A comparative three-dimensional(3D)analysis for Casson-nanofluid and Carreau-nanofluid flows due to a flat body in a magnetohydrodynamic(MHD)stratified environment is presented.Flow is estimated to be suspended in a D...A comparative three-dimensional(3D)analysis for Casson-nanofluid and Carreau-nanofluid flows due to a flat body in a magnetohydrodynamic(MHD)stratified environment is presented.Flow is estimated to be suspended in a Darcy-Forchheimer medium.Soret and Dufour responses are also accommodated in the flow field.A moving(rotating)coordinate system is exercised to examine the bidirectionally stretched flow fields(flow,heat transfer,and mass transfer).Nanofluid is compounded by taking ethylene glycol/sodium alginate as base fluid and ferric-oxide(Fe3O4)as nanoparticles.Governing equations are handled by the application of optimal homotopy asymptotic method(OHAM),where convergence parameters are optimized through the classical least square procedure.The novel mechanism(hidden physics)due to appearing parameters is explored with the assistance of tabular and graphical expositions.Outcomes reveal the double behavior state for temperature field with thermal stratification/Dufour number,and for concentration field with Soret number due to the presence of turning points.展开更多
In the present paper, we study the polynomial approximation of entire functions of several complex variables. The characterizations of generalized order and generalized type of entire functions of slow growth are obta...In the present paper, we study the polynomial approximation of entire functions of several complex variables. The characterizations of generalized order and generalized type of entire functions of slow growth are obtained in terms of approximation and interpolation errors.展开更多
In the present paper, we study the polynomial approximation of analytic functions of several complex variables. The characterizations of generalized type of analytic functions of several complex variables have been ob...In the present paper, we study the polynomial approximation of analytic functions of several complex variables. The characterizations of generalized type of analytic functions of several complex variables have been obtained in terms of approximation and interpolation errors.展开更多
Understanding the irrational sentiments of the market participants is necessary for making good investment decisions.Despite the recent academic effort to examine the role of investors’sentiments in market dynamics,t...Understanding the irrational sentiments of the market participants is necessary for making good investment decisions.Despite the recent academic effort to examine the role of investors’sentiments in market dynamics,there is a lack of consensus in delineating the structural aspect of market sentiments.This research is an attempt to address this gap.The study explores the role of irrational investors’sentiments in determining stock market volatility.By employing monthly data on market-related implicit indices,we constructed an irrational sentiment index using principal component analysis.This sentiment index was modelled in the GARCH and Granger causality framework to analyse its contribution to volatility.The results showed that irrational sentiment significantly causes excess market volatility.Moreover,the study indicates that the asymmetrical aspects of an inefficient market contribute to excess volatility and returns.The findings are crucial for retail investors as well as portfolio managers seeking to make an optimum portfolio to maximise profits.展开更多
Indigenous peoples are the custodians of traditional knowledge,encompassing their ideas,innovations,and methods.Throughout history,both plants and animals have served as valuable sources for medicinal remedies,capable...Indigenous peoples are the custodians of traditional knowledge,encompassing their ideas,innovations,and methods.Throughout history,both plants and animals have served as valuable sources for medicinal remedies,capable of treating or preventing illnesses.This article aims to offer a concise overview of the traditional medical uses of vertebrates and the derived products in both human and veterinary medicine.Animal species are utilized as raw materials,and the resulting products are employed to cure a wide array of ailments.In different regions of India,indigenous peoples have diverse traditional applications for vertebrates and their by-products,which are utilized to treat human and animal illnesses.In various parts of India,medical practices involve the use of forty percent mammals,seven percent birds,eleven percent reptiles,eight percent fish,and two percent amphibians.Kerala employs around 69 different animal species and their by-products for the treatment of human and veterinary ailments.Similarly,the Theni district of Tamil Nadu utilizes 69 animals,the state of Madhya Pradesh employs 18 animals,the state of Tripura utilizes 25 animals,and the state of Assam employs 44 animals for the treatment of human and veterinary illnesses.Consequently,the main objective of this review is to provide a summary of the traditional therapeutic applications of animals and the resulting products.展开更多
