are effective in long-term weight management.However,available findings suggest potential benefits of seaweed components on obesity.Future investigations are required to establish the therapeutic efficacy in the management of overweight and obesity in humans and elucidate the underlying mechanisms of actions.展开更多
Bacteria appeared early in the evolution of cellular life on planet Earth, and therefore the universally essential genes or biological pathways found across bacterial domains may represent fundamental genetic or cellu...Bacteria appeared early in the evolution of cellular life on planet Earth, and therefore the universally essential genes or biological pathways found across bacterial domains may represent fundamental genetic or cellular systems used in early life. The essential genes and the minimal gene set required to support bacterial life have recently been experimentally and computationally identified. It is, however,still hard to estimate the ancient genes present in primitive cells compared to the essential genes in contemporary bacteria, because we do not know how ancestral primitive cells lived and proliferated, and therefore cannot directly evaluate the essentiality of the genes in ancestral primitive cells. The cell wall is normally essential for bacterial proliferation and cellular division of walled bacterial cells is normally highly controlled by the essential FtsZ cell division machinery. But, bacteria are capable of reverting to their cell wall deficient ancestral form, called the ＂L-form＂. Unlike ＂normal＂ cells, L-forms divide by a simple physical mechanism based on the effects of membrane dynamics, suggesting a mode of primitive proliferation before the appearance of the cell wall. In this review, we summarize the experimental and computational investigations of minimal gene sets and discuss the minimal cellular modules required to support the proliferation of primitive cells, based on L-form proliferation.展开更多
Alzheimer’s disease(AD)is a progressive neurodegenerative disorder characterized by decline in cognitive functions and associated with the neuropathological hallmarks of amyloid-peptide plaques and neurofibrillary ta...Alzheimer’s disease(AD)is a progressive neurodegenerative disorder characterized by decline in cognitive functions and associated with the neuropathological hallmarks of amyloid-peptide plaques and neurofibrillary tangles.Cerebral glucose uptake and metabolism deteriorate in AD and this hypometabolism precedes the onset of clinical signs in AD.The early decline in brain glucose metabolism in AD has become a potential target for therapeutic intervention.This has led to investigations assessing the supplementation of the normal glucose supply with ketone bodies which are produced by the body during glucose deprivation and can be metabolized by the brain when glucose utilization is impaired.The present review provides a synopsis of preclinical studies and clinical trials assessing the efficacy of ketogenic diets in the treatment of AD.Both the direct administration of ketone bodies and the use of high-fat,low-carbohydrate ketogenic diets have been shown to be efficacious in animal models of AD and clinical trials with AD patients.The mechanism underlying the efficacy of ketogenic diets remains unclear,but some evidence points to the normalization of aberrant energy metabolism.At present there is only limited evidence of the usefulness of ketogenic diets in AD.However,this dietary approach seems to be promising and deserves further clinical investigations.展开更多
A method is described for creating a measurable unbalanced gravitational acceleration using a gravitomagnetic field surrounding a superconducting toroid. A gravitomagnetic toroid for unbalanced force production has be...A method is described for creating a measurable unbalanced gravitational acceleration using a gravitomagnetic field surrounding a superconducting toroid. A gravitomagnetic toroid for unbalanced force production has been experimentally realized as quite impractical. However recent advances in nanorod superconducting wire technology has enabled a new class of SMES devices operating at current densities and magnetic field strengths sufficient to develop measurable gravitomagnetic fields, while still maintaining mechanical integrity. It is proposed that an experimental SMES toroid configuration uses an absolute quantum gravimeter to measure acceleration fields along the axis of symmetry of a toroidal coil, thus providing experimental confirmation of the additive nature of the gravitomagnetic fields, as well as the production of a linear component of the overall acceleration field. In the present paper relativistic enhancement of this effect is also explored, as well as alternating current (AC) operations of the superconducting toroid to create gravitational waves. Lorentz force concerns are also addressed in Appendix.展开更多
