Alstonia scholaris(L.)R.Br(Apocynaceae)is a well-documented medicinal plant for treating respiratory diseases,liver diseases and diabetes traditionally.The current study aimed to investigate the effects of TA on non-a...Alstonia scholaris(L.)R.Br(Apocynaceae)is a well-documented medicinal plant for treating respiratory diseases,liver diseases and diabetes traditionally.The current study aimed to investigate the effects of TA on non-alcoholic fatty liver disease(NAFLD).A NAFLD model was established using mice fed a high-fat diet(HFD)and administered with TA(7.5,15 and 30 mg/kg)orally for 6 weeks.The biochemical parameters,expressions of lipid metabolism-related genes or proteins were analyzed.Furthermore,histopathological examinations were evaluated with Hematoxylin-Eosin and MASSON staining.TA treatment significantly decreased the bodyweight of HFD mice.The concentrations of low-density lipoprotein(LDL),triglyceride(TG),aspartate aminotransferase(AST)and alanine aminotransferase(ALT)were also decreased significantly in TA-treated mice group,accompanied by an increase in high-density lipoprotein(HDL).Furthermore,TA alleviated hepatic steatosis injury and lipid droplet accumulation of liver tissues.The liver mRNA levels involved in hepatic lipid synthesis such as sterol regulatory element-binding protein 1C(SREBP-1C),regulators of liver X receptorα(LXRα),peroxisome proliferator activated receptor(PPAR)γ,acetyl-CoA carboxylase(ACC1)and stearyl coenzyme A dehydrogenase-1(SCD1),were markedly decreased,while the expressions involved in the regulation of fatty acid oxidation,PPARα,carnitine palmitoyl transterase 1(CPT1A),and acyl coenzyme A oxidase 1(ACOX1)were increased in TA-treated mice.TA might attenuate NAFLD by regulating hepatic lipogenesis and fatty acid oxidation.展开更多
Sterculia gum,the dry exudate of Sterculia versicolor and other members of the same genus,is used as a thickener and emulsifier in foods.It is generally considered safe as a food or drug,and its adverse reactions,such...Sterculia gum,the dry exudate of Sterculia versicolor and other members of the same genus,is used as a thickener and emulsifier in foods.It is generally considered safe as a food or drug,and its adverse reactions,such as Sterculia-induced liver injury,have never been reported.A 46-year-old woman was admitted to hospital with fatigue,nausea,abdominal distension,jaundice and a>16-fold increase in transaminase and bilirubin level.The patient had used Sterculia gum prior to the onset of her symptoms.Her symptoms and clinical indicators improved after treatment.The possibility of acute viral hepatitis,autoimmune hepatitis,and metabolic liver disease was excluded.After discharge from hospital,the patient had a severe liver injury again when re-exposed to Sterculia gum.And the Roussel Uclaf Causality Assessment Method score was updated from 5 to 7,which was consistent with probable drug-induced liver injury.This is the first report of Sterculia-induced liver injury.Clinicians need to be aware of the potential hepatotoxicity of Sterculia.展开更多
基金Yunnan Province Innovation Team of Intestinal Microecology-Related Disease Research and Technological Transformation (202005AE160010)National Natural Science Foundation of China (81860437)+2 种基金Prominent Physician Project of Yunnan province (YNWR-MY-2019-072)Yunnan Major Science and Technology Project (2019ZF004)Digestive Endoscopy Medical Center (2019LCZXKF-XH05) for financial support.
文摘Alstonia scholaris(L.)R.Br(Apocynaceae)is a well-documented medicinal plant for treating respiratory diseases,liver diseases and diabetes traditionally.The current study aimed to investigate the effects of TA on non-alcoholic fatty liver disease(NAFLD).A NAFLD model was established using mice fed a high-fat diet(HFD)and administered with TA(7.5,15 and 30 mg/kg)orally for 6 weeks.The biochemical parameters,expressions of lipid metabolism-related genes or proteins were analyzed.Furthermore,histopathological examinations were evaluated with Hematoxylin-Eosin and MASSON staining.TA treatment significantly decreased the bodyweight of HFD mice.The concentrations of low-density lipoprotein(LDL),triglyceride(TG),aspartate aminotransferase(AST)and alanine aminotransferase(ALT)were also decreased significantly in TA-treated mice group,accompanied by an increase in high-density lipoprotein(HDL).Furthermore,TA alleviated hepatic steatosis injury and lipid droplet accumulation of liver tissues.The liver mRNA levels involved in hepatic lipid synthesis such as sterol regulatory element-binding protein 1C(SREBP-1C),regulators of liver X receptorα(LXRα),peroxisome proliferator activated receptor(PPAR)γ,acetyl-CoA carboxylase(ACC1)and stearyl coenzyme A dehydrogenase-1(SCD1),were markedly decreased,while the expressions involved in the regulation of fatty acid oxidation,PPARα,carnitine palmitoyl transterase 1(CPT1A),and acyl coenzyme A oxidase 1(ACOX1)were increased in TA-treated mice.TA might attenuate NAFLD by regulating hepatic lipogenesis and fatty acid oxidation.
基金the support of Yunnan (Kunming) Zhang Wenhong expert workstation (YSZJGZZ-2020051)
文摘Sterculia gum,the dry exudate of Sterculia versicolor and other members of the same genus,is used as a thickener and emulsifier in foods.It is generally considered safe as a food or drug,and its adverse reactions,such as Sterculia-induced liver injury,have never been reported.A 46-year-old woman was admitted to hospital with fatigue,nausea,abdominal distension,jaundice and a>16-fold increase in transaminase and bilirubin level.The patient had used Sterculia gum prior to the onset of her symptoms.Her symptoms and clinical indicators improved after treatment.The possibility of acute viral hepatitis,autoimmune hepatitis,and metabolic liver disease was excluded.After discharge from hospital,the patient had a severe liver injury again when re-exposed to Sterculia gum.And the Roussel Uclaf Causality Assessment Method score was updated from 5 to 7,which was consistent with probable drug-induced liver injury.This is the first report of Sterculia-induced liver injury.Clinicians need to be aware of the potential hepatotoxicity of Sterculia.