Objectives:To gather updated information on the traditional uses,phytochemistry,and pharmacological activities of Valeriana jatamansi Jones.Background:V.jatamansi is indigenous to the Himalayas immensely used as tradi...Objectives:To gather updated information on the traditional uses,phytochemistry,and pharmacological activities of Valeriana jatamansi Jones.Background:V.jatamansi is indigenous to the Himalayas immensely used as traditional folk remedy.It contains a variety of secondary metabolites that give it a high medicinal and therapeutic values.For the purpose of collecting relevant information on V.jatamansi,a comprehensive literature search was conducted.Based on ethnobotanical sources and historical records,traditional uses were compiled.Scientific articles and databases were consulted for phytochemical data.In order to assess the plant’s therapeutic properties,pharmacological studies were reviewed.Summary:The botanical is known for its ethnobotanical uses ranging from sedative and anxiolytic effects to treating insomnia,epilepsy,and gastrointestinal disorders.Indigenous healing practices rely heavily on its traditional uses.Based on the phytochemical analysis,it contains a diverse array of bioactive compounds,including sesquiterpenoids and iridoids.Valerenic acid and jatamansinol,among other compounds,contribute to its therapeutic potential.A broad spectrum of pharmacological activities is found including anxiety-relieving,sedative,anti-inflammatory,neuroprotective,and antimicrobial effects.Outlook:Based on the evidence supporting ethnomedicinal uses of V.jatamansi,its immense biopotential and multiple pharmacological roles,standard clinical trials are required to evaluate its therapeutic potential.展开更多
Scrub typhus is a neglected disease and one of the most serious health problems in the Asia-Pacific region.The disease is caused by an obligate intracellular bacteria Orientia tsutsugamushi,which is transmitted by chi...Scrub typhus is a neglected disease and one of the most serious health problems in the Asia-Pacific region.The disease is caused by an obligate intracellular bacteria Orientia tsutsugamushi,which is transmitted by chigger bites or larval mite bites.Scrub typhus is a threat to billions of people worldwide causing different health complications and acute encephalitis in infants and growing children.The disease causes multiple organ failure and mortality rates may reach up to 70%due to a lack of appropriate healthcare.Currently available genome and proteome databases,and bioinformatics methods are valuable tools to develop novel therapeutics to curb the pathogen.This review discusses the state-of-the-art of information about Orientia tsutsugamushi-mediated scrub typhus and delineates the role of omics technologies to develop drugs against the pathogen.The role of proteome-wide in silico approaches for the identification of therapeutic targets is also highlighted.展开更多
The various methods for microwave processing of materials exhibit numerous advantages,such as short processing times,high yield,expanded reaction conditions,high reproducibility,and high purity of products.Microwave-a...The various methods for microwave processing of materials exhibit numerous advantages,such as short processing times,high yield,expanded reaction conditions,high reproducibility,and high purity of products.Microwave-assisted synthesis strategies have been widely adopted for the preparation of highperformance graphene-based materials for supercapacitor electrodes.Metal oxides,mixed metal oxides,metal hydroxides,layered double hydroxides,carbon nanotubes and conducting polymers are some of the main materials which have been added to graphene derivatives for advanced composite/hybrid electrodes.This review article first provides a brief introduction and an overview of microwave heating and its advantages for processing graphene-based electrode materials.After that,a systematic survey of recently published research on microwave irradiation-assisted processing is presented,focusing on:(i)transformation of graphite/graphite oxide into graphene/graphene oxide by exfoliation and reduction;(ii)formation of graphene derivatives in various liquid and gaseous media;(iii)modification of graphene derivatives with various metal oxides/hydroxides,carbon nanotubes,and conducting polymers for use in supercapacitors.Major challenges and future perspectives for microwave-assisted processing of graphene-based materials for cutting-edge supercapacitor electrode applications are also summarized in the conclusion.展开更多
