This work focuses on an integrated approach for lake ecological status assessment, elaborated according to the requirements of the European Water Framework Directive (WFD). Data from five lowland and semi-mountain lak...This work focuses on an integrated approach for lake ecological status assessment, elaborated according to the requirements of the European Water Framework Directive (WFD). Data from five lowland and semi-mountain lakes in Bulgaria (Southeast Europe) collected from two years (2011-2012) form the basis for an integrated assessment and the definition of reference conditions. Several metrics were applied in combination, to classify lakes into five ecological status classes. Assemblages of aquatic organisms: phytoplankton, macrophytes and benthic macroinvertebrates, together with 11 supporting physico-chemical parameters were studied. The assessed unique conditions suggested that reference conditions of Bulgarian lakes have natural variability. This first baseline study illustrated specific cases within the lake types that should be assessed in details before providing standardized classification systems in compliance with the requirements of WFD.展开更多
How can music be a modus of accomplishing what Husserl calls“a radical,skeptical epochē”,that is,a way of refraining from judgment about all that is to be known?In order to answer the question,we have to first subm...How can music be a modus of accomplishing what Husserl calls“a radical,skeptical epochē”,that is,a way of refraining from judgment about all that is to be known?In order to answer the question,we have to first submit music itself to the act of epochē.This will allow us to get free from the widespread opinion that music is only an art,and to understand it in a broad sense,namely as a sphere of Being.This sphere is founded on the tone which,on its part,is thinkable not as an expression of the number(as in the Pythagorean tradition)or a medium for voicing,supplementing,or accompanying words,but as a primary essence enabling us to reach the truth of Being in a direct and immediate way.Hence,music provides an advantage for the one who chooses it as a way of accomplishing epochē.In providing immediate access to the truth of all thinkable things and of Being itself,it releases him from the necessity to cover any distance to it by passing through concepts,notions,and ideas in relation to which he is required to exercise the discipline of epochē.展开更多
The current study was performed to evaluate the liver function status as well as molecular characterization of the recovered worms in rats experimentally infected with F. hepatica. Sixteen male Wister rats aged 30 day...The current study was performed to evaluate the liver function status as well as molecular characterization of the recovered worms in rats experimentally infected with F. hepatica. Sixteen male Wister rats aged 30 days were randomly allocated into two groups (n = 8). The first group was infected orally with 15 viable encysted metacercaria of F. hepatica per animal. The other group was kept non-infected (control group). At zero time (before infection), the 2<sup>nd</sup>, 4<sup>th</sup>, 6<sup>th</sup>, 8<sup>th</sup>, 10<sup>th</sup>, 12<sup>th</sup> and 14<sup>th</sup> weeks post-infection (WPI), blood and serum samples were collected via puncture of retro-orbital plexus of veins from each rat. Serum enzyme level (AST and ALT) and total protein were measured, and the serum protein profile was carried out using agarose gel electrophoresis. During the period of the experiment, serum ALT and AST activities and serum total globulins significantly increased while serum total proteins and albumin markedly decreased in the infected group. On the 14<sup>th</sup> WPI, the data of the electropherogram showed that globulin fractions (α1-, β- and γ-globulin) levels were significantly increased while α2-globulin was markedly decreased in the infected group. The molecular analysis confirmed the amplification of the ITS1, ITS2 and NDI genes of F. hepatica recovered from the infected liver of rats with amplicon sizes of 630, 510 and 560 bp, respectively. Sequencing of the amplified ITS gene resulted in the determination of 3 strains (PP108836, PP108837, and PP108838). Also, analysis of the ITS2 gene resulted in obtaining 3 isolates under the accession numbers (PP109065, PP109066, and PP109067). In conclusion, fasciolosis in the rat model is suitable for routine experimental infections and caused a pronounced liver dysfunction with discharging of the Fasciola eggs in the faeces and the development of adult stages in the bile ducts. Furthermore, molecular techniques are a sensitive tool for the identification and characterisation of the Fasciola parasite.展开更多
A prominent Iranian philosopher Ahmad Fardid considered the influential German philosopher Martin Heidegger as“the only Western philosopher who understood the world and the only philosopher whose insights were congru...A prominent Iranian philosopher Ahmad Fardid considered the influential German philosopher Martin Heidegger as“the only Western philosopher who understood the world and the only philosopher whose insights were congruent with the principles of the Islamic Republic”.The report aimed to present Fardid’s interpretation of Heidegger in the light of Iranian-Islamic wisdom.Iranian philosopher believes that Heidegger’s thought responds to the most important intellectual crisis of the West civilization that is nihilism and to reach the possibility of an“other beginning”of thinking that he calls“No-longer-metaphysical-thought”.Considering these two fundamental features,Fardid founds powerful religious-spiritual tendencies in Heidegger’s thinking.展开更多
The work analyzes the basic assumption in Mach’s principle, namely that the inertia of material bodies is determined by their gravitational interaction with distant masses in the universe. However, while Mach’s prin...The work analyzes the basic assumption in Mach’s principle, namely that the inertia of material bodies is determined by their gravitational interaction with distant masses in the universe. However, while Mach’s principle is based on the so-called “long-range gravitational interaction” characterized by an infinitely large propagation velocity, our study is based on a “modified” long-range principle, assuming a very large but finite propagation velocity of the gravitational interaction between local material objects and distant matter. Thus, it is postulated that there are two types of gravitational interaction—short-range gravitational interaction between local objects and long-range gravitational interaction between local objects and distant matter in the universe, which are characterized by different propagation speeds, but with the same gravitational constant. On the basis of the modified long-range principle, a model