During the past few decades, it has become clear that the distribution, sizes, and masses of cosmic structures are best described as fractal rather than homogeneous. This means that an entirely different formalism is ...During the past few decades, it has become clear that the distribution, sizes, and masses of cosmic structures are best described as fractal rather than homogeneous. This means that an entirely different formalism is needed to replace the standard perturbation model of structure formation. Recently, we have been developing a model of cosmology that accounts for a large number of the observed properties of the universe. A key component of this model is that fractal structures that later regulated the creation of both matter and radiation came into existence during the initial Planck-era inflation. Initially, the vacuum was the only existence and since time, distance, and energy were uncertain, its only property, the curvature (or energy), was most likely distributed randomly. Everything that happened after the Planck era can be described by the known laws of physics so the remaining fundamental problem is to discover how such a random beginning could organize itself into the hierarchy of highly non-random self-similar structures on all length scales that are necessary to explain the existence of all cosmic structures. In this paper, we present a variation of the standard sandpile model that points to a solution. Incidental to our review of the distributions of cosmic structures, we discovered that the apparent transition from a fractal to a homogeneous distribution of structures at a distance of about 150 Mpc is a consequence of the finite size of the universe rather than a change in the underlying statistics of the distributions.展开更多
Security issues in cloud networks and edge computing have become very common. This research focuses on analyzing such issues and developing the best solutions. A detailed literature review has been conducted in this r...Security issues in cloud networks and edge computing have become very common. This research focuses on analyzing such issues and developing the best solutions. A detailed literature review has been conducted in this regard. The findings have shown that many challenges are linked to edge computing, such as privacy concerns, security breaches, high costs, low efficiency, etc. Therefore, there is a need to implement proper security measures to overcome these issues. Using emerging trends, like machine learning, encryption, artificial intelligence, real-time monitoring, etc., can help mitigate security issues. They can also develop a secure and safe future in cloud computing. It was concluded that the security implications of edge computing can easily be covered with the help of new technologies and techniques.展开更多
The traditional Chinese medicine(TCM)industry is critical to not only for public health but also for economic growth.According to the European Union(EU)directives,under the EU framework for(traditional)herbal medicina...The traditional Chinese medicine(TCM)industry is critical to not only for public health but also for economic growth.According to the European Union(EU)directives,under the EU framework for(traditional)herbal medicinal products,herbal medicines with long history of use can be registered in EU.However,there is a condition in this directive in which only those that have at least 10e15 years in the EU market are accepted for registration and/or marketing authorization.In author opinion,the condition of 10-15 years of use in EU countries set within the EU regulatory framework is with consideration of the genetic differences which can result in variation in adverse drug responses among different world populations.With this concept in mind,it is reasonable to project the principal of the EU directive to the Asian countries where TCM is originated.Countries like China,Singapore,Japan and South Korea that have well established drug registration framework are in best position in executing the best practice and facilitate harmonization of registration for TCM within the region.Furthermore,the registration process itself allows more safety and efficacy data to be collected systemically before and after product registration/marketing authorization.These are valuable information for future drug development.The therapeutic value of TCM is limitless,it has been left out in the EU regulatory framework,and the opportunity for it to be expanded and carried forward in modern medicines is shadowed by the limited number of TCM that are qualified to be registered under the EU regulatory framework.An early establishment of a harmonized risk-based registration process for TCM in Asian countries is important.This will strengthen the database to substantiate the history of safe use and further preserving and expanding the therapeutic values of TCM within and beyond the Asian region.展开更多
Monitoring temporal changes in sea level is important in assessing coastal risk.Sea level anomalies at a tide gauge station,if kinematically conceived,include systematic variations such as trend,acceleration,periodic ...Monitoring temporal changes in sea level is important in assessing coastal risk.Sea level anomalies at a tide gauge station,if kinematically conceived,include systematic variations such as trend,acceleration,periodic oscillations,and random disturbances.Among them,the non-stationary nature of the random sea level variations of known or unknown origin at coastal regions has been long recognized by the sea level community.This study proposes the analyses of subgroups of random residual statistics of a rigorously formulated kinematic model solution of tide gauge variations using X-bar and S control charts.The approach is demonstrated using Key West,Florida tide gauge records.The mean and standard errors of 5-year-long subgroups of the residuals revealed that sea level changes at this location have been progressively intensifying from 1913 to the present.Increasing oscillations in sea level at this locality may be attributed partly to the thermal expansion of seawater with increasing temperatures causing larger buoyancy-related sea level fluctuations as well as the intensification of atmospheric events including wind patterns and the impact of changes in inverted barometer effects that will alter coastal risk assessments for the future.展开更多
