Research on the ecohydrological processes of terrestrial plants is a frontier field comprising ecology,hydrology and global change research,yielding the key theoretical foundations of ecohydrology.In karst areas,due t...Research on the ecohydrological processes of terrestrial plants is a frontier field comprising ecology,hydrology and global change research,yielding the key theoretical foundations of ecohydrology.In karst areas,due to its unique geological background,the karst landscape is strongly developed,with high bedrock exposure,high permeability,fragmented soils,shallow soils,and high spatial heterogeneity,resulting in very limited water storage for plant uptake and growth in rock fissures and shallow soils.Therefore,water conditions are an important ecological factor influencing plant growth.To comprehensively understand the current progress and development trends in plant water use research focusing on karst areas,this paper uses the VOSviewer software to analyze the literature on plant water use in karst areas between 1984 and 2022.The results showed that:(1)Research on plant water use in karst areas has developed rapidly worldwide,and the number of relevant studies in the literature have increased year by year,which together means that it is attracting more and more attention.(2)The investigation of plant water sources,geological background of karst areas,seasonal arid tropical climates,the relationship betweenδ13C values and plant water use efficiency,karst plant water use in karst savannas and subtropical areas,and ecosystems under climate change yields the knowledge base in this field.(3)Most studies in this area focus on the division of water sources of plants in karst areas,the methods of studying the water use sources of plants,and the water use strategies and efficiency of plants.(4)Future research will focus on how plant water use in karst areas is influenced by Earth’s critical zones,climate change,and ecohydrological separation.These studies will provide a key scientific basis for guiding ecological restoration and promoting sustainable development in karst areas.展开更多
The Napo-Qinzhou Tectonic Belt （NQTB） lies at the junction of the Yangtze, Cathaysia and Indochina （North Vietnam） Blocks, which is composed of five major lithotectonic subunits： the Qinzhou-Fangcheng Suture Zone...The Napo-Qinzhou Tectonic Belt （NQTB） lies at the junction of the Yangtze, Cathaysia and Indochina （North Vietnam） Blocks, which is composed of five major lithotectonic subunits： the Qinzhou-Fangcheng Suture Zone （QFSZ）, the Shiwandashan Basin （SB）, the Pingxiang-Nanning Suture Zone （PNSZ）, the Damingshan Block （DB） and the Babu-Lingma Suture Zone （BLSZ）. On the basis of geochemical compositions, the Permian mafic igneous rocks can be divided into three distinct groups： （1） mafic igneous rocks （Group 1） from the Longjing region in the PNSZ and Hurun region in the BLSZ, which are characterized by intermediate Ti, P and Zr with low Ni and Cr contents; （2） mafic igneous rocks （Group 2） from the Naxiao and Chongzuo region in the DB, characterized by low-intermediate Ti, P and Zr with high Ni and Cr concentrations; and （3） mafic igneous rocks （Group 3） from the Siming region in the Jingxi carbonate platform of the northwestern margin of the NQTB, with intermediate-high Ti, P and Zr and low Ni and Cr contents. The Group 1 rocks yield a weighted mean 206 Pb/ 238 U age of 250.5±2.8 Ma and are geochemically similar to basalts occurring in back-arc basin settings. The Group 2 rocks exhibit geochemical features to those basalts in island arcs, whereas the Group 3 rocks show geochemical similarity to that of ocean island basalts. All three groups are characterized by relatively low ε Nd （t） values （-2.61 to ＋1.10） and high initial 87 Sr/ 86 Sr isotopic ratios （0.705309-0.707434）, indicating that they were derived from a subduction-modified lithospheric mantle and experienced assimilation, fractional crystallization, and crustal contamination or mixing during magmatic evolution. Accordingly, we propose the existence of an arc-back arc basin system that developed along the NQTB at the border of SW Guangxi Province （SW China） and northern Vietnam, and it was formed by continued northwestward subduction of the Cathaysian （or Yunkai） Block under the Yangtze Block, and northeastward subduction of the Indochina Block beneath the Yangtze Block during Permian time.展开更多
The low temperature process of cold dew wind( from September 19 to 27 in 2011) for late rice production was dynamically monitored by using CLDAS temperature,combined with the background information of rice cultivation...The low temperature process of cold dew wind( from September 19 to 27 in 2011) for late rice production was dynamically monitored by using CLDAS temperature,combined with the background information of rice cultivation from multi-source satellite database together with an reference to the monitoring indexes of cold dew wind disaster to verify the precision of CLDAS data,so as to provide a reference for monitoring chilling damage caused by cold dew wind in late rice production in Guangxi. The results showed that the cold wind dew caused heavy damage to an area of 3 159. 76 km^2,moderate damage to an area of 559. 77 km^2 and light damage to an area of 2 452. 14 km^2. The correlation coefficients between CLDAS inversion temperature and actual temperature of 12 verification meteorological stations were all larger than 0. 93,and the difference in daily average temperature was 0. 3 ℃. The time difference between maximum and minimum temperature provided by CLDAS and corresponding actual temperature from 12 meteorological stations was less than 1 h. The temperature data provided by CLDAS was in accordance with actual temperature data. With an advantage of rapidly,minutely and accurately monitoring the grade distribution of local cold dew wind disaster for late rice,CLDAS can be used in monitoring cold dew wind in late rice production in Guangxi.展开更多
In order to screen the Medicago sativa(alfalfa)varieties suitable for planting in Guangxi,six domestic and foreign heat-resistant alfalfa varieties,namely WL903,WL712,WL525HQ,59N59,Elite 9 and Longwei 6010,were select...In order to screen the Medicago sativa(alfalfa)varieties suitable for planting in Guangxi,six domestic and foreign heat-resistant alfalfa varieties,namely WL903,WL712,WL525HQ,59N59,Elite 9 and Longwei 6010,were selected and tested for growth performance,nutritional value and over-summer rate by the random block method.The results showed that the alfalfa varieties with better plant height and fresh grass yield were 59N59 and WL903,which showed the plant heights reaching 62.01 and 62.53 cm,respectively,and the fresh grass yields up to 40.93 and 38.38 t/hm 2,respectively,exhibiting extremely significant differences from the poorly performing Longwei 6010(P<0.01).The nutritional value of each tested variety was good,and the crude protein content was more than 20%.Among them,Elite 9 had a crude protein content as high as 28.43%.The over-summer rates of the six alfalfa varieties were all higher than 75%.It showed that the alfalfa varieties with fast growth,high yield,high nutritional value and high over-summer rate in this experimental area were 59N59 and WL903,which are suitable as the first varieties for planting in Guangxi.展开更多
1.Objective The Nandan-Yizhou faulting basin,which is located in Longtou-Limiao,Guangxi,is in the southern margin of the Yangtze Block,the depression zone of south Hunan and north Guangxi.It is a carbonate Manganese (...1.Objective The Nandan-Yizhou faulting basin,which is located in Longtou-Limiao,Guangxi,is in the southern margin of the Yangtze Block,the depression zone of south Hunan and north Guangxi.It is a carbonate Manganese (Mn)ore deposit in the Baping Group,where occurs the Nongzhu large Mn deposit in a 100 km long anticlinorium with great Mn resource potential (Fig.1).展开更多