This paper presents a new BIST method for RTL data paths based on single-control testability, a new concept of testability. The BIST method adopts hierarchical test. Test pattern generators are placed only on primary ...This paper presents a new BIST method for RTL data paths based on single-control testability, a new concept of testability. The BIST method adopts hierarchical test. Test pattern generators are placed only on primary inputs and test patterns are propagated to and fed into each module. Test responses are similarly propagated to response analyzers placed only on primary outputs. For the propagation of test patterns and test responses paths existing in the data path are utilized. The DFT method for the single-control testability is also proposed. The advantages of the proposed method are high fault coverage (for single Stuck-at faults), low hardware overhead and capability of at-speed test. Moreover, test patterns generated by test pattern generators can be fed into each module at consecutive system clocks, and thus, the BIST can also detect some faults of other fault models (e.g., transition faults and delay faults) that require consecutive application of test patterns at speed of system clock.展开更多
We present a method of test generation for acyclic sequential circuits with hold registers. A complete (100% fault efficiency) test sequence for an acyclic sequential circuit can be obtained by applying a combinationa...We present a method of test generation for acyclic sequential circuits with hold registers. A complete (100% fault efficiency) test sequence for an acyclic sequential circuit can be obtained by applying a combinational test generator to all the maximal time-expansion models (TEMs) of the circuit. We propose a class of acyclic sequential circuits for which the number of maximal TEMs is one, i.e, the maximum TEM exists. For a circuit in the class, test generation can be performed by using only the maximum TEM. The proposed class of sequential circuits with the maximum TEM properly includes several known classes of acyclic sequential circuits such as balanced structures and acyclic sequential circuits without hold registers for which test generation can be also performed by using a combinational test generator. Therefore, in general, the hardware overhead for partial scan based on the proposed structure is smaller than that based on balanced or acyclic sequential structure without hold registers.展开更多
This paper analyzes users’ trust decision patterns for detecting phishing sites. Our previous work proposed HumanBoost [1] which improves the accuracy of detecting phishing sites by using users’ Past Trust Decisions...This paper analyzes users’ trust decision patterns for detecting phishing sites. Our previous work proposed HumanBoost [1] which improves the accuracy of detecting phishing sites by using users’ Past Trust Decisions (PTDs). Web users are generally required to make trust decisions whenever their personal information is requested by a website. Human-Boostassumed that a database of Web user’s PTD would be transformed into a binary vector, representing phishing or not-phishing, and the binary vector can be used for detecting phishing sites, similar to the existing heuristics. Here, this paper explores the types of the users whose PTDs are useful by running a subject experiment, where 309 participants- browsed 40 websites, judged whether the site appeared to be a phishing site, and described the criterion while assessing the credibility of the site. Based on the result of the experiment, this paper classifies the participants into eight groups by clustering approach and evaluates the detection accuracy for each group. It then clarifies the types of the users who can make suitable trust decisions for HumanBoost.展开更多
Several authors have shown the beneficial role to incorporate silicon into hydroxyapatite lattice, although, the mechanism behind the enhanced bioactivity of this Si-hydroxyapatite (Si-HA) is poorly understood. The in...Several authors have shown the beneficial role to incorporate silicon into hydroxyapatite lattice, although, the mechanism behind the enhanced bioactivity of this Si-hydroxyapatite (Si-HA) is poorly understood. The incorporation of Si into the HA lattice alters the surface charge of HA, leading to more negative values. Due to the importance of the surface properties on the interaction between biomaterials, physiological fluids, and the host tissue, it is important to further characterize the surface of Si-HA by determining its surface energy and wettability. Our results showed that the incorporation of Si increased the hydrophilicity