of distant matter is built in the form of a hollow spherical layer with negligible thickness. The phenomenological assumption is made that the movement with acceleration of the local reference frame (RF) is related to a change in the spherically symmetric distribution of the lines of gravitational interaction of this RF with distant matter, which is expressed in a corresponding asymmetric distribution of the effective mass density on the hollow sphere. A simplified (idealized) model of the effective change of the hollow sphere of distant matter by cutting off separate segments of the sphere is proposed. On the basis of the model, the possibility of representing the inertial effects in three simplest types of reference frames through a corresponding gravitational interaction is considered: 1) inertial RF;2) RF moving in a straight line with constant acceleration;3) RF rotating with constant angular velocity. Expressions were obtained for the gravitational accelerations acting on the test body located inside the hollow sphere with a corresponding change (“cutting”). It is concluded that these accelerations can in a first approximation represent the inertial accelerations of the main types noted above. It is shown that in order to obtain reasonable values of the truncation parameters of the hollow sphere, it is necessary to assume that the gravitational interaction inside this sphere is not of the Newtonian type, i.e. the same depends on the distance not according to the law 1/r2, but according to modified law with a non-integer (fractional) exponent. This law corresponds to a fractal structure of the source of attraction inside the truncated sphere of distant matter. The issue of the possibility of the supposed modified long-range interaction is briefly discussed on the basis of a comparison of the finding a connection with the lines of force of the same with the “cosmic strings” assumed by a number of researchers, along which corresponding excitations (waves, particles) moving at super-light speed. The work advances the idea of the presence of unity and at the same time oppositeness of the inertia of material objects and the known gravitational interaction between them, which are generated by the properties of symmetry of the long-range gravitational interaction. Moreover, while the inertia of the bodies is due to the violation of this symmetry caused by their movement with acceleration, the gravitational interaction between the bodies is due to the aspiration to restore the symmetry of a far-reaching gravitational interaction, which is disturbed by the presence of local material bodies. In the conclusion of the work, the important physico-philosophical significance of Mach’s principle is emphasized, expressed in the understanding that not only the world of microscopic objects (“micro-world”), but also the world of huge cosmic objects (“mega-world”) can have a corresponding impact on our “macroscopic” world.展开更多
The experimental research programs of 1950s, to understand the adsorption of CO on W surfaces, changed to ab initio studies in 2000s. The goals were to seek improved practical applications. Most of the studies were ba...The experimental research programs of 1950s, to understand the adsorption of CO on W surfaces, changed to ab initio studies in 2000s. The goals were to seek improved practical applications. Most of the studies were based on density functional theory. Many studies also used programs, such as VASP (Vienna Abinitio simulation package) and CPMD. The computational procedures used plane wave approximations. This needed studies with selection of K points and cutoff energy selection to assure convergence in energy calculations. Observations and analysis of papers published from 2006 to 2022 indicate that the cutoff energies were selected arbitrarily without any needed convergence studies. By selecting a published 2006 paper, this paper has clearly showed that an arbitrary selection of cutoff energy, such as 460 eV, is not in the range of, cutoff energies that assure convergence of energy calculations, with ab initio methods and have indicated correction procedures. .展开更多
Finite element simulations are carried out to examine the mechanical behavior of the metallic hollow sphere （MHS） material during their large plastic deformation and to estimate the energy absorbing capacity of thes...Finite element simulations are carried out to examine the mechanical behavior of the metallic hollow sphere （MHS） material during their large plastic deformation and to estimate the energy absorbing capacity of these materials under uniaxial compression. A simplified model is proposed from experimental observations to describe the connection between the neighboring spheres, which greatly improves the computation efficiency. The effects of the governing physical and geometrical parameters are evaluated; whilst a special attention is paid to the plateau stress, which is directly related to the energy absorbing capacity. Finally, the empirical functions of the relative material density are proposed for the elastic modulus, yield strength and plateau stress for FCC packing arrangement of hollow spheres, showing a good agreement with the experimental results obtained in our previous study.展开更多
According to the minimal criteria of the International Society of Cellular Therapy, mesenchymal stem cells(MSCs) are a population of undifferentiated cells defined by their ability to adhere to plastic surfaces when c...According to the minimal criteria of the International Society of Cellular Therapy, mesenchymal stem cells(MSCs) are a population of undifferentiated cells defined by their ability to adhere to plastic surfaces when cultured under standard conditions, express a certain panel of phenotypic markers and can differentiate into osteogenic, chondrogenic and adipogenic lineages when cultured in specific inducing media. In parallel with their major role as undifferentiated cell reserves, MSCs have immunomodulatory functions which are exerted by direct cell-to-cell contacts, secretion of cytokines and/or by a combination of both mechanisms. There are no convincing data about a principal difference in the profile of cytokines secreted by MSCs isolated from different tissue sources, although some papers report some quantitative but not qualitative differences in cytokine secretion. The present review focuses on the basic cytokines secreted by MSCs as described in the literature by which the MSCs exert immunodulatory effects. It should be pointed out that MSCs themselves are objects of cytokine regulation. Hypothetical mechanisms by which the MSCs exert their immunoregulatory effects are also discussed in this review. These mechanisms may either influence the target immune cells directly or indirectly by affecting the activities of predominantly dendritic cells. Chemokines are also discussed as participants in this process by recruiting cells of the immune systems and thus making them targets of immunosuppression. This review aims to present and discuss the published data and the personal experience of the authors regarding cytokines secreted by MSCs and their effects on the cells of the immune system.展开更多
