生殖道微生物群与女性生育息息相关。育龄期妇女微生物群稳态失衡会影响生殖健康及妊娠并发症,从而影响母儿健康,生殖道微生物群对生育的相关影响近年来备受关注。随着辅助生殖技术的不断发展,最近的研究将女性生殖道微生物群与其相关...生殖道微生物群与女性生育息息相关。育龄期妇女微生物群稳态失衡会影响生殖健康及妊娠并发症,从而影响母儿健康,生殖道微生物群对生育的相关影响近年来备受关注。随着辅助生殖技术的不断发展,最近的研究将女性生殖道微生物群与其相关联。因此,本综述概述了女性生殖道各部分之间微生物群差异,及其在不孕女性生殖健康中的作用,包括其对ART治疗的影响。此外,还总结了微生物种群变化对ART结局影响的最新进展。Reproductive tract microbiota is closely associated with female fertility. Imbalances in the homeostasis of microbiota among women of childbearing age can impact reproductive health and pregnancy complications, ultimately affecting both maternal and fetal well-being. The influence of reproductive tract microbiota on fertility has attracted much attention in recent years. With the development of assisted reproductive technology. Recent studies have linked the female reproductive tract microbiota to it. This review provides an overview of the differences in microbiota across various parts of the female reproductive tract and their role in infertility, including implications for ART therapy. Additionally, recent progress regarding the effects of changes in microbial populations on ART outcomes is summarized.展开更多
目的:探讨子宫动脉血流参数联合血小板聚集功能预测不明原因复发性流产(URSA)的价值。方法:将2021年9月至2023年8月本院收治的94例URSA患者作为URSA组,另外将同期在本院进行产检的110例正常妊娠孕妇作为对照组。URSA患者随访至妊娠28周...目的:探讨子宫动脉血流参数联合血小板聚集功能预测不明原因复发性流产(URSA)的价值。方法:将2021年9月至2023年8月本院收治的94例URSA患者作为URSA组,另外将同期在本院进行产检的110例正常妊娠孕妇作为对照组。URSA患者随访至妊娠28周,根据妊娠结局分为正常妊娠组(n = 25)和流产组(n = 69)。比较2组患者子宫动脉血流参数、血小板聚集率;采用受试者工作特性(ROC)曲线评估子宫动脉血流参数、血小板聚集率对URSA患者妊娠结局的预测价值;采用二分类Logistic逐步回归分析探讨URSA患者妊娠结局的影响因素。结果:在搏动指数(PI)、动脉血流阻力指数(RI)、收缩期/舒张期血流速度比值(S/D)、血小板聚集率指标方面,URSA组相较于对照组更高(P P P Objective: To explore the value of the combination of uterine artery flow parameters and platelet aggregation function in predicting unexplained recurrent abortion (URSA). Methods: 94 patients with URSA from September 2021 to August 2023 were selected as the URSA group, and 110 normal pregnant women who underwent prenatal examination were selected as the control group. The URSA patients were followed up until 28 weeks of gestation and divided into the normal pregnancy group (n = 25) and the abortion group (n = 69) according to the pregnancy outcome. The uterine artery blood flow parameters and platelet aggregation rate were compared between the two groups. The predictive value of the uterine artery flow parameters and platelet aggregation rate for the pregnancy outcomes of URSA patients was evaluated by ROC. Binary Logistic stepwise regression was employed to explore the influencing factors of the pregnancy outcomes of URSA patients. Results: The indexes of the pulse index (PI), the arterial flow resistance index (RI), the systolic/diastolic blood flow velocity ratio (S/D), and the platelet aggregation rate in the URSA group were higher than those in the control group (P P P < 0.05). The ROC curve demonstrated that the area under the curve (AUC) (95% CI) of the uterine artery flow parameters, the platelet aggregation rate, and their combined prediction of the pregnancy outcomes of URSA patients were 0.858 (0.807~0.910), 0.764 (0.753~0.816), and 0.903 (0.852~0.955), respectively. Conclusion: The level of the uterine artery blood flow parameters and the increase of the platelet aggregation rate are closely associated with the pregnancy outcome of URSA patients, and the combined value of the two is highly significant in predicting the pregnancy outcome of URSA patients.展开更多