of HA, leading to a higher interfacial tension. Another important property for osteointegration is the formation of an apatite layer. The dissolution of Si-HA in the presence of serum-free simulated body fluid (SBF) started at early time points and using atomic force microscopy (AFM) it was possible to observe the dissolution at the grain boundaries and grains, therefore an apatite layer was formed in a short period of time. As the dissolution-precipitation process is much more complex in vivo, we tried to mimic the initial stages of the in vivo reaction by incubating the Si-HA in serum-SBF. It was shown that the dissolution kinetics in serum-SBF was slower when compared to the dissolution in serum free-SBF. At the same time point, no significant dissolution features were observed or apatite layer was visualized. The phase imaging AFM indicated the presence of a layer on top of these materials that could be a proteinaceous layer, as XPS analysis detected an increase on the concentration of nitrogen on the surface of the samples incubated in the presence of proteins.展开更多
Amazake is a sweet and non-alcoholic beverage with a long history in Japan.There are two types of amazake,koji amazake produced from rice koji and sakekasu amazake made from sake lees.Amazake has been suggested to be ...Amazake is a sweet and non-alcoholic beverage with a long history in Japan.There are two types of amazake,koji amazake produced from rice koji and sakekasu amazake made from sake lees.Amazake has been suggested to be a functional food with various health benefits and cosmetic effects.The efficacy of both koji amazake and sakekasu amazake in improving bowel movements and defecation has been well studied.Amazake may be useful as a food with constipation relieving effects.Furthermore,beneficial effects of amazake on skin barrier function and skin water content in humans have been well established in randomized controlled trials.The findings of amazake effects on gut microbiota,intestinal environment and gut barrier function,mainly demonstrated in animal models,suggest a role of substances contained in amazake as prebiotics.Preliminary evidence indicates the potential value of amazake in the management of obesity,metabolic syndrome and nonalcoholic fatty liver disease.Long-term and excessive intake tests have demonstrated that the consumption of koji amazake is safe.There are few concerns regarding weight gain or increases in blood sugar levels.The functional compounds and mechanisms involved in the health effects of amazake need to be identified in future research.展开更多
Recently,intelligent reflecting surface(IRS)assisted mmWave networks are emerging,which bear the potential to address the blockage issue of the millimeter wave(mmWave)communication in a more cost-effective way.In part...Recently,intelligent reflecting surface(IRS)assisted mmWave networks are emerging,which bear the potential to address the blockage issue of the millimeter wave(mmWave)communication in a more cost-effective way.In particular,IRS is built by passive and programmable electromagnetic elements that can manipulate the mmWave propagation channel into a more favorable condition that is free of blockage via judicious joint base station(BS)-IRS transmission design.However,the coexistence of IRSs and mmWave BSs complicates the network architecture,and thus poses great challenges for efficient beam management(BM)that is one critical prerequisite for high performance mmWave networks.In this paper,we systematically evaluate the key issues and challenges of BM for IRS-assisted mmWave networks to bring insights into the future network design.Specifically,we carefully classify and discuss the extensibility and limitations of the existing BM of conventional mmWave towards the IRS-assisted new paradigm.Moreover,we propose a novel machine learning empowered BM framework for IRS-assisted networks with representative showcases,which processes environmental and mobility awareness to achieve highly efficient BM with significantly reduced system overhead.Finally,some interesting future directions are also suggested to inspire further researches.展开更多
基金Grant-in-Aid for Scientific Research(B)from the Japan Society for the Promotion of Science(JSPS,No.18350055).
文摘Precise,efficient copolymerizations of ethylene with cyclic olefins[norbornene(NBE),cyclopentene(CPE)]using nonbridged half-titanocenes of type,Cp TiCl_2(L)(Cp =cyclopentadienyl group,L=aryloxo,ketimide)-MAO catalyst systems have been summarized.CpTiCl_2(N=C Bu_2)exhibited both remarkable catalytic activity and efficient NBE incorporation for ethylene/NBE copolymerization:the NBE incorporation by Cp TiCl_2(X)(X=N=C Bu_2,O-2,6- Pr_2C_6H_3; Cp =Cp,C_5Me_5,indenyl)was related to the calculated coordination ene...