Variables fields such as enstrophy, meridional-wind and zonal-wind variables are derived from monthly 500 hPa geopotential height anomalous fields. In this work, we select original predictors from monthly 500-hPa geop...Variables fields such as enstrophy, meridional-wind and zonal-wind variables are derived from monthly 500 hPa geopotential height anomalous fields. In this work, we select original predictors from monthly 500-hPa geopotential height anomalous fields and their variables in June of 1958 - 2001, and determine comprehensive predictors by conducting empirical orthogonal function (EOF) respectively with the original predictors. A downscaling forecast model based on the back propagation (BP) neural network is built by use of the comprehensive predictors to predict the monthly precipitation in June over Guangxi with the monthly dynamic extended range forecast products. For comparison, we also build another BP neural network model with the same predictands by using the former comprehensive predictors selected from 500-hPa geopotential height anomalous fields in May to December of 1957 - 2000 and January to April of 1958 - 2001. The two models are tested and results show that the precision of superposition of the downscaling model is better than that of the one based on former comprehensive predictors, but the prediction accuracy of the downscaling model depends on the output of monthly dynamic extended range forecast.展开更多
[Objectives]This trial was conducted to investigate the effects of diet with"Lianteng"additive of Chinese herbal medicine on blood biochemical indexes,immune and antioxidant function of Guangxi Sanhuang chic...[Objectives]This trial was conducted to investigate the effects of diet with"Lianteng"additive of Chinese herbal medicine on blood biochemical indexes,immune and antioxidant function of Guangxi Sanhuang chickens.[Methods]480 Guangxi Sanhuang chickens at the age of 1 d were divided into 4 groups randomly and each group was assigned to 6 replicates with 20 chicks in each replicate;groups A,B and C were treatment groups and fed basal diets with 0.1%,0.2%and 0.4%of"Lianteng"additive of Chinese herbal medicine respectively during a trial of 70 d.Group D was control group and fed only basal diet.The serum samples were taken from 6 chicks in each group at the age of 21,35 and 49 d respectively and analyzed for biochemical,immune and antioxidant parameters in serum.[Results]Results from the trial showed that no difference was found in serum content of GLU,TG,TP,TC,and UN in the measurement at the age of 21,35 and 49 d(P>0.05);however,the content of ALB from groups A and B at 35 d was significantly higher than that from group D(P<0.01),and the ALB content from group B at 49 d was also higher than that from group D(P<0.05);the IgM content at 49 d from group A was lower than that from group D(P<0.05),in addition to this,there was no differences found in the contents of IgG,IgM and IFN-y among groups A,B,C and D during the trial(P>0.05);but the content of IL-2 from groups A and B at 49 d was significantly greater than that from group D(P<0.05);T-AOC from groups A,B and C at 49 d was very significantly higher than that from group D(P<0.01),and the one of group B at 35 d was still obviously higher than that of group D(P<0.05);also at 49 d,the GSH content in groups A and B was much greater than that in group D(P<0.01);T-SOD activity of group B and C at 35 d was distinctly greater than that of group D(P<0.05).[Conclusions]It can be concluded that the addition of 0.2%of"Lianteng"additive of Chinese herbal medicine in diet can increase immune function in a certain extent and promote the antioxidant ability observably for Guangxi Sanhuang chickens.展开更多
Decadal circulation differences between more and less rainfall periods in the annually first rainy season of Guangxi and their association with sea surface temperature (SST) of the austral Indian Ocean are investigate...Decadal circulation differences between more and less rainfall periods in the annually first rainy season of Guangxi and their association with sea surface temperature (SST) of the austral Indian Ocean are investigated by using the NCEP/NCAR reanalysis data. The results are shown as follows. A pattern in which there is uniform change of the Guangxi precipitation shows a 20-year decadal oscillation and a 3-year interannual change. In contrast, a pattern of reversed-phase change between the north and the south of Guangxi has a 6-year interannual periodicity and quasi-biennial oscillation. In the period of more precipitation, the surface temperature in Eurasia is positively anomalous so as to lead to stronger low pressure systems on land and larger thermal contrast between land and ocean. Therefore, the air column is more unstable and ascending flows over Guangxi are intensified while the Hadley cell is weakened. Furthermore, the weaker western Pacific subtropical high and South Asia High, together with a stronger cross-equatorial flow, result in the transportation of more humidity and the appearance of more precipitation. The correlation analysis indicates that the Indian Ocean SST in Southern Hemisphere is closely associated with the variation of the seasonal precipitation of Guangxi on the decadal scale by influencing the Asian monsoon through the cross-equatorial flow.展开更多
Totally 150 individuals of 1-day-old Guangxi Jinling partridges were randomly divided into five groups, 30 chickens each group. Chickens in control group were fed with basal diet, while chickens in experimental groups...Totally 150 individuals of 1-day-old Guangxi Jinling partridges were randomly divided into five groups, 30 chickens each group. Chickens in control group were fed with basal diet, while chickens in experimental groups were fed with the diet containing antibiotics, Chinese herbal medicine, probiotics and acidifi- er. The entire trial lasted 50 d, and growth performance and apparent nutrient digestibility of tested chickens were observed and measured. Compared with control group, the feed gain ratio in experimental groups significantly decreased （P 〈 0.05 ）, while that in probiotics group was the lowest. The average daily gain in pmbi- otics group was significantly higher than that in control group or other experimental groups （P 〈 0.05）. The apparent digestibility of crude protein, crude fat and energy in probiotics group were significantly higher than that in control group or other experimental groups （P 〈 0.05 ）. The apparent digestibility of phosphorus, crude fat, crude fiber, calcium and crude protein in antibiotics group were significantly higher than that in control group （P 〈 0.05 ）. The apparent digestibility of crude protein, crude fiber and phosphorus in Chinese herbal medicine group were significantly higher than that in control group （P 〈 0.05 ）. The apparent digesti- bility of nutrient in acidifier group were significantly lower than that in control group or other experimental groups （ P 〈 0.05 ）. Therefore, pmbiotics had better effects on growth performance and apparent nutrient digestibility of chickens than antibiotics, while Chinese herbal medicine and acidifier had inferior effect than an- tibiotics.展开更多
In this paper,the scientific research status of Zexie(Rhizoma Alismatis)was comprehensively expounded from the aspects of plant characteristics,source,chemical composition,pharmacological research and quality control ...In this paper,the scientific research status of Zexie(Rhizoma Alismatis)was comprehensively expounded from the aspects of plant characteristics,source,chemical composition,pharmacological research and quality control methods,etc.The market situation of Rhizoma Alismatis was systematically analyzed from historical and current perspectives;aiming at the problems of poor quality and irregular processing of Chinese medicinal herbs Rhizoma Alismatis,some ideas were put forward to improve the quality and market value of medicinal materials of Rhizoma Alismatis,so as to make the Chinese herbal medicine industry develop towards a healthy and efficient direction.展开更多