Many studies demonstrate that conventional anticancer drugs elevate intracellular level of reactive oxygen species （ROS） and alter redox-homeostasis of cancer cells. It is widely accepted that anticancer effect of t...Many studies demonstrate that conventional anticancer drugs elevate intracellular level of reactive oxygen species （ROS） and alter redox-homeostasis of cancer cells. It is widely accepted that anticancer effect of these chemotherapeutics is due to induction of oxidative stress and ROS-mediated apoptosis in cancer. On the other hand, the harmful side effects of conventional anticancer chemotherapy are also due to increased production of ROS and disruption of redox-homeostasis of normal cells and tissues. This article describes the mechanisms for triggering and modulation of apoptosis through ROS-dependent and ROS^independent pathways. We try to answer the question： ＂Is it possible to induce highly specific apoptosis only in cancer cells, without overproduction of ROS, as well as without harmful effects on normal cells and tissues？＂ The review also suggests a new therapeutic strategy for selective killing of cancer cells, without significant impact on viability of normal cells and tissues, by combining anticancer drugs with redox-modulators, affecting specific signaling pathways and avoiding oxidative stress.展开更多
The polyphenol content,antioxidant and antimicrobial activities of the extracts obtained by classical, ultrasonic and Soxhlet extractions from dry aerial parts of two Artemisia species(Artemisia vulgaris and Artemisia...The polyphenol content,antioxidant and antimicrobial activities of the extracts obtained by classical, ultrasonic and Soxhlet extractions from dry aerial parts of two Artemisia species(Artemisia vulgaris and Artemisia campestris)were compared.Ultrasound positively affected the yield of extractive substance and the kinetics of extraction,but the extract obtained by the classical extraction showed the highest antioxidant activities and contained higher total contents of phenolic compounds and flavonoids than the extracts obtained by two other extraction techniques.Both flavonoid aglycones(apigenin,quercetin,quercetin 3,3′-dimethyl ether)and flavonoid glycosides(rutin,hyperoside and kaempferol 3-rhamnoside)were identified by thin layer chromatograph(TLC)analysis in the extracts from both species.A.campestris extracts were richer in quercetin than A.vulgaris and its antimicrobial activity was also better than A.vulgaris.Extracts obtained from both species were found to be more effective on the tested yeasts than bacteria.The kinetics of the total extractive substances,such as phenolic,flavonoids and quercetin extraction,was successfully described by the model of unsteady-state diffusion.展开更多
Finite time blow up of the solutions to Boussinesq equation with linear restoring force and combined power nonlinearities is studied. Sufficient conditions on the initial data for nonexistence of global solutions are ...Finite time blow up of the solutions to Boussinesq equation with linear restoring force and combined power nonlinearities is studied. Sufficient conditions on the initial data for nonexistence of global solutions are derived. The results are valid for initial data with arbitrary high positive energy. The proofs are based on the concave method and new sign preserving functionals.展开更多
Jebba area southwestern Nigeria forms part of the Nigerian basement complex which lies in the Neoproterozoic PanAfrican mobile belt. It is underlain by several lithological units among which is a polydeformed granitic...Jebba area southwestern Nigeria forms part of the Nigerian basement complex which lies in the Neoproterozoic PanAfrican mobile belt. It is underlain by several lithological units among which is a polydeformed granitic gneiss. This rock has been dated by LA-ICP-MS yielding a concordant U-Pb zircon age of 2207 ± 20 Ma indicating the crystallization age of the granite protolith. This early Rhyacian age and its affinity with within-plate granites indicates emplacement during crustal extension and rifting presceding the main phase of the Eburnean orogeny. The strong, early, shear fabric, S1, in the rock is interpreted to be also of Paleoproterozoic age i.e. imprinted during the Eburnean orogeny. The Jebba granitic gneiss is thus correlatable with the widely abundant Paleoproterozoic granitic magmatism now represented by many orthogneisses and documented in other parts of southwestern Nigeria, the West African craton, the Borborema Province, the Gurupi Belt, Sao Luis craton and Sao Francisco craton in Brazil.展开更多
Fe-, Y-Fe-Al- and Y-Ce-Fe- citrates were synthesized in ethylene glycol （EG） medium under conditions similar to those used in the polymerized complex method. Their elemental composition, IR,^ 13C and ^1H NMR, X-ray ...Fe-, Y-Fe-Al- and Y-Ce-Fe- citrates were synthesized in ethylene glycol （EG） medium under conditions similar to those used in the polymerized complex method. Their elemental composition, IR,^ 13C and ^1H NMR, X-ray photoelectron and Mossbauer spectra were studied, and formulae describing their composition were proposed. The complexes contained EG bonded as adduct and ester with citric acid ligand and did not contain ligands with deprotonated alcoholic groups. The complexes consisted of agglomerated spheres, 0.7-3 μm in diameter. The local composition of the products was established by energy dispersive X-ray microanalysis. The comparison of the number of the ligands, their average electrical charge and the esterification degree of mono-, di- and trimetallic complexes proved the mixed-metal nature of the species studied. The thermal decomposition of the complexes was studied and a general scheme of the processes taking place was proposed. Highly crystalline, phase homogeneous YaFe4AlO12 was produced after heating the respective complex at 1000 ℃. Ce-doped yttrium-iron garnet, similarly prepared, contained traces of CeO2.展开更多