文摘In this paper, we report the design and moleculardocking study of analogues of antimycin A3 as inhibitors of anti-apoptotic Bcl-2 of breast cancer. Twenty designed compounds and the original antimycin A3 were docked based on their interaction with breast tumor receptor binding target Bcl-2. The docking resulted in the five top-ranked compounds, namely, compounds 11, 14, 15, 16, and 20, which have a lower G binding energy, better affinity and stronger hydrogen bonding interactions to the active site of Bcl-2 than antimycin A3. Among those five top-ranked compounds, analogue compounds 11 and 14, which have an 18-membered tetralactone core and 18-membered tetraol core, respectively, exhibited the strongest hydrogen bond interaction, formed high stability conformation, and demonstrated the greatest inhibitory activity on the catalytic site of Bcl-2.
基金supported by JSPS Grant-in-Aid for Scientific Research(20K15151)Australian Research Council Discovery Projects(DP200102269)+2 种基金JSPS Core-to-Core programAmada FoundationWhite Rock Foundation。
文摘Cell rotation is one of the most important techniques for cell manipulation in modern bioscience,as it not only permits cell observation from any arbitrary angle,but also simplifies the procedures for analyzing the mechanical properties of cells,characterizing cell physiology,and performing microsurgery.Numerous approaches have been reported for rotating cells in a wide range of academic and industrial applications.Among them,the most popular are micro-robot-based direct contact manipulation and field-based non-contact methods(e.g.,optical,magnetic,electric,acoustic,and hydrodynamic methods).This review first summarizes the fundamental mechanisms,merits,and demerits of these six main groups of approaches,and then discusses their differences and limitations in detail.We aim to bridge the gap between each method and illustrate the development progress,current advances,and prospects in the field of cell rotation.
基金supported by the National Key R&D Program of China(2021YFC3101300)National Natural Science Foundation of China(42222606,52070006,62103400,42376219,42211540003)+3 种基金Independent Project Deployed by the Innovative Academy of Marine Information Technology of CAS(CXBS202103)2024 Hainan International Science and Technolog.Cooperation Research and Development Project(GHYF2024013)Sanya Science and Technology Special Fund 2022KJCX66CAS Key Laboratory of Science and Technology on Operational Oceanography(No.OOST2021-07).
文摘Equipment used in underwater sensing and exploration typically relies on cables or batteries for energy supply,resulting in a limited and inconvenient energy supply and marine environmental pollution that hinder the sustainable development of distributed ocean sensing networks.Here,we design a deep-sea differential-pressure triboelectric nanogenerator(DP-TENG)based on a spiral shaft drive using modified polymer materials to harness the hydrostatic pressure gradient energy at varying ocean depths to power underwater equipment.The spiral shaft structure converts a single compression into multiple rotations of the TENG rotor,achieving efficient conversion of differential pressure energy.The multi-pair electrode design enables the DP-TENG to generate a peak current of 61.7μA,the instantaneous current density can reach 0.69μA cm^(-2),and the output performance can be improved by optimizing the spiral angle of the shaft.The DP-TENG can charge a 33μF capacitor to 17.5 V within five working cycles.It can also power a digital calculator and light up 116 commercial power light-emitting diodes,demonstrating excellent output capability.With its simple structure,low production cost,and small form factor,the DP-TENG can be seamlessly integrated with underwater vehicles.The results hold broad prospects for underwater blue energy harvesting and are expected to contribute to the development of self-powered equipment toward emerging“smart ocean”and blue economy applications.
文摘Improved photovoltaic performance of perovskite solar cells is demonstrated through the synergistic effect of electrodeposited ZnO nanorods and rubrene：P3HT bilayer as electron and hole-transporting layers,respectively. Highly crystalline ZnO nanorods were obtained by electrochemical deposition in a chloride medium. Additionally, rubrene interlayer was able to passivate or cover the grain boundaries of perovskite film effectively that led to reduced leakage current. A perovskite solar cell optimized with ZnO nanorods and rubrene：P3HT bilayer achieved a maximum efficiency of 4.9% showing reduced hysteresis behavior compared with the device having P3HT as the only hole-transporting layer. The application of longer nanorods led to better perovskite infiltration and shorter charge carrier path length. These results highlight the potential of electrodeposited ZnO nanorods and rubrene：P3HT bilayer as charge selective layers for efficient perovskite solar cells.