Xanthomonas oryzae pv.oryzae(Xoo) is an important rice pathogen.This is a vascular pathogen entering the plant via the hydathodes causing rice bacterial blight.It has been known that most regulation of pathogenicity f...Xanthomonas oryzae pv.oryzae(Xoo) is an important rice pathogen.This is a vascular pathogen entering the plant via the hydathodes causing rice bacterial blight.It has been known that most regulation of pathogenicity factor F(RpfF) genes in Xanthomonas regulates virulence in response to the diffusible signal factor(DSF).The RpfF recognized as an attractive drug target in bacterial rice blight disease.In this study,we performed the gene-gene interaction of RpfF and pathway functional analysis.3 D structure of RpfF protein was predicted using a homology modelling tool Swiss-Model and refined by molecular dynamics(MD) simulation.The refined model protein was predicted structural assessment using various tools such as PROCHECK,ERRAT,and VERIFY-3 D.We have collected 2 500 rifampicin analogues from Zinc Database by virtual screening.The screened compounds were docked into the active site of the RpfF protein using AutoDock Vina in PyRx Virtual Screening Tool.Furthermore,docking result and in silico ADMET analysis described that the compounds ZINC03056414,ZINC03205310,ZINC08673779,ZINC09100848,ZINC09729566,ZINC11415953,ZINC12810788,ZINC24989313,ZINC27441787 and ZINC32739565 have best binding energies and less toxicity than reference compound.This study revealed that the active site residues such as HIS-118,HIS-147,THR-148,ARG-179,ASP-207,ARG-240 and THR-244 are key roles in the pathogenicity.It could be beneficial in the design of small molecule therapeutics or the treatment of rice bacterial blight disease.展开更多
Background:The severe acute respiratory syndrome Coronavirus-2 causing COVID-19 viral infection was first reported in late December 2019,spreading swiftly across all over the world.WHO declared it a pandemic by March ...Background:The severe acute respiratory syndrome Coronavirus-2 causing COVID-19 viral infection was first reported in late December 2019,spreading swiftly across all over the world.WHO declared it a pandemic by March 2020.Many problems emerged worldwide healthcare system and economic burden due to viral outbreak.High transmission rate and infectious nature make COVID-19 pandemic.Effectively managing outbreak and controlling spread is challenging.Despite valiant efforts to contain the COVID-19 outbreak,the situation has deteriorated to the point that there were no viable preventive therapies to treat this disease.Developing effective treatment for COVID-19 has been a complex and ongoing endeavor.Objective:The aim of this systematic review is to evaluate the structure,epidemiology,pathophysiology,po-tential therapeutic treatments,and preventive measures adopted in Traditional Chinese Medicine(TCM)in the management of Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)virus.Methods:A systematic methodology has been adopted in this study following PRISMA guidelines.Several key-words like“COVID-19”“SARS-CoV-2”“Coronavirus”and“Traditional Chinese Medicine”were searched in var-ious databases like ScienceDirect,Google Scholar,PubMed,and ResearchGate during the time span of 2010-2023.Clinical trials and studies relevant to this study were identified through a systematic search strategy fol-lowing PRISMA methodology.Results:In this systematic review,after careful evaluation and reviewing of literature through PRISMA guidelines,145 relevant studies were identified,reviewed and included in this systematic review.A detailed study has been summarized on virus structure,etiology,epidemiology characteristics,pathophysiology,and potential therapeutic treatments and preventive measures adopted in traditional medicinal system in the treatment of infected COVID-19 patients.Conclusion:SARS-CoV-2 transmission dynamics and pathogenesis were revealed by the etiology analysis.COVID-19 symptoms and severe disease outcomes can be managed with certain repurposed drugs,traditional medicinal system and antivirals,which have been shown to be effective in treating COVID-19 infection.展开更多
The significance of graphene and its two-dimensional(2D)analogous inorganic layered materials especially as hexagonal boron nitride(h-BN)and molybdenum disulphide(MoS2)for“clean energy”applications became apparent o...The significance of graphene and its two-dimensional(2D)analogous inorganic layered materials especially as hexagonal boron nitride(h-BN)and molybdenum disulphide(MoS2)for“clean energy”applications became apparent over the last few years due to their extraordinary properties.In this review article we study the current progress and selected challenges in the syntheses of graphene,h-BN and MoS2 including energy storage applications as supercapacitors and batteries.Various substrates/catalysts(metals/insulator/semiconducting)have been used to obtain graphene,h-BN and MoS2 using different kinds of precursors.The most widespread methods for synthesis of graphene,h-BN and MoS2 layers are chemical vapor deposition(CVD),plasma-enhanced CVD,hydro/solvothermal methods,liquid phase exfoliation,physical methods etc.Current research has shown that graphene,h-BN and MoS2 layered materials modified with metal oxide can have an insightful influence on the performance of energy storage devices as supercapacitors and batteries.This review article also contains the discussion on the opportunities and perspectives of these materials(graphene,h-BN and MoS2)in the energy storage fields.We expect that this witen review article including recent research on energy storage will help in generating new insights for further development and practical applications of graphene,h-BN and MoS2 layers based materials.展开更多
