The aim of presented study is to compare parameters of oxidative stress in untrained volunteers, patients with chronic, non-motor related disease (dialysis patients) and professional athletes before and after exhausti...The aim of presented study is to compare parameters of oxidative stress in untrained volunteers, patients with chronic, non-motor related disease (dialysis patients) and professional athletes before and after exhaustive exercise. 40 subjects participated in the study: 14 healthy, untrained subjects, 12 hemodialysis patients and 14 professional rowers. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and non-transferrin bound iron (NTBI) were determined before and after exercise. Dialysis patients have increased oxidative stress at rest with highest NTBI, and show adaptation with increased values of GPx and decreased SOD. Professional athletes have low level of oxidative stress at basic circumstances with lowest NTBI, SOD, CAT and GPx as compared to untrained volunteers and dialysis patients. After strenuous exercise elevation of antioxidative enzymes is observed only in athletes, but not in untrained and dialysis patients. Due to limited antioxidative capacity, extreme physical effort is probably not recommended to dialysis patients and untrained people.展开更多
We aimed to investigate the short-term correlation between blood lead levels and oxidative stress generation in coal miners. The study involved 94 male coal miners from the Velenje Coal mine, arranged into four groups...We aimed to investigate the short-term correlation between blood lead levels and oxidative stress generation in coal miners. The study involved 94 male coal miners from the Velenje Coal mine, arranged into four groups： three groups according to the number of consecutive working days, and a fourth control group. Miners who worked for three consecutive days had higher blood levels of lead and 8-isoprostane than the control group（P 〈 0.001）. Correlation between lead and 8-isoprostane was of medium strength（r = 0.512, P 〈 0.001）. Short-term lead environmental exposure can potentially harmful and should be considered when formulating improvements in working processes.展开更多
The objective of the present study was to evaluate the relation between maternal blood levels of selected toxic and potentially toxic elements （manganese （Mn）, copper （Cu）, zinc （Zn）, arsenic （As）, selenium ...The objective of the present study was to evaluate the relation between maternal blood levels of selected toxic and potentially toxic elements （manganese （Mn）, copper （Cu）, zinc （Zn）, arsenic （As）, selenium （Se）, cadmium （Cd）, lead （Pb） and mercury （Hg）） and birth weight of their new-borns in a Slovenian population, taking into account maternal socio-demographic characteristics and dietary habits. 535 women from 12 regions of Slovenia were recruited at delivery. Maternal blood was collected at 1.5 months after birth. Associations between birth weight and a） predictors obtained through the questionnaires and b） levels of selected elements were tested using bivariate tests and multiple linear regression. Multiple regression models revealed maternal age as an additional predictor for birth weight and confirmed pre-pregnancy body mass, estimated gestational age and gender of the baby as the main predictors for birth weight. Mn in maternal blood was significantly and positively associated with birth weight. The positive association observed between birth weight and Mn in maternal blood could be explained by the essentiality of Mn in foetal development as an important cofactor in enzymereactions in bone formation and in metabolic regulation for amino acid, lipid, protein and carbohydrate levels.展开更多
This study was to investigate whether working in conditions of elevated concentrations of mine gases （CO2, CO, CH4, DMS） and dust may result in oxidative stress. Coal miners （n=94） from the Velenje Coal mine who w...This study was to investigate whether working in conditions of elevated concentrations of mine gases （CO2, CO, CH4, DMS） and dust may result in oxidative stress. Coal miners （n=94） from the Velenje Coal mine who were arranged into control group and three groups according to a number of consecutive working days. 8-isoprostane as a biological marker of oxidative stress was measured in exhaled breath condensate （EBC）.展开更多
文摘The aim of presented study is to compare parameters of oxidative stress in untrained volunteers, patients with chronic, non-motor related disease (dialysis patients) and professional athletes before and after exhaustive exercise. 40 subjects participated in the study: 14 healthy, untrained subjects, 12 hemodialysis patients and 14 professional rowers. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and non-transferrin bound iron (NTBI) were determined before and after exercise. Dialysis patients have increased oxidative stress at rest with highest NTBI, and show adaptation with increased values of GPx and decreased SOD. Professional athletes have low level of oxidative stress at basic circumstances with lowest NTBI, SOD, CAT and GPx as compared to untrained volunteers and dialysis patients. After strenuous exercise elevation of antioxidative enzymes is observed only in athletes, but not in untrained and dialysis patients. Due to limited antioxidative capacity, extreme physical effort is probably not recommended to dialysis patients and untrained people.
文摘We aimed to investigate the short-term correlation between blood lead levels and oxidative stress generation in coal miners. The study involved 94 male coal miners from the Velenje Coal mine, arranged into four groups： three groups according to the number of consecutive working days, and a fourth control group. Miners who worked for three consecutive days had higher blood levels of lead and 8-isoprostane than the control group（P 〈 0.001）. Correlation between lead and 8-isoprostane was of medium strength（r = 0.512, P 〈 0.001）. Short-term lead environmental exposure can potentially harmful and should be considered when formulating improvements in working processes.
文摘The objective of the present study was to evaluate the relation between maternal blood levels of selected toxic and potentially toxic elements （manganese （Mn）, copper （Cu）, zinc （Zn）, arsenic （As）, selenium （Se）, cadmium （Cd）, lead （Pb） and mercury （Hg）） and birth weight of their new-borns in a Slovenian population, taking into account maternal socio-demographic characteristics and dietary habits. 535 women from 12 regions of Slovenia were recruited at delivery. Maternal blood was collected at 1.5 months after birth. Associations between birth weight and a） predictors obtained through the questionnaires and b） levels of selected elements were tested using bivariate tests and multiple linear regression. Multiple regression models revealed maternal age as an additional predictor for birth weight and confirmed pre-pregnancy body mass, estimated gestational age and gender of the baby as the main predictors for birth weight. Mn in maternal blood was significantly and positively associated with birth weight. The positive association observed between birth weight and Mn in maternal blood could be explained by the essentiality of Mn in foetal development as an important cofactor in enzymereactions in bone formation and in metabolic regulation for amino acid, lipid, protein and carbohydrate levels.
文摘This study was to investigate whether working in conditions of elevated concentrations of mine gases （CO2, CO, CH4, DMS） and dust may result in oxidative stress. Coal miners （n=94） from the Velenje Coal mine who were arranged into control group and three groups according to a number of consecutive working days. 8-isoprostane as a biological marker of oxidative stress was measured in exhaled breath condensate （EBC）.
