Objective:To investigate the gastroprotective activity of hydroalcoholic extract leaves of Ficus religiosa(F.religiosa) in different experimental models of gastric ulcer in rats.Methods:The hydroalcoholic extract leav...Objective:To investigate the gastroprotective activity of hydroalcoholic extract leaves of Ficus religiosa(F.religiosa) in different experimental models of gastric ulcer in rats.Methods:The hydroalcoholic extract leaves of F.religiosa were studied at two dose levels(250 and 500 mg/ kg,oral) in rats against absolute ethanol(0.2 mL oral),aspirin(200 mg/kg) and pyloric ligation induced gastric ulcer.Ranitidine(50 mg/kg,oral) was used as a standard drug.Mean ulcer indices and oxidative stress were measured.Phytochemical tests and acute toxicity tests were also carried out.Results:Administration of F.religiosa to rats significantly decreased the ulcer index value when compared with the control treated group.Ranitidine(50 mg/kg,oral) also produced a significant decrease the ulcer index value when compared with the control treated group.Phytochemical analysis revealed the presence of tannins,sterols,saponins,flavonoids, carbohydrates and proteins.Conclusions:The results suggest that the leaves of the F.religiosa possess significant anti ulcer activity.展开更多
Nanotechnology has changed the entire paradigm of drug targeting and has shown tremendous potential in the area of cancer therapy due to its specificity. In cancer, several targets have been explored which could be ut...Nanotechnology has changed the entire paradigm of drug targeting and has shown tremendous potential in the area of cancer therapy due to its specificity. In cancer, several targets have been explored which could be utilized for the better treatment of disease. Mitochondria, the so-called powerhouse of cell, portrays significant role in the survival and death of cells, and has emerged as potential target for cancer therapy. Direct targeting and nanotechnology based approaches can be tailor-made to target mitochondria and thus improve the survival rate of patients suffering from cancer. With this backdrop, in present review, we have reemphasized the role of mitochondria in cancer progression and inhibition, highlighting the different targets that can be explored for targeting of disease. Moreover, we have also summarized different nanoparticulate systems that have been used for treatment of cancer via mitochondrial targeting.展开更多
Wound closing is one of the widely performed and prominent clinical practices in the surgical intervention process.A physician or surgeon has several options ranging from surgical sutures and adhesive strips to fibrin...Wound closing is one of the widely performed and prominent clinical practices in the surgical intervention process.A physician or surgeon has several options ranging from surgical sutures and adhesive strips to fibrin glue for effective wound closure to close the commonly occurring surgical cuts and deep skin tissue injuries.However,all the commercially available wound closure devices have some limitations in each and another perspective.From the beginning of the late 90s,surgical staples got tremendous attention as efficient wound closure devices for their time-effective and sufficient mechanical strength,performance feasibility,fewer chances of surgical site infection and require minimal expertise characteristics in consideration of remote location.Even in the context of the recent COVID19 pandemic,the clinical acceptance and patient compliance for the staples have increased due to minimizing the chances of prolonged interaction between the patient and physicians.The surgical staples application is extensive and diversified,ranging from common external cuts to highly complex surgery procedures like laparoscopic appendectomy,intestinal anastomosis,etc.Thus,in this literature review,we try to give a comprehensive glimpse of the development and current state-of-the-art surgical staples in consideration with research from a commercial point of view.On a special note,this review also describes a very brief outline of the regulatory aspects and some common internationally acceptable‘de jure standards for the development of commercially viable surgical staples.展开更多
Tissue engineering is a well-proven technique for the creation of functional alternatives for regenerative medicine and plays a critical role in patient treatment.Several natural-origin biopolymers such as chitosan,hy...Tissue engineering is a well-proven technique for the creation of functional alternatives for regenerative medicine and plays a critical role in patient treatment.Several natural-origin biopolymers such as chitosan,hyaluronic acid,gelatin,collagen,etc.are extensively explored for various biomedical applications.Among,these polymers are exclusively investigated in tissue engineering applications due to their highly favorable properties,such as high biocompatibility,slow degradation,mechanical tenability,structural similarity with native tissues,bioactivity,etc.The present review summarizes the recent advances of biopolymers in bone tissue engineering It also covers the topic of natural polymer modification to achieve superior characteristics primarily mechanical properties towards bone regeneration and discussed the best methods for dealing with them.Therefore,the review can drive the development of biomimetic materials for futuristic applications.展开更多
Stroke is devastating and the second leading cause of disability and death worldwide.The pathophysiology of stroke is intricate involving oxidative stress,ionic imbalance,and excitotoxicity leading to cell death.The c...Stroke is devastating and the second leading cause of disability and death worldwide.The pathophysiology of stroke is intricate involving oxidative stress,ionic imbalance,and excitotoxicity leading to cell death.The current therapeutic strategies for ischemic stroke primarily aim to restore cerebral blood flow by removing clots using intravenous thrombolysis and mechanical thrombectomy.However,hemorrhagic stroke requires different therapeutic interventions,where intravenous thrombolysis worsens the persistent condition.Nevertheless,the present treatment strategies do not provide effective neuroprotection as they have limitations such as narrow time window,specialized clinics and personnel,and higher expense.Therefore,studies on novel therapeutic strategies that can render neuroprotection over an extended time with minimum adverse effects are solicited.Xenobiotics are agents that are foreign to the biological system but can regulate their metabolism by binding to different xenobiotic receptors(XRs)to produce toxic substances.Modulation of XRs in different preclinical studies have shown benefits in the stroke outcome.Therefore,targeting XRs may be a future therapeutic strategy for stroke intervention.The present review briefly discusses various implications of xenobiotics and their receptors to evolve as a potential therapeutic target for prospective use as an adjunctive therapy for stroke.展开更多
文摘Objective:To investigate the gastroprotective activity of hydroalcoholic extract leaves of Ficus religiosa(F.religiosa) in different experimental models of gastric ulcer in rats.Methods:The hydroalcoholic extract leaves of F.religiosa were studied at two dose levels(250 and 500 mg/ kg,oral) in rats against absolute ethanol(0.2 mL oral),aspirin(200 mg/kg) and pyloric ligation induced gastric ulcer.Ranitidine(50 mg/kg,oral) was used as a standard drug.Mean ulcer indices and oxidative stress were measured.Phytochemical tests and acute toxicity tests were also carried out.Results:Administration of F.religiosa to rats significantly decreased the ulcer index value when compared with the control treated group.Ranitidine(50 mg/kg,oral) also produced a significant decrease the ulcer index value when compared with the control treated group.Phytochemical analysis revealed the presence of tannins,sterols,saponins,flavonoids, carbohydrates and proteins.Conclusions:The results suggest that the leaves of the F.religiosa possess significant anti ulcer activity.