文摘Parkinson’s disease (PD) is a slowly progressive neurodegenerative disorder with motor and non-motorsigns, which begins long before the diagnosis can be made. Pharmacotherapy with dopaminergic drugsis the mainstay of PD therapy. There is no currently available cure or disease-modifying treatment. Dietand various foods have been proposed as possible risk factors for PD. Nutritional supplementation withomega-3 fatty acids, vitamin D, B vitamins, and coenzyme Q may have potential in the management ofPD. In addition, several strategies could possibly lead to the development of medical foods in PD. Forexample, ketogenic diets may have effects complementary to pharmacotherapy. Gut microbial dysbiosisand altered microbial metabolites found in PD may lead to chronic low-grade inflammation in gut andbrain. Interventions targeting gut microbiota, such as the supplementation of probiotics, may providenovel approaches to PD in regard to both symptomatic treatment and disease modification. High qualityrandomized controlled trials need to be conducted in order to evaluate whether these food-basedstrategies have symptomatic efficacy or the potential to delay the progression of PD.
文摘Potential therapeutic benefits of seaweed consumption have been reported in the management of body weight and obesity.In vitro and in vivo animal studies provide the majority of data available at present.The majority of studies assessing the short-term effects of alginate consumption indicate that alginate may increase satiety,reduce energy intake and support weight reduction.Mechanisms suggested for these effects include delayed gastric clearance,stimulation of gastric stretch receptors and attenuated nutrient absorption.Long-term studies in humans are required in order to allow firm conclusions.Animal studies have investigated potential anti-obesity effects of seaweeds on adipogenesis and the inhibition of major lipid hydrolyzing and metabolizing enzymes.The results of these studies suggest beneficial effects of seaweed components such as fucoxanthin on body weight and the percentage of abdominal white adipose tissue.It is premature to extrapolate these findings to humans since consistent findings are still lacking.There is at present no solid evidence indicating that seaweeds are effective in long-term weight management.However,available findings suggest potential benefits of seaweed components on obesity.Future investigations are required to establish the therapeutic efficacy in the management of overweight and obesity in humans and elucidate the underlying mechanisms of actions.
基金supported by Grant-in-Aid for Scientific Research on Innovative Areas(26106001)
文摘Bacteria appeared early in the evolution of cellular life on planet Earth, and therefore the universally essential genes or biological pathways found across bacterial domains may represent fundamental genetic or cellular systems used in early life. The essential genes and the minimal gene set required to support bacterial life have recently been experimentally and computationally identified. It is, however,still hard to estimate the ancient genes present in primitive cells compared to the essential genes in contemporary bacteria, because we do not know how ancestral primitive cells lived and proliferated, and therefore cannot directly evaluate the essentiality of the genes in ancestral primitive cells. The cell wall is normally essential for bacterial proliferation and cellular division of walled bacterial cells is normally highly controlled by the essential FtsZ cell division machinery. But, bacteria are capable of reverting to their cell wall deficient ancestral form, called the ＂L-form＂. Unlike ＂normal＂ cells, L-forms divide by a simple physical mechanism based on the effects of membrane dynamics, suggesting a mode of primitive proliferation before the appearance of the cell wall. In this review, we summarize the experimental and computational investigations of minimal gene sets and discuss the minimal cellular modules required to support the proliferation of primitive cells, based on L-form proliferation.
