Objective: To investigate how medical students process Western medicine(WM) terms vs. traditional Chinese medicine(TCM) terms and how this is impacted by analogical priming from the perspective of cognitive neuroscien...Objective: To investigate how medical students process Western medicine(WM) terms vs. traditional Chinese medicine(TCM) terms and how this is impacted by analogical priming from the perspective of cognitive neuroscience.Methods: The experiments were designed as a 2(TCM terms vs. WM terms) × 2(correct terms vs.incorrect terms) × 2(analogical priming task vs. non-priming task) scheme. A total of 26 medical students completed a non-priming judgment task and an analogical priming judgment task on medical terms. During the tasks, the participants were asked to make correct/incorrect judgments on WM terms and TCM terms, and their behavioral data and event-related potentials(ERPs) were recorded.Results: Behaviorally, the response speed and accuracy of WM terms were higher than those of TCM terms(both P <.001), indicating a prominent concreteness effect. Analogical priming shortened the response time to medical terms(P <.001), and the response time to TCM terms was shortened more significantly(P =.001). For ERPs, WM terms induced a larger P200(an early positive ERP component), a smaller N400(a negative ERP component), and a higher late positive ERP component, indicating superiority of attention adjustment, smaller-scale semantic activation, and a higher cost of late semantic analysis and integration. However, the analogical priming eliminated the difference between WM and TCM terms in P200 and N400 while maintaining it in the LPC. This suggests that WM terms are sensitive to analogical attention adjustment, and TCM terms are susceptible to analogical semantic integration.Conclusion: Our findings suggest that WM and TCM disease behavior terms may initially differ in concreteness or the use of a verbal-linguistic system. Analogy is more conducive to understanding TCM terms. This research provides important neuroscientific evidence of the difference in thinking between TCM and WM.展开更多
OBJECTIVE:To assess the efficacy and safety of Jiawei Xiaoyao (JWXY) capsules on mild to moderate depression with anxiety symptoms,a randomized,double-blind,double-dummy controlled,multicenter,parallel-treatment trial...OBJECTIVE:To assess the efficacy and safety of Jiawei Xiaoyao (JWXY) capsules on mild to moderate depression with anxiety symptoms,a randomized,double-blind,double-dummy controlled,multicenter,parallel-treatment trial was carried out among 210 outpatients with mild to moderate depression and anxiety symptoms from three hospitals in Beijing China.METHODS:Participants were randomized into the JWXY group or the sertraline group.Each group received JWXY treatment and sertraline placebo,or sertraline and JWXY placebo for 8 weeks.Main outcomes were measured using the Hamilton Depression Rating Scale (HAMD),Hamilton Anxiety Rating Scale (HAMA) and the Clinical Global Impression Scale.RESULTS:JWXY and sertraline had the equivalent effect on HAMD at every interview point.JWXY was more effective at reducing the HAMA scores at the 2nd and 12th week,HAMD sleep disturbance subscale scores at the 8th and 12th week,and HAMA somatic anxiety subscale scores at the 12th week.The rate of adverse events in the two groups was the same.CONCLUSION:For mild to moderate depression with anxiety symptoms,JWXY could be as effective as sertraline in alleviating depressive symptoms.For anxiety symptoms,JWXY may be effective more quickly and with longer lasting effects than sertraline.In particular,it may also improve quality of sleep and somatic anxiety symptoms.JWXY is safe and cheaper than conventional antidepressants,and may be the first alternative choice for depression with anxiety symptoms.展开更多
Objective:To analyze the effect of acupuncture versus hormone replacement therapy(HRT)for premature ovarian insufficiency(POI).Methods:China National Knowledge Infrastructure(CNKI),Wanfang Academic Journal Full-text D...Objective:To analyze the effect of acupuncture versus hormone replacement therapy(HRT)for premature ovarian insufficiency(POI).Methods:China National Knowledge Infrastructure(CNKI),Wanfang Academic Journal Full-text Database(Wanfang),Chongqing VIP Database(CQVIP),China Biology Medicine Disc(CBM),Web of Science,Cochrane Library,PubMed,and Excerpta Medica Database(EMBASE)were searched up to January 31st,2019 to identify randomized controlled trials(RCTs)evaluating the effect of acupuncture for POI.The primary outcome was the level of basal serum follicle-stimulating hormone(FSH).Secondary outcomes included serum levels of luteinizing hormone(LH),estradiol(E2)and anti-Müllerian hormone(AMH).Two authors extracted data independently and assessed the risk of bias and the methodological quality using the Cochrane's tool.Meta-analysis was conducted by RevMan version 5.3.Results:Eight eligible RCTs with a total of 496 POI patients were included in the meta-analysis.The pooled results showed that there was a significant reduction in the basal serum FSH level(MD=-5.82,95%CI:-9.76 to-1.87,I2=82%,P=0.004)and a remarkable elevation in the basal E2 level(SMD=0.93,95%CI:0.34 to 1.52,I2=88%,P=0.002)in the acupuncture group when compared with the control.Subgroup analysis showed that compared with HRT,a significant decrease in the FSH level was observed in both acupuncture alone(MD=-4.53,95%CI:-8.96 to-0.10,I2=73%,P=0.04)and acupuncture plus HRT(MD=-9.60,95%CI:-17.60 to-1.61,I2=50%,P=0.02),while a remarkable elevation of E2 was only found in acupuncture plus HRT(SMD=1.43,95%CI:1.03 to 1.82,I2=0%,P<0.00001).There was no significant difference in the LH level between acupuncture and HRT(MD=-3.16,95%CI:-9.41 to 3.10,I2=0%,P=0.32),only one trial reported AMH,and no significant difference was found between acupuncture and HRT.Conclusion:The present study indicated that acupuncture had an advantage over HRT in reducing serum FSH level and increasing serum E2 level in women with POI.However,evidence supporting the finding is limited due to the small sample size,potential methodological flaws and significant heterogeneity.Hence,this conclusion still needs to be verified by high-quality RCTs.展开更多