A study has been reported on <sup>208</sup>Pb/<sup>206</sup>Pb and <sup>207</sup>Pb/<sup>206</sup>Pb ratio variations in ancient drums and Cu-., Pb- ores from Guangxi, C...A study has been reported on <sup>208</sup>Pb/<sup>206</sup>Pb and <sup>207</sup>Pb/<sup>206</sup>Pb ratio variations in ancient drums and Cu-., Pb- ores from Guangxi, China and can indicate that the Cu- and Pb- bearing ores for making the Beiliu and the Lingshan type drums were taken from Tongshiling of Beiliu County and its vicinity, that were not only ancient sites for smelting the copper ores, but possibly also for casting the bronze drums. Some of the Lengshuichong type drums have abnormal Pb isotopic ratios, which means that they were made of special ore sources, one of the possibilities is that the ore material or the drums were transported from South- East Asia to Guangxi Province, because they have been excavated there too.展开更多
[Objectives] This study aimed to investigate the anti-inflammatory effects of Baeckea frutescence L.in vitro and in vivo.[Methods]The anti-inflammatory activity of B.frutescence was measured by mouse peritoneal capill...[Objectives] This study aimed to investigate the anti-inflammatory effects of Baeckea frutescence L.in vitro and in vivo.[Methods]The anti-inflammatory activity of B.frutescence was measured by mouse peritoneal capillary permeability test,mouse auricle swelling test and rat cotton granuloma test.The RAW264.7 macrophage model was stimulated by lipopolysaccharide(LPS),and the effects of B.frutescence on tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) were detected by enzyme-linked immunosorbent assay(ELISA),and the relative expression of inducible nitric oxide synthase(i NOS) and cyclooxygenase-2(COX-2) proteins was detected by Western blot.Thus,the in vitro anti-inflammatory activity of B.frutescence was studied.[Results] B.frutescence significantly inhibited mouse peritoneal capillary permeability,inhibited xylene-induced mouse auricle swelling and rat cotton granuloma,significantly inhibited TNF-α and IL-6 levels,and down-regulated the expression of i NOS and COX-2 proteins in cells.[Conclusions]B.frutescence showed good anti-inflammatory activity both in vitro and in vivo,and the mechanism may be related to the release inhibition of inflammatory factors TNF-α and the regulation of COX-2.展开更多
A new large-bodied theropod dinosaur, Datanglong guangxiensis gen. et sp. nov., was recovered from the Lower Cretaceous Xinlong Formation of the Datang Basin, Guangxi. It is unique in several features including： post...A new large-bodied theropod dinosaur, Datanglong guangxiensis gen. et sp. nov., was recovered from the Lower Cretaceous Xinlong Formation of the Datang Basin, Guangxi. It is unique in several features including： posteriormost dorsal vertebra with teardrop-shaped pneumatic foramen confined by enlarged pcdl, acpl and the centrum; posteriormost dorsal with well-developed, horizontal prpl; posteriormost dorsal with a parapophysis projecting more laterally than the diapophysis; brevis fossa shallow with short, ridge-like medial blade; and iliac pubic peduncle with posteroventrally expanded margin. Cladistic analysis supports the idea that this new taxon Datanglong guangxiensis is a primitive member of the Carcharodontosauria in possessing two unambiguous synapomorphies： large external pneumatic foramina and internal spaces present in the lateral surface of ilium, and a peg-and-socket ischiac articulation with the ilium. The presence of the new taxon from Guangxi further confirms that Carcharodontosauria were cosmopolitan large-bodied predators during the Early-mid Cretaceous.展开更多
The present situation of sugarcane production in Guangxi was introduced.The main practices of Guangxi green food cane sugar industry development were overviewed in terms of the green production for improving quality o...The present situation of sugarcane production in Guangxi was introduced.The main practices of Guangxi green food cane sugar industry development were overviewed in terms of the green production for improving quality of sugarcane in Guangxi,green mechanism and joint development,block management for ensuring quality,green recycling and turning waste into treasure,building double-high bases for improving quality and increasing quantity,and sustainable development and thoroughly implementation by taking up residence.Prospects for the future development of the green food cane sugar industry in Guangxi were put forward.展开更多
[Objective] This trial was to investigate the effect of dietary Picria felterrae Lour extracts on serum biochemical indexes and immune function of Guangxi Partridge chickens. [Method] Totally 500 individuals of 1-day-...[Objective] This trial was to investigate the effect of dietary Picria felterrae Lour extracts on serum biochemical indexes and immune function of Guangxi Partridge chickens. [Method] Totally 500 individuals of 1-day-old Guangxi Partridge chickens were randomly divided into five groups, five replicates each group and 20 chicks each replicate. Groups A, B and C were treatment groups supplemented with 0.70%, 0.35% and0.175% P. felterrae extracts in the basal diet, respectively; group D was a medical control group supplemented with 0.01% colistin sulfate premix in the basal diet; and group E was a control group with basal diet. Serum samples were collected from 10 chickens in each group at 21, 35 and 49 days of age, to analyze the biochemical and immune indexes. [Result] It had no significant impact on serum TP and GLU contents of chickens by adding different levels of P. felterrae extracts in the basal diet（P 〉0.05）. However, at 21 and 35 days of age, the TBILI content of chickens in groups A, B and C were extremely lower or significantly lower than that in group E（ P〈0.01; P〈0.05）. At 35 days of age, the serum AKP activities in groups A, B and C were extremely higher than that in group E（P〈0.01）, and the serum GOT activities at 21 and 35 days of age in group C were significantly higher than that in group E（P〈0.05）. At 49 days of age, the serum Ig G content in groups A, B and C and the IL-2 content in group B and group C were significantly lower or extremely lower than that in group E（ P〈0.05; P〈0.01）; the T-AOC content in group B was significantly higher than that in group E（P〈0.05）; the GSH content in groups A, B and C were significantly higher than that in group E（ P〈0.05）. Adding different levels of P. felterrae extracts in the diet significantly decreased the TBILI content, reduced the Ig G, IL-2 and IL-6 contents, and improved the AKP and GOT activities and the T-AOC and GSH contents of Guangxi Partridge chicken. [Conclusion] Adding 0.35% P. felterrae extracts in the basal diet received the best effort.展开更多
