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Alcohol consumption and fatty liver disease 被引量:1
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作者 Ren-Nan Feng Guo-Dong Sun +2 位作者 Yan Zhao Fu-Chuan Guo Chang-Hao Sun 《World Journal of Gastroenterology》 SCIE CAS 2013年第13期2129-2130,共2页
Hamaguchi et al recently reported some interesting observations on alcohol consumption and risk of fatty liver disease from a large population. However, we feel that it might be necessary to discuss some concerns in t... Hamaguchi et al recently reported some interesting observations on alcohol consumption and risk of fatty liver disease from a large population. However, we feel that it might be necessary to discuss some concerns in this study. As the alcohol consumption categorization was defined by the same criteria in both men and women, which might affect their results. As another factor is soft drinks consumption. It has been proved that soft drinks, especially fructose, contributes to the development of obesity, diabetes, metabolic syndrome, and nonalcoholic fatty liver disease. However, this confounding factor was not adjusted or discussed in this article. The third is the genetic background, for some genetic factors are related with the development of fatty liver disease, which was also not considered yet. 展开更多
关键词 ALCOHOL FATTY liver disease OBESITY DIABETES METABOLIC SYNDROME
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Pregnancy after liver transplantation:Four-year follow-up of the first case in China's Mainland 被引量:1
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作者 Dong Xia Hong-Yuan He +6 位作者 Liang Xu Yi Quan Huai-Quan Zuo Lu-Nan Yan Bo Li Yong Zeng Guang-Dong Pan 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第47期7264-7266,共3页
The safety and feasibility of pregnancy following liver transplantation(LT) have been accredited in a series of LT center.The first case in China's Mainland is reported.The follow-up data of a 22-year-old pregnant... The safety and feasibility of pregnancy following liver transplantation(LT) have been accredited in a series of LT center.The first case in China's Mainland is reported.The follow-up data of a 22-year-old pregnant patient with end-stage liver disease undergone orthotopic liver transplantation were analyzed retrospectively.After surgery,the patient was uneventfully recovered and became pregnant 33 mo after LT.The patient was closely monitored and treated with a standard and individualized triple-drug immunosuppressive therapy throughout her pregnancy.Caesarean section was performed in March 18,2004,and a health live-born infant was delivered.After the delivery,a 4-year follow-up period indicated that the patient was satisfactory with her condition and her baby was healthy.Our case shows that a successful pregnancy following LT is possible and safe in women with end-stage liver diseases under close monitoring.Three factors including mother,baby,and transplanted liver function must be considered for the safety of high-risk pregnancies. 展开更多
关键词 PREGNANCY Liver transplantation FOLLOW-UP
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Comment on“Outcomes of curative liver resection for hepatocellular carcinoma in patients with cirrhosis” 被引量:1
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作者 Xiao-Long Tang Yan-Dong Miao Deng-Hai Mi 《World Journal of Gastrointestinal Oncology》 SCIE 2022年第1期366-368,共3页
The present letter to the editor is in response to the research“Outcomes of curative liver resection for hepatocellular carcinoma in patients with cirrhosis”by Elshaarawy et al in World J Gastroenterol 2021;13(5):42... The present letter to the editor is in response to the research“Outcomes of curative liver resection for hepatocellular carcinoma in patients with cirrhosis”by Elshaarawy et al in World J Gastroenterol 2021;13(5):424–439.The preoperative assessment of the liver reserve function in hepatocellular carcinoma(HCC)patients with cirrhosis is crucial,and there is no universal consensus on how to assess it.Based on a retrospective study,Elshaarawy et al investigated the impact of various classical clinical indicators on liver failure and the prognosis after hepatectomy in HCC patients with cirrhosis.We recommend that we should strive to explore new appraisal indicators,such as the indocyanine green retention rate at 15 min. 展开更多
关键词 ICG-R15 HEPATECTOMY CIRRHOSIS Hepatocellular carcinoma
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Difficulties and Countermeasures of Rural Human Settlement Environment Governance in Tianjin 被引量:1