文摘Alzheimer’s disease(AD)is a progressive neurodegenerative disorder characterized by decline in cognitive functions and associated with the neuropathological hallmarks of amyloid-peptide plaques and neurofibrillary tangles.Cerebral glucose uptake and metabolism deteriorate in AD and this hypometabolism precedes the onset of clinical signs in AD.The early decline in brain glucose metabolism in AD has become a potential target for therapeutic intervention.This has led to investigations assessing the supplementation of the normal glucose supply with ketone bodies which are produced by the body during glucose deprivation and can be metabolized by the brain when glucose utilization is impaired.The present review provides a synopsis of preclinical studies and clinical trials assessing the efficacy of ketogenic diets in the treatment of AD.Both the direct administration of ketone bodies and the use of high-fat,low-carbohydrate ketogenic diets have been shown to be efficacious in animal models of AD and clinical trials with AD patients.The mechanism underlying the efficacy of ketogenic diets remains unclear,but some evidence points to the normalization of aberrant energy metabolism.At present there is only limited evidence of the usefulness of ketogenic diets in AD.However,this dietary approach seems to be promising and deserves further clinical investigations.
文摘A method is described for creating a measurable unbalanced gravitational acceleration using a gravitomagnetic field surrounding a superconducting toroid. A gravitomagnetic toroid for unbalanced force production has been experimentally realized as quite impractical. However recent advances in nanorod superconducting wire technology has enabled a new class of SMES devices operating at current densities and magnetic field strengths sufficient to develop measurable gravitomagnetic fields, while still maintaining mechanical integrity. It is proposed that an experimental SMES toroid configuration uses an absolute quantum gravimeter to measure acceleration fields along the axis of symmetry of a toroidal coil, thus providing experimental confirmation of the additive nature of the gravitomagnetic fields, as well as the production of a linear component of the overall acceleration field. In the present paper relativistic enhancement of this effect is also explored, as well as alternating current (AC) operations of the superconducting toroid to create gravitational waves. Lorentz force concerns are also addressed in Appendix.
文摘This paper presents a new BIST method for RTL data paths based on single-control testability, a new concept of testability. The BIST method adopts hierarchical test. Test pattern generators are placed only on primary inputs and test patterns are propagated to and fed into each module. Test responses are similarly propagated to response analyzers placed only on primary outputs. For the propagation of test patterns and test responses paths existing in the data path are utilized. The DFT method for the single-control testability is also proposed. The advantages of the proposed method are high fault coverage (for single Stuck-at faults), low hardware overhead and capability of at-speed test. Moreover, test patterns generated by test pattern generators can be fed into each module at consecutive system clocks, and thus, the BIST can also detect some faults of other fault models (e.g., transition faults and delay faults) that require consecutive application of test patterns at speed of system clock.
文摘We present a method of test generation for acyclic sequential circuits with hold registers. A complete (100% fault efficiency) test sequence for an acyclic sequential circuit can be obtained by applying a combinational test generator to all the maximal time-expansion models (TEMs) of the circuit. We propose a class of acyclic sequential circuits for which the number of maximal TEMs is one, i.e, the maximum TEM exists. For a circuit in the class, test generation can be performed by using only the maximum TEM. The proposed class of sequential circuits with the maximum TEM properly includes several known classes of acyclic sequential circuits such as balanced structures and acyclic sequential circuits without hold registers for which test generation can be also performed by using a combinational test generator. Therefore, in general, the hardware overhead for partial scan based on the proposed structure is smaller than that based on balanced or acyclic sequential structure without hold registers.
文摘This paper analyzes users’ trust decision patterns for detecting phishing sites. Our previous work proposed HumanBoost [1] which improves the accuracy of detecting phishing sites by using users’ Past Trust Decisions (PTDs). Web users are generally required to make trust decisions whenever their personal information is requested by a website. Human-Boostassumed that a database of Web user’s PTD would be transformed into a binary vector, representing phishing or not-phishing, and the binary vector can be used for detecting phishing sites, similar to the existing heuristics. Here, this paper explores the types of the users whose PTDs are useful by running a subject experiment, where 309 participants- browsed 40 websites, judged whether the site appeared to be a phishing site, and described the criterion while assessing the credibility of the site. Based on the result of the experiment, this paper classifies the participants into eight groups by clustering approach and evaluates the detection accuracy for each group. It then clarifies the types of the users who can make suitable trust decisions for HumanBoost.