基金the Department of Science and Technology and SERB (INSPIRE Grant no: IFA-LSBM-13 and EMR/2016/007966/HS) for project funds。
文摘Nanotechnology has changed the entire paradigm of drug targeting and has shown tremendous potential in the area of cancer therapy due to its specificity. In cancer, several targets have been explored which could be utilized for the better treatment of disease. Mitochondria, the so-called powerhouse of cell, portrays significant role in the survival and death of cells, and has emerged as potential target for cancer therapy. Direct targeting and nanotechnology based approaches can be tailor-made to target mitochondria and thus improve the survival rate of patients suffering from cancer. With this backdrop, in present review, we have reemphasized the role of mitochondria in cancer progression and inhibition, highlighting the different targets that can be explored for targeting of disease. Moreover, we have also summarized different nanoparticulate systems that have been used for treatment of cancer via mitochondrial targeting.
文摘Wound closing is one of the widely performed and prominent clinical practices in the surgical intervention process.A physician or surgeon has several options ranging from surgical sutures and adhesive strips to fibrin glue for effective wound closure to close the commonly occurring surgical cuts and deep skin tissue injuries.However,all the commercially available wound closure devices have some limitations in each and another perspective.From the beginning of the late 90s,surgical staples got tremendous attention as efficient wound closure devices for their time-effective and sufficient mechanical strength,performance feasibility,fewer chances of surgical site infection and require minimal expertise characteristics in consideration of remote location.Even in the context of the recent COVID19 pandemic,the clinical acceptance and patient compliance for the staples have increased due to minimizing the chances of prolonged interaction between the patient and physicians.The surgical staples application is extensive and diversified,ranging from common external cuts to highly complex surgery procedures like laparoscopic appendectomy,intestinal anastomosis,etc.Thus,in this literature review,we try to give a comprehensive glimpse of the development and current state-of-the-art surgical staples in consideration with research from a commercial point of view.On a special note,this review also describes a very brief outline of the regulatory aspects and some common internationally acceptable‘de jure standards for the development of commercially viable surgical staples.
文摘Tissue engineering is a well-proven technique for the creation of functional alternatives for regenerative medicine and plays a critical role in patient treatment.Several natural-origin biopolymers such as chitosan,hyaluronic acid,gelatin,collagen,etc.are extensively explored for various biomedical applications.Among,these polymers are exclusively investigated in tissue engineering applications due to their highly favorable properties,such as high biocompatibility,slow degradation,mechanical tenability,structural similarity with native tissues,bioactivity,etc.The present review summarizes the recent advances of biopolymers in bone tissue engineering It also covers the topic of natural polymer modification to achieve superior characteristics primarily mechanical properties towards bone regeneration and discussed the best methods for dealing with them.Therefore,the review can drive the development of biomimetic materials for futuristic applications.
文摘Stroke is devastating and the second leading cause of disability and death worldwide.The pathophysiology of stroke is intricate involving oxidative stress,ionic imbalance,and excitotoxicity leading to cell death.The current therapeutic strategies for ischemic stroke primarily aim to restore cerebral blood flow by removing clots using intravenous thrombolysis and mechanical thrombectomy.However,hemorrhagic stroke requires different therapeutic interventions,where intravenous thrombolysis worsens the persistent condition.Nevertheless,the present treatment strategies do not provide effective neuroprotection as they have limitations such as narrow time window,specialized clinics and personnel,and higher expense.Therefore,studies on novel therapeutic strategies that can render neuroprotection over an extended time with minimum adverse effects are solicited.Xenobiotics are agents that are foreign to the biological system but can regulate their metabolism by binding to different xenobiotic receptors(XRs)to produce toxic substances.Modulation of XRs in different preclinical studies have shown benefits in the stroke outcome.Therefore,targeting XRs may be a future therapeutic strategy for stroke intervention.The present review briefly discusses various implications of xenobiotics and their receptors to evolve as a potential therapeutic target for prospective use as an adjunctive therapy for stroke.