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作者 Di WANG Yongyi WANG Chunjie LI 《Asian Agricultural Research》 2021年第3期11-13,16,共4页
The course of rural human settlement environment governance in Tianjin could be roughly divided into four stages:germination,initiation,promotion and deepening.After the development for nearly 20 years,rural human set... The course of rural human settlement environment governance in Tianjin could be roughly divided into four stages:germination,initiation,promotion and deepening.After the development for nearly 20 years,rural human settlement environment governance of Tianjin is faced with many difficulties,such as imperfect village construction planning,poor use effect of sewage facilities,low participation of farmers,and insufficient financial investment.Therefore,some countermeasures and suggestions are put forward,such as scientific planning and overall consideration,innovating financing mechanism,encouraging diversified investment of funds,and strengthening the publicity of rural human settlement environment governance. 展开更多
关键词 Rural human settlement environment Governance dilemma Capital investment TIANJIN
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Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model
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作者 Yan-Dong Miao Jiang-Tao Wang +1 位作者 Xiao-Long Tang Deng-Hai Mi 《World Journal of Gastroenterology》 SCIE CAS 2021年第47期8194-8198,共5页
CXCL12 expression was significantly lower in tumor samples than in corresponding normal samples.CXCL12 expression was significantly positively related to the infiltration levels of T cells,dendritic cells(DCs),immatur... CXCL12 expression was significantly lower in tumor samples than in corresponding normal samples.CXCL12 expression was significantly positively related to the infiltration levels of T cells,dendritic cells(DCs),immature DCs,cytotoxic cells,Tfh cells,mast cells,B cells,Th1 cells,natural killer(NK)cells,pDCs,neutrophils,and T helper cells(Spearman correlation coefficient>0.5,P<0.001)and negatively correlated with the infiltration level of NK CD56bright cells.In addition,pancreatic hTERT-HPNE cells treated with three diverse CXCL12 isoforms exhibited changes mainly in the regulation of the epithelialmesenchymal transition activation pathway. 展开更多
关键词 CXCL12 Pancreatic cancer Splicing isoforms Bioinformatics analysis Tumor microenvironment Pathway
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Assessment on the component pattern of mountain vacation potential suitability in Hunan Province, China
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作者 DU Ting-ting LI Da-li ZHONG Yong-de 《Journal of Mountain Science》 SCIE CSCD 2022年第3期892-908,共17页
In China,mountain destinations offer more opportunities for vacation than beaches and springs,with a larger national coverage,richer landscapes and various diverse folk cultures.Hunan Province,for example,serves as a ... In China,mountain destinations offer more opportunities for vacation than beaches and springs,with a larger national coverage,richer landscapes and various diverse folk cultures.Hunan Province,for example,serves as a typical mountain tourism destination.Our research aims to assess the potential suitability and component pattern of holidaymaking in Hunan Province to support for scientific endeavors and sustainable use of mountain resources in Hunan.An approach for mapping potential suitability was constructed based on Weighted Linear Combination(WLC)of six primary factors including terrain,climate suitability period,biology and environment,human activity culture,hydrological landscape,and road infrastructure,which is calculated on the base of eleven secondary factors used as suitability criteria.Analytic hierarchy process(AHP)and geographic information system(GIS)were also integrated into the evaluation models to prepare six single and complex factor suitability maps for mountain vacation.Multivariate clustering was used to clarify the component pattern of single factor combinations in each mountain vacation suitability index(MVSI)class.The results have shown that:1)Regions with high suitability are distributed with characteristics of significant dispersion and limited aggregation;2)15.89%of the sample mountains are highly suitable,30.78%are moderately suitable,42.61%are marginally suitable and 10.72%are poorly suitable;3)The complexity of index combination corresponding to each level is different;4)Different combinations emphasize different destination needs.The study reveals the suitability class,characteristics,and limiting factors of mountain vacation in different geographical locations on the provincial scale.These elements play an instructive role in scientific decision-making and orderly exploitation of resources among Hunan’s Mountain destinations.Furthermore,the study can also be used as a basis for the suitability evaluation of mountain vacation in other areas. 展开更多