[Objectives]To investigate the effects of quercetin extracted from flower buds of Sophora japonica cv.jinhuai on the proliferation,apoptosis and migration of human breast cancer MCF-7 cells.[Methods]MTT assay,inverted...[Objectives]To investigate the effects of quercetin extracted from flower buds of Sophora japonica cv.jinhuai on the proliferation,apoptosis and migration of human breast cancer MCF-7 cells.[Methods]MTT assay,inverted microscope observation,hoechst33342 staining,flow cytometry(FCM)and wound healing assay were adopted to investigate the proliferation,morphological changes,apoptosis level and cell migration ability of human breast cancer MCF-7 cells,respectively.[Results]The morphological changes of cells in the treatment groups included gradually decreased number,reduced volume,vague cell contour,loose intercellular connection,uneven cytoplasm distribution and increased cell debris.With the increase of drug concentration,quercetin significantly inhibited the proliferation of human breast cancer MCF-7 cells(P<0.05).The number of apoptotic bodies increased gradually.When the concentration reached 100μmol/L,a large number of nuclear fragments appeared,and the level of apoptosis was statistically different(P<0.05).The mobility and migration ability of cells showed a decreasing trend,and the differences were statistically significant(P<0.05).[Conclusions]This study can provide experimental basis for clinical application of quercetin against breast cancer.展开更多
Podostemaceae(riverweed family),one of the largest aquatic plant families in the world,comprises about 350 species in 51 genera placed in three subfamilies,Podostemoideae,Weddellinoideae,and Tristichoideae(Koi et al.,...Podostemaceae(riverweed family),one of the largest aquatic plant families in the world,comprises about 350 species in 51 genera placed in three subfamilies,Podostemoideae,Weddellinoideae,and Tristichoideae(Koi et al.,2022).Most Podostemaceae genera(~38)are monotypic or oligotypic,with a high level of endemism(Koi et al.,2018,2022).Members of Podostemaceae adhere to rocks in fast-flowing rivers,streams,or waterfalls in the subtropics and tropics(Koi et al.,2018).As an adaptation to fastrunning currents,the morphological structure of river-weeds tends to be extremely reduced,including a loss or reduction of primary shoots or roots(Koi and Kato,2007).The vegetative mass of these plants resembles lichens or bryophytes,and are thus known commonly as“dream bryophytes”(Philbrick and Retana,1998).Podostemaceae plants flower when the water level drops during the dry season.In recent years,anthropogenic factors and climate change have severely affected river weed habitats,decreasing populations of these plants.展开更多
[Objectives]To study the utilization efficiency of different diets for juvenile Scylla paramamosain.[Methods]Low-value fish,shrimp,clam and clamworm were fed to overwintering young mud crabs,and the performance of the...[Objectives]To study the utilization efficiency of different diets for juvenile Scylla paramamosain.[Methods]Low-value fish,shrimp,clam and clamworm were fed to overwintering young mud crabs,and the performance of the feed was evaluated by growth,feed utilization and energy allocation.[Results]Shrimp-fed mud crabs showed the best growth performance,while fish-fed mud crabs showed the worst growth performance and converted the least protein and energy for growth.Shrimp-fed mud crabs molted more frequently,and the dry matter mass and energy of Exuviation were significantly higher than those of fish-fed mud crabs.The shrimp-fed crabs also had significantly higher food intake than those fish-fed crabs.The order of feed conversion efficiency(FCE)of fish-fed mud crabs was Polychaete>clam>shrimp>fish,while the order of FCE calculated with FCE-P and FCE-E was Polychaete>clam>shrimp>fish.Fish-fed mud crabs had the least energy intake and the least energy for growth,molting,excretion,metabolism,and feces.Among the four treatments,the mud crabs fed on Polychaete had the largest proportion of energy used for growth,while the mud crabs fed on fish had the largest proportion of energy used for molting.The proportion of energy consumed by mud crabs fed on Polychaete was the smallest,which may be the main reason for the higher FCE-P and FCE-E of mud crabs fed on Polychaete.[Conclusions]The results of this experiment showed that the utilization of low-value fish by mud crabs was the worst,suggesting that fish should not be used as control or reference food when studying the formula feed of mud crabs.展开更多
Background:Cooked rhubarb(CR)is obtained by steaming raw rhubarb(Rheum palmatum L.,Rheum officinale Baill.,or Rheum tanguticum Maxim.ex Balf.)with millet wine.It is used as a traditional Chinese medicine for treating ...Background:Cooked rhubarb(CR)is obtained by steaming raw rhubarb(Rheum palmatum L.,Rheum officinale Baill.,or Rheum tanguticum Maxim.ex Balf.)with millet wine.It is used as a traditional Chinese medicine for treating cerebral stroke,where patients often face severe constipation.This study explored the pharmacological effects and mechanisms of CR against ischemic stroke(IS)in rats.We used integrated analysis of gut microbiota,metabolomics,and network pharmacology.Methods:The compounds in CR were identified using LC-MS/MS.The impact of CR on rat middle cerebral artery occlusion/reperfusion(MCAO/R)-induced cerebral infarct size and brain tissue pathology was assessed through 2,3,5-triphenyl tetrazolium chloride and HE staining.Changes in hemorheology were measured by evaluating blood viscosity,and serum levels of pro-inflammatory cytokine were also determined.Gut microbiota composition was analyzed through 16S rRNA gene sequencing.Serum metabolites were examined using untargeted metabolomics and Spearman correlation analysis.The pseudo-germ-free test was used to determine whether tumour necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)improvement in IS are dependent on gut microbiota.Results:In vivo studies showed CR enhances neurobehavioral function in MCAO/R rats and reduces cerebral infarction area.CR also ameliorates brain and intestinal barrier damage caused by stroke.It also decreased inflammation and oxidative stress in IS rats.Furthermore,CR promotes the growth of Akkermansia and Verrucomicrobia,aiding in intestinal barrier repair.Notably,CR primarily influences the primary bile acid biosynthesis pathway.The pseudo-germ-free experiment and network pharmacology confirmed TNF-αand IL-1βas potential targets.CR relies on gut microbiota for its anti-inflammatory effects to improve IS.Conclusion:Cooked rhubarb offers neuroprotective benefits by enhancing beneficial bacteria abundance and regulating bile acid metabolism.It emerges as a potential therapeutic agent for IS.展开更多
Background:The paclitaxel liposome formulation,encapsulating paclitaxel within a phospholipid bilayer,ad-dresses the insolubility of traditional paclitaxel formulations,thereby reducing toxicity without compromising i...Background:The paclitaxel liposome formulation,encapsulating paclitaxel within a phospholipid bilayer,ad-dresses the insolubility of traditional paclitaxel formulations,thereby reducing toxicity without compromising its antitumor efficacy.Methods:This multicenter,open-label,non-inferiority randomized controlled trial(ChiCTR2000038555)evalu-ates the efficacy and safety of paclitaxel liposome in comparison to the standard regimen of paclitaxel combined with carboplatin(PLC vs.PC)as first-line therapy in patients with epithelial ovarian cancer.Results:An analysis of median progression-free survival(PFS)revealed non-inferior outcomes between 263 pa-tients in the PLC group and 260 patients in the PC group(32.3 vs.29.9 months,hazard ratio[HR],0.89[95%CI,0.64−1.25]),using a non-inferior margin of 1.3.Although the overall incidence of treatment-related adverse events was comparable between groups,the PLC group experienced significantly fewer non-hematologic toxicities than those treated with the PC regimen.Conclusion:The findings affirm the non-inferiority of paclitaxel liposome compared to the combination of pa-clitaxel and carboplatin regarding therapeutic efficacy,with an enhanced safety profile marked by reduced non-hematologic toxicities.展开更多
基金This work was supported by the National Key Research and Development Program of China(2021YFE0107100)Guangxi Key Research and Development Program(GuikeAB22035004)Guangxi Science and Technology Base and Talent Special Project(Guike AD20297090).