文摘生殖道微生物群与女性生育息息相关。育龄期妇女微生物群稳态失衡会影响生殖健康及妊娠并发症,从而影响母儿健康,生殖道微生物群对生育的相关影响近年来备受关注。随着辅助生殖技术的不断发展,最近的研究将女性生殖道微生物群与其相关联。因此,本综述概述了女性生殖道各部分之间微生物群差异,及其在不孕女性生殖健康中的作用,包括其对ART治疗的影响。此外,还总结了微生物种群变化对ART结局影响的最新进展。Reproductive tract microbiota is closely associated with female fertility. Imbalances in the homeostasis of microbiota among women of childbearing age can impact reproductive health and pregnancy complications, ultimately affecting both maternal and fetal well-being. The influence of reproductive tract microbiota on fertility has attracted much attention in recent years. With the development of assisted reproductive technology. Recent studies have linked the female reproductive tract microbiota to it. This review provides an overview of the differences in microbiota across various parts of the female reproductive tract and their role in infertility, including implications for ART therapy. Additionally, recent progress regarding the effects of changes in microbial populations on ART outcomes is summarized.
文摘目的:探讨子宫动脉血流参数联合血小板聚集功能预测不明原因复发性流产(URSA)的价值。方法:将2021年9月至2023年8月本院收治的94例URSA患者作为URSA组,另外将同期在本院进行产检的110例正常妊娠孕妇作为对照组。URSA患者随访至妊娠28周,根据妊娠结局分为正常妊娠组(n = 25)和流产组(n = 69)。比较2组患者子宫动脉血流参数、血小板聚集率;采用受试者工作特性(ROC)曲线评估子宫动脉血流参数、血小板聚集率对URSA患者妊娠结局的预测价值;采用二分类Logistic逐步回归分析探讨URSA患者妊娠结局的影响因素。结果:在搏动指数(PI)、动脉血流阻力指数(RI)、收缩期/舒张期血流速度比值(S/D)、血小板聚集率指标方面,URSA组相较于对照组更高(P P P Objective: To explore the value of the combination of uterine artery flow parameters and platelet aggregation function in predicting unexplained recurrent abortion (URSA). Methods: 94 patients with URSA from September 2021 to August 2023 were selected as the URSA group, and 110 normal pregnant women who underwent prenatal examination were selected as the control group. The URSA patients were followed up until 28 weeks of gestation and divided into the normal pregnancy group (n = 25) and the abortion group (n = 69) according to the pregnancy outcome. The uterine artery blood flow parameters and platelet aggregation rate were compared between the two groups. The predictive value of the uterine artery flow parameters and platelet aggregation rate for the pregnancy outcomes of URSA patients was evaluated by ROC. Binary Logistic stepwise regression was employed to explore the influencing factors of the pregnancy outcomes of URSA patients. Results: The indexes of the pulse index (PI), the arterial flow resistance index (RI), the systolic/diastolic blood flow velocity ratio (S/D), and the platelet aggregation rate in the URSA group were higher than those in the control group (P P P < 0.05). The ROC curve demonstrated that the area under the curve (AUC) (95% CI) of the uterine artery flow parameters, the platelet aggregation rate, and their combined prediction of the pregnancy outcomes of URSA patients were 0.858 (0.807~0.910), 0.764 (0.753~0.816), and 0.903 (0.852~0.955), respectively. Conclusion: The level of the uterine artery blood flow parameters and the increase of the platelet aggregation rate are closely associated with the pregnancy outcome of URSA patients, and the combined value of the two is highly significant in predicting the pregnancy outcome of URSA patients.
