The aim of the study was to investigate the antibacterial potential of garlic(Allium sativum),pinus(Pinus elliottii),eucalyptus(Eucalyptus sp.),yerba mate(Ilex paraguariensis)and guava tree(Psidium guajava Linn.)in vi...The aim of the study was to investigate the antibacterial potential of garlic(Allium sativum),pinus(Pinus elliottii),eucalyptus(Eucalyptus sp.),yerba mate(Ilex paraguariensis)and guava tree(Psidium guajava Linn.)in vitro and the effect of yerba mate supplementation on Oreochromis niloticus physiology and resistance to Aeromonas hydrophila.The in vitro antibacterial potential of the plants was verified by the minimum inhibitory concentration(MIC)method and by the antimicrobial sensitivity test(TSA).The in vivo assay was performed using diet supplementation with yerba mate and challenge with A.hydrophila.After the supplementation and challenge periods biochemical,immune and physiological parameters were evaluated.The in vitro assays showed that only yerba mate presented antibacterial potential against A.hydrophila and no one of the plant extracts were effective against Streptococcus agalactiae.The use of yerba mate in the diet did not influence the immune and metabolic status of O.niloticus.Also,the supplementation did not act as a growth promoter for the fishes.Considering the challenge of O.niloticus with A.hydrophila,the yerba mate did not improve the resistance of the fishes to the bacteria.The yerba mate extract presented potential to be used as an antibacterial agent for fish diseases.Also,more detailed studies are necessary to stablish effective doses and times required for fish treatments.展开更多
The crop yield is related to several factors, among these, soil tillage, soil compaction and crop rotation. This study aimed to evaluate the winter cover crops and crop rotation influence on soil physical properties a...The crop yield is related to several factors, among these, soil tillage, soil compaction and crop rotation. This study aimed to evaluate the winter cover crops and crop rotation influence on soil physical properties and grain yield of dry beans, maize and soybean for two growing seasons. Three experiments were conducted, corresponding to dry beans, maize and soybean crops. It was used the randomized block design with three treatments and four replications consisted by 3 × 10 m plots. The treatments were: two cover crops systems and crop rotation in no-till, and the control, consisting of winter fallow and conventional tillage. The cover crop dry matter, soil physical properties and grain yield for dry beans, maize and soybean in the two growing seasons were evaluated. Crop rotation systems and cover crops showed a trend to increase maize and soybean yields. Crop rotation in no-till increases soil compaction in the superficial layer compared to conventional tillage, but does not reduce the dry beans, maize and soybean yields.展开更多
This paper deals with the efficiency of the search, with a method of organization and storage of the information that allows better results than the research trees or binary trees. No one ever dared to present better ...This paper deals with the efficiency of the search, with a method of organization and storage of the information that allows better results than the research trees or binary trees. No one ever dared to present better results than 0(log n) complexity, and when they wish to improve, they use balanced trees, but they continue to use principles that do not impact the pre-semantic information treatment. The Heru search method has as main characteristic the total or partial substitution of the use of the binary trees, enabling the elimination of the approximate results and informing the user the desired information instead of occurrences by sampling outside the desired information. The breakdown of the 0(log n) paradigm and the refinement of the searches are achieved with the use of a set of unpublished mathematical formulas and concepts called Infinite Series with Multiple Ratios.展开更多
Cancers have high morbidity and mortality rates worldwide.Current anticancer therapies have demonstrated specific signaling pathways as a target in the involvement of carcinogenesis.Autophagy is a quality control syst...Cancers have high morbidity and mortality rates worldwide.Current anticancer therapies have demonstrated specific signaling pathways as a target in the involvement of carcinogenesis.Autophagy is a quality control system for proteins and plays a fundamental role in cancer carcinogenesis,exerting an anticarcinogenic role in normal cells and can inhibit the transformation of malignant cells.Therefore,drugs aimed at autophagy can function as antitumor agents.Flavonoids are a class of polyphenolic secondary metabolites commonly found in plants and,consequently,consumed in diets.In this review,the systematic search strategy was used,which included the search for descriptors"flavonoids"AND"mTOR pathway"AND"cancer"AND"autophagy",in the electronic databases of PubMed,Cochrane Library,Web of Science and Scopus,from January 2011 to January 2021.The current literature demonstrates that flavonoids have anticarcinogenic properties,including inhibition of cell proliferation,induction of apoptosis,autophagy,necrosis,cell cycle arrest,senescence,impaired cell migration,invasion,tumor angiogenesis and reduced resistance to multiple drugs in tumor cells.We demonstrate the available evidence on the roles of flavonoids and autophagy in cancer progression and inhibition.(Registration No.CRD42021243071 at PROSPERO)展开更多
In recent decades,third-generation(3G)biofuels have become a more attractive method of fuel production,as algae cultivation does not infringe on resources needed for food production.Additionally,algae can adapt to dif...In recent decades,third-generation(3G)biofuels have become a more attractive method of fuel production,as algae cultivation does not infringe on resources needed for food production.Additionally,algae can adapt to different environments,has high photosynthetic efficiency(CO_(2)fixation),and has a high potential for carbohydrate accumulation.The prevalence of algae worldwide demonstrates its ability to adapt to different environments and climates,proving its biodiversity and versatility.Algae can be grown in wastewater,seawater,and even sewage,thus ensuring a lower water footprint and greater energy efficiency during algal biomass production.Because of this,the optimization of 3G ethanol production appears to be an excellent alternative to mitigate environmental impacts and increase energy and food security.This critical review presents(i)the stages of cultivation and processing of micro and macroalgae;(ii)the selection of yeasts(through engineering and/or bioprospecting)to produce ethanol from these biomasses;(iii)the potential of seawater-based facilities to reduce water footprint;and(iv)the mass and energy balances of 3G ethanol production in the world energy matrix.This article is,above all,a brainstorm on the environmental viability of algae bioethanol.展开更多
文摘The aim of the study was to investigate the antibacterial potential of garlic(Allium sativum),pinus(Pinus elliottii),eucalyptus(Eucalyptus sp.),yerba mate(Ilex paraguariensis)and guava tree(Psidium guajava Linn.)in vitro and the effect of yerba mate supplementation on Oreochromis niloticus physiology and resistance to Aeromonas hydrophila.The in vitro antibacterial potential of the plants was verified by the minimum inhibitory concentration(MIC)method and by the antimicrobial sensitivity test(TSA).The in vivo assay was performed using diet supplementation with yerba mate and challenge with A.hydrophila.After the supplementation and challenge periods biochemical,immune and physiological parameters were evaluated.The in vitro assays showed that only yerba mate presented antibacterial potential against A.hydrophila and no one of the plant extracts were effective against Streptococcus agalactiae.The use of yerba mate in the diet did not influence the immune and metabolic status of O.niloticus.Also,the supplementation did not act as a growth promoter for the fishes.Considering the challenge of O.niloticus with A.hydrophila,the yerba mate did not improve the resistance of the fishes to the bacteria.The yerba mate extract presented potential to be used as an antibacterial agent for fish diseases.Also,more detailed studies are necessary to stablish effective doses and times required for fish treatments.