Background: On the analogy of the non-pathogenic microbiota found in oral cavity, skin and gastrointestinal tract, existence of blood microbiota was confirmed by DNA sequencing, but never deeply characterized. Hypothe...Background: On the analogy of the non-pathogenic microbiota found in oral cavity, skin and gastrointestinal tract, existence of blood microbiota was confirmed by DNA sequencing, but never deeply characterized. Hypothesis for the existence of dormant blood microbiota in healthy humans have been arisen and single species have been isolated. The aim of our study was to resuscitate and investigate the biodiversity of bacterial and fungal dormant blood microbiota in healthy individuals by blood culturing and NGS DNA sequencing. Results: Twenty eight blood samples of healthy individuals, seven for each blood type, were studied. Several culture media were tested. Blood microbiota resuscitation was performed in BHI broth supplemented with vitamin K 1 mg/ml, 2% sucrose, 0.25% sodium citrate and 0.2% yeastolate at 43?C for 72 h. All tested blood samples were culture positive, as confirmed by Gram staining and TEM. TEM images demonstrated well defined cell structures. Analysis for bacterial and eukaryotic species was performed by 16S rRNA and ITS2 targeted sequencing. The obtained sequences were clustered (≥97% identity) in Operational Taxonomic Units (OTUs). Among cultured and uncultured samples we identified OTUs similarity with 47 bacterial orders belonging to 15 phyla and 39 fungi orders blonging to 2 phyla. For the first time we demonstrated isolation and sequencing identification of fungal blood microbiota in healthy individuals. Blood-group differences were identified among the bacterial microbiome compositions. Conclusion: The dormant blood microbiome is innate of the healthy individuals. Interventional strategies to bind the host blood microbiome with the states of health and disease remain an unmet research goal.展开更多
Young pea plants grown as a water culture were sprayed with hydrogen peroxide and 24 h later were treated with the herbicide paraquat. The effects of paraquat and H2O2 treatment were investigated on the endogenous con...Young pea plants grown as a water culture were sprayed with hydrogen peroxide and 24 h later were treated with the herbicide paraquat. The effects of paraquat and H2O2 treatment were investigated on the endogenous concentrations of free proline, and free and conjugated putrescine, spermidine and spermine. Application of PQ increased the free proline and Put, and decreased conjugated and bound polyamines. The results clearly demonstrate the oxidative damages provoked by PQ application. Single treatment with H2O2 provoked considerable decrease in the free fraction of the three PAs studied 2 h after light exposition, but caused an increase in their respective conjugated fractions. Data suggest that PA changes after H2O2 treatment are due to conversion from free to conjugated form. Three hours later free PAs in H2O2 treated-plants reached control levels;however the conjugated remained higher than the control. No alterations were detected in proline concentration after H2O2 treatment. Pretreatment with Н2О2 activated some component of the plant protection mechanisms by causing an alteration in free/conjugated PAs ratio in plants subsequently subjected to PQ treatment. Data concerning PA and proline concentrations in plants treated with both compounds supposed that H2O2 shows a protective role against PQ and improves the plant tolerance to the oxidative stress generated by paraquat.展开更多
This is a study of the Durand-Kerner and Nourein methods for finding the roots of a given algebraic equation simultaneously. We consider the conditions under which the iterative methods fail. The numerical example is ...This is a study of the Durand-Kerner and Nourein methods for finding the roots of a given algebraic equation simultaneously. We consider the conditions under which the iterative methods fail. The numerical example is presented.展开更多
This research reveals relationships between climate variables and inter-annual dynamics in the area of the glacieret located in the cirque Golemiya Kazan in the Pirin Mountains. The study period is 1993–2017. The cor...This research reveals relationships between climate variables and inter-annual dynamics in the area of the glacieret located in the cirque Golemiya Kazan in the Pirin Mountains. The study period is 1993–2017. The correlations are identified using statistical methods. Also, a statistical model is constructed, including some climate variables as predictors. Despite the evident decrease of the glacieret's size in the period from the 1950 s onwards, the long-term trends for the last decades have been insignificant. The main climatic factors influencing the inter-annual dynamics in the area of the glacieret are air temperature, precipitation, zonal and meridional winds and relative humidity. With respect to the dynamics in the area of the glacieret, the important trends in the different climate variables are those of the warm period air temperatures and zonal(u) wind. They also determine to a great extent its future development by acting in two opposite directions – rising temperatures in the warm period will lead to a rapid decrease of its area by the end of the melting season, while the change of wind directionfrom west to east in the warm period will increase its area. The influence of the zonal wind in the warm period is explained mainly by the location of the glacieret in the cirque. Generally, the glacieret is tilted downwards from west to east. Thus, westerly winds facilitate blowing away the snow from the surface of the glacieret, assisting its melting in the warm period. Easterly winds do not have such an effect. The combination of the opposite effects of these two most important climate variables leads to the most likely scenario for the future development of the glacieret, according to which by the middle of this century it is expected to turn into a semi-permanent snow patch, which disappears after some summers, and by the end of the century to completely melt every year before the end of the melting season.展开更多
A steady-state, rigid-plastic rolling problem for temperature and strain-rate dependent materials with nonlocal friction is considered. A variational formulation is derived, coupling a nonlinear variational inequality...A steady-state, rigid-plastic rolling problem for temperature and strain-rate dependent materials with nonlocal friction is considered. A variational formulation is derived, coupling a nonlinear variational inequality for the velocity and a nonlinear vari- ational equation for the temperature. The existence and uniqueness results are obtained by a proposed fixed point method.展开更多
