217 cases of chronic bronchitis and asthma were clinically treated and analyzed for the effects of combining electric stimulation with topical application of drug on acupoints. The results suggested that the combi... 217 cases of chronic bronchitis and asthma were clinically treated and analyzed for the effects of combining electric stimulation with topical application of drug on acupoints. The results suggested that the combined therapy was superior to unitary therapy (P<0.05). It is indicated that the combined therapy has a good curative effect in both short- and long-terms.展开更多
Objective: The aim of the study was to discuss the diagnostic value of dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) in distinguishing malignant tumors of breast from benign lesions. Methods: A DCE-MR...Objective: The aim of the study was to discuss the diagnostic value of dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) in distinguishing malignant tumors of breast from benign lesions. Methods: A DCE-MRI study was performed on 18 benign lesions, 16 malignant tumors and 2 borderline lesions of breast (mean age 51.7 years). The seven items including shape, marginal feature, spreading signs, time-signal intensity curve, maximum slope of increase (MSI), signal enhancement ratio (SER) and signal enhanced extent (SEE) were compared between patients with benign lesions and those with malignant tumors. Results: Shape, marginal feature, spreading signs, time-signal intensity curve, SEE and SER between the benign and malignant groups of breast represented significantly difference except MSI. The 36 cases with breast lesion displayed sensitivity, specificity, accuracy for diagnosing malignant tumor of breast using the scoring method was 93.8%, 83.3% and 88.2%, respectively. Conclusion: DCE-MRI combined with morphology and dynamic enhanced feature of breast lesion has well efficacy to differentiate malignant tumor from benign lesions.展开更多
Objective To investigate the expression of phosphatase and tension homolog(PTEN) in adipose tissue of KKAy diabetic mice, a mouse model of type 2 diabetes. Methods KKAy diabetic mice were fed with high fat diet for 4 ...Objective To investigate the expression of phosphatase and tension homolog(PTEN) in adipose tissue of KKAy diabetic mice, a mouse model of type 2 diabetes. Methods KKAy diabetic mice were fed with high fat diet for 4 weeks. After blood glucose met the criteria of diabetes(over 16.7 mmol/L), mice were randomly divided into 3 groups: a control group(without any treatment), a rosiglitazone group(treated with rosiglitazone 12.5 mg/kg·d once per day), and a metformin group(treated with metformin 3 g/kg·d twice daily). After 4 weeks, we then determined the expression of PTEN and phosphoserine 473-Akt(pS473-Akt) in the epididymal adipose tissue with Western blots. The mice in each group were further divided into the insulin(-) subgroup and insulin(+) subgroup, which were intraperitoneally injected with saline and insulin(5 mU/g body weight), respectively. Results The expression of PTEN was elevated in the epididymal adipose tissue obtained from KKAy diabetic mice compared with that from the C57BL/6J mice(P<0.001). In accordance with the enhanced expression of PTEN, the level of pS473-Akt stimulated by insulin was decreased in the adipose tissue of KKAy mice compared to the C57BL/6J mice(P<0.001). Treatment with the insulin-sensitizing agents, rosiglitazone and metformin did not inhibit the elevated expression of PTEN in adipose tissue of KKAy diabetic mice. Conclusion PTEN may play an important role in the development of insulin resistance in adipose tissue of type 2 diabetes mice model.展开更多
文摘 217 cases of chronic bronchitis and asthma were clinically treated and analyzed for the effects of combining electric stimulation with topical application of drug on acupoints. The results suggested that the combined therapy was superior to unitary therapy (P<0.05). It is indicated that the combined therapy has a good curative effect in both short- and long-terms.
基金Supported by a grant from the Sciences Foundation of West district, Beijing, China (No. 06027)
文摘Objective: The aim of the study was to discuss the diagnostic value of dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) in distinguishing malignant tumors of breast from benign lesions. Methods: A DCE-MRI study was performed on 18 benign lesions, 16 malignant tumors and 2 borderline lesions of breast (mean age 51.7 years). The seven items including shape, marginal feature, spreading signs, time-signal intensity curve, maximum slope of increase (MSI), signal enhancement ratio (SER) and signal enhanced extent (SEE) were compared between patients with benign lesions and those with malignant tumors. Results: Shape, marginal feature, spreading signs, time-signal intensity curve, SEE and SER between the benign and malignant groups of breast represented significantly difference except MSI. The 36 cases with breast lesion displayed sensitivity, specificity, accuracy for diagnosing malignant tumor of breast using the scoring method was 93.8%, 83.3% and 88.2%, respectively. Conclusion: DCE-MRI combined with morphology and dynamic enhanced feature of breast lesion has well efficacy to differentiate malignant tumor from benign lesions.
基金Supported by National Natural Science Foundation of China(81270878)National Key Program of Clinical Science of China(WBYZ2011-873)
文摘Objective To investigate the expression of phosphatase and tension homolog(PTEN) in adipose tissue of KKAy diabetic mice, a mouse model of type 2 diabetes. Methods KKAy diabetic mice were fed with high fat diet for 4 weeks. After blood glucose met the criteria of diabetes(over 16.7 mmol/L), mice were randomly divided into 3 groups: a control group(without any treatment), a rosiglitazone group(treated with rosiglitazone 12.5 mg/kg·d once per day), and a metformin group(treated with metformin 3 g/kg·d twice daily). After 4 weeks, we then determined the expression of PTEN and phosphoserine 473-Akt(pS473-Akt) in the epididymal adipose tissue with Western blots. The mice in each group were further divided into the insulin(-) subgroup and insulin(+) subgroup, which were intraperitoneally injected with saline and insulin(5 mU/g body weight), respectively. Results The expression of PTEN was elevated in the epididymal adipose tissue obtained from KKAy diabetic mice compared with that from the C57BL/6J mice(P<0.001). In accordance with the enhanced expression of PTEN, the level of pS473-Akt stimulated by insulin was decreased in the adipose tissue of KKAy mice compared to the C57BL/6J mice(P<0.001). Treatment with the insulin-sensitizing agents, rosiglitazone and metformin did not inhibit the elevated expression of PTEN in adipose tissue of KKAy diabetic mice. Conclusion PTEN may play an important role in the development of insulin resistance in adipose tissue of type 2 diabetes mice model.
