Ferroptosis,an iron-dependent cell death:Ferroptosis is a type of regulated necrosis,characterized by redox-active iron accumulation and increased free radical production derived by Fenton chemistry,that triggers oxid...Ferroptosis,an iron-dependent cell death:Ferroptosis is a type of regulated necrosis,characterized by redox-active iron accumulation and increased free radical production derived by Fenton chemistry,that triggers oxidation of polyunsaturated fatty acids in phospholipids,loss of cellular membranes integrity,and leakage of intracellular contents.展开更多
See related article,pp 357-363Several decades have passed since programmedcell death(PCD)was identified.Apoptosis was first defined by Kerr in 1972,and later described by the Nobel Prices in Physiology or Medicine 200...See related article,pp 357-363Several decades have passed since programmedcell death(PCD)was identified.Apoptosis was first defined by Kerr in 1972,and later described by the Nobel Prices in Physiology or Medicine 2002,Sydney Brenner,John Sulston and Robert Horwitz,who defined genetic regulators of apoptosis(Diamantis et al.,2008).However,it was in 1858 when the German pathologist and biologist Rudolf Virchow identified for the first time the phenomenon of apoptosis,which he named necrobiosis,arguing that this form of cell death was completely different from the uncontrolled necrosis,suggesting the existence of two different types of cell death.Today,the knowledge in the field of cell death regulation is extensive,but still under continuous expansion.展开更多
Axonal regeneration after injuries to the nervous system has been extensively studied due to its implication in motor and sensory functional recovery. Distinct types of regeneration has been identified, such as canoni...Axonal regeneration after injuries to the nervous system has been extensively studied due to its implication in motor and sensory functional recovery. Distinct types of regeneration has been identified, such as canonical axonal regeneration, defined as the growth of axons from the transected axonal stump to reinnervate the original target, or regenerative sprouting, in which the growth occurs from a region of the damaged axon either close or far from the injury site(Tuszynski and Steward, 2012).展开更多
Peripheral neuropathies refer to a group of conditions in which the peripheral nervous system(PNS)is damaged.These pathological state are are associated with weakness,pain,and loss of motor and sensory control.More th...Peripheral neuropathies refer to a group of conditions in which the peripheral nervous system(PNS)is damaged.These pathological state are are associated with weakness,pain,and loss of motor and sensory control.More than 100 types of peripheral neuropathies have been identified,with distinct symptoms and prognosis classified according to the type of damage to the nerves.Injury to peripheral nerves results in disabling loss of sensory and motor func-展开更多
基金supported by FONDECYT Initiation in Research,grant number 11201141,awarded to PJU.
文摘Ferroptosis,an iron-dependent cell death:Ferroptosis is a type of regulated necrosis,characterized by redox-active iron accumulation and increased free radical production derived by Fenton chemistry,that triggers oxidation of polyunsaturated fatty acids in phospholipids,loss of cellular membranes integrity,and leakage of intracellular contents.
基金supported by grants from the Geroscience Centerfor Brain Health and Metabolism,FONDA P-15150012(to FAC)Fondo Nacional de Desarrollo Cientifico y Tecnologico(FONDECYT)No.1150766(to FAC)Agencia Nacional de Investigación y Desarrollo(ANID)FONDECYT Iniciación N°11220120(to MSA)。
文摘See related article,pp 357-363Several decades have passed since programmedcell death(PCD)was identified.Apoptosis was first defined by Kerr in 1972,and later described by the Nobel Prices in Physiology or Medicine 2002,Sydney Brenner,John Sulston and Robert Horwitz,who defined genetic regulators of apoptosis(Diamantis et al.,2008).However,it was in 1858 when the German pathologist and biologist Rudolf Virchow identified for the first time the phenomenon of apoptosis,which he named necrobiosis,arguing that this form of cell death was completely different from the uncontrolled necrosis,suggesting the existence of two different types of cell death.Today,the knowledge in the field of cell death regulation is extensive,but still under continuous expansion.
文摘Axonal regeneration after injuries to the nervous system has been extensively studied due to its implication in motor and sensory functional recovery. Distinct types of regeneration has been identified, such as canonical axonal regeneration, defined as the growth of axons from the transected axonal stump to reinnervate the original target, or regenerative sprouting, in which the growth occurs from a region of the damaged axon either close or far from the injury site(Tuszynski and Steward, 2012).
基金funded by FONDAP program 15150012(to CH and FAC)Millennium Institute,No.P09-015-F+12 种基金the Frick Foundation 20014-15ALS Therapy Alliance 2014-F-059Muscular Dystrophy Association 382453CONICYT-USA 2013-0003Michael J Fox Foundation for Parkinson′s Research–Target Validation grant No.9277COPEC-UC Foundation 2013.R.40Ecos-Conicyt C13S02FONDECYT No.1140549Office of Naval Research-Global(ONR-G)N62909-16-1-2003ALSRP Therapeutic Idea Award AL150111(to CH)Millennium Nucleus-P-07-011-FFONDECYT,No.1110987(to FAC)PhD fellow supported by CONICYT,No.21130843(to MO)
文摘Peripheral neuropathies refer to a group of conditions in which the peripheral nervous system(PNS)is damaged.These pathological state are are associated with weakness,pain,and loss of motor and sensory control.More than 100 types of peripheral neuropathies have been identified,with distinct symptoms and prognosis classified according to the type of damage to the nerves.Injury to peripheral nerves results in disabling loss of sensory and motor func-