The“University”proposes the proposition of“investigating things to acquire knowledge”,presenting the rudimentary form of Chinese philosophical epistemology.Over the following 2,500 years,it has undergone numerous ...The“University”proposes the proposition of“investigating things to acquire knowledge”,presenting the rudimentary form of Chinese philosophical epistemology.Over the following 2,500 years,it has undergone numerous debates on the relationship between knowledge and action;however,no philosopher has developed a comprehensive epistemological system that explores the nature,source,formation,application,truth,testing,structure of human knowledge,as well as the relationship between language and thinking.The concept of“know”in the philosophy of“investigating things to attain knowledge”is equivalent to concepts such as“idea”and“meaning”in Western philosophy.However,the cognitive state of“know”has not been fully explored and expanded upon,nor has the distinction between empirical and rational recognition of“know”been made.Confucianism advocated the“learning”of language communication as one of the ways to acquire knowledge,but it failed to evolve a method of using language to conduct formal logical reasoning to acquire knowledge and test truth.The“eight trigrams”deduction and yin-yang and five elements theory in the“I Ching”have stifled the emergence of modern scientific epistemological methods in China in terms of thinking mode.Confucian epistemology:focuses on“reason”and interpersonal relationships,with an emphasis on the establishment of moral ethics and social order.Taoist epistemology:pursues a realm beyond experience and social conventions,understanding the world through introspection and insight;it focuses on grasping“Tao”,providing vague guidance for determining universal truths and acquiring precise knowledge;it is prone to falling into the dilemma of nihilism and relativism.The concept of unity between heaven and man and unity between knowledge and action has led to the lack of differentiation in Chinese philosophical epistemology regarding the study of the relationship between subject and object,not involving the way in which the subject understands the object,the limitations of understanding,and the interaction between subject and object in the process of understanding.展开更多
Confucianism and Daoism share the same origin in Chinese philosophy.The Huang-Lao school,which emerged during the early Han dynasty,produced two branches:Confucianism and Daoism.This school used Chinese society as a l...Confucianism and Daoism share the same origin in Chinese philosophy.The Huang-Lao school,which emerged during the early Han dynasty,produced two branches:Confucianism and Daoism.This school used Chinese society as a laboratory for social science experiments based on The Book of Changes(Yijing)and Laozi,aiming to establish a universal society based on the ideal of“great unity”(datong).展开更多
This paper applies Gödel’s Incompleteness Theorems to the evolution and development of human social systems.Although Gödel’s Incompleteness Theorems originated in the field of mathematics,their influence h...This paper applies Gödel’s Incompleteness Theorems to the evolution and development of human social systems.Although Gödel’s Incompleteness Theorems originated in the field of mathematics,their influence has long extended beyond mathematics,making an impact on philosophy,systems science,and the humanities and social sciences.The paper analyzes the autonomy and completeness of human social systems,arguing that evolving human societies are generally self-consistent.However,if the completeness of a human social system is compromised,the system either maintains self-consistency,ceases to evolve forward,enters a death spiral,and eventually decays and disintegrates.Or the system addresses the completeness issue,enters a state of non-self-consistency,introduces new axioms,becomes self-governing again,and enters a new form.From the sociological perspective,this is articulated as social revolution-the system continues to evolve forward;the absence of social revolution-the system does not evolve forward(Jin,1988).展开更多
Based on the two roots of“to be”in Indo-European languages,this paper proposes that Brahman,Buddha,and bhutatathata all come from the second root,of“bhu(to be)”,because“bhu”belongs to the same root as the Greek ...Based on the two roots of“to be”in Indo-European languages,this paper proposes that Brahman,Buddha,and bhutatathata all come from the second root,of“bhu(to be)”,because“bhu”belongs to the same root as the Greek root“phy”,physis from“phy”,is naturalism.Therefore,Brahma,Buddha,and bhutatathata are all knowledge related to natural science.The first root of“as(to be)”has led to the debate in buddhist philosophy about the asmiti and anasmiti.The spread of Buddhist philosophy in China is due to the lack of“as/bhu(to be)”,vocabulary and grammar in Chinese;as a result,the Buddhist verses translated in ancient China became a philosophy without“as/bhu(to be)”.At the same time,some Buddhist words have lost their connection with the root and the grammatical features of“as/bhu(to be)”,resulting in the spread of Buddhist philosophy in China having been into a language game.We should put Buddhist philosophy back into the Indo-European language family;it transforms the Buddhist philosophy of speaking ancient Chinese into the Buddhist modern philosophical language,and makes Buddhist philosophy develop into a set of understandable and logical normative philosophy.展开更多
Cloud computing plays a significant role in modern information technology, providing organizations with numerous benefits, including flexibility, scalability, and cost-efficiency. However, it has become essential for ...Cloud computing plays a significant role in modern information technology, providing organizations with numerous benefits, including flexibility, scalability, and cost-efficiency. However, it has become essential for organizations to ensure the security of their applications, data, and cloud-based networks to use cloud services effectively. This systematic literature review aims to determine the latest information regarding cloud computing security, with a specific emphasis on threats and mitigation strategies. Additionally, it highlights some common threats related to cloud computing security, such as distributed denial-of-service (DDoS) attacks, account hijacking, malware attacks, and data breaches. This research also explores some mitigation strategies, including security awareness training, vulnerability management, security information and event management (SIEM), identity and access management (IAM), and encryption techniques. It discusses emerging trends in cloud security, such as integrating artificial intelligence (AI) and machine learning (ML), serverless computing, and containerization, as well as the effectiveness of the shared responsibility model and its related challenges. The importance of user awareness and the impact of emerging technologies on cloud security have also been discussed in detail to mitigate security risks. A literature review of previous research and scholarly articles has also been conducted to provide insights regarding cloud computing security. It shows the need for continuous research and innovation to address emerging threats and maintain a security-conscious culture in the company.展开更多
The content of current third-wave feminism differs significantly from that of previous feminist movements,which sought equal human and civil rights for women.In third-wave feminism,gender is primarily understood as a ...The content of current third-wave feminism differs significantly from that of previous feminist movements,which sought equal human and civil rights for women.In third-wave feminism,gender is primarily understood as a social category that is linguistically constructed.The now classic work Gender Trouble(1990)by philosopher Judith Butler is decisive for this“linguistic turn”in the social sciences.However,Butler’s work is systematically based on two philosophical traditions that are already highly controversial in themselves:sophism and existentialism,linked to a pre-modern magical worldview.The following essay is a critique of these lines of tradition,followed by the question of the extent to which they can serve citizens of an enlightened society in naming and constructively addressing actual social grievances.展开更多