关键词 Mountain vacation Suitability evaluation Component pattern Analytic hierarchy process Geographic information system Hunan Province
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Effect of Rare Earth Elements on Thermal Fatigue Property of Low Chromium Semi-Steel
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作者 常立民 刘建华 +3 位作者 张瑞军 邵利 于升学 谌岩 《Journal of Rare Earths》 SCIE EI CAS CSCD 2003年第2期172-175,共4页
The effect of rare earth elements on eutectic carbide′s morphology of low chromium semi steel in as cast state and after heat treatment was investigated, and accordingly, the thermal fatigue property of this mater... The effect of rare earth elements on eutectic carbide′s morphology of low chromium semi steel in as cast state and after heat treatment was investigated, and accordingly, the thermal fatigue property of this material was studied. The results show that RE can improve the eutectic carbide′s morphology, inhibit the formation and propagation of thermal fatigue cracks, therefore, promote the thermal fatigue property, which is more noticeable in case of the RE modification in combination with heat treatment. The optimal thermal fatigue property can be obtained when treated with 0.2% RE modification as well as normalization at 950 ℃ for 3 h. 展开更多
关键词 metal materials low chromium semi steel thermal fatigue property rare earths
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Prevention of late complications of endoscopic resection of colorectal lesions with a coverage agent:Current status of gastrointestinal endoscopy
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作者 Yan-Dong Miao Xiao-Long Tang +1 位作者 Jiang-Tao Wang Deng-Hai Mi 《World Journal of Gastrointestinal Oncology》 SCIE 2022年第2期543-546,共4页
Endoscopic ectomy of large nonpedunculated colorectal lesions(≥20 mm)might cause significant adverse incidents,such as delayed perforation and delayed bleeding,despite the closure of mucosal lesions with clips.The co... Endoscopic ectomy of large nonpedunculated colorectal lesions(≥20 mm)might cause significant adverse incidents,such as delayed perforation and delayed bleeding,despite the closure of mucosal lesions with clips.The conventional utilization of prophylactic clipping has not decreased the risk of postprocedural delayed adverse events,and additional outcomes and cost-effectiveness research is needed for patients with proximal lesions≥20 mm,in whom prophylactic clipping might be useful.Coverage of the wound after endoscopic excision offers shield protection against delayed concomitant diseases. 展开更多
关键词 Endoscopic resection Non-pedunculated colorectal lesions COMPLICATION Delayed bleeding Delayed perforation Coverage agents
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Research on Cooperation Mechanism of China's Financial Regulation and Supervision System
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作者 赵卫花 汤兵勇 姬广凯 《Journal of Donghua University(English Edition)》 EI CAS 2012年第3期280-282,共3页
Financial regulation and supervision is an important subject in finance research. After the U. S. subprime mortgage crisis,the weakness in this field becomes the research focus. Every country attaches importance to st... Financial regulation and supervision is an important subject in finance research. After the U. S. subprime mortgage crisis,the weakness in this field becomes the research focus. Every country attaches importance to strengthen the financial supervision and management. But the financial regulatory system is a large system,and the process of model building and index selection is very complicated. A model for China's financial regulation and supervision system was proposed and a system evaluation method was improved. A more exact result was drawn by choosing 2003- 2009 index data. 展开更多
关键词 system science SYNERGETICS financial regulation and supervision system evaluation
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Analysis on the Economic Ethics Thoughts in the Economic and Philosophical Manuscripts of 1844