Indus river valley basin in Northwest Indian Himalaya is tectonically unstable, exhibiting a complex topography, landscape relief and varied Quaternary sedimentation. A 422 km transact along the Indus river valley fro...Indus river valley basin in Northwest Indian Himalaya is tectonically unstable, exhibiting a complex topography, landscape relief and varied Quaternary sedimentation. A 422 km transact along the Indus river valley from Nyoma to Batalik in Ladakh(Trans Himalayas) reveals the damming of the river four places and existence of four major palaeolakes in the Late Quaternary Period. The commencement and breeching of the palaeolake sequences and the seismites preserved therein mark of the tectonic pluses in the area but the contribution of climate cannot be ruled out. The major geomorphic landforms are alluvial fans, debris cones, unsorted pedestals, fluvio-lacustrine deposits, scree, talus cone etc. Ubiquitous mass movements and catastrophic land sliding, due to tectonic activity and abnormally high precipitation has transported the material from steep slopes to valley bottoms, was responsible of forming lakes(preserved as thick piles of fine sediment), while the outburst floods redistributed the sediment down valley. Chronologies of two lakes are available which reveal the presence of one during post LGM times around 17000 a BP which breached out prior to Older Dryas indicating of warmer and congenial rainfall and melt water supply between these two globally marked cold episode. Other lake was formed after the Younger Dryas and existed till ~1000 a BP indicative of the Holocene warming responsible for its sustenance.展开更多
In this problem,simultaneous effects of Joule and viscous dissipation in three-dimensional flow of nanoliquid have been addressed in slip flow regime under time dependent rotational oscillations.Silver nanoparticles a...In this problem,simultaneous effects of Joule and viscous dissipation in three-dimensional flow of nanoliquid have been addressed in slip flow regime under time dependent rotational oscillations.Silver nanoparticles are submerged in the base fluid(water)due to their chemical and biological features.To increment the novelty,effects of cubic autocatalysis chemical reactions and radiative heat transfer have been incorporated in the related boundary layer equations.Dimensionless partial differential system is solved by employing the proposed implicit finite difference approach.Convergence conditions and stability criteria are obtained to ensure the convergence and accuracy of solutions.A comparative analysis is proposed for no-slip nanofluid flow(NSNF)and slip nanofluid flow(SNF).Variations in skin-friction coefficients,Sherwood and Nusselt numbers against physical parameters are tabulated.It is investigated that velocity slip and temperature jump significantly control drag forces and rate of heat transfer.展开更多
The aim of this study is to construct inverse potentials for various ℓ-channels of neutron-proton scattering using a piece-wise smooth Morse function as a reference.The phase equations for single-channel states and th...The aim of this study is to construct inverse potentials for various ℓ-channels of neutron-proton scattering using a piece-wise smooth Morse function as a reference.The phase equations for single-channel states and the coupled equations of multi-channel scattering are solved numerically using the 5^(th) order Runge-kutta method.We employ a piece-wise smooth reference potential comprising three Morse functions as the initial input.Leveraging a machine learning-based genetic algorithm,we optimize the model parameters to minimize the mean-squared error between simulated and anticipated phase shifts.Our approach yields inverse potentials for both single and multichannel scattering,achieving convergence to a mean-squared error≤10^(-3).The resulting scattering lengths"a_(0)"and effective ranges"r"for ^(3)S_(1) and ^(1)S_(0) states,expressed as[a_(0),r],are found to be[5.445(5.424),1.770(1.760)]and[–23.741(–23.749),2.63(2.81)],respectively;these values are in excellent agreement with experimental ones.Furthermore,the calculated total scattering cross-sections are highly consistent with their experimental counterparts,having a percentage error of less than 1%.This computational approach can be easily extended to obtain interaction potentials for charged particle scattering.展开更多