The three-dimensional(3D)cell culture system has garnered significant attention in recent years as a means of studying cell behavior and tissue development,as opposed to traditional two-dimensional cultures.These syst...The three-dimensional(3D)cell culture system has garnered significant attention in recent years as a means of studying cell behavior and tissue development,as opposed to traditional two-dimensional cultures.These systems can induce specific cell reactions,promote specific tissue functions,and serve as valuable tools for research in tissue engineering,regenerative medicine,and drug discovery.This paper discusses current developments in the field of three-dimensional cell culture and the potential applications of 3D type 1 collagen gels to enhance the growth and maturation of dendritic cells.展开更多
Nanobiomaterials demonstrate great potential in bone and dental tissue regeneration.These materials mimic the natural extracellular matrix in the human body,promoting the controlled release of growth factors and other...Nanobiomaterials demonstrate great potential in bone and dental tissue regeneration.These materials mimic the natural extracellular matrix in the human body,promoting the controlled release of growth factors and other bioactive molecules to enhance tissue regeneration and integration.Nanobioceramics mimic the structure and composition of natural bone.A major challenge in hard tissue healing is creating scaffolds that incorporate stem cells for bone tissue engineering.Scaffolds and implants for regenerative medicine should be designed using computer-aided design(CAD)and three-dimensional(3D)printing to replicate the tissue's anatomical structure.Future studies should examine the relationship between the size of bioceramics and biological reactions.The more interacting nature of nanoceramics better triggers the cellular processes,facilitating the regeneration of calcified tissue.Osteoblasts and osteoclasts are crucial in the development and maintenance of calcified tissue in vivo,and nanoceramics enhance the functionality of orthopedic and dental implants.展开更多
The higher concentration of PM_(10) and PM_(2.5) in the lower atmosphere is severely harmful for human health and it also makes visibility diminution along with weather and climate modifications.The main objective is ...The higher concentration of PM_(10) and PM_(2.5) in the lower atmosphere is severely harmful for human health and it also makes visibility diminution along with weather and climate modifications.The main objective is to find out the spatiotemporal variation and dispersal of PM_(10) and PM_(2.5) along with COVID-19 infection in the dusty city Kolkata.The consecutive two years PM_(10) and PM_(2.5) data of different stations have been obtained from State Pollution Control Board,Govt.of West Bengal.Forward trajectory analysis has been done through HYSPLIT(Hybrid Single Particle Lagrangian Integrated Trajectory)model to find the path and direction of air particles.The result showed that the various meteorological or environmental factors(such as temperature,relative humidity,wind,wind speed,pressure and gusty wind)and geographical location regulate the spatiotemporal variation of PM_(10) and PM_(2.5).These factors like high temperature with relative humidity and strong wind influence to disperse the particulate matters from north to south direction from city to outside during summer in Kolkata metropolitan city.During summer(both pre and lockdown years),the height of particles is extended up to 1000 m owing to active atmospheric ventilation whereas in winter it is confined within 100 m.The HYSPLIT model clearly specified that the particles dispersed from south,south-west to north and north east direction due to strong wind.The constant magnification of PM_(10) and PM_(2.5) in the lower atmosphere leads to greater frequency of COVID-19 infections and deaths.In Kolkata,the one of the crucial reasons of high infection and deaths(COVID-19)is co-morbidity of people.展开更多
Within the public health sector of Hong Kong(China),there is a consensus around the important role of traditional Chinese medicines.For Hong Kong(China)to play a bridging role to bring Chinese medicines to the global ...Within the public health sector of Hong Kong(China),there is a consensus around the important role of traditional Chinese medicines.For Hong Kong(China)to play a bridging role to bring Chinese medicines to the global market requires a concerted effort from the government,academic institutes and industries.The release of the final version of the European Medicines Agencies guidance document,which details the acceptance of minimum requirements to nonclinical package in bibliographical applications,grants the opportunity for well-established and traditional herbal medicines to demonstrate an‘acceptable safe’status for registration in the European Union.It is anticipated that this minimum nonclinical package can be applied to demonstrate the safe use of many traditional Chinese medicines regardless of their eligibility to be registered under the simplified procedure within the European Union.This paper conceptualizes an integration of a simplified evaluation route for eligible proprietary Chinese medicines(pCm)with long history of use into the existing drug regulatory framework in Hong Kong(China).Such integration utilizing the minimum nonclinical package,based on bibliographical data or expert report,as proof of evidence to demonstrate safety for pCm with long history of use requires less demand in scientific resources.With Hong Kong(China)conducting‘first hand’review for eligible pCm,it provides an option for overseas and local pharmaceutical companies to register their products in Hong Kong(China)without the need to rely on issuance of Certificate of Pharmaceutical Product from other countries.This could bring eligible pCm with long history of use to reach international risk-based standard and to be marketed globally as‘medicines’to reach their full therapeutic potential.An important process to positioning Hong Kong(China)to compete with other countries in promoting importation and exportation of pCm to better serve the global health.展开更多