文摘Research on the ecohydrological processes of terrestrial plants is a frontier field comprising ecology,hydrology and global change research,yielding the key theoretical foundations of ecohydrology.In karst areas,due to its unique geological background,the karst landscape is strongly developed,with high bedrock exposure,high permeability,fragmented soils,shallow soils,and high spatial heterogeneity,resulting in very limited water storage for plant uptake and growth in rock fissures and shallow soils.Therefore,water conditions are an important ecological factor influencing plant growth.To comprehensively understand the current progress and development trends in plant water use research focusing on karst areas,this paper uses the VOSviewer software to analyze the literature on plant water use in karst areas between 1984 and 2022.The results showed that:(1)Research on plant water use in karst areas has developed rapidly worldwide,and the number of relevant studies in the literature have increased year by year,which together means that it is attracting more and more attention.(2)The investigation of plant water sources,geological background of karst areas,seasonal arid tropical climates,the relationship betweenδ13C values and plant water use efficiency,karst plant water use in karst savannas and subtropical areas,and ecosystems under climate change yields the knowledge base in this field.(3)Most studies in this area focus on the division of water sources of plants in karst areas,the methods of studying the water use sources of plants,and the water use strategies and efficiency of plants.(4)Future research will focus on how plant water use in karst areas is influenced by Earth’s critical zones,climate change,and ecohydrological separation.These studies will provide a key scientific basis for guiding ecological restoration and promoting sustainable development in karst areas.
基金Financial support for this study was jointly provided by the Hundred Talents Project of Ministry of Land and Resources of China, the Ten-Hundred-Thousand Talent Project of Guangxi (Grant No. 2006218)Guangxi Science Foundation (Grant No.0728089)+1 种基金Institute of Mineral Resources, Chinese Academy of Geological Sciences (Grant No. K0914)China Geological Survey (Grant No. 201111020 and1212010510805)
文摘The Napo-Qinzhou Tectonic Belt （NQTB） lies at the junction of the Yangtze, Cathaysia and Indochina （North Vietnam） Blocks, which is composed of five major lithotectonic subunits： the Qinzhou-Fangcheng Suture Zone （QFSZ）, the Shiwandashan Basin （SB）, the Pingxiang-Nanning Suture Zone （PNSZ）, the Damingshan Block （DB） and the Babu-Lingma Suture Zone （BLSZ）. On the basis of geochemical compositions, the Permian mafic igneous rocks can be divided into three distinct groups： （1） mafic igneous rocks （Group 1） from the Longjing region in the PNSZ and Hurun region in the BLSZ, which are characterized by intermediate Ti, P and Zr with low Ni and Cr contents; （2） mafic igneous rocks （Group 2） from the Naxiao and Chongzuo region in the DB, characterized by low-intermediate Ti, P and Zr with high Ni and Cr concentrations; and （3） mafic igneous rocks （Group 3） from the Siming region in the Jingxi carbonate platform of the northwestern margin of the NQTB, with intermediate-high Ti, P and Zr and low Ni and Cr contents. The Group 1 rocks yield a weighted mean 206 Pb/ 238 U age of 250.5±2.8 Ma and are geochemically similar to basalts occurring in back-arc basin settings. The Group 2 rocks exhibit geochemical features to those basalts in island arcs, whereas the Group 3 rocks show geochemical similarity to that of ocean island basalts. All three groups are characterized by relatively low ε Nd （t） values （-2.61 to ＋1.10） and high initial 87 Sr/ 86 Sr isotopic ratios （0.705309-0.707434）, indicating that they were derived from a subduction-modified lithospheric mantle and experienced assimilation, fractional crystallization, and crustal contamination or mixing during magmatic evolution. Accordingly, we propose the existence of an arc-back arc basin system that developed along the NQTB at the border of SW Guangxi Province （SW China） and northern Vietnam, and it was formed by continued northwestward subduction of the Cathaysian （or Yunkai） Block under the Yangtze Block, and northeastward subduction of the Indochina Block beneath the Yangtze Block during Permian time.
基金Supported by the National Agricultural Science and Technology Achievements Transformation Project of China(2014GB2E100281)the Science and Technology Key R&D Program of Guangxi(Guike AB17195037)
文摘The low temperature process of cold dew wind( from September 19 to 27 in 2011) for late rice production was dynamically monitored by using CLDAS temperature,combined with the background information of rice cultivation from multi-source satellite database together with an reference to the monitoring indexes of cold dew wind disaster to verify the precision of CLDAS data,so as to provide a reference for monitoring chilling damage caused by cold dew wind in late rice production in Guangxi. The results showed that the cold wind dew caused heavy damage to an area of 3 159. 76 km^2,moderate damage to an area of 559. 77 km^2 and light damage to an area of 2 452. 14 km^2. The correlation coefficients between CLDAS inversion temperature and actual temperature of 12 verification meteorological stations were all larger than 0. 93,and the difference in daily average temperature was 0. 3 ℃. The time difference between maximum and minimum temperature provided by CLDAS and corresponding actual temperature from 12 meteorological stations was less than 1 h. The temperature data provided by CLDAS was in accordance with actual temperature data. With an advantage of rapidly,minutely and accurately monitoring the grade distribution of local cold dew wind disaster for late rice,CLDAS can be used in monitoring cold dew wind in late rice production in Guangxi.
基金Supported by the Special Fund for the Development of Local Science and Technology Guided by Central Government(YDZX20174500004910,ZY18076011)the Key Research&Development of Guangxi Zhuang Autonomous Region(GKG15248003-21)the Guangxi Science and Technology Base and Specialized Talents(GKAD16450015).
文摘In order to screen the Medicago sativa(alfalfa)varieties suitable for planting in Guangxi,six domestic and foreign heat-resistant alfalfa varieties,namely WL903,WL712,WL525HQ,59N59,Elite 9 and Longwei 6010,were selected and tested for growth performance,nutritional value and over-summer rate by the random block method.The results showed that the alfalfa varieties with better plant height and fresh grass yield were 59N59 and WL903,which showed the plant heights reaching 62.01 and 62.53 cm,respectively,and the fresh grass yields up to 40.93 and 38.38 t/hm 2,respectively,exhibiting extremely significant differences from the poorly performing Longwei 6010(P<0.01).The nutritional value of each tested variety was good,and the crude protein content was more than 20%.Among them,Elite 9 had a crude protein content as high as 28.43%.The over-summer rates of the six alfalfa varieties were all higher than 75%.It showed that the alfalfa varieties with fast growth,high yield,high nutritional value and high over-summer rate in this experimental area were 59N59 and WL903,which are suitable as the first varieties for planting in Guangxi.