Over the last few years,the need of a cloud environment with the ability to detect illegal behaviours along with a secured data storage capability has increased largely.This study presents such a secured cloud storage...Over the last few years,the need of a cloud environment with the ability to detect illegal behaviours along with a secured data storage capability has increased largely.This study presents such a secured cloud storage framework comprising of a deoxyribonucleic acid(DNA)based encryption key which has been generated to make the framework unbreakable,thus ensuring a better and secured distributed cloud storage environment.Furthermore,this work proposes a novel DNA-based encryption technique inspired by the biological characteristics of DNA and the protein synthesis mechanism.The introduced DNA based model also has an additional advantage of being able to decide on selecting suitable storage servers from an existing pool of storage servers on which the data must be stored.A fuzzy-based technique for order of preference by similarity to ideal solution(TOFSIS)multi-criteria decisionmaking(MCDM)model has been employed to achieve the above-mentioned goal.This can decide the set of suitable storage servers and also results in a reduction in execution time by keeping up the level of security to an improved grade.This study also investigates and analyzes the strength of the proposed S-Box and encryption technique against some standard criteria and benchmarks,such as avalanche effect,correlation coefficient,information entropy,linear probability,and differential probability etc.After the avalanche effect analysis,the average change in cipher-text has been found to be 51.85%.Moreover,thorough security,sensitivity and functionality analysis show that the proposed scheme guarantees high security with robustness.展开更多
文摘A comparative three-dimensional(3D)analysis for Casson-nanofluid and Carreau-nanofluid flows due to a flat body in a magnetohydrodynamic(MHD)stratified environment is presented.Flow is estimated to be suspended in a Darcy-Forchheimer medium.Soret and Dufour responses are also accommodated in the flow field.A moving(rotating)coordinate system is exercised to examine the bidirectionally stretched flow fields(flow,heat transfer,and mass transfer).Nanofluid is compounded by taking ethylene glycol/sodium alginate as base fluid and ferric-oxide(Fe3O4)as nanoparticles.Governing equations are handled by the application of optimal homotopy asymptotic method(OHAM),where convergence parameters are optimized through the classical least square procedure.The novel mechanism(hidden physics)due to appearing parameters is explored with the assistance of tabular and graphical expositions.Outcomes reveal the double behavior state for temperature field with thermal stratification/Dufour number,and for concentration field with Soret number due to the presence of turning points.
文摘In the present paper, we study the polynomial approximation of entire functions of several complex variables. The characterizations of generalized order and generalized type of entire functions of slow growth are obtained in terms of approximation and interpolation errors.
文摘In the present paper, we study the polynomial approximation of analytic functions of several complex variables. The characterizations of generalized type of analytic functions of several complex variables have been obtained in terms of approximation and interpolation errors.
文摘Understanding the irrational sentiments of the market participants is necessary for making good investment decisions.Despite the recent academic effort to examine the role of investors’sentiments in market dynamics,there is a lack of consensus in delineating the structural aspect of market sentiments.This research is an attempt to address this gap.The study explores the role of irrational investors’sentiments in determining stock market volatility.By employing monthly data on market-related implicit indices,we constructed an irrational sentiment index using principal component analysis.This sentiment index was modelled in the GARCH and Granger causality framework to analyse its contribution to volatility.The results showed that irrational sentiment significantly causes excess market volatility.Moreover,the study indicates that the asymmetrical aspects of an inefficient market contribute to excess volatility and returns.The findings are crucial for retail investors as well as portfolio managers seeking to make an optimum portfolio to maximise profits.
文摘Indigenous peoples are the custodians of traditional knowledge,encompassing their ideas,innovations,and methods.Throughout history,both plants and animals have served as valuable sources for medicinal remedies,capable of treating or preventing illnesses.This article aims to offer a concise overview of the traditional medical uses of vertebrates and the derived products in both human and veterinary medicine.Animal species are utilized as raw materials,and the resulting products are employed to cure a wide array of ailments.In different regions of India,indigenous peoples have diverse traditional applications for vertebrates and their by-products,which are utilized to treat human and animal illnesses.In various parts of India,medical practices involve the use of forty percent mammals,seven percent birds,eleven percent reptiles,eight percent fish,and two percent amphibians.Kerala employs around 69 different animal species and their by-products for the treatment of human and veterinary ailments.Similarly,the Theni district of Tamil Nadu utilizes 69 animals,the state of Madhya Pradesh employs 18 animals,the state of Tripura utilizes 25 animals,and the state of Assam employs 44 animals for the treatment of human and veterinary illnesses.Consequently,the main objective of this review is to provide a summary of the traditional therapeutic applications of animals and the resulting products.