In a previous, primary treatise of the author the mathematical description of electron trajectories in the excited states of the H-atom could be demonstrated, starting from Bohr’s original model but modifying it thre...In a previous, primary treatise of the author the mathematical description of electron trajectories in the excited states of the H-atom could be demonstrated, starting from Bohr’s original model but modifying it three dimensionally. In a subsequent treatise, Bohr’s theorem of an unalterable angular momentum h/2π, determining the ground state of the H-atom, was revealed as an inducement by the—unalterable—electron spin. Starting from this presumption, a model of the H2-molecule could be created which exhibits well-defined electron trajectories, and which enabled computing the bond length precisely. In the present treatise, Bohr’s theorem is adapted to the atom models of helium and of neon. But while this was feasible exactly in the case of helium, the neon atom turned out to be too complex for a mathematical modelling. Nevertheless, a rough ball-and-stick model can be presented, assuming electron rings instead of electron clouds, which in the outer shell are orientated as a tetrahedron. It entails the principal statement that the neon atom does not represent a static construction with constant electron distances and velocities, but a pulsating dynamic one with permanently changing internal distances. Thus, the helium atom marks the limit for precisely describing an atom, whereby at and under this limit such a precise description is feasible, being also demonstrated in the author’s previous work. This contradicts the conventional quantum mechanical theory which claims that such a—locally and temporally—precise description of any atom or molecule structure is generally not possible, also not for the H2-molecule, and not even for the H-atom.展开更多
Electronic machines in the guise of digital computers have transformed our world―social,family,commerce,and politics―although not yet health.Each iteration spawns expectations of yet more astonishing wonders.We wait...Electronic machines in the guise of digital computers have transformed our world―social,family,commerce,and politics―although not yet health.Each iteration spawns expectations of yet more astonishing wonders.We wait for the next unbelievable invention to fall into our lap,possibly without limit.How realistic is this?What are the limits,and have we now reached them?A recent survey in The Economist suggests that we have.It describes cycles of misery,where inflated expectations are inevitably followed,a few years later,by disillusion.Yet another Artificial Intelligence(AI)winter is coming―“After years of hype,many people feel AI has failed to deliver”.The current paper not only explains why this was bound to happen,but offers a clear and simple pathway as to how to avoid it happening again.Costly investments in time and effort can only show solid,reliable benefits when full weight is given to the fundamental binary nature of the digital machine,and to the equally unique human faculty of‘intent’.‘Intent’is not easy to define;it suffers acutely from verbal fuzziness―a point made extensively in two earlier papers:“The scientific evidence that‘intent’is vital for healthcare”and“Why Quakerism is more scientific than Einstein”.This paper argues that by putting‘intent’centre stage,first healthcare,and then democracy can be rescued.Suppose every medical consultation were supported by realistic data usage?What if,using only your existing smartphone,your entire medical history were scanned,and instantly compared,within microseconds,with up-to-the-minute information on contraindications and efficacy,from around the globe,for the actual drug you were about to receive,before you actually received it?This is real-time retrieval of clinical data―it increases the security of both doctor and patient,in a way that is otherwise unachievable.My 1980 Ph.D.thesis extolled the merits of digitising the medical record―and,just as digitisation has changed our use of audio and video beyond recognition,so a data-rich medical consultation is unprecedented―prepare to be surprised.This paper has four sections:(1)where binaries help;(2)where binaries ensure extinction;(3)computers in healthcare and civilisation;and(4)data-rich doctoring.Health is vital for economic success,as the current pandemic demonstrates,inescapably.Politics,too,is routinely corrupted―unless we rectify both,failures in AI will be the least of our troubles.展开更多
This study represents an example of investigating the associations between the joint exposure to ozone (O3) and particulate matter of sizes less than or equal to 2.5 micrometers in aerodynamic diameter (PM2.5) and car...This study represents an example of investigating the associations between the joint exposure to ozone (O3) and particulate matter of sizes less than or equal to 2.5 micrometers in aerodynamic diameter (PM2.5) and cardiovascular disease (CVD) emergency room (ER) visits and chronic obstructive pulmonary disease (COPD) ER visits using multivariate geostatistics in Houston, Texas, from 2004 to 2009. Analyses showed lack of strong pair-wise association among the predictors of O3, PM2.5, wind speed, relative humidity, and temperature. Whereas CVD and COPD ER visits exhibited a strong positive correlation. Both outcomes drastically increased from 2006 possibly due to immigration from neighboring locations. Parametric testing showed that the data differed significantly between the years. Multivariate multiple regression results on the 2009 data showed that PM2.5, relative humidity, and temperature were significant to both CVD and COPD ER visits. Codispersion coefficients were constant which justified the assumption of intrinsic correlation. That is, our predictors had strong influence on the spatial variability of CVD and COPD ER visits. This multivariate geostatistics approach predicted an increase of 34% in CVD ER visits and 24% increase in COPD ER visits, which calls for more attention from policy makers. The use of multivariate geostatistics analyses enabled us to successfully detect the effects of risk factors on both outcomes.展开更多
This paper mainly investigated the value of the rainwater by introducing a “Logic of Encounter” that is a new logic beyond the logos and lemma through the metaphors which compare the real rainwater to one’s life. A...This paper mainly investigated the value of the rainwater by introducing a “Logic of Encounter” that is a new logic beyond the logos and lemma through the metaphors which compare the real rainwater to one’s life. A consideration regarding sustainable rainwater resource utilization has been described and the main results are summarized in the paper.展开更多
Shifting focus from the patient’s body to the healer’s body,this essay focuses on how Chinese physicians instrumentalized their bodies to heal(ie,body-as-technology)and their hands to think with(ie,hand-memory techn...Shifting focus from the patient’s body to the healer’s body,this essay focuses on how Chinese physicians instrumentalized their bodies to heal(ie,body-as-technology)and their hands to think with(ie,hand-memory techniques or simply,hand mnemonics).When physicians used their hands to memorize concepts related to clinical practice,calculate with time variables,and carry out ritual gestures intended to reduce risk,improve fortune,and even cure,their hands became extensions of their minds.This essay has three parts that follow the discovery process of the author’s research on hand-memory techniques found in Chinese medical texts.The first part“Divination and Revelation”explains the significance of how the author first learned about Chinese divination practices that used hand mnemonics.The second part“Original Frame”introduces the scholarship on arts of memory in Europe that informed interpretations of the earliest hand mnemonics found in Chinese medical texts.The third part“Expanded Frame”deploys some concepts from cognitive science to help situate Chinese medical hand mnemonics more broadly as an example of extended cognition.The essay concludes with an important distinction:sometimes Chinese healers’hands were used separately from their bodies to think through things and sometimes hand and body had to be integrated in order for the healer’s body-as-technology to act as a therapeutically effective instrument.展开更多