文摘1.Objective The Nandan-Yizhou faulting basin,which is located in Longtou-Limiao,Guangxi,is in the southern margin of the Yangtze Block,the depression zone of south Hunan and north Guangxi.It is a carbonate Manganese (Mn)ore deposit in the Baping Group,where occurs the Nongzhu large Mn deposit in a 100 km long anticlinorium with great Mn resource potential (Fig.1).
基金Publicity of New Techniques of China Meteorological Administration (CMATG2005M38)
文摘Variables fields such as enstrophy, meridional-wind and zonal-wind variables are derived from monthly 500 hPa geopotential height anomalous fields. In this work, we select original predictors from monthly 500-hPa geopotential height anomalous fields and their variables in June of 1958 - 2001, and determine comprehensive predictors by conducting empirical orthogonal function (EOF) respectively with the original predictors. A downscaling forecast model based on the back propagation (BP) neural network is built by use of the comprehensive predictors to predict the monthly precipitation in June over Guangxi with the monthly dynamic extended range forecast products. For comparison, we also build another BP neural network model with the same predictands by using the former comprehensive predictors selected from 500-hPa geopotential height anomalous fields in May to December of 1957 - 2000 and January to April of 1958 - 2001. The two models are tested and results show that the precision of superposition of the downscaling model is better than that of the one based on former comprehensive predictors, but the prediction accuracy of the downscaling model depends on the output of monthly dynamic extended range forecast.
基金Supported by the Special Project of Basic Scientific Research Business Expenses of Public Welfare Scientific Research Institutes Directly under Guangxi District(Gui Mu Yan Ke 2019-9)Guangxi Innovation Team Construction Project of National Modern Agricultural Industrial Technology System(nycytxgxcxtd).
文摘[Objectives]This trial was conducted to investigate the effects of diet with"Lianteng"additive of Chinese herbal medicine on blood biochemical indexes,immune and antioxidant function of Guangxi Sanhuang chickens.[Methods]480 Guangxi Sanhuang chickens at the age of 1 d were divided into 4 groups randomly and each group was assigned to 6 replicates with 20 chicks in each replicate;groups A,B and C were treatment groups and fed basal diets with 0.1%,0.2%and 0.4%of"Lianteng"additive of Chinese herbal medicine respectively during a trial of 70 d.Group D was control group and fed only basal diet.The serum samples were taken from 6 chicks in each group at the age of 21,35 and 49 d respectively and analyzed for biochemical,immune and antioxidant parameters in serum.[Results]Results from the trial showed that no difference was found in serum content of GLU,TG,TP,TC,and UN in the measurement at the age of 21,35 and 49 d(P>0.05);however,the content of ALB from groups A and B at 35 d was significantly higher than that from group D(P<0.01),and the ALB content from group B at 49 d was also higher than that from group D(P<0.05);the IgM content at 49 d from group A was lower than that from group D(P<0.05),in addition to this,there was no differences found in the contents of IgG,IgM and IFN-y among groups A,B,C and D during the trial(P>0.05);but the content of IL-2 from groups A and B at 49 d was significantly greater than that from group D(P<0.05);T-AOC from groups A,B and C at 49 d was very significantly higher than that from group D(P<0.01),and the one of group B at 35 d was still obviously higher than that of group D(P<0.05);also at 49 d,the GSH content in groups A and B was much greater than that in group D(P<0.01);T-SOD activity of group B and C at 35 d was distinctly greater than that of group D(P<0.05).[Conclusions]It can be concluded that the addition of 0.2%of"Lianteng"additive of Chinese herbal medicine in diet can increase immune function in a certain extent and promote the antioxidant ability observably for Guangxi Sanhuang chickens.
基金Research on the Evolutionary Patterns of Droughts and Floods in Guangxi Under the Conditions of Climate Warming, a Guangxi Young Scientists project (0542001)Soft Science Project from China Meteorological Administration (2008012)Research and Technical Development for Guangxi Institute of Meteorological Sciences (200713)
文摘Decadal circulation differences between more and less rainfall periods in the annually first rainy season of Guangxi and their association with sea surface temperature (SST) of the austral Indian Ocean are investigated by using the NCEP/NCAR reanalysis data. The results are shown as follows. A pattern in which there is uniform change of the Guangxi precipitation shows a 20-year decadal oscillation and a 3-year interannual change. In contrast, a pattern of reversed-phase change between the north and the south of Guangxi has a 6-year interannual periodicity and quasi-biennial oscillation. In the period of more precipitation, the surface temperature in Eurasia is positively anomalous so as to lead to stronger low pressure systems on land and larger thermal contrast between land and ocean. Therefore, the air column is more unstable and ascending flows over Guangxi are intensified while the Hadley cell is weakened. Furthermore, the weaker western Pacific subtropical high and South Asia High, together with a stronger cross-equatorial flow, result in the transportation of more humidity and the appearance of more precipitation. The correlation analysis indicates that the Indian Ocean SST in Southern Hemisphere is closely associated with the variation of the seasonal precipitation of Guangxi on the decadal scale by influencing the Asian monsoon through the cross-equatorial flow.
基金Supported by Program for Science and Technology Development of Guangxi Province(1123007-1)China Agricultural Industry Research System"Special Project for Guangxi Broiler Industry Innovation Team"(nycytxgxcxtd-04-20)
文摘Totally 150 individuals of 1-day-old Guangxi Jinling partridges were randomly divided into five groups, 30 chickens each group. Chickens in control group were fed with basal diet, while chickens in experimental groups were fed with the diet containing antibiotics, Chinese herbal medicine, probiotics and acidifi- er. The entire trial lasted 50 d, and growth performance and apparent nutrient digestibility of tested chickens were observed and measured. Compared with control group, the feed gain ratio in experimental groups significantly decreased （P 〈 0.05 ）, while that in probiotics group was the lowest. The average daily gain in pmbi- otics group was significantly higher than that in control group or other experimental groups （P 〈 0.05）. The apparent digestibility of crude protein, crude fat and energy in probiotics group were significantly higher than that in control group or other experimental groups （P 〈 0.05 ）. The apparent digestibility of phosphorus, crude fat, crude fiber, calcium and crude protein in antibiotics group were significantly higher than that in control group （P 〈 0.05 ）. The apparent digestibility of crude protein, crude fiber and phosphorus in Chinese herbal medicine group were significantly higher than that in control group （P 〈 0.05 ）. The apparent digesti- bility of nutrient in acidifier group were significantly lower than that in control group or other experimental groups （ P 〈 0.05 ）. Therefore, pmbiotics had better effects on growth performance and apparent nutrient digestibility of chickens than antibiotics, while Chinese herbal medicine and acidifier had inferior effect than an- tibiotics.
基金Supported by the Project of Guangxi Natural Science Foundation(2017-GXNSFBA198239)Guangxi Major Special Project(Gui Ke Zhong 1598005-10)
文摘In this paper,the scientific research status of Zexie(Rhizoma Alismatis)was comprehensively expounded from the aspects of plant characteristics,source,chemical composition,pharmacological research and quality control methods,etc.The market situation of Rhizoma Alismatis was systematically analyzed from historical and current perspectives;aiming at the problems of poor quality and irregular processing of Chinese medicinal herbs Rhizoma Alismatis,some ideas were put forward to improve the quality and market value of medicinal materials of Rhizoma Alismatis,so as to make the Chinese herbal medicine industry develop towards a healthy and efficient direction.