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作者 Shunqian LI Qing LI 《International Journal of Technology Management》 2015年第9期12-13,共2页
Economic and Philosophical Manuscripts of 1844 are one of Marx' s early works with great significance. It marked the thought development of Marx to a new stage. Marx in the Manuscripts through the criticism of the na... Economic and Philosophical Manuscripts of 1844 are one of Marx' s early works with great significance. It marked the thought development of Marx to a new stage. Marx in the Manuscripts through the criticism of the national economics, alienation labor theory to the problem of human essence, existing in the capitalist society of economic development and the moral result inverse problem and the communism theory expounds main contents such as the economic reality of capitalist society in profound ethical criticism, reveals the capitalist society economy inhumane between moral and ethical relations, in all of his criticism is always full of profound urges and powerful strength of moral criticism and deep ethical care, contained in the Manuscripts of economic ethics in today still has the significant theory significance and practical guiding value. 展开更多
关键词 Economic and Philosophical Manuscripts of 1844 Economic Ethics Thought Briefly
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Emotion of Physiological Signals Classification Based on TS Feature Selection
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作者 Wang Yujing Mo Jianlin 《无线互联科技》 2015年第22期68-70,81,共4页
This paper propose a method of TS-MLP about emotion recognition of physiological signal.It can recognize emotion successfully by Tabu search which selects features of emotion’s physiological signals and multilayer pe... This paper propose a method of TS-MLP about emotion recognition of physiological signal.It can recognize emotion successfully by Tabu search which selects features of emotion’s physiological signals and multilayer perceptron that is used to classify emotion.Simulation shows that it has achieved good emotion classification performance. 展开更多
关键词 EMOTION recognition Tabu SEARCH physiologicalsignals FEATURE selection MULTILAYER PERCEPTRON
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Design of The Principle of Remote Sensing Network Course Based on Blackboard Academic Suite
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作者 席武俊 罗仁芝 《科技信息》 2010年第3期19-20,共2页
Blackboard academic suite is an excellent teaching software,Design of the principle of remote sensing network course based on it includes five kernel parts:course content construction,experimental process recurrence,i... Blackboard academic suite is an excellent teaching software,Design of the principle of remote sensing network course based on it includes five kernel parts:course content construction,experimental process recurrence,interactive cooperation creation,exercises evaluation,course data evaluation and feedback.Teacher also should use some tactics to motivate students use blackboard academic suite,so as to improve students' learning interest and initiative,and teaching quality of the principle of remote sensing course. 展开更多
关键词 教学软件 遥感网络 教学方法 教师
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"Co-construction"to"Symbiosis":Research on the Integrated Governance Mechanism of Industrial Colleges in Higher Vocational Colleges
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作者 Yan Wang 《Journal of Contemporary Educational Research》 2021年第9期142-146,共5页
Industrial colleges are the connection point between higher vocational colleges and enterprises to carry out in-depth collaborative education.At present,there are three forms of industrial colleges:surface cooperative... Industrial colleges are the connection point between higher vocational colleges and enterprises to carry out in-depth collaborative education.At present,there are three forms of industrial colleges:surface cooperative industrial college focusing on order cooperation,middle-level industrial college relying on industry development,and deep cooperative industrial college with integrated development.There are several common problems among the three forms of industrial colleges,such as vague positioning,unclear division of responsibilities and rights between both parties,and "free riding"at all levels.In order to establish symbiotic industrial colleges,there is a need to change the concept first,then establish and improve the system,and finally,establish a cross-border teacher pool. 展开更多