The Pre-Raphaelite painter Edward Burne-Jones(1833-1898)conceived the subject of The Mirror of Venus between 1865 and 1867.He painted two versions:a small version in gouache and oil and a larger version in oil on canv...The Pre-Raphaelite painter Edward Burne-Jones(1833-1898)conceived the subject of The Mirror of Venus between 1865 and 1867.He painted two versions:a small version in gouache and oil and a larger version in oil on canvas.In composing this subject Burne-Jones was inspired by the poetic and chromatic description of a lyrical stanza on“The Hill of Venus”in the long epic poem Earthly Paradise,written by his close friend and collaborator William Morris.1 This study comprises three parts:Burne-Jones’s history of the paintings,his iconographical sources,and an iconological interpretation of The Mirror of Venus.展开更多
文摘During the past few decades, it has become clear that the distribution, sizes, and masses of cosmic structures are best described as fractal rather than homogeneous. This means that an entirely different formalism is needed to replace the standard perturbation model of structure formation. Recently, we have been developing a model of cosmology that accounts for a large number of the observed properties of the universe. A key component of this model is that fractal structures that later regulated the creation of both matter and radiation came into existence during the initial Planck-era inflation. Initially, the vacuum was the only existence and since time, distance, and energy were uncertain, its only property, the curvature (or energy), was most likely distributed randomly. Everything that happened after the Planck era can be described by the known laws of physics so the remaining fundamental problem is to discover how such a random beginning could organize itself into the hierarchy of highly non-random self-similar structures on all length scales that are necessary to explain the existence of all cosmic structures. In this paper, we present a variation of the standard sandpile model that points to a solution. Incidental to our review of the distributions of cosmic structures, we discovered that the apparent transition from a fractal to a homogeneous distribution of structures at a distance of about 150 Mpc is a consequence of the finite size of the universe rather than a change in the underlying statistics of the distributions.
文摘Security issues in cloud networks and edge computing have become very common. This research focuses on analyzing such issues and developing the best solutions. A detailed literature review has been conducted in this regard. The findings have shown that many challenges are linked to edge computing, such as privacy concerns, security breaches, high costs, low efficiency, etc. Therefore, there is a need to implement proper security measures to overcome these issues. Using emerging trends, like machine learning, encryption, artificial intelligence, real-time monitoring, etc., can help mitigate security issues. They can also develop a secure and safe future in cloud computing. It was concluded that the security implications of edge computing can easily be covered with the help of new technologies and techniques.
文摘The traditional Chinese medicine(TCM)industry is critical to not only for public health but also for economic growth.According to the European Union(EU)directives,under the EU framework for(traditional)herbal medicinal products,herbal medicines with long history of use can be registered in EU.However,there is a condition in this directive in which only those that have at least 10e15 years in the EU market are accepted for registration and/or marketing authorization.In author opinion,the condition of 10-15 years of use in EU countries set within the EU regulatory framework is with consideration of the genetic differences which can result in variation in adverse drug responses among different world populations.With this concept in mind,it is reasonable to project the principal of the EU directive to the Asian countries where TCM is originated.Countries like China,Singapore,Japan and South Korea that have well established drug registration framework are in best position in executing the best practice and facilitate harmonization of registration for TCM within the region.Furthermore,the registration process itself allows more safety and efficacy data to be collected systemically before and after product registration/marketing authorization.These are valuable information for future drug development.The therapeutic value of TCM is limitless,it has been left out in the EU regulatory framework,and the opportunity for it to be expanded and carried forward in modern medicines is shadowed by the limited number of TCM that are qualified to be registered under the EU regulatory framework.An early establishment of a harmonized risk-based registration process for TCM in Asian countries is important.This will strengthen the database to substantiate the history of safe use and further preserving and expanding the therapeutic values of TCM within and beyond the Asian region.
文摘Monitoring temporal changes in sea level is important in assessing coastal risk.Sea level anomalies at a tide gauge station,if kinematically conceived,include systematic variations such as trend,acceleration,periodic oscillations,and random disturbances.Among them,the non-stationary nature of the random sea level variations of known or unknown origin at coastal regions has been long recognized by the sea level community.This study proposes the analyses of subgroups of random residual statistics of a rigorously formulated kinematic model solution of tide gauge variations using X-bar and S control charts.The approach is demonstrated using Key West,Florida tide gauge records.The mean and standard errors of 5-year-long subgroups of the residuals revealed that sea level changes at this location have been progressively intensifying from 1913 to the present.Increasing oscillations in sea level at this locality may be attributed partly to the thermal expansion of seawater with increasing temperatures causing larger buoyancy-related sea level fluctuations as well as the intensification of atmospheric events including wind patterns and the impact of changes in inverted barometer effects that will alter coastal risk assessments for the future.