The Late Devonian-early Carboniferous deposits of the Anarak section in northeastern Isfahan,Central Iran,evaluated based on conodont biostratigraphy,sedimentary environment and sequence stratigraphy.According to the ...The Late Devonian-early Carboniferous deposits of the Anarak section in northeastern Isfahan,Central Iran,evaluated based on conodont biostratigraphy,sedimentary environment and sequence stratigraphy.According to the field observations,five lithological units were identified.Investigating the conodont fauna of the Late Devonian-Carboniferous(Mississippian-Pennsylvanian)deposits of Bahram,Shishtu,and Qaleh(Sardar 1)formations in Anarak section led to the identification of 67 species of 18 conodont genera,and accordingly 22 conodont biozones were differentiated.The correlation of sea-level change curves,regarding to the conodont biofacies with the global sea-level curve,demonstrates the relative correlation in the mentioned times due to the shallow condition of the central Iran basin compared to the European and American basins.The microfacies analysis led to the identification of 12 microfacies related to the open sea,bioclastic barrier,lagoon and tidal flat sub-sedimentary environments in a homoclinal carbonate ramp environment.Based on sequence stratigraphy studies,three 3rd order sequences were identified.The first sequence,which is of the Late Devonian(upper part of the Bahram Formation,32.5 m),the second sequence(12.5 m)is the Late Devonian(uppermost part of the Bahram Formation),and the third sequence(68 m)is the early Carboniferous(the Shishtu I Formation).展开更多
This paper reports results from the first long-term BV(RI)c photometric CCD observations of three variable pre-main-sequence stars collected during the period from February 2007 to January 2020. The investigated stars...This paper reports results from the first long-term BV(RI)c photometric CCD observations of three variable pre-main-sequence stars collected during the period from February 2007 to January 2020. The investigated stars are located in the field of the PMS star V733 Cep within the Cepheus OB3 association. All stars from our study show rapid photometric variability in all-optical passbands. In this paper, we describe and discuss the photometric behavior of these stars and the possible reasons for their variability. In the light variation of two of the stars, we found periodicity.展开更多
文摘This work focuses on an integrated approach for lake ecological status assessment, elaborated according to the requirements of the European Water Framework Directive (WFD). Data from five lowland and semi-mountain lakes in Bulgaria (Southeast Europe) collected from two years (2011-2012) form the basis for an integrated assessment and the definition of reference conditions. Several metrics were applied in combination, to classify lakes into five ecological status classes. Assemblages of aquatic organisms: phytoplankton, macrophytes and benthic macroinvertebrates, together with 11 supporting physico-chemical parameters were studied. The assessed unique conditions suggested that reference conditions of Bulgarian lakes have natural variability. This first baseline study illustrated specific cases within the lake types that should be assessed in details before providing standardized classification systems in compliance with the requirements of WFD.
基金financial support of the Scientific Research Fund attached to the Bulgarian Ministry of Education and Science within the framework of scientific project No.10/6,15.12.2016“Contemporary musical composition,theory and philosophy”.
文摘How can music be a modus of accomplishing what Husserl calls“a radical,skeptical epochē”,that is,a way of refraining from judgment about all that is to be known?In order to answer the question,we have to first submit music itself to the act of epochē.This will allow us to get free from the widespread opinion that music is only an art,and to understand it in a broad sense,namely as a sphere of Being.This sphere is founded on the tone which,on its part,is thinkable not as an expression of the number(as in the Pythagorean tradition)or a medium for voicing,supplementing,or accompanying words,but as a primary essence enabling us to reach the truth of Being in a direct and immediate way.Hence,music provides an advantage for the one who chooses it as a way of accomplishing epochē.In providing immediate access to the truth of all thinkable things and of Being itself,it releases him from the necessity to cover any distance to it by passing through concepts,notions,and ideas in relation to which he is required to exercise the discipline of epochē.
文摘The current study was performed to evaluate the liver function status as well as molecular characterization of the recovered worms in rats experimentally infected with F. hepatica. Sixteen male Wister rats aged 30 days were randomly allocated into two groups (n = 8). The first group was infected orally with 15 viable encysted metacercaria of F. hepatica per animal. The other group was kept non-infected (control group). At zero time (before infection), the 2<sup>nd</sup>, 4<sup>th</sup>, 6<sup>th</sup>, 8<sup>th</sup>, 10<sup>th</sup>, 12<sup>th</sup> and 14<sup>th</sup> weeks post-infection (WPI), blood and serum samples were collected via puncture of retro-orbital plexus of veins from each rat. Serum enzyme level (AST and ALT) and total protein were measured, and the serum protein profile was carried out using agarose gel electrophoresis. During the period of the experiment, serum ALT and AST activities and serum total globulins significantly increased while serum total proteins and albumin markedly decreased in the infected group. On the 14<sup>th</sup> WPI, the data of the electropherogram showed that globulin fractions (α1-, β- and γ-globulin) levels were significantly increased while α2-globulin was markedly decreased in the infected group. The molecular analysis confirmed the amplification of the ITS1, ITS2 and NDI genes of F. hepatica recovered from the infected liver of rats with amplicon sizes of 630, 510 and 560 bp, respectively. Sequencing of the amplified ITS gene resulted in the determination of 3 strains (PP108836, PP108837, and PP108838). Also, analysis of the ITS2 gene resulted in obtaining 3 isolates under the accession numbers (PP109065, PP109066, and PP109067). In conclusion, fasciolosis in the rat model is suitable for routine experimental infections and caused a pronounced liver dysfunction with discharging of the Fasciola eggs in the faeces and the development of adult stages in the bile ducts. Furthermore, molecular techniques are a sensitive tool for the identification and characterisation of the Fasciola parasite.
文摘A prominent Iranian philosopher Ahmad Fardid considered the influential German philosopher Martin Heidegger as“the only Western philosopher who understood the world and the only philosopher whose insights were congruent with the principles of the Islamic Republic”.The report aimed to present Fardid’s interpretation of Heidegger in the light of Iranian-Islamic wisdom.Iranian philosopher believes that Heidegger’s thought responds to the most important intellectual crisis of the West civilization that is nihilism and to reach the possibility of an“other beginning”of thinking that he calls“No-longer-metaphysical-thought”.Considering these two fundamental features,Fardid founds powerful religious-spiritual tendencies in Heidegger’s thinking.