文摘A study has been reported on <sup>208</sup>Pb/<sup>206</sup>Pb and <sup>207</sup>Pb/<sup>206</sup>Pb ratio variations in ancient drums and Cu-., Pb- ores from Guangxi, China and can indicate that the Cu- and Pb- bearing ores for making the Beiliu and the Lingshan type drums were taken from Tongshiling of Beiliu County and its vicinity, that were not only ancient sites for smelting the copper ores, but possibly also for casting the bronze drums. Some of the Lengshuichong type drums have abnormal Pb isotopic ratios, which means that they were made of special ore sources, one of the possibilities is that the ore material or the drums were transported from South- East Asia to Guangxi Province, because they have been excavated there too.
基金Supported by Key Science and Technology Project of Guangxi(Gui Ke Zhong1355001-4)Youth Innovation Fund Project of Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards(Gui Zhong Zhong Xi 201105)Open Project of Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards(Gui Zhong Zhong Kai 201303)
文摘[Objectives] This study aimed to investigate the anti-inflammatory effects of Baeckea frutescence L.in vitro and in vivo.[Methods]The anti-inflammatory activity of B.frutescence was measured by mouse peritoneal capillary permeability test,mouse auricle swelling test and rat cotton granuloma test.The RAW264.7 macrophage model was stimulated by lipopolysaccharide(LPS),and the effects of B.frutescence on tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) were detected by enzyme-linked immunosorbent assay(ELISA),and the relative expression of inducible nitric oxide synthase(i NOS) and cyclooxygenase-2(COX-2) proteins was detected by Western blot.Thus,the in vitro anti-inflammatory activity of B.frutescence was studied.[Results] B.frutescence significantly inhibited mouse peritoneal capillary permeability,inhibited xylene-induced mouse auricle swelling and rat cotton granuloma,significantly inhibited TNF-α and IL-6 levels,and down-regulated the expression of i NOS and COX-2 proteins in cells.[Conclusions]B.frutescence showed good anti-inflammatory activity both in vitro and in vivo,and the mechanism may be related to the release inhibition of inflammatory factors TNF-α and the regulation of COX-2.
基金supported by China Bureau of Geological Survey,the Department of Land and Resources of Guangxithe National Natural Science Foundation of China(grant#40862001)
文摘A new large-bodied theropod dinosaur, Datanglong guangxiensis gen. et sp. nov., was recovered from the Lower Cretaceous Xinlong Formation of the Datang Basin, Guangxi. It is unique in several features including： posteriormost dorsal vertebra with teardrop-shaped pneumatic foramen confined by enlarged pcdl, acpl and the centrum; posteriormost dorsal with well-developed, horizontal prpl; posteriormost dorsal with a parapophysis projecting more laterally than the diapophysis; brevis fossa shallow with short, ridge-like medial blade; and iliac pubic peduncle with posteroventrally expanded margin. Cladistic analysis supports the idea that this new taxon Datanglong guangxiensis is a primitive member of the Carcharodontosauria in possessing two unambiguous synapomorphies： large external pneumatic foramina and internal spaces present in the lateral surface of ilium, and a peg-and-socket ischiac articulation with the ilium. The presence of the new taxon from Guangxi further confirms that Carcharodontosauria were cosmopolitan large-bodied predators during the Early-mid Cretaceous.
基金Supported by Youth Fund Project of National Natural Science Foundation of China(42105175)。
文摘The present situation of sugarcane production in Guangxi was introduced.The main practices of Guangxi green food cane sugar industry development were overviewed in terms of the green production for improving quality of sugarcane in Guangxi,green mechanism and joint development,block management for ensuring quality,green recycling and turning waste into treasure,building double-high bases for improving quality and increasing quantity,and sustainable development and thoroughly implementation by taking up residence.Prospects for the future development of the green food cane sugar industry in Guangxi were put forward.
基金Supported by Science and Technology Development Program of Nanning City(20155181)Key Technology Research and Development Program of Guangxi Province(14121003-3-3)
文摘[Objective] This trial was to investigate the effect of dietary Picria felterrae Lour extracts on serum biochemical indexes and immune function of Guangxi Partridge chickens. [Method] Totally 500 individuals of 1-day-old Guangxi Partridge chickens were randomly divided into five groups, five replicates each group and 20 chicks each replicate. Groups A, B and C were treatment groups supplemented with 0.70%, 0.35% and0.175% P. felterrae extracts in the basal diet, respectively; group D was a medical control group supplemented with 0.01% colistin sulfate premix in the basal diet; and group E was a control group with basal diet. Serum samples were collected from 10 chickens in each group at 21, 35 and 49 days of age, to analyze the biochemical and immune indexes. [Result] It had no significant impact on serum TP and GLU contents of chickens by adding different levels of P. felterrae extracts in the basal diet（P 〉0.05）. However, at 21 and 35 days of age, the TBILI content of chickens in groups A, B and C were extremely lower or significantly lower than that in group E（ P〈0.01; P〈0.05）. At 35 days of age, the serum AKP activities in groups A, B and C were extremely higher than that in group E（P〈0.01）, and the serum GOT activities at 21 and 35 days of age in group C were significantly higher than that in group E（P〈0.05）. At 49 days of age, the serum Ig G content in groups A, B and C and the IL-2 content in group B and group C were significantly lower or extremely lower than that in group E（ P〈0.05; P〈0.01）; the T-AOC content in group B was significantly higher than that in group E（P〈0.05）; the GSH content in groups A, B and C were significantly higher than that in group E（ P〈0.05）. Adding different levels of P. felterrae extracts in the diet significantly decreased the TBILI content, reduced the Ig G, IL-2 and IL-6 contents, and improved the AKP and GOT activities and the T-AOC and GSH contents of Guangxi Partridge chicken. [Conclusion] Adding 0.35% P. felterrae extracts in the basal diet received the best effort.
基金Guilin Scientific Research and Technology Development Program(20210202-120220104-4)Special Project of the Central Government in Guidance of Local Science and Technology Development(ZY20230102).
文摘[Objectives]To investigate the effects of quercetin extracted from flower buds of Sophora japonica cv.jinhuai on the proliferation,apoptosis and migration of human breast cancer MCF-7 cells.[Methods]MTT assay,inverted microscope observation,hoechst33342 staining,flow cytometry(FCM)and wound healing assay were adopted to investigate the proliferation,morphological changes,apoptosis level and cell migration ability of human breast cancer MCF-7 cells,respectively.[Results]The morphological changes of cells in the treatment groups included gradually decreased number,reduced volume,vague cell contour,loose intercellular connection,uneven cytoplasm distribution and increased cell debris.With the increase of drug concentration,quercetin significantly inhibited the proliferation of human breast cancer MCF-7 cells(P<0.05).The number of apoptotic bodies increased gradually.When the concentration reached 100μmol/L,a large number of nuclear fragments appeared,and the level of apoptosis was statistically different(P<0.05).The mobility and migration ability of cells showed a decreasing trend,and the differences were statistically significant(P<0.05).[Conclusions]This study can provide experimental basis for clinical application of quercetin against breast cancer.
