甘油三酯–葡萄糖体重指数(TyG-BMI指数)是最新研究发现的一种联合性指标,通过简单计算空腹甘油三酯、血糖及BMI的数值即可快捷地评估胰岛素功能。既往研究表明胰岛素抵抗通过各种病理生理机制引起临床众多代谢性疾病,同时TyG-BMI指数...甘油三酯–葡萄糖体重指数(TyG-BMI指数)是最新研究发现的一种联合性指标,通过简单计算空腹甘油三酯、血糖及BMI的数值即可快捷地评估胰岛素功能。既往研究表明胰岛素抵抗通过各种病理生理机制引起临床众多代谢性疾病,同时TyG-BMI指数在识别和诊断常见疾病方面,也有极高的临床价值。本文通过探讨临床常见疾病与甘油三酯–葡萄糖体重指数以及胰岛素抵抗的相关研究进展进行深一步的探讨和总结,从多方面分析胰岛素抵抗导致机体疾病发生的协同作用,帮助临床医生对病情发展进行更好和更早的评估,帮助患者提升远期生活质量。The Triglyceride-Glucose Body Mass Index (TyG-BMI) is a composite measure identified in recent research. A simple calculation involving fasting triglyceride levels, blood glucose, and BMI allows for a quick assessment of insulin function. Prior investigations have demonstrated that insulin resistance contributes to a variety of clinical metabolic disorders through different pathophysiological pathways, with the TyG-BMI index proving to be highly valuable for the identification and diagnosis of prevalent diseases. This paper further explores and synthesizes the latest research developments related to common clinical conditions, triglyceride-glucose BMI, and insulin resistance. It examines the combined effects of insulin resistance on the emergence of body disorders from multiple perspectives, aiming to assist clinicians in improving their assessments of disease progression, and enhance patients’ long-term quality of life.展开更多
铁死亡(Ferroptosis)是一种新型程序性死亡模式,主要由铁依赖的脂质过氧化和铁离子聚集引起。心力衰竭是一种严重危害人类健康的重大疾病,其发病率和死亡率在全球范围内持续升高。最新研究表明,铁死亡是心衰的关键环节。铁死亡与心衰之...铁死亡(Ferroptosis)是一种新型程序性死亡模式,主要由铁依赖的脂质过氧化和铁离子聚集引起。心力衰竭是一种严重危害人类健康的重大疾病,其发病率和死亡率在全球范围内持续升高。最新研究表明,铁死亡是心衰的关键环节。铁死亡与心衰之间的相关性已成为当前研究的热点。本文对铁代谢调节的机制及其与心力衰竭的关系进行综述。Ferroptosis is a novel mode of programmed death caused mainly by iron-dependent lipid peroxidation and iron ion aggregation. Heart failure is a major disease that seriously jeopardizes human health, and its morbidity and mortality continue to increase worldwide. Recent studies have shown that ferroptosis is a key component of heart failure. The correlation between ferroptosis and heart failure has become a hot topic of current research. In this paper, we review the mechanisms of iron metabolism regulation and its relationship with heart failure.展开更多
缺血性心肌病是导致死亡和发病的重要原因,特别需要准确的诊断和预后特征。心脏磁共振(CMR)可以通过对心肌功能、灌注和组织成分进行全面评估来帮助满足这些要求,在指导已知或疑似缺血性心肌病患者的临床管理方面具有实用性。CMR能够提...缺血性心肌病是导致死亡和发病的重要原因,特别需要准确的诊断和预后特征。心脏磁共振(CMR)可以通过对心肌功能、灌注和组织成分进行全面评估来帮助满足这些要求,在指导已知或疑似缺血性心肌病患者的临床管理方面具有实用性。CMR能够提供有关心脏病理生理的准确性(功能与灌注)或特殊(组织特征)信息,同时避免暴露于电离辐射并克服与成像窗口质量相关的限制。特别是,应力灌注被证明是准确、安全、具体成本效益的,并且作为检测心肌缺血严重程度和分布的非侵入性测试具有临床价值。然而心脏MRI提供了重要的临床信息,其广泛应用仍面临高成本、设备可获取性及操作技术要求高等挑战。未来研究需继续优化成像技术,扩大技术的可接受度和可访问性,同时降低成本,提高设备普及率,以便更多患者能够受益。Ischemic cardiomyopathy is an important cause of death and morbidity, requiring accurate diagnosis and prognostic features. Cardiac magnetic resonance imaging (CMR) can help meet these requirements by comprehensively evaluating cardiac function, perfusion, and tissue composition, and is practical in guiding clinical management of patients with known or suspected ischemic myocardium. CMR can provide accurate (functional and perfusion) or specific (tissue characteristics) information about cardiac pathophysiology, while avoiding exposure to ionizing radiation and overcoming limitations related to imaging window quality. Especially, stress perfusion has been proven to be accurate, safe, and cost-effective, and has clinical value as a non-invasive test for detecting the severity and distribution of myocardial ischemia. However, cardiac MRI provides important clinical information, but its widespread application still faces challenges such as high cost, equipment accessibility, and high operational technical requirements. Future research needs to continue optimizing imaging technology, expanding its acceptability and accessibility, while reducing costs and increasing device adoption, so that more patients can benefit.展开更多