文摘The work analyzes the basic assumption in Mach’s principle, namely that the inertia of material bodies is determined by their gravitational interaction with distant masses in the universe. However, while Mach’s principle is based on the so-called “long-range gravitational interaction” characterized by an infinitely large propagation velocity, our study is based on a “modified” long-range principle, assuming a very large but finite propagation velocity of the gravitational interaction between local material objects and distant matter. Thus, it is postulated that there are two types of gravitational interaction—short-range gravitational interaction between local objects and long-range gravitational interaction between local objects and distant matter in the universe, which are characterized by different propagation speeds, but with the same gravitational constant. On the basis of the modified long-range principle, a model of distant matter is built in the form of a hollow spherical layer with negligible thickness. The phenomenological assumption is made that the movement with acceleration of the local reference frame (RF) is related to a change in the spherically symmetric distribution of the lines of gravitational interaction of this RF with distant matter, which is expressed in a corresponding asymmetric distribution of the effective mass density on the hollow sphere. A simplified (idealized) model of the effective change of the hollow sphere of distant matter by cutting off separate segments of the sphere is proposed. On the basis of the model, the possibility of representing the inertial effects in three simplest types of reference frames through a corresponding gravitational interaction is considered: 1) inertial RF;2) RF moving in a straight line with constant acceleration;3) RF rotating with constant angular velocity. Expressions were obtained for the gravitational accelerations acting on the test body located inside the hollow sphere with a corresponding change (“cutting”). It is concluded that these accelerations can in a first approximation represent the inertial accelerations of the main types noted above. It is shown that in order to obtain reasonable values of the truncation parameters of the hollow sphere, it is necessary to assume that the gravitational interaction inside this sphere is not of the Newtonian type, i.e. the same depends on the distance not according to the law 1/r2, but according to modified law with a non-integer (fractional) exponent. This law corresponds to a fractal structure of the source of attraction inside the truncated sphere of distant matter. The issue of the possibility of the supposed modified long-range interaction is briefly discussed on the basis of a comparison of the finding a connection with the lines of force of the same with the “cosmic strings” assumed by a number of researchers, along which corresponding excitations (waves, particles) moving at super-light speed. The work advances the idea of the presence of unity and at the same time oppositeness of the inertia of material objects and the known gravitational interaction between them, which are generated by the properties of symmetry of the long-range gravitational interaction. Moreover, while the inertia of the bodies is due to the violation of this symmetry caused by their movement with acceleration, the gravitational interaction between the bodies is due to the aspiration to restore the symmetry of a far-reaching gravitational interaction, which is disturbed by the presence of local material bodies. In the conclusion of the work, the important physico-philosophical significance of Mach’s principle is emphasized, expressed in the understanding that not only the world of microscopic objects (“micro-world”), but also the world of huge cosmic objects (“mega-world”) can have a corresponding impact on our “macroscopic” world.
文摘The experimental research programs of 1950s, to understand the adsorption of CO on W surfaces, changed to ab initio studies in 2000s. The goals were to seek improved practical applications. Most of the studies were based on density functional theory. Many studies also used programs, such as VASP (Vienna Abinitio simulation package) and CPMD. The computational procedures used plane wave approximations. This needed studies with selection of K points and cutoff energy selection to assure convergence in energy calculations. Observations and analysis of papers published from 2006 to 2022 indicate that the cutoff energies were selected arbitrarily without any needed convergence studies. By selecting a published 2006 paper, this paper has clearly showed that an arbitrary selection of cutoff energy, such as 460 eV, is not in the range of, cutoff energies that assure convergence of energy calculations, with ab initio methods and have indicated correction procedures. .
基金The project supported by the Hong Kong Research Grant Council(RGC)(HKUST 6079/00E)the National Natural Science Foundation of China(10532020).
文摘Finite element simulations are carried out to examine the mechanical behavior of the metallic hollow sphere （MHS） material during their large plastic deformation and to estimate the energy absorbing capacity of these materials under uniaxial compression. A simplified model is proposed from experimental observations to describe the connection between the neighboring spheres, which greatly improves the computation efficiency. The effects of the governing physical and geometrical parameters are evaluated; whilst a special attention is paid to the plateau stress, which is directly related to the energy absorbing capacity. Finally, the empirical functions of the relative material density are proposed for the elastic modulus, yield strength and plateau stress for FCC packing arrangement of hollow spheres, showing a good agreement with the experimental results obtained in our previous study.
文摘According to the minimal criteria of the International Society of Cellular Therapy, mesenchymal stem cells(MSCs) are a population of undifferentiated cells defined by their ability to adhere to plastic surfaces when cultured under standard conditions, express a certain panel of phenotypic markers and can differentiate into osteogenic, chondrogenic and adipogenic lineages when cultured in specific inducing media. In parallel with their major role as undifferentiated cell reserves, MSCs have immunomodulatory functions which are exerted by direct cell-to-cell contacts, secretion of cytokines and/or by a combination of both mechanisms. There are no convincing data about a principal difference in the profile of cytokines secreted by MSCs isolated from different tissue sources, although some papers report some quantitative but not qualitative differences in cytokine secretion. The present review focuses on the basic cytokines secreted by MSCs as described in the literature by which the MSCs exert immunodulatory effects. It should be pointed out that MSCs themselves are objects of cytokine regulation. Hypothetical mechanisms by which the MSCs exert their immunoregulatory effects are also discussed in this review. These mechanisms may either influence the target immune cells directly or indirectly by affecting the activities of predominantly dendritic cells. Chemokines are also discussed as participants in this process by recruiting cells of the immune systems and thus making them targets of immunosuppression. This review aims to present and discuss the published data and the personal experience of the authors regarding cytokines secreted by MSCs and their effects on the cells of the immune system.
