血脑屏障(blood brain barrier, BBB)是存在于外周血液和脑组织之间的结构,保护大脑免受内源性及外源性毒素和病原体的侵害,从而维持脑内环境稳定。在中枢神经系统疾病中,血脑屏障的破坏将进一步加剧疾病的进展。研究表明血小板源性生...血脑屏障(blood brain barrier, BBB)是存在于外周血液和脑组织之间的结构,保护大脑免受内源性及外源性毒素和病原体的侵害,从而维持脑内环境稳定。在中枢神经系统疾病中,血脑屏障的破坏将进一步加剧疾病的进展。研究表明血小板源性生长因子(platelet-derived growth factor, PDGF)在血脑屏障的形成及功能维持中发挥重要作用,本文总结了PDGF及其受体在生理及病理情况下对血脑屏障的影响,初步探讨PDGF在中枢神经系统疾病中的治疗可能性,并对当前靶向PDGF及其受体的治疗手段进行简要综述。The blood brain barrier (BBB) is a structure that exists between peripheral blood and brain tissue, protecting the brain from endogenous and exogenous toxins and pathogens, thereby maintaining the stability of the brain internal environment. In central nervous system diseases, the disruption of BBB further exacerbates disease progression. Compelling data indicates that platelet-derived growth factor (PDGF) plays an important role in the maintenance and formation of BBB. This article summarizes the effects of PDGFs and their receptors on the integrity of BBB under physiological and pathological conditions. Finally, we briefly summarize the potential therapeutic strategy of PDGFs in central nervous system diseases, and review the current therapeutic methods targeting PDGFR.展开更多
目的:探讨精子核成熟度与早期不明原因复发性流产的相关性。方法:收集配偶具有早期不明原因复发性流产史的患者50例为URM组,正常生育的男性30例为对照组,通过计算机辅助精液分析仪检测精子的浓度和活动力等,精子染色质扩散实验检测精子...目的:探讨精子核成熟度与早期不明原因复发性流产的相关性。方法:收集配偶具有早期不明原因复发性流产史的患者50例为URM组,正常生育的男性30例为对照组,通过计算机辅助精液分析仪检测精子的浓度和活动力等,精子染色质扩散实验检测精子DNA完整性,苯胺蓝染色法检测精子核蛋白组型转换,分别比较两组精子DNA完整性、精子核蛋白组型转换率和精液参数的差异。结果:URM组与对照组之间精液量(3.23±1.13 vs 3.37±1.23)mL、精子浓度(29.33±3.76 vs 31.16±4.29)×10~6/mL的比较差异没有统计学意义(P>0.05);精子前向运动(35.19±7.26 vs 50.12±10.84)%、精子正常形态(2.07±2.94 vs 8.69±4.13)%、精子DNA碎片率(39.28±15.95 vs 23.16±15.17)%及精子核蛋白组型转换率(41.99±8.63 vs 18.81±7.53)%比较差异有统计学意义(P<0.05)。结论:早期不明原因复发性流产可能与精子核成熟度异常有关,建议RSA患者常规检测夫精精子核成熟度。展开更多
文摘血脑屏障(blood brain barrier, BBB)是存在于外周血液和脑组织之间的结构,保护大脑免受内源性及外源性毒素和病原体的侵害,从而维持脑内环境稳定。在中枢神经系统疾病中,血脑屏障的破坏将进一步加剧疾病的进展。研究表明血小板源性生长因子(platelet-derived growth factor, PDGF)在血脑屏障的形成及功能维持中发挥重要作用,本文总结了PDGF及其受体在生理及病理情况下对血脑屏障的影响,初步探讨PDGF在中枢神经系统疾病中的治疗可能性,并对当前靶向PDGF及其受体的治疗手段进行简要综述。The blood brain barrier (BBB) is a structure that exists between peripheral blood and brain tissue, protecting the brain from endogenous and exogenous toxins and pathogens, thereby maintaining the stability of the brain internal environment. In central nervous system diseases, the disruption of BBB further exacerbates disease progression. Compelling data indicates that platelet-derived growth factor (PDGF) plays an important role in the maintenance and formation of BBB. This article summarizes the effects of PDGFs and their receptors on the integrity of BBB under physiological and pathological conditions. Finally, we briefly summarize the potential therapeutic strategy of PDGFs in central nervous system diseases, and review the current therapeutic methods targeting PDGFR.
文摘目的:探讨精子核成熟度与早期不明原因复发性流产的相关性。方法:收集配偶具有早期不明原因复发性流产史的患者50例为URM组,正常生育的男性30例为对照组,通过计算机辅助精液分析仪检测精子的浓度和活动力等,精子染色质扩散实验检测精子DNA完整性,苯胺蓝染色法检测精子核蛋白组型转换,分别比较两组精子DNA完整性、精子核蛋白组型转换率和精液参数的差异。结果:URM组与对照组之间精液量(3.23±1.13 vs 3.37±1.23)mL、精子浓度(29.33±3.76 vs 31.16±4.29)×10~6/mL的比较差异没有统计学意义(P>0.05);精子前向运动(35.19±7.26 vs 50.12±10.84)%、精子正常形态(2.07±2.94 vs 8.69±4.13)%、精子DNA碎片率(39.28±15.95 vs 23.16±15.17)%及精子核蛋白组型转换率(41.99±8.63 vs 18.81±7.53)%比较差异有统计学意义(P<0.05)。结论:早期不明原因复发性流产可能与精子核成熟度异常有关,建议RSA患者常规检测夫精精子核成熟度。