文摘Objectives:To gather updated information on the traditional uses,phytochemistry,and pharmacological activities of Valeriana jatamansi Jones.Background:V.jatamansi is indigenous to the Himalayas immensely used as traditional folk remedy.It contains a variety of secondary metabolites that give it a high medicinal and therapeutic values.For the purpose of collecting relevant information on V.jatamansi,a comprehensive literature search was conducted.Based on ethnobotanical sources and historical records,traditional uses were compiled.Scientific articles and databases were consulted for phytochemical data.In order to assess the plant’s therapeutic properties,pharmacological studies were reviewed.Summary:The botanical is known for its ethnobotanical uses ranging from sedative and anxiolytic effects to treating insomnia,epilepsy,and gastrointestinal disorders.Indigenous healing practices rely heavily on its traditional uses.Based on the phytochemical analysis,it contains a diverse array of bioactive compounds,including sesquiterpenoids and iridoids.Valerenic acid and jatamansinol,among other compounds,contribute to its therapeutic potential.A broad spectrum of pharmacological activities is found including anxiety-relieving,sedative,anti-inflammatory,neuroprotective,and antimicrobial effects.Outlook:Based on the evidence supporting ethnomedicinal uses of V.jatamansi,its immense biopotential and multiple pharmacological roles,standard clinical trials are required to evaluate its therapeutic potential.
基金Department of Health Research,Government of India,New Delhi,India(Grant number:YSS/2020/000116/PRCYSS)。
文摘Scrub typhus is a neglected disease and one of the most serious health problems in the Asia-Pacific region.The disease is caused by an obligate intracellular bacteria Orientia tsutsugamushi,which is transmitted by chigger bites or larval mite bites.Scrub typhus is a threat to billions of people worldwide causing different health complications and acute encephalitis in infants and growing children.The disease causes multiple organ failure and mortality rates may reach up to 70%due to a lack of appropriate healthcare.Currently available genome and proteome databases,and bioinformatics methods are valuable tools to develop novel therapeutics to curb the pathogen.This review discusses the state-of-the-art of information about Orientia tsutsugamushi-mediated scrub typhus and delineates the role of omics technologies to develop drugs against the pathogen.The role of proteome-wide in silico approaches for the identification of therapeutic targets is also highlighted.
基金Science and Engineering Research Board(SERB),Department of Science&Technology(DST),New Delhi,India for providing research fund under Ramanujan Fellowship/Award(SB/S2/RJN-159/2017)。
文摘The various methods for microwave processing of materials exhibit numerous advantages,such as short processing times,high yield,expanded reaction conditions,high reproducibility,and high purity of products.Microwave-assisted synthesis strategies have been widely adopted for the preparation of highperformance graphene-based materials for supercapacitor electrodes.Metal oxides,mixed metal oxides,metal hydroxides,layered double hydroxides,carbon nanotubes and conducting polymers are some of the main materials which have been added to graphene derivatives for advanced composite/hybrid electrodes.This review article first provides a brief introduction and an overview of microwave heating and its advantages for processing graphene-based electrode materials.After that,a systematic survey of recently published research on microwave irradiation-assisted processing is presented,focusing on:(i)transformation of graphite/graphite oxide into graphene/graphene oxide by exfoliation and reduction;(ii)formation of graphene derivatives in various liquid and gaseous media;(iii)modification of graphene derivatives with various metal oxides/hydroxides,carbon nanotubes,and conducting polymers for use in supercapacitors.Major challenges and future perspectives for microwave-assisted processing of graphene-based materials for cutting-edge supercapacitor electrode applications are also summarized in the conclusion.
文摘Xanthomonas oryzae pv.oryzae(Xoo) is an important rice pathogen.This is a vascular pathogen entering the plant via the hydathodes causing rice bacterial blight.It has been known that most regulation of pathogenicity factor F(RpfF) genes in Xanthomonas regulates virulence in response to the diffusible signal factor(DSF).The RpfF recognized as an attractive drug target in bacterial rice blight disease.In this study,we performed the gene-gene interaction of RpfF and pathway functional analysis.3 D structure of RpfF protein was predicted using a homology modelling tool Swiss-Model and refined by molecular dynamics(MD) simulation.The refined model protein was predicted structural assessment using various tools such as PROCHECK,ERRAT,and VERIFY-3 D.We have collected 2 500 rifampicin analogues from Zinc Database by virtual screening.The screened compounds were docked into the active site of the RpfF protein using AutoDock Vina in PyRx Virtual Screening Tool.Furthermore,docking result and in silico ADMET analysis described that the compounds ZINC03056414,ZINC03205310,ZINC08673779,ZINC09100848,ZINC09729566,ZINC11415953,ZINC12810788,ZINC24989313,ZINC27441787 and ZINC32739565 have best binding energies and less toxicity than reference compound.This study revealed that the active site residues such as HIS-118,HIS-147,THR-148,ARG-179,ASP-207,ARG-240 and THR-244 are key roles in the pathogenicity.It could be beneficial in the design of small molecule therapeutics or the treatment of rice bacterial blight disease.