文摘Many studies demonstrate that conventional anticancer drugs elevate intracellular level of reactive oxygen species （ROS） and alter redox-homeostasis of cancer cells. It is widely accepted that anticancer effect of these chemotherapeutics is due to induction of oxidative stress and ROS-mediated apoptosis in cancer. On the other hand, the harmful side effects of conventional anticancer chemotherapy are also due to increased production of ROS and disruption of redox-homeostasis of normal cells and tissues. This article describes the mechanisms for triggering and modulation of apoptosis through ROS-dependent and ROS^independent pathways. We try to answer the question： ＂Is it possible to induce highly specific apoptosis only in cancer cells, without overproduction of ROS, as well as without harmful effects on normal cells and tissues？＂ The review also suggests a new therapeutic strategy for selective killing of cancer cells, without significant impact on viability of normal cells and tissues, by combining anticancer drugs with redox-modulators, affecting specific signaling pathways and avoiding oxidative stress.
基金Supported by the Ministry of Science and Environmental Protection,Republic of Serbia(172047)
文摘The polyphenol content,antioxidant and antimicrobial activities of the extracts obtained by classical, ultrasonic and Soxhlet extractions from dry aerial parts of two Artemisia species(Artemisia vulgaris and Artemisia campestris)were compared.Ultrasound positively affected the yield of extractive substance and the kinetics of extraction,but the extract obtained by the classical extraction showed the highest antioxidant activities and contained higher total contents of phenolic compounds and flavonoids than the extracts obtained by two other extraction techniques.Both flavonoid aglycones(apigenin,quercetin,quercetin 3,3′-dimethyl ether)and flavonoid glycosides(rutin,hyperoside and kaempferol 3-rhamnoside)were identified by thin layer chromatograph(TLC)analysis in the extracts from both species.A.campestris extracts were richer in quercetin than A.vulgaris and its antimicrobial activity was also better than A.vulgaris.Extracts obtained from both species were found to be more effective on the tested yeasts than bacteria.The kinetics of the total extractive substances,such as phenolic,flavonoids and quercetin extraction,was successfully described by the model of unsteady-state diffusion.
基金partially supported by Grant No.DFNI I-02/9 of the Bulgarian Science Fund
文摘Finite time blow up of the solutions to Boussinesq equation with linear restoring force and combined power nonlinearities is studied. Sufficient conditions on the initial data for nonexistence of global solutions are derived. The results are valid for initial data with arbitrary high positive energy. The proofs are based on the concave method and new sign preserving functionals.
文摘Jebba area southwestern Nigeria forms part of the Nigerian basement complex which lies in the Neoproterozoic PanAfrican mobile belt. It is underlain by several lithological units among which is a polydeformed granitic gneiss. This rock has been dated by LA-ICP-MS yielding a concordant U-Pb zircon age of 2207 ± 20 Ma indicating the crystallization age of the granite protolith. This early Rhyacian age and its affinity with within-plate granites indicates emplacement during crustal extension and rifting presceding the main phase of the Eburnean orogeny. The strong, early, shear fabric, S1, in the rock is interpreted to be also of Paleoproterozoic age i.e. imprinted during the Eburnean orogeny. The Jebba granitic gneiss is thus correlatable with the widely abundant Paleoproterozoic granitic magmatism now represented by many orthogneisses and documented in other parts of southwestern Nigeria, the West African craton, the Borborema Province, the Gurupi Belt, Sao Luis craton and Sao Francisco craton in Brazil.
文摘Fe-, Y-Fe-Al- and Y-Ce-Fe- citrates were synthesized in ethylene glycol （EG） medium under conditions similar to those used in the polymerized complex method. Their elemental composition, IR,^ 13C and ^1H NMR, X-ray photoelectron and Mossbauer spectra were studied, and formulae describing their composition were proposed. The complexes contained EG bonded as adduct and ester with citric acid ligand and did not contain ligands with deprotonated alcoholic groups. The complexes consisted of agglomerated spheres, 0.7-3 μm in diameter. The local composition of the products was established by energy dispersive X-ray microanalysis. The comparison of the number of the ligands, their average electrical charge and the esterification degree of mono-, di- and trimetallic complexes proved the mixed-metal nature of the species studied. The thermal decomposition of the complexes was studied and a general scheme of the processes taking place was proposed. Highly crystalline, phase homogeneous YaFe4AlO12 was produced after heating the respective complex at 1000 ℃. Ce-doped yttrium-iron garnet, similarly prepared, contained traces of CeO2.
文摘Background: On the analogy of the non-pathogenic microbiota found in oral cavity, skin and gastrointestinal tract, existence of blood microbiota was confirmed by DNA sequencing, but never deeply characterized. Hypothesis for the existence of dormant blood microbiota in healthy humans have been arisen and single species have been isolated. The aim of our study was to resuscitate and investigate the biodiversity of bacterial and fungal dormant blood microbiota in healthy individuals by blood culturing and NGS DNA sequencing. Results: Twenty eight blood samples of healthy individuals, seven for each blood type, were studied. Several culture media were tested. Blood microbiota resuscitation was performed in BHI broth supplemented with vitamin K 1 mg/ml, 2% sucrose, 0.25% sodium citrate and 0.2% yeastolate at 43?C for 72 h. All tested blood samples were culture positive, as confirmed by Gram staining and TEM. TEM images demonstrated well defined cell structures. Analysis for bacterial and eukaryotic species was performed by 16S rRNA and ITS2 targeted sequencing. The obtained sequences were clustered (≥97% identity) in Operational Taxonomic Units (OTUs). Among cultured and uncultured samples we identified OTUs similarity with 47 bacterial orders belonging to 15 phyla and 39 fungi orders blonging to 2 phyla. For the first time we demonstrated isolation and sequencing identification of fungal blood microbiota in healthy individuals. Blood-group differences were identified among the bacterial microbiome compositions. Conclusion: The dormant blood microbiome is innate of the healthy individuals. Interventional strategies to bind the host blood microbiome with the states of health and disease remain an unmet research goal.
