目的探讨血栓通注射液联合奥拉西坦对老年缺血性脑卒中(ischemic stroke,IS)的作用。方法选取106例老年IS患者作为研究对象,随机分为观察组和对照组,每组53例。对照组用奥拉西坦治疗,观察组在对照组治疗的基础上联合血栓通注射液治疗,比...目的探讨血栓通注射液联合奥拉西坦对老年缺血性脑卒中(ischemic stroke,IS)的作用。方法选取106例老年IS患者作为研究对象,随机分为观察组和对照组,每组53例。对照组用奥拉西坦治疗,观察组在对照组治疗的基础上联合血栓通注射液治疗,比较2组的临床疗效、神经功能[用美国国立卫生研究院卒中量表评分(national institute of health stroke scale,NIHSS)评估]、运动功能(用日常生活活动能力(activities of daily living,ADL)量表评估)、颈动脉狭窄程度(颈动脉内中膜厚度和狭窄率)、血流动力学(全血黏度、血流速度和血流阻力)、神经损伤因子[神经胶质原纤维酸性蛋白(glial fibrillary acidic protein,GFAP)、神经元特异性烯醇化酶(neuron-specific enolase,NSE)和脑源性神经生长因子(brain-derived neurotrophic factor,BDNF)]和氧化应激指标[丙二醛(malondialdehyde,MDA)和超氧化物歧化酶(superoxide dismutase,SOD)]水平。结果观察组的总有效率为98.11%,高于对照组的86.79%(P<0.05);治疗后,观察组的NIHSS评分为(10.14±1.91)分,低于对照组的(12.43±2.12)分,P<0.05;观察组的ADL评分为(64.49±8.30)分,高于对照组的(58.37±7.26)分,P<0.05;观察组颈动脉内中膜厚度和狭窄率分别为(1.27±0.11)mm、(74.84%±5.14%),低于对照组[(1.33±0.13)mm、(78.92%±5.95%)],P<0.05;观察组(高切和低切)全血黏度和血流阻力分别为(4.72±0.91)mPa·s、(10.99±2.25)mPa·s、(1.52±0.24)Pa·s·L^(-1),低于对照组[(5.86±1.17)mPa·s、(13.40±2.77)mPa·s、(1.64±0.27)Pa·s·L^(-1)],血流速度为(18.33±3.85)cm·s^(-1),高于对照组[(16.51±3.61)cm·s^(-1)],P<0.05;观察组的GFAP和NSE分别为(5.62±1.11)、(23.88±4.25)ng·mL^(-1),低于对照组[(6.57±1.30)、(27.17±4.76)ng·mL^(-1)],BDNF为(3.06±0.77)ng·mL^(-1),高于对照组[(2.38±0.52)ng·mL^(-1)],P<0.05;观察组的MDA为(3.62±0.63)μmol·L^(-1),低于对照组[(4.05±0.78)μmol·L^(-1)],SOD为(105.20±15.63)U·mL^(-1),高于对照组[(93.42±13.27)U·mL^(-1)],P<0.05。结论血栓通注射液联合奥拉西坦对老年IS患者疗效显著,可通过调节神经损伤因子和氧化应激因子水平及改善血流动力学,提高患者的神经功能和运动功能,改善颈动脉狭窄。展开更多
慢性肾脏病(CKD)是全球性公共卫生问题,其发病率高、知晓率低,且与多种因素相关。近年来,大气颗粒物(PM)作为环境因素之一,与CKD的关联性受到广泛关注。该综述旨在探讨不同粒径的大气PM (包括PM10、PM2.5和PM1)对CKD发病风险的影响,并...慢性肾脏病(CKD)是全球性公共卫生问题,其发病率高、知晓率低,且与多种因素相关。近年来,大气颗粒物(PM)作为环境因素之一,与CKD的关联性受到广泛关注。该综述旨在探讨不同粒径的大气PM (包括PM10、PM2.5和PM1)对CKD发病风险的影响,并分析其潜在的生物学机制。研究表明,长期暴露于大气PM与CKD的发病率和进展风险增加有关。PM可能通过氧化应激、炎症反应、免疫反应、细胞自噬与凋亡以及血流动力学改变等途径影响肾脏功能。此外,PM中特定化学组分对肾脏的损害作用亦不容忽视。因此,该综述强调了制定有效的PM干预政策对于预防和控制CKD的重要性,并为未来的研究方向提供了新的视角。Chronic kidney disease (CKD) is a prevalent global public health concern characterized by high incidence rates, low awareness levels, and a multitude of associated factors. Recently, the correlation between atmospheric particulate matter (PM), as one of the environmental factors, and CKD has garnered substantial attention. This review aims to investigate the impacts of atmospheric PM of varying particle sizes, including PM10, PM2.5, and PM1, on the susceptibility to CKD and delve into the potential biological mechanisms. Findings indicate that long-term exposure to atmospheric PM is linked to a heightened incidence and risk of progression of CKD. PM may affect renal function via pathways involving oxidative stress, inflammation, immune response, cellular autophagy and apoptosis, and hemodynamic changes. Furthermore, the detrimental effects of specific chemical components within PM on kidney health should be considered. Consequently, this review highlights the necessity of implementing effective PM intervention policies for the prevention and control of CKD, thereby offering novel research avenues for exploration in the future.展开更多