关键词 Industrial college School enterprise community of common destiny Symbiotic development
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轻型缺血性卒中或短暂性脑缺血发作的早期双联抗血小板治疗 被引量:8
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作者 王拥军 S. Claiborne Johnston +12 位作者 Philip M Bath James C. Grotta 潘岳松 Pierre Amarenco 王伊龙 Tabassome Simon Jong Sung Kim Jiann-Shing Jeng 刘丽萍 林毅 Ka Sing Lawrence Wong David Wang 李昊 《英国医学杂志中文版》 2019年第5期262-265,共4页
王拥军及同事探讨了应用双联抗血小板治疗预防卒中复发或短暂性脑缺血发作的最新证据。轻型缺血性卒中和短暂性脑缺血发作(TIA)患者在头几周内有较高的卒中及其他血管事件的复发风险(5%~11.7%严。双联抗血小板治疗,包括氯吡格雷和阿司匹... 王拥军及同事探讨了应用双联抗血小板治疗预防卒中复发或短暂性脑缺血发作的最新证据。轻型缺血性卒中和短暂性脑缺血发作(TIA)患者在头几周内有较高的卒中及其他血管事件的复发风险(5%~11.7%严。双联抗血小板治疗,包括氯吡格雷和阿司匹林,是减少卒中复发的有效治疗策略Magic Group的专家小组(http://magicproject.org/)最近在The BMJ中发表了一个强烈的快速推荐建议,即对于轻型缺血性卒中和TIA患者应在症状出现24小时内开始双联抗血小板治疗,并持续10~21天3。 展开更多
关键词 短暂性脑缺血发作 抗血小板治疗 缺血性卒中 轻型 早期 复发风险 阿司匹林 有效治疗
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Efficiency and Productivity of County-level Public Hospitals Based on the Data Envelopment Analysis Model and Malmquist Index in Anhui, China 被引量:4
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作者 Nian-Nian Li Cun-Hui Wang +1 位作者 Hong Ni Heng Wang 《Chinese Medical Journal》 SCIE CAS CSCD 2017年第23期2836-2843,共8页
Background: China began to implement the national medical and health system and public hospital reforms in 2009 and 2012, respectively. Anhui Province is one of the four pilot provinces, and the medical reform measur... Background: China began to implement the national medical and health system and public hospital reforms in 2009 and 2012, respectively. Anhui Province is one of the four pilot provinces, and the medical reform measures received wide attention nationwide. The effectiveness of the above reform needs to get attention. This study aimed to master the efficiency and productivity of county-level public hospitals based on the data envelopment analysis (DEA) model and Malmquist index in Anhui, China, and then provide improvement measures for the future hospital development. Methods: We chose 12 country-level hospitals based on geographical distribution and the economic development level inAnhui Province. Relevant data that were collected in the field and then sorted were provided by the administrative departments of the hospitals. DEA models were used to calculate the dynamic efficiency and Malmquist index factors for the 12 institutions. Results: During 2010-2015, the overall average relative service efficiency of 12 county-level public hospitals was 0.926, and the number of hospitals achieved an effective DEA for each year from 2010 to 2015 was 4, 6, 7, 7, 6, and 8, respectively, as measured using DEA. During this same period, the average overall production efficiency was 0.983, and the total productivity factor had declined. The overall production efficiency of five hospitals was 〉1, and the rest are 〈1 between 2010 and 2015. Conclusions: In 2010-2015, the relative service efficiency of 12 county-level public hospitals in Anhui Province showed a decreasing trend, and the service efficiency of each hospital changed. In the past 6 years, although some hospitals have been effective, the efficiency of the county-level public hospitals in Anhui Province has not improved significantly, and the total factor productivity has not been effectively improved. County-level public hospitals need to combine their own reality to find their own deficiencies. 展开更多
关键词 China County Level Public Hospital Data Envelopment Analysis Malmquist Index Service Efficiency
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Intense single-band red upconversion emission in BiOCl:Er3+ layered semiconductor via co-doping Ho3+ 被引量:3
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作者 Yuehong Peng Jincai Peng +6 位作者 Jiajun Han Tianhui Wang Zhaoyi Yin Jianbei Qiu Qi W ang Zhengwen Yang Zhiguo Song 《Journal of Rare Earths》 SCIE EI CAS CSCD 2020年第6期577-583,共7页
Exploring a new tuning way to facilely realize single-band red emission in trivalent rare-earth ions(RE3+) doped upconversion(UC) materials is still desirable.In this work,the intense single-band red emission is achie... Exploring a new tuning way to facilely realize single-band red emission in trivalent rare-earth ions(RE3+) doped upconversion(UC) materials is still desirable.In this work,the intense single-band red emission is achieved by co-doping only Ho3+in the BiOCl:Er3+ under 1550 nm excitation.In the BiOCl layered host,co-doping Ho3+can further enhance the red emission and simultaneously suppress the green emission of Er3+,and thus obviously improve the red-to-green(R/G) ratio.It is found that Ho3+does not se rve as ene rgy trapping through the 5 I6 state as in traditional UC materials but acts as ET bridge(4 S3/2,2 H11/2(Er3+)→5 F4,5 S2(Ho3+)→4 F9/2(Er3+)).The tuning mechanism of Ho3+is discussed in detail and further confirms through a comparative experiment.Our research gives an unusual perspective to tune the UC behavior of Er3+through co-doping Ho3+,which might be inspiring for achievement of single-band red UC emission. 展开更多