基金supported by the National Natural Science Foundation of China (81874514)
文摘Objective: To investigate how medical students process Western medicine(WM) terms vs. traditional Chinese medicine(TCM) terms and how this is impacted by analogical priming from the perspective of cognitive neuroscience.Methods: The experiments were designed as a 2(TCM terms vs. WM terms) × 2(correct terms vs.incorrect terms) × 2(analogical priming task vs. non-priming task) scheme. A total of 26 medical students completed a non-priming judgment task and an analogical priming judgment task on medical terms. During the tasks, the participants were asked to make correct/incorrect judgments on WM terms and TCM terms, and their behavioral data and event-related potentials(ERPs) were recorded.Results: Behaviorally, the response speed and accuracy of WM terms were higher than those of TCM terms(both P <.001), indicating a prominent concreteness effect. Analogical priming shortened the response time to medical terms(P <.001), and the response time to TCM terms was shortened more significantly(P =.001). For ERPs, WM terms induced a larger P200(an early positive ERP component), a smaller N400(a negative ERP component), and a higher late positive ERP component, indicating superiority of attention adjustment, smaller-scale semantic activation, and a higher cost of late semantic analysis and integration. However, the analogical priming eliminated the difference between WM and TCM terms in P200 and N400 while maintaining it in the LPC. This suggests that WM terms are sensitive to analogical attention adjustment, and TCM terms are susceptible to analogical semantic integration.Conclusion: Our findings suggest that WM and TCM disease behavior terms may initially differ in concreteness or the use of a verbal-linguistic system. Analogy is more conducive to understanding TCM terms. This research provides important neuroscientific evidence of the difference in thinking between TCM and WM.
文摘OBJECTIVE:To assess the efficacy and safety of Jiawei Xiaoyao (JWXY) capsules on mild to moderate depression with anxiety symptoms,a randomized,double-blind,double-dummy controlled,multicenter,parallel-treatment trial was carried out among 210 outpatients with mild to moderate depression and anxiety symptoms from three hospitals in Beijing China.METHODS:Participants were randomized into the JWXY group or the sertraline group.Each group received JWXY treatment and sertraline placebo,or sertraline and JWXY placebo for 8 weeks.Main outcomes were measured using the Hamilton Depression Rating Scale (HAMD),Hamilton Anxiety Rating Scale (HAMA) and the Clinical Global Impression Scale.RESULTS:JWXY and sertraline had the equivalent effect on HAMD at every interview point.JWXY was more effective at reducing the HAMA scores at the 2nd and 12th week,HAMD sleep disturbance subscale scores at the 8th and 12th week,and HAMA somatic anxiety subscale scores at the 12th week.The rate of adverse events in the two groups was the same.CONCLUSION:For mild to moderate depression with anxiety symptoms,JWXY could be as effective as sertraline in alleviating depressive symptoms.For anxiety symptoms,JWXY may be effective more quickly and with longer lasting effects than sertraline.In particular,it may also improve quality of sleep and somatic anxiety symptoms.JWXY is safe and cheaper than conventional antidepressants,and may be the first alternative choice for depression with anxiety symptoms.
文摘Objective:To analyze the effect of acupuncture versus hormone replacement therapy(HRT)for premature ovarian insufficiency(POI).Methods:China National Knowledge Infrastructure(CNKI),Wanfang Academic Journal Full-text Database(Wanfang),Chongqing VIP Database(CQVIP),China Biology Medicine Disc(CBM),Web of Science,Cochrane Library,PubMed,and Excerpta Medica Database(EMBASE)were searched up to January 31st,2019 to identify randomized controlled trials(RCTs)evaluating the effect of acupuncture for POI.The primary outcome was the level of basal serum follicle-stimulating hormone(FSH).Secondary outcomes included serum levels of luteinizing hormone(LH),estradiol(E2)and anti-Müllerian hormone(AMH).Two authors extracted data independently and assessed the risk of bias and the methodological quality using the Cochrane's tool.Meta-analysis was conducted by RevMan version 5.3.Results:Eight eligible RCTs with a total of 496 POI patients were included in the meta-analysis.The pooled results showed that there was a significant reduction in the basal serum FSH level(MD=-5.82,95%CI:-9.76 to-1.87,I2=82%,P=0.004)and a remarkable elevation in the basal E2 level(SMD=0.93,95%CI:0.34 to 1.52,I2=88%,P=0.002)in the acupuncture group when compared with the control.Subgroup analysis showed that compared with HRT,a significant decrease in the FSH level was observed in both acupuncture alone(MD=-4.53,95%CI:-8.96 to-0.10,I2=73%,P=0.04)and acupuncture plus HRT(MD=-9.60,95%CI:-17.60 to-1.61,I2=50%,P=0.02),while a remarkable elevation of E2 was only found in acupuncture plus HRT(SMD=1.43,95%CI:1.03 to 1.82,I2=0%,P<0.00001).There was no significant difference in the LH level between acupuncture and HRT(MD=-3.16,95%CI:-9.41 to 3.10,I2=0%,P=0.32),only one trial reported AMH,and no significant difference was found between acupuncture and HRT.Conclusion:The present study indicated that acupuncture had an advantage over HRT in reducing serum FSH level and increasing serum E2 level in women with POI.However,evidence supporting the finding is limited due to the small sample size,potential methodological flaws and significant heterogeneity.Hence,this conclusion still needs to be verified by high-quality RCTs.