文摘The“University”proposes the proposition of“investigating things to acquire knowledge”,presenting the rudimentary form of Chinese philosophical epistemology.Over the following 2,500 years,it has undergone numerous debates on the relationship between knowledge and action;however,no philosopher has developed a comprehensive epistemological system that explores the nature,source,formation,application,truth,testing,structure of human knowledge,as well as the relationship between language and thinking.The concept of“know”in the philosophy of“investigating things to attain knowledge”is equivalent to concepts such as“idea”and“meaning”in Western philosophy.However,the cognitive state of“know”has not been fully explored and expanded upon,nor has the distinction between empirical and rational recognition of“know”been made.Confucianism advocated the“learning”of language communication as one of the ways to acquire knowledge,but it failed to evolve a method of using language to conduct formal logical reasoning to acquire knowledge and test truth.The“eight trigrams”deduction and yin-yang and five elements theory in the“I Ching”have stifled the emergence of modern scientific epistemological methods in China in terms of thinking mode.Confucian epistemology:focuses on“reason”and interpersonal relationships,with an emphasis on the establishment of moral ethics and social order.Taoist epistemology:pursues a realm beyond experience and social conventions,understanding the world through introspection and insight;it focuses on grasping“Tao”,providing vague guidance for determining universal truths and acquiring precise knowledge;it is prone to falling into the dilemma of nihilism and relativism.The concept of unity between heaven and man and unity between knowledge and action has led to the lack of differentiation in Chinese philosophical epistemology regarding the study of the relationship between subject and object,not involving the way in which the subject understands the object,the limitations of understanding,and the interaction between subject and object in the process of understanding.
文摘Confucianism and Daoism share the same origin in Chinese philosophy.The Huang-Lao school,which emerged during the early Han dynasty,produced two branches:Confucianism and Daoism.This school used Chinese society as a laboratory for social science experiments based on The Book of Changes(Yijing)and Laozi,aiming to establish a universal society based on the ideal of“great unity”(datong).
文摘This paper applies Gödel’s Incompleteness Theorems to the evolution and development of human social systems.Although Gödel’s Incompleteness Theorems originated in the field of mathematics,their influence has long extended beyond mathematics,making an impact on philosophy,systems science,and the humanities and social sciences.The paper analyzes the autonomy and completeness of human social systems,arguing that evolving human societies are generally self-consistent.However,if the completeness of a human social system is compromised,the system either maintains self-consistency,ceases to evolve forward,enters a death spiral,and eventually decays and disintegrates.Or the system addresses the completeness issue,enters a state of non-self-consistency,introduces new axioms,becomes self-governing again,and enters a new form.From the sociological perspective,this is articulated as social revolution-the system continues to evolve forward;the absence of social revolution-the system does not evolve forward(Jin,1988).
文摘Based on the two roots of“to be”in Indo-European languages,this paper proposes that Brahman,Buddha,and bhutatathata all come from the second root,of“bhu(to be)”,because“bhu”belongs to the same root as the Greek root“phy”,physis from“phy”,is naturalism.Therefore,Brahma,Buddha,and bhutatathata are all knowledge related to natural science.The first root of“as(to be)”has led to the debate in buddhist philosophy about the asmiti and anasmiti.The spread of Buddhist philosophy in China is due to the lack of“as/bhu(to be)”,vocabulary and grammar in Chinese;as a result,the Buddhist verses translated in ancient China became a philosophy without“as/bhu(to be)”.At the same time,some Buddhist words have lost their connection with the root and the grammatical features of“as/bhu(to be)”,resulting in the spread of Buddhist philosophy in China having been into a language game.We should put Buddhist philosophy back into the Indo-European language family;it transforms the Buddhist philosophy of speaking ancient Chinese into the Buddhist modern philosophical language,and makes Buddhist philosophy develop into a set of understandable and logical normative philosophy.
文摘Cloud computing plays a significant role in modern information technology, providing organizations with numerous benefits, including flexibility, scalability, and cost-efficiency. However, it has become essential for organizations to ensure the security of their applications, data, and cloud-based networks to use cloud services effectively. This systematic literature review aims to determine the latest information regarding cloud computing security, with a specific emphasis on threats and mitigation strategies. Additionally, it highlights some common threats related to cloud computing security, such as distributed denial-of-service (DDoS) attacks, account hijacking, malware attacks, and data breaches. This research also explores some mitigation strategies, including security awareness training, vulnerability management, security information and event management (SIEM), identity and access management (IAM), and encryption techniques. It discusses emerging trends in cloud security, such as integrating artificial intelligence (AI) and machine learning (ML), serverless computing, and containerization, as well as the effectiveness of the shared responsibility model and its related challenges. The importance of user awareness and the impact of emerging technologies on cloud security have also been discussed in detail to mitigate security risks. A literature review of previous research and scholarly articles has also been conducted to provide insights regarding cloud computing security. It shows the need for continuous research and innovation to address emerging threats and maintain a security-conscious culture in the company.
文摘The content of current third-wave feminism differs significantly from that of previous feminist movements,which sought equal human and civil rights for women.In third-wave feminism,gender is primarily understood as a social category that is linguistically constructed.The now classic work Gender Trouble(1990)by philosopher Judith Butler is decisive for this“linguistic turn”in the social sciences.However,Butler’s work is systematically based on two philosophical traditions that are already highly controversial in themselves:sophism and existentialism,linked to a pre-modern magical worldview.The following essay is a critique of these lines of tradition,followed by the question of the extent to which they can serve citizens of an enlightened society in naming and constructively addressing actual social grievances.