文摘Background:The severe acute respiratory syndrome Coronavirus-2 causing COVID-19 viral infection was first reported in late December 2019,spreading swiftly across all over the world.WHO declared it a pandemic by March 2020.Many problems emerged worldwide healthcare system and economic burden due to viral outbreak.High transmission rate and infectious nature make COVID-19 pandemic.Effectively managing outbreak and controlling spread is challenging.Despite valiant efforts to contain the COVID-19 outbreak,the situation has deteriorated to the point that there were no viable preventive therapies to treat this disease.Developing effective treatment for COVID-19 has been a complex and ongoing endeavor.Objective:The aim of this systematic review is to evaluate the structure,epidemiology,pathophysiology,po-tential therapeutic treatments,and preventive measures adopted in Traditional Chinese Medicine(TCM)in the management of Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)virus.Methods:A systematic methodology has been adopted in this study following PRISMA guidelines.Several key-words like“COVID-19”“SARS-CoV-2”“Coronavirus”and“Traditional Chinese Medicine”were searched in var-ious databases like ScienceDirect,Google Scholar,PubMed,and ResearchGate during the time span of 2010-2023.Clinical trials and studies relevant to this study were identified through a systematic search strategy fol-lowing PRISMA methodology.Results:In this systematic review,after careful evaluation and reviewing of literature through PRISMA guidelines,145 relevant studies were identified,reviewed and included in this systematic review.A detailed study has been summarized on virus structure,etiology,epidemiology characteristics,pathophysiology,and potential therapeutic treatments and preventive measures adopted in traditional medicinal system in the treatment of infected COVID-19 patients.Conclusion:SARS-CoV-2 transmission dynamics and pathogenesis were revealed by the etiology analysis.COVID-19 symptoms and severe disease outcomes can be managed with certain repurposed drugs,traditional medicinal system and antivirals,which have been shown to be effective in treating COVID-19 infection.
基金R.K.acknowledges Japan Society for the Promotion of Science(JSPSStandard)for international postdoctoral fellowship(P18063)and this research work was supported by JSPS KAKENHI Grant No.18F18063.A.M.acknowledges the financial support from JSPS KAKENHI Grant JP-18H03841 and JSPS KAKENHI Grant JP-17K18985.R.K.and A.M.would like to thanks Toyohashi University of Technology,Toyohashi,Aichi,Japan for providing the necessarily support and facilities to complete this work.S.S.acknowledges DST-SERB,India for the national postdoctoral fellowship(NPDF File No.PDF/2017/000328).D.P.S.acknowledges with gratitude the financial support from Millennium Institute for Research in Optics(MIRO),CHILE.R.K.would like to dedicate this work to the memory of late Prof.Yoshiyuki Suda.
文摘The significance of graphene and its two-dimensional(2D)analogous inorganic layered materials especially as hexagonal boron nitride(h-BN)and molybdenum disulphide(MoS2)for“clean energy”applications became apparent over the last few years due to their extraordinary properties.In this review article we study the current progress and selected challenges in the syntheses of graphene,h-BN and MoS2 including energy storage applications as supercapacitors and batteries.Various substrates/catalysts(metals/insulator/semiconducting)have been used to obtain graphene,h-BN and MoS2 using different kinds of precursors.The most widespread methods for synthesis of graphene,h-BN and MoS2 layers are chemical vapor deposition(CVD),plasma-enhanced CVD,hydro/solvothermal methods,liquid phase exfoliation,physical methods etc.Current research has shown that graphene,h-BN and MoS2 layered materials modified with metal oxide can have an insightful influence on the performance of energy storage devices as supercapacitors and batteries.This review article also contains the discussion on the opportunities and perspectives of these materials(graphene,h-BN and MoS2)in the energy storage fields.We expect that this witen review article including recent research on energy storage will help in generating new insights for further development and practical applications of graphene,h-BN and MoS2 layers based materials.