基金supported by grants from the National Natural Science Foundation of China(Nos.32100186 and 32300182)the Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection(Guangxi Normal University),Ministry of Education,China(No.ERESEP2022K03).
文摘Podostemaceae(riverweed family),one of the largest aquatic plant families in the world,comprises about 350 species in 51 genera placed in three subfamilies,Podostemoideae,Weddellinoideae,and Tristichoideae(Koi et al.,2022).Most Podostemaceae genera(~38)are monotypic or oligotypic,with a high level of endemism(Koi et al.,2018,2022).Members of Podostemaceae adhere to rocks in fast-flowing rivers,streams,or waterfalls in the subtropics and tropics(Koi et al.,2018).As an adaptation to fastrunning currents,the morphological structure of river-weeds tends to be extremely reduced,including a loss or reduction of primary shoots or roots(Koi and Kato,2007).The vegetative mass of these plants resembles lichens or bryophytes,and are thus known commonly as“dream bryophytes”(Philbrick and Retana,1998).Podostemaceae plants flower when the water level drops during the dry season.In recent years,anthropogenic factors and climate change have severely affected river weed habitats,decreasing populations of these plants.
基金Supported by Guangxi Natural Science Foundation(2017GXNSFAA198022)Guangxi Key R&D Program(Guike AB16380105)+1 种基金Open Fund of Guangxi Key Laboratory of Marine Biodiversity Conservation(2023KA01)Doctoral Initiation Funding Project of Guangxi University of Chinese Medicine(2018BS034).
文摘[Objectives]To study the utilization efficiency of different diets for juvenile Scylla paramamosain.[Methods]Low-value fish,shrimp,clam and clamworm were fed to overwintering young mud crabs,and the performance of the feed was evaluated by growth,feed utilization and energy allocation.[Results]Shrimp-fed mud crabs showed the best growth performance,while fish-fed mud crabs showed the worst growth performance and converted the least protein and energy for growth.Shrimp-fed mud crabs molted more frequently,and the dry matter mass and energy of Exuviation were significantly higher than those of fish-fed mud crabs.The shrimp-fed crabs also had significantly higher food intake than those fish-fed crabs.The order of feed conversion efficiency(FCE)of fish-fed mud crabs was Polychaete>clam>shrimp>fish,while the order of FCE calculated with FCE-P and FCE-E was Polychaete>clam>shrimp>fish.Fish-fed mud crabs had the least energy intake and the least energy for growth,molting,excretion,metabolism,and feces.Among the four treatments,the mud crabs fed on Polychaete had the largest proportion of energy used for growth,while the mud crabs fed on fish had the largest proportion of energy used for molting.The proportion of energy consumed by mud crabs fed on Polychaete was the smallest,which may be the main reason for the higher FCE-P and FCE-E of mud crabs fed on Polychaete.[Conclusions]The results of this experiment showed that the utilization of low-value fish by mud crabs was the worst,suggesting that fish should not be used as control or reference food when studying the formula feed of mud crabs.
基金supported by Projects of The National Natural Science Foundation of China(Grant No.82173972,82374172,82004086,81473413,81274060)The National Major Scientific and Technological Special Project for“Significant New Drugs Development”during the 13th Five-year Plan Period(Grant No.2017ZX09301077)2021 Traditional Chinese Medicine(Medicine of South China)Industry Talents Project-Innovation Team of South China Medicine Resources,Guangdong Provincial Basic and Applied Basic Research Fund(Grant No.2023A1515011147).
文摘Background:Cooked rhubarb(CR)is obtained by steaming raw rhubarb(Rheum palmatum L.,Rheum officinale Baill.,or Rheum tanguticum Maxim.ex Balf.)with millet wine.It is used as a traditional Chinese medicine for treating cerebral stroke,where patients often face severe constipation.This study explored the pharmacological effects and mechanisms of CR against ischemic stroke(IS)in rats.We used integrated analysis of gut microbiota,metabolomics,and network pharmacology.Methods:The compounds in CR were identified using LC-MS/MS.The impact of CR on rat middle cerebral artery occlusion/reperfusion(MCAO/R)-induced cerebral infarct size and brain tissue pathology was assessed through 2,3,5-triphenyl tetrazolium chloride and HE staining.Changes in hemorheology were measured by evaluating blood viscosity,and serum levels of pro-inflammatory cytokine were also determined.Gut microbiota composition was analyzed through 16S rRNA gene sequencing.Serum metabolites were examined using untargeted metabolomics and Spearman correlation analysis.The pseudo-germ-free test was used to determine whether tumour necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)improvement in IS are dependent on gut microbiota.Results:In vivo studies showed CR enhances neurobehavioral function in MCAO/R rats and reduces cerebral infarction area.CR also ameliorates brain and intestinal barrier damage caused by stroke.It also decreased inflammation and oxidative stress in IS rats.Furthermore,CR promotes the growth of Akkermansia and Verrucomicrobia,aiding in intestinal barrier repair.Notably,CR primarily influences the primary bile acid biosynthesis pathway.The pseudo-germ-free experiment and network pharmacology confirmed TNF-αand IL-1βas potential targets.CR relies on gut microbiota for its anti-inflammatory effects to improve IS.Conclusion:Cooked rhubarb offers neuroprotective benefits by enhancing beneficial bacteria abundance and regulating bile acid metabolism.It emerges as a potential therapeutic agent for IS.
基金funded by the Optimization Study of Treatment Regimen and Clinical Practice in Ovarian Cancer(grant number:2016YFC1303702).
文摘Background:The paclitaxel liposome formulation,encapsulating paclitaxel within a phospholipid bilayer,ad-dresses the insolubility of traditional paclitaxel formulations,thereby reducing toxicity without compromising its antitumor efficacy.Methods:This multicenter,open-label,non-inferiority randomized controlled trial(ChiCTR2000038555)evalu-ates the efficacy and safety of paclitaxel liposome in comparison to the standard regimen of paclitaxel combined with carboplatin(PLC vs.PC)as first-line therapy in patients with epithelial ovarian cancer.Results:An analysis of median progression-free survival(PFS)revealed non-inferior outcomes between 263 pa-tients in the PLC group and 260 patients in the PC group(32.3 vs.29.9 months,hazard ratio[HR],0.89[95%CI,0.64−1.25]),using a non-inferior margin of 1.3.Although the overall incidence of treatment-related adverse events was comparable between groups,the PLC group experienced significantly fewer non-hematologic toxicities than those treated with the PC regimen.Conclusion:The findings affirm the non-inferiority of paclitaxel liposome compared to the combination of pa-clitaxel and carboplatin regarding therapeutic efficacy,with an enhanced safety profile marked by reduced non-hematologic toxicities.