文摘Young pea plants grown as a water culture were sprayed with hydrogen peroxide and 24 h later were treated with the herbicide paraquat. The effects of paraquat and H2O2 treatment were investigated on the endogenous concentrations of free proline, and free and conjugated putrescine, spermidine and spermine. Application of PQ increased the free proline and Put, and decreased conjugated and bound polyamines. The results clearly demonstrate the oxidative damages provoked by PQ application. Single treatment with H2O2 provoked considerable decrease in the free fraction of the three PAs studied 2 h after light exposition, but caused an increase in their respective conjugated fractions. Data suggest that PA changes after H2O2 treatment are due to conversion from free to conjugated form. Three hours later free PAs in H2O2 treated-plants reached control levels;however the conjugated remained higher than the control. No alterations were detected in proline concentration after H2O2 treatment. Pretreatment with Н2О2 activated some component of the plant protection mechanisms by causing an alteration in free/conjugated PAs ratio in plants subsequently subjected to PQ treatment. Data concerning PA and proline concentrations in plants treated with both compounds supposed that H2O2 shows a protective role against PQ and improves the plant tolerance to the oxidative stress generated by paraquat.
文摘This is a study of the Durand-Kerner and Nourein methods for finding the roots of a given algebraic equation simultaneously. We consider the conditions under which the iterative methods fail. The numerical example is presented.
基金funded by the research project "Current impacts of global changes on evolution of karst (based on the integrated monitoring of model karst geosystems in Bulgaria)"Science Research Fund (Grant No. DN14/10/20.12.2017)+1 种基金funded by the South-west University of Blagoevgrad (grants RP-A 10/15, RP-A 13/17)SRF (SRF 02/70)
文摘This research reveals relationships between climate variables and inter-annual dynamics in the area of the glacieret located in the cirque Golemiya Kazan in the Pirin Mountains. The study period is 1993–2017. The correlations are identified using statistical methods. Also, a statistical model is constructed, including some climate variables as predictors. Despite the evident decrease of the glacieret's size in the period from the 1950 s onwards, the long-term trends for the last decades have been insignificant. The main climatic factors influencing the inter-annual dynamics in the area of the glacieret are air temperature, precipitation, zonal and meridional winds and relative humidity. With respect to the dynamics in the area of the glacieret, the important trends in the different climate variables are those of the warm period air temperatures and zonal(u) wind. They also determine to a great extent its future development by acting in two opposite directions – rising temperatures in the warm period will lead to a rapid decrease of its area by the end of the melting season, while the change of wind directionfrom west to east in the warm period will increase its area. The influence of the zonal wind in the warm period is explained mainly by the location of the glacieret in the cirque. Generally, the glacieret is tilted downwards from west to east. Thus, westerly winds facilitate blowing away the snow from the surface of the glacieret, assisting its melting in the warm period. Easterly winds do not have such an effect. The combination of the opposite effects of these two most important climate variables leads to the most likely scenario for the future development of the glacieret, according to which by the middle of this century it is expected to turn into a semi-permanent snow patch, which disappears after some summers, and by the end of the century to completely melt every year before the end of the melting season.
文摘A steady-state, rigid-plastic rolling problem for temperature and strain-rate dependent materials with nonlocal friction is considered. A variational formulation is derived, coupling a nonlinear variational inequality for the velocity and a nonlinear vari- ational equation for the temperature. The existence and uniqueness results are obtained by a proposed fixed point method.
文摘The Late Devonian-early Carboniferous deposits of the Anarak section in northeastern Isfahan,Central Iran,evaluated based on conodont biostratigraphy,sedimentary environment and sequence stratigraphy.According to the field observations,five lithological units were identified.Investigating the conodont fauna of the Late Devonian-Carboniferous(Mississippian-Pennsylvanian)deposits of Bahram,Shishtu,and Qaleh(Sardar 1)formations in Anarak section led to the identification of 67 species of 18 conodont genera,and accordingly 22 conodont biozones were differentiated.The correlation of sea-level change curves,regarding to the conodont biofacies with the global sea-level curve,demonstrates the relative correlation in the mentioned times due to the shallow condition of the central Iran basin compared to the European and American basins.The microfacies analysis led to the identification of 12 microfacies related to the open sea,bioclastic barrier,lagoon and tidal flat sub-sedimentary environments in a homoclinal carbonate ramp environment.Based on sequence stratigraphy studies,three 3rd order sequences were identified.The first sequence,which is of the Late Devonian(upper part of the Bahram Formation,32.5 m),the second sequence(12.5 m)is the Late Devonian(uppermost part of the Bahram Formation),and the third sequence(68 m)is the early Carboniferous(the Shishtu I Formation).
基金partly supported by the Bulgarian Ministry of Education and Science under the National Program for Research“Young Scientists and Postdoctoral Students”partial support by grant DN 18-13/2017 from the Bulgarian National Science Fund。
文摘This paper reports results from the first long-term BV(RI)c photometric CCD observations of three variable pre-main-sequence stars collected during the period from February 2007 to January 2020. The investigated stars are located in the field of the PMS star V733 Cep within the Cepheus OB3 association. All stars from our study show rapid photometric variability in all-optical passbands. In this paper, we describe and discuss the photometric behavior of these stars and the possible reasons for their variability. In the light variation of two of the stars, we found periodicity.