文摘目的探讨血栓通注射液联合奥拉西坦对老年缺血性脑卒中(ischemic stroke,IS)的作用。方法选取106例老年IS患者作为研究对象,随机分为观察组和对照组,每组53例。对照组用奥拉西坦治疗,观察组在对照组治疗的基础上联合血栓通注射液治疗,比较2组的临床疗效、神经功能[用美国国立卫生研究院卒中量表评分(national institute of health stroke scale,NIHSS)评估]、运动功能(用日常生活活动能力(activities of daily living,ADL)量表评估)、颈动脉狭窄程度(颈动脉内中膜厚度和狭窄率)、血流动力学(全血黏度、血流速度和血流阻力)、神经损伤因子[神经胶质原纤维酸性蛋白(glial fibrillary acidic protein,GFAP)、神经元特异性烯醇化酶(neuron-specific enolase,NSE)和脑源性神经生长因子(brain-derived neurotrophic factor,BDNF)]和氧化应激指标[丙二醛(malondialdehyde,MDA)和超氧化物歧化酶(superoxide dismutase,SOD)]水平。结果观察组的总有效率为98.11%,高于对照组的86.79%(P<0.05);治疗后,观察组的NIHSS评分为(10.14±1.91)分,低于对照组的(12.43±2.12)分,P<0.05;观察组的ADL评分为(64.49±8.30)分,高于对照组的(58.37±7.26)分,P<0.05;观察组颈动脉内中膜厚度和狭窄率分别为(1.27±0.11)mm、(74.84%±5.14%),低于对照组[(1.33±0.13)mm、(78.92%±5.95%)],P<0.05;观察组(高切和低切)全血黏度和血流阻力分别为(4.72±0.91)mPa·s、(10.99±2.25)mPa·s、(1.52±0.24)Pa·s·L^(-1),低于对照组[(5.86±1.17)mPa·s、(13.40±2.77)mPa·s、(1.64±0.27)Pa·s·L^(-1)],血流速度为(18.33±3.85)cm·s^(-1),高于对照组[(16.51±3.61)cm·s^(-1)],P<0.05;观察组的GFAP和NSE分别为(5.62±1.11)、(23.88±4.25)ng·mL^(-1),低于对照组[(6.57±1.30)、(27.17±4.76)ng·mL^(-1)],BDNF为(3.06±0.77)ng·mL^(-1),高于对照组[(2.38±0.52)ng·mL^(-1)],P<0.05;观察组的MDA为(3.62±0.63)μmol·L^(-1),低于对照组[(4.05±0.78)μmol·L^(-1)],SOD为(105.20±15.63)U·mL^(-1),高于对照组[(93.42±13.27)U·mL^(-1)],P<0.05。结论血栓通注射液联合奥拉西坦对老年IS患者疗效显著,可通过调节神经损伤因子和氧化应激因子水平及改善血流动力学,提高患者的神经功能和运动功能,改善颈动脉狭窄。
文摘慢性肾脏病(CKD)是全球性公共卫生问题,其发病率高、知晓率低,且与多种因素相关。近年来,大气颗粒物(PM)作为环境因素之一,与CKD的关联性受到广泛关注。该综述旨在探讨不同粒径的大气PM (包括PM10、PM2.5和PM1)对CKD发病风险的影响,并分析其潜在的生物学机制。研究表明,长期暴露于大气PM与CKD的发病率和进展风险增加有关。PM可能通过氧化应激、炎症反应、免疫反应、细胞自噬与凋亡以及血流动力学改变等途径影响肾脏功能。此外,PM中特定化学组分对肾脏的损害作用亦不容忽视。因此,该综述强调了制定有效的PM干预政策对于预防和控制CKD的重要性,并为未来的研究方向提供了新的视角。Chronic kidney disease (CKD) is a prevalent global public health concern characterized by high incidence rates, low awareness levels, and a multitude of associated factors. Recently, the correlation between atmospheric particulate matter (PM), as one of the environmental factors, and CKD has garnered substantial attention. This review aims to investigate the impacts of atmospheric PM of varying particle sizes, including PM10, PM2.5, and PM1, on the susceptibility to CKD and delve into the potential biological mechanisms. Findings indicate that long-term exposure to atmospheric PM is linked to a heightened incidence and risk of progression of CKD. PM may affect renal function via pathways involving oxidative stress, inflammation, immune response, cellular autophagy and apoptosis, and hemodynamic changes. Furthermore, the detrimental effects of specific chemical components within PM on kidney health should be considered. Consequently, this review highlights the necessity of implementing effective PM intervention policies for the prevention and control of CKD, thereby offering novel research avenues for exploration in the future.