基金The authors acknowledge Fundacao para a Ciencia e Tecnologia,Portugal,for supporting Claudia Botelho grant(SFRHBPD/20987/2004).
文摘Several authors have shown the beneficial role to incorporate silicon into hydroxyapatite lattice, although, the mechanism behind the enhanced bioactivity of this Si-hydroxyapatite (Si-HA) is poorly understood. The incorporation of Si into the HA lattice alters the surface charge of HA, leading to more negative values. Due to the importance of the surface properties on the interaction between biomaterials, physiological fluids, and the host tissue, it is important to further characterize the surface of Si-HA by determining its surface energy and wettability. Our results showed that the incorporation of Si increased the hydrophilicity of HA, leading to a higher interfacial tension. Another important property for osteointegration is the formation of an apatite layer. The dissolution of Si-HA in the presence of serum-free simulated body fluid (SBF) started at early time points and using atomic force microscopy (AFM) it was possible to observe the dissolution at the grain boundaries and grains, therefore an apatite layer was formed in a short period of time. As the dissolution-precipitation process is much more complex in vivo, we tried to mimic the initial stages of the in vivo reaction by incubating the Si-HA in serum-SBF. It was shown that the dissolution kinetics in serum-SBF was slower when compared to the dissolution in serum free-SBF. At the same time point, no significant dissolution features were observed or apatite layer was visualized. The phase imaging AFM indicated the presence of a layer on top of these materials that could be a proteinaceous layer, as XPS analysis detected an increase on the concentration of nitrogen on the surface of the samples incubated in the presence of proteins.
文摘Amazake is a sweet and non-alcoholic beverage with a long history in Japan.There are two types of amazake,koji amazake produced from rice koji and sakekasu amazake made from sake lees.Amazake has been suggested to be a functional food with various health benefits and cosmetic effects.The efficacy of both koji amazake and sakekasu amazake in improving bowel movements and defecation has been well studied.Amazake may be useful as a food with constipation relieving effects.Furthermore,beneficial effects of amazake on skin barrier function and skin water content in humans have been well established in randomized controlled trials.The findings of amazake effects on gut microbiota,intestinal environment and gut barrier function,mainly demonstrated in animal models,suggest a role of substances contained in amazake as prebiotics.Preliminary evidence indicates the potential value of amazake in the management of obesity,metabolic syndrome and nonalcoholic fatty liver disease.Long-term and excessive intake tests have demonstrated that the consumption of koji amazake is safe.There are few concerns regarding weight gain or increases in blood sugar levels.The functional compounds and mechanisms involved in the health effects of amazake need to be identified in future research.
基金the National Natural Science Foundation of China under Grant 61790553,61901049,62071071the Fundamental Research Funds for the Central Universities(2019XD-A13).
文摘Recently,intelligent reflecting surface(IRS)assisted mmWave networks are emerging,which bear the potential to address the blockage issue of the millimeter wave(mmWave)communication in a more cost-effective way.In particular,IRS is built by passive and programmable electromagnetic elements that can manipulate the mmWave propagation channel into a more favorable condition that is free of blockage via judicious joint base station(BS)-IRS transmission design.However,the coexistence of IRSs and mmWave BSs complicates the network architecture,and thus poses great challenges for efficient beam management(BM)that is one critical prerequisite for high performance mmWave networks.In this paper,we systematically evaluate the key issues and challenges of BM for IRS-assisted mmWave networks to bring insights into the future network design.Specifically,we carefully classify and discuss the extensibility and limitations of the existing BM of conventional mmWave towards the IRS-assisted new paradigm.Moreover,we propose a novel machine learning empowered BM framework for IRS-assisted networks with representative showcases,which processes environmental and mobility awareness to achieve highly efficient BM with significantly reduced system overhead.Finally,some interesting future directions are also suggested to inspire further researches.