关键词 Single-band red emission BiOCl ER3+ Ho3+ Rare Earths
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Soluble salt deposit in the Nihewan beds and its environmental significance 被引量:1
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作者 李容全 乔建国 +2 位作者 邱维理 翟秋敏 李永良 《Science China Earth Sciences》 SCIE EI CAS 2000年第5期464-479,共16页
Observation and experimental analysis of soluble salt deposit along four profiles across the strata deposited in Nihewan paleolake basin enabled us to recognize the nature and evolution stages of the Nihewan paleolake... Observation and experimental analysis of soluble salt deposit along four profiles across the strata deposited in Nihewan paleolake basin enabled us to recognize the nature and evolution stages of the Nihewan paleolake and its significance in stratigraphical division and pa-leo-environmental reconstruction. The Nihewan paleolake was at least a weak-saline to semi-saline lake and represents an intracontinental lake in the semi-arid region. The lower member of sedimentary strata in the paleolake contains gypsum layer and gypsum lamellae. Soluble salt is mainly composed of SO42- and Ca2+ ions, representing a trend of the paleolake evolvinginto a stage of sulfate lake. The upper member of the strata has predominantly Cl-, K+, and Na+ ions in soluble salt, indicating a starting development of the paleolake to chlorite lake, but no salt rock was deposited, indicating a drying trend of the area. 展开更多
关键词 Nihewan BEDS SOLUBLE salt DEPOSIT PALEO-ENVIRONMENT semi-saline lake.
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A Cross-sectional Study Assessing Predictors of Essential Medicines Prescribing Behavior Based on Information-motivation-behavioral Skills Model among County Hospitals in Anhui, China 被引量:2
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作者 Yun-Wu Zhao Jing-Ya Wu +6 位作者 Heng Wang Nian-Nian Li Cheng Bian Shu-Man Xu Peng Li Hua Lu Lei Xu 《Chinese Medical Journal》 SCIE CAS CSCD 2015年第21期2887-2895,共9页
Background: The self-consciousness and practicality of preferentially prescribed essential medicines (EMs) are not high enough in county hospitals. The purposes of this study were to use the information-motivation-... Background: The self-consciousness and practicality of preferentially prescribed essential medicines (EMs) are not high enough in county hospitals. The purposes of this study were to use the information-motivation-behavioral skills (IM B) model to identify the predictors of essential medicines prescribing behavior (EMPB) among doctors and to examine the association between demographic variables, IMB, and EMPB. Methods: A cross-sectional study was carried out to assess predictive relationships among demographic variables and IM B model variables using an anonymous questionnaire administered in nine county hospitals of Anhui province. A structural equation model was constructed for the I MB model to test the instruments using analysis of moment structures 17.0. Results: A total of 732 participants completed the survey. The average age of the participants was 37.7 ± 8.9 years old (range: 22-67 years old). The correct rate of information was 90.64%. The average scores of the motivation and behavioral skills were 45.46 a: 7.34 (hundred mark system: 75.77) and 19.92 ± 3.44 (hundred mark system: 79.68), respectively. Approximately half(50.8%) of respondents reported that the proportion of EM prescription was below 60%. The final revised model indicated a good fit to the data (x^2/df= 4.146, goodness of fit index = 0.948, comparative fit index = 0.938, root mean square error of approximation = 0.066). More work experience (β = 0.153, P 〈 0.001 ) and behavioral skills (β = 0.449, P 〈 0.001 ) predicted more EMPB. Higher income predicted less information (β = -0.197, P 〈 0.001) and motivation (β =0.204, P 〈 0.001 ). Behavioral skills were positively predicted by information (β = 0.135, P 〈 0.001 ) and motivation (β = 0.742, P 〈 0.001 ). Conclusion: The present study predicted some factors of EMPB, and specified the relationships among the model variables. The utilization rate of EM was not high enough. Motivation and behavior skills were crucial factors affecting EMPB. The influence of demographic variables, such as income and work experience, on EMPB should be fully appreciated. Comprehensive intervention measures should be implemented from multiple perspectives. 展开更多