文摘The crop yield is related to several factors, among these, soil tillage, soil compaction and crop rotation. This study aimed to evaluate the winter cover crops and crop rotation influence on soil physical properties and grain yield of dry beans, maize and soybean for two growing seasons. Three experiments were conducted, corresponding to dry beans, maize and soybean crops. It was used the randomized block design with three treatments and four replications consisted by 3 × 10 m plots. The treatments were: two cover crops systems and crop rotation in no-till, and the control, consisting of winter fallow and conventional tillage. The cover crop dry matter, soil physical properties and grain yield for dry beans, maize and soybean in the two growing seasons were evaluated. Crop rotation systems and cover crops showed a trend to increase maize and soybean yields. Crop rotation in no-till increases soil compaction in the superficial layer compared to conventional tillage, but does not reduce the dry beans, maize and soybean yields.
文摘This paper deals with the efficiency of the search, with a method of organization and storage of the information that allows better results than the research trees or binary trees. No one ever dared to present better results than 0(log n) complexity, and when they wish to improve, they use balanced trees, but they continue to use principles that do not impact the pre-semantic information treatment. The Heru search method has as main characteristic the total or partial substitution of the use of the binary trees, enabling the elimination of the approximate results and informing the user the desired information instead of occurrences by sampling outside the desired information. The breakdown of the 0(log n) paradigm and the refinement of the searches are achieved with the use of a set of unpublished mathematical formulas and concepts called Infinite Series with Multiple Ratios.
文摘Cancers have high morbidity and mortality rates worldwide.Current anticancer therapies have demonstrated specific signaling pathways as a target in the involvement of carcinogenesis.Autophagy is a quality control system for proteins and plays a fundamental role in cancer carcinogenesis,exerting an anticarcinogenic role in normal cells and can inhibit the transformation of malignant cells.Therefore,drugs aimed at autophagy can function as antitumor agents.Flavonoids are a class of polyphenolic secondary metabolites commonly found in plants and,consequently,consumed in diets.In this review,the systematic search strategy was used,which included the search for descriptors"flavonoids"AND"mTOR pathway"AND"cancer"AND"autophagy",in the electronic databases of PubMed,Cochrane Library,Web of Science and Scopus,from January 2011 to January 2021.The current literature demonstrates that flavonoids have anticarcinogenic properties,including inhibition of cell proliferation,induction of apoptosis,autophagy,necrosis,cell cycle arrest,senescence,impaired cell migration,invasion,tumor angiogenesis and reduced resistance to multiple drugs in tumor cells.We demonstrate the available evidence on the roles of flavonoids and autophagy in cancer progression and inhibition.(Registration No.CRD42021243071 at PROSPERO)
基金the Coordination for the Improvement of Higher Education Personnel(CAPES)the National Council of Technological and Scientific Development(CNPq)and the Research Support Foundation of the State of Rio Grande do Sul(FAPERGS,16/2551-0000522-2,17/2551-0000893-6,19/2551-0001261-6)for the financial support+3 种基金C.Müller thanks CAPES/PNPD(88887.352933/2019-00)for a postdoctoral fellowship.M.V.Tres(308936/2017-5)G.L.Zabot(304882/2018-6)H.Treichel(305258/2018-4)L.M.Colla(305935/2017-8)thank CNPq for the productivity grants.
文摘In recent decades,third-generation(3G)biofuels have become a more attractive method of fuel production,as algae cultivation does not infringe on resources needed for food production.Additionally,algae can adapt to different environments,has high photosynthetic efficiency(CO_(2)fixation),and has a high potential for carbohydrate accumulation.The prevalence of algae worldwide demonstrates its ability to adapt to different environments and climates,proving its biodiversity and versatility.Algae can be grown in wastewater,seawater,and even sewage,thus ensuring a lower water footprint and greater energy efficiency during algal biomass production.Because of this,the optimization of 3G ethanol production appears to be an excellent alternative to mitigate environmental impacts and increase energy and food security.This critical review presents(i)the stages of cultivation and processing of micro and macroalgae;(ii)the selection of yeasts(through engineering and/or bioprospecting)to produce ethanol from these biomasses;(iii)the potential of seawater-based facilities to reduce water footprint;and(iv)the mass and energy balances of 3G ethanol production in the world energy matrix.This article is,above all,a brainstorm on the environmental viability of algae bioethanol.