文摘Indus river valley basin in Northwest Indian Himalaya is tectonically unstable, exhibiting a complex topography, landscape relief and varied Quaternary sedimentation. A 422 km transact along the Indus river valley from Nyoma to Batalik in Ladakh(Trans Himalayas) reveals the damming of the river four places and existence of four major palaeolakes in the Late Quaternary Period. The commencement and breeching of the palaeolake sequences and the seismites preserved therein mark of the tectonic pluses in the area but the contribution of climate cannot be ruled out. The major geomorphic landforms are alluvial fans, debris cones, unsorted pedestals, fluvio-lacustrine deposits, scree, talus cone etc. Ubiquitous mass movements and catastrophic land sliding, due to tectonic activity and abnormally high precipitation has transported the material from steep slopes to valley bottoms, was responsible of forming lakes(preserved as thick piles of fine sediment), while the outburst floods redistributed the sediment down valley. Chronologies of two lakes are available which reveal the presence of one during post LGM times around 17000 a BP which breached out prior to Older Dryas indicating of warmer and congenial rainfall and melt water supply between these two globally marked cold episode. Other lake was formed after the Younger Dryas and existed till ~1000 a BP indicative of the Holocene warming responsible for its sustenance.
文摘In this problem,simultaneous effects of Joule and viscous dissipation in three-dimensional flow of nanoliquid have been addressed in slip flow regime under time dependent rotational oscillations.Silver nanoparticles are submerged in the base fluid(water)due to their chemical and biological features.To increment the novelty,effects of cubic autocatalysis chemical reactions and radiative heat transfer have been incorporated in the related boundary layer equations.Dimensionless partial differential system is solved by employing the proposed implicit finite difference approach.Convergence conditions and stability criteria are obtained to ensure the convergence and accuracy of solutions.A comparative analysis is proposed for no-slip nanofluid flow(NSNF)and slip nanofluid flow(SNF).Variations in skin-friction coefficients,Sherwood and Nusselt numbers against physical parameters are tabulated.It is investigated that velocity slip and temperature jump significantly control drag forces and rate of heat transfer.
基金Support provided by Department of Science and Technology(DST),Government of India vide Grant No.DST/INSPIRE Fellowship/2020/IF200538。
文摘The aim of this study is to construct inverse potentials for various ℓ-channels of neutron-proton scattering using a piece-wise smooth Morse function as a reference.The phase equations for single-channel states and the coupled equations of multi-channel scattering are solved numerically using the 5^(th) order Runge-kutta method.We employ a piece-wise smooth reference potential comprising three Morse functions as the initial input.Leveraging a machine learning-based genetic algorithm,we optimize the model parameters to minimize the mean-squared error between simulated and anticipated phase shifts.Our approach yields inverse potentials for both single and multichannel scattering,achieving convergence to a mean-squared error≤10^(-3).The resulting scattering lengths"a_(0)"and effective ranges"r"for ^(3)S_(1) and ^(1)S_(0) states,expressed as[a_(0),r],are found to be[5.445(5.424),1.770(1.760)]and[–23.741(–23.749),2.63(2.81)],respectively;these values are in excellent agreement with experimental ones.Furthermore,the calculated total scattering cross-sections are highly consistent with their experimental counterparts,having a percentage error of less than 1%.This computational approach can be easily extended to obtain interaction potentials for charged particle scattering.
基金This publication was an outcome of the R&D work undertaken project under the Visvesvaraya PhD Scheme of Ministry of Electronics&Information Technology,Government of India,being implemented by Digital India Corporation.
文摘Over the last few years,the need of a cloud environment with the ability to detect illegal behaviours along with a secured data storage capability has increased largely.This study presents such a secured cloud storage framework comprising of a deoxyribonucleic acid(DNA)based encryption key which has been generated to make the framework unbreakable,thus ensuring a better and secured distributed cloud storage environment.Furthermore,this work proposes a novel DNA-based encryption technique inspired by the biological characteristics of DNA and the protein synthesis mechanism.The introduced DNA based model also has an additional advantage of being able to decide on selecting suitable storage servers from an existing pool of storage servers on which the data must be stored.A fuzzy-based technique for order of preference by similarity to ideal solution(TOFSIS)multi-criteria decisionmaking(MCDM)model has been employed to achieve the above-mentioned goal.This can decide the set of suitable storage servers and also results in a reduction in execution time by keeping up the level of security to an improved grade.This study also investigates and analyzes the strength of the proposed S-Box and encryption technique against some standard criteria and benchmarks,such as avalanche effect,correlation coefficient,information entropy,linear probability,and differential probability etc.After the avalanche effect analysis,the average change in cipher-text has been found to be 51.85%.Moreover,thorough security,sensitivity and functionality analysis show that the proposed scheme guarantees high security with robustness.