关键词 China County Hospitals Essential Medicines Information-motivation-behavioral Skills Model PrescribingBehavior Structural Equation Model
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Effects of N concentration on electronic and optical properties of N-doped PbTiO_3 被引量:1
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作者 赵银女 闫金良 《Journal of Semiconductors》 EI CAS CSCD 2015年第9期36-40,共5页
The p-type N-doped PbTiO3 with different doping concentrations have been studied by first-principles calculations. The charge density differences, band structures, density of states and optical properties have been in... The p-type N-doped PbTiO3 with different doping concentrations have been studied by first-principles calculations. The charge density differences, band structures, density of states and optical properties have been investigated. After an oxygen atom is substituted by a nitrogen atom in the crystals, the valance bands move to high energy levels and the Fermi energy level gets into the top of the valance bands. Results show that the values of the band gaps are decreased and the stability is weakened when the N concentration increases. The 2.5 at% N-doped PbTiO3 shows the best p-type conductivity and the visible-light absorption can be enhanced most at this doping concentration, which is necessary in semiconductors or photocatalysts. 展开更多
关键词 semiconductor doping electric property optical property electronic structure
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Haoqin Qingdan Decoction(蒿芩清胆汤)and Ribavirin Therapy Downregulate CD14 and Toll-Like Receptor 4 in Febrile Disease with Dampness-Heat Syndrome in A Mouse Model 被引量:1
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作者 骆欢欢 张奉学 +1 位作者 吴薇 王新华 《Chinese Journal of Integrative Medicine》 SCIE CAS CSCD 2016年第10期768-773,共6页
Objective: To evaluate the effect of Chinese medicine Haoqin Qingdan Decoction (蒿芩清胆汤, HQD) for febrile disease dampness-heat syndrome (FDDHS). Methods: Forty mice were divided into four groups, including n... Objective: To evaluate the effect of Chinese medicine Haoqin Qingdan Decoction (蒿芩清胆汤, HQD) for febrile disease dampness-heat syndrome (FDDHS). Methods: Forty mice were divided into four groups, including normal control, FDDHS (induced by Radix et Rhizoma Rhei recipe and influenza virus A1 FM1 model), HQD, and the ribavirin groups (10 in each). The normal control and FDDHS groups were administered normal saline. HQD and the ribavirin groups were administered HQD and ribavirin intragastrically once daily at a dose of 64 g/(kg.d) and 0.07 g/(kg.d), respectively for 7 days. Lethargy, rough hair, diarrhea, tongue color and sole color were evaluated for pathological changes in morphology. The tongue and lung tissues were collected for histology. The CD14 and toll-like receptor 4 (TLR4) expression levels were measured using real-time quantitative polymerase chain reaction. Results: More than 80% of the FDDHS mice showed hypokinesia and lethargy, and pathological changes associated with rough hair, diarrhea, tongue color and sole color. With advanced treatment for 7 days, the thick greasy tongue fur of the HQD and ribavirin groups were thinner than that of the FDDHS group (P〈0.05), and it was the thinnest in the ribavirin group as compared with that in other groups (P〈0.05). The CD14 and TLR4 expression levels in the lung tissues of HQD and ribavirin groups significantly delined compared with the model group (P〈0.05 or P〈0.01). CD14 was down-regulated more remarkably in the HQD group compared with the ribavirin group (P〈0.05), whereas the converse was true with TLR4 (P〈0.05). Conclusions: We established a FDDHS mouse model showing systemic clinical symptoms. Both HQD and ribavirin can inhibit the expression of CD14 and TLR4 in FDDHS mice, while the effect of ribavirin might be much more violent. The expression changes of CD14 and TLR4 consistently refers to lipopolysaccharide, the commonly and hotly inducing factor in FDDHS. 展开更多
关键词 CD14 toll-like receptor 4 febrile disease dampness-heat syndrome Haoqin Qingdan Decoction ribavirin Chinese medicine
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