文摘The three-dimensional(3D)cell culture system has garnered significant attention in recent years as a means of studying cell behavior and tissue development,as opposed to traditional two-dimensional cultures.These systems can induce specific cell reactions,promote specific tissue functions,and serve as valuable tools for research in tissue engineering,regenerative medicine,and drug discovery.This paper discusses current developments in the field of three-dimensional cell culture and the potential applications of 3D type 1 collagen gels to enhance the growth and maturation of dendritic cells.
文摘Nanobiomaterials demonstrate great potential in bone and dental tissue regeneration.These materials mimic the natural extracellular matrix in the human body,promoting the controlled release of growth factors and other bioactive molecules to enhance tissue regeneration and integration.Nanobioceramics mimic the structure and composition of natural bone.A major challenge in hard tissue healing is creating scaffolds that incorporate stem cells for bone tissue engineering.Scaffolds and implants for regenerative medicine should be designed using computer-aided design(CAD)and three-dimensional(3D)printing to replicate the tissue's anatomical structure.Future studies should examine the relationship between the size of bioceramics and biological reactions.The more interacting nature of nanoceramics better triggers the cellular processes,facilitating the regeneration of calcified tissue.Osteoblasts and osteoclasts are crucial in the development and maintenance of calcified tissue in vivo,and nanoceramics enhance the functionality of orthopedic and dental implants.
文摘The higher concentration of PM_(10) and PM_(2.5) in the lower atmosphere is severely harmful for human health and it also makes visibility diminution along with weather and climate modifications.The main objective is to find out the spatiotemporal variation and dispersal of PM_(10) and PM_(2.5) along with COVID-19 infection in the dusty city Kolkata.The consecutive two years PM_(10) and PM_(2.5) data of different stations have been obtained from State Pollution Control Board,Govt.of West Bengal.Forward trajectory analysis has been done through HYSPLIT(Hybrid Single Particle Lagrangian Integrated Trajectory)model to find the path and direction of air particles.The result showed that the various meteorological or environmental factors(such as temperature,relative humidity,wind,wind speed,pressure and gusty wind)and geographical location regulate the spatiotemporal variation of PM_(10) and PM_(2.5).These factors like high temperature with relative humidity and strong wind influence to disperse the particulate matters from north to south direction from city to outside during summer in Kolkata metropolitan city.During summer(both pre and lockdown years),the height of particles is extended up to 1000 m owing to active atmospheric ventilation whereas in winter it is confined within 100 m.The HYSPLIT model clearly specified that the particles dispersed from south,south-west to north and north east direction due to strong wind.The constant magnification of PM_(10) and PM_(2.5) in the lower atmosphere leads to greater frequency of COVID-19 infections and deaths.In Kolkata,the one of the crucial reasons of high infection and deaths(COVID-19)is co-morbidity of people.
文摘Within the public health sector of Hong Kong(China),there is a consensus around the important role of traditional Chinese medicines.For Hong Kong(China)to play a bridging role to bring Chinese medicines to the global market requires a concerted effort from the government,academic institutes and industries.The release of the final version of the European Medicines Agencies guidance document,which details the acceptance of minimum requirements to nonclinical package in bibliographical applications,grants the opportunity for well-established and traditional herbal medicines to demonstrate an‘acceptable safe’status for registration in the European Union.It is anticipated that this minimum nonclinical package can be applied to demonstrate the safe use of many traditional Chinese medicines regardless of their eligibility to be registered under the simplified procedure within the European Union.This paper conceptualizes an integration of a simplified evaluation route for eligible proprietary Chinese medicines(pCm)with long history of use into the existing drug regulatory framework in Hong Kong(China).Such integration utilizing the minimum nonclinical package,based on bibliographical data or expert report,as proof of evidence to demonstrate safety for pCm with long history of use requires less demand in scientific resources.With Hong Kong(China)conducting‘first hand’review for eligible pCm,it provides an option for overseas and local pharmaceutical companies to register their products in Hong Kong(China)without the need to rely on issuance of Certificate of Pharmaceutical Product from other countries.This could bring eligible pCm with long history of use to reach international risk-based standard and to be marketed globally as‘medicines’to reach their full therapeutic potential.An important process to positioning Hong Kong(China)to compete with other countries in promoting importation and exportation of pCm to better serve the global health.
文摘In a previous, primary treatise of the author the mathematical description of electron trajectories in the excited states of the H-atom could be demonstrated, starting from Bohr’s original model but modifying it three dimensionally. In a subsequent treatise, Bohr’s theorem of an unalterable angular momentum h/2π, determining the ground state of the H-atom, was revealed as an inducement by the—unalterable—electron spin. Starting from this presumption, a model of the H2-molecule could be created which exhibits well-defined electron trajectories, and which enabled computing the bond length precisely. In the present treatise, Bohr’s theorem is adapted to the atom models of helium and of neon. But while this was feasible exactly in the case of helium, the neon atom turned out to be too complex for a mathematical modelling. Nevertheless, a rough ball-and-stick model can be presented, assuming electron rings instead of electron clouds, which in the outer shell are orientated as a tetrahedron. It entails the principal statement that the neon atom does not represent a static construction with constant electron distances and velocities, but a pulsating dynamic one with permanently changing internal distances. Thus, the helium atom marks the limit for precisely describing an atom, whereby at and under this limit such a precise description is feasible, being also demonstrated in the author’s previous work. This contradicts the conventional quantum mechanical theory which claims that such a—locally and temporally—precise description of any atom or molecule structure is generally not possible, also not for the H2-molecule, and not even for the H-atom.
文摘Electronic machines in the guise of digital computers have transformed our world―social,family,commerce,and politics―although not yet health.Each iteration spawns expectations of yet more astonishing wonders.We wait for the next unbelievable invention to fall into our lap,possibly without limit.How realistic is this?What are the limits,and have we now reached them?A recent survey in The Economist suggests that we have.It describes cycles of misery,where inflated expectations are inevitably followed,a few years later,by disillusion.Yet another Artificial Intelligence(AI)winter is coming―“After years of hype,many people feel AI has failed to deliver”.The current paper not only explains why this was bound to happen,but offers a clear and simple pathway as to how to avoid it happening again.Costly investments in time and effort can only show solid,reliable benefits when full weight is given to the fundamental binary nature of the digital machine,and to the equally unique human faculty of‘intent’.‘Intent’is not easy to define;it suffers acutely from verbal fuzziness―a point made extensively in two earlier papers:“The scientific evidence that‘intent’is vital for healthcare”and“Why Quakerism is more scientific than Einstein”.This paper argues that by putting‘intent’centre stage,first healthcare,and then democracy can be rescued.Suppose every medical consultation were supported by realistic data usage?What if,using only your existing smartphone,your entire medical history were scanned,and instantly compared,within microseconds,with up-to-the-minute information on contraindications and efficacy,from around the globe,for the actual drug you were about to receive,before you actually received it?This is real-time retrieval of clinical data―it increases the security of both doctor and patient,in a way that is otherwise unachievable.My 1980 Ph.D.thesis extolled the merits of digitising the medical record―and,just as digitisation has changed our use of audio and video beyond recognition,so a data-rich medical consultation is unprecedented―prepare to be surprised.This paper has four sections:(1)where binaries help;(2)where binaries ensure extinction;(3)computers in healthcare and civilisation;and(4)data-rich doctoring.Health is vital for economic success,as the current pandemic demonstrates,inescapably.Politics,too,is routinely corrupted―unless we rectify both,failures in AI will be the least of our troubles.
文摘This study represents an example of investigating the associations between the joint exposure to ozone (O3) and particulate matter of sizes less than or equal to 2.5 micrometers in aerodynamic diameter (PM2.5) and cardiovascular disease (CVD) emergency room (ER) visits and chronic obstructive pulmonary disease (COPD) ER visits using multivariate geostatistics in Houston, Texas, from 2004 to 2009. Analyses showed lack of strong pair-wise association among the predictors of O3, PM2.5, wind speed, relative humidity, and temperature. Whereas CVD and COPD ER visits exhibited a strong positive correlation. Both outcomes drastically increased from 2006 possibly due to immigration from neighboring locations. Parametric testing showed that the data differed significantly between the years. Multivariate multiple regression results on the 2009 data showed that PM2.5, relative humidity, and temperature were significant to both CVD and COPD ER visits. Codispersion coefficients were constant which justified the assumption of intrinsic correlation. That is, our predictors had strong influence on the spatial variability of CVD and COPD ER visits. This multivariate geostatistics approach predicted an increase of 34% in CVD ER visits and 24% increase in COPD ER visits, which calls for more attention from policy makers. The use of multivariate geostatistics analyses enabled us to successfully detect the effects of risk factors on both outcomes.
文摘This paper mainly investigated the value of the rainwater by introducing a “Logic of Encounter” that is a new logic beyond the logos and lemma through the metaphors which compare the real rainwater to one’s life. A consideration regarding sustainable rainwater resource utilization has been described and the main results are summarized in the paper.
基金International Consortium for Research in the Humanities(IKJF),University of Erlangen-Nürnberg(2011-2012,2014,2016)Elizabeth and J.Richardson Dilworth Fellow,Institute for Advanced Study,Princeton(2017-2018)+1 种基金National Endowment for Humanities Fellowship,US Government(2019)Visiting Scholar,Max Planck Institute for the History of Science,Berlin(2021-2022).
文摘Shifting focus from the patient’s body to the healer’s body,this essay focuses on how Chinese physicians instrumentalized their bodies to heal(ie,body-as-technology)and their hands to think with(ie,hand-memory techniques or simply,hand mnemonics).When physicians used their hands to memorize concepts related to clinical practice,calculate with time variables,and carry out ritual gestures intended to reduce risk,improve fortune,and even cure,their hands became extensions of their minds.This essay has three parts that follow the discovery process of the author’s research on hand-memory techniques found in Chinese medical texts.The first part“Divination and Revelation”explains the significance of how the author first learned about Chinese divination practices that used hand mnemonics.The second part“Original Frame”introduces the scholarship on arts of memory in Europe that informed interpretations of the earliest hand mnemonics found in Chinese medical texts.The third part“Expanded Frame”deploys some concepts from cognitive science to help situate Chinese medical hand mnemonics more broadly as an example of extended cognition.The essay concludes with an important distinction:sometimes Chinese healers’hands were used separately from their bodies to think through things and sometimes hand and body had to be integrated in order for the healer’s body-as-technology to act as a therapeutically effective instrument.
基金I want to express my gratitude to the auction houses,libraries,museums,photographic collections(Wikipedia,Wiki Commons Images),and private collections here cited for their assistance in granting me permission to photograph or reproduce the images in this essay.
文摘The Pre-Raphaelite painter Edward Burne-Jones(1833-1898)conceived the subject of The Mirror of Venus between 1865 and 1867.He painted two versions:a small version in gouache and oil and a larger version in oil on canvas.In composing this subject Burne-Jones was inspired by the poetic and chromatic description of a lyrical stanza on“The Hill of Venus”in the long epic poem Earthly Paradise,written by his close friend and collaborator William Morris.1 This study comprises three parts:Burne-Jones’s history of the paintings,his iconographical sources,and an iconological interpretation of The Mirror of Venus.