文摘甘油三酯–葡萄糖体重指数(TyG-BMI指数)是最新研究发现的一种联合性指标,通过简单计算空腹甘油三酯、血糖及BMI的数值即可快捷地评估胰岛素功能。既往研究表明胰岛素抵抗通过各种病理生理机制引起临床众多代谢性疾病,同时TyG-BMI指数在识别和诊断常见疾病方面,也有极高的临床价值。本文通过探讨临床常见疾病与甘油三酯–葡萄糖体重指数以及胰岛素抵抗的相关研究进展进行深一步的探讨和总结,从多方面分析胰岛素抵抗导致机体疾病发生的协同作用,帮助临床医生对病情发展进行更好和更早的评估,帮助患者提升远期生活质量。The Triglyceride-Glucose Body Mass Index (TyG-BMI) is a composite measure identified in recent research. A simple calculation involving fasting triglyceride levels, blood glucose, and BMI allows for a quick assessment of insulin function. Prior investigations have demonstrated that insulin resistance contributes to a variety of clinical metabolic disorders through different pathophysiological pathways, with the TyG-BMI index proving to be highly valuable for the identification and diagnosis of prevalent diseases. This paper further explores and synthesizes the latest research developments related to common clinical conditions, triglyceride-glucose BMI, and insulin resistance. It examines the combined effects of insulin resistance on the emergence of body disorders from multiple perspectives, aiming to assist clinicians in improving their assessments of disease progression, and enhance patients’ long-term quality of life.
文摘铁死亡(Ferroptosis)是一种新型程序性死亡模式,主要由铁依赖的脂质过氧化和铁离子聚集引起。心力衰竭是一种严重危害人类健康的重大疾病,其发病率和死亡率在全球范围内持续升高。最新研究表明,铁死亡是心衰的关键环节。铁死亡与心衰之间的相关性已成为当前研究的热点。本文对铁代谢调节的机制及其与心力衰竭的关系进行综述。Ferroptosis is a novel mode of programmed death caused mainly by iron-dependent lipid peroxidation and iron ion aggregation. Heart failure is a major disease that seriously jeopardizes human health, and its morbidity and mortality continue to increase worldwide. Recent studies have shown that ferroptosis is a key component of heart failure. The correlation between ferroptosis and heart failure has become a hot topic of current research. In this paper, we review the mechanisms of iron metabolism regulation and its relationship with heart failure.
文摘缺血性心肌病是导致死亡和发病的重要原因,特别需要准确的诊断和预后特征。心脏磁共振(CMR)可以通过对心肌功能、灌注和组织成分进行全面评估来帮助满足这些要求,在指导已知或疑似缺血性心肌病患者的临床管理方面具有实用性。CMR能够提供有关心脏病理生理的准确性(功能与灌注)或特殊(组织特征)信息,同时避免暴露于电离辐射并克服与成像窗口质量相关的限制。特别是,应力灌注被证明是准确、安全、具体成本效益的,并且作为检测心肌缺血严重程度和分布的非侵入性测试具有临床价值。然而心脏MRI提供了重要的临床信息,其广泛应用仍面临高成本、设备可获取性及操作技术要求高等挑战。未来研究需继续优化成像技术,扩大技术的可接受度和可访问性,同时降低成本,提高设备普及率,以便更多患者能够受益。Ischemic cardiomyopathy is an important cause of death and morbidity, requiring accurate diagnosis and prognostic features. Cardiac magnetic resonance imaging (CMR) can help meet these requirements by comprehensively evaluating cardiac function, perfusion, and tissue composition, and is practical in guiding clinical management of patients with known or suspected ischemic myocardium. CMR can provide accurate (functional and perfusion) or specific (tissue characteristics) information about cardiac pathophysiology, while avoiding exposure to ionizing radiation and overcoming limitations related to imaging window quality. Especially, stress perfusion has been proven to be accurate, safe, and cost-effective, and has clinical value as a non-invasive test for detecting the severity and distribution of myocardial ischemia. However, cardiac MRI provides important clinical information, but its widespread application still faces challenges such as high cost, equipment accessibility, and high operational technical requirements. Future research needs to continue optimizing imaging technology, expanding its acceptability and accessibility, while reducing costs and increasing device adoption, so that more patients can benefit.
文摘目的静脉注射胺碘酮治疗老年重度心力衰竭合并快速心律失常的临床分析。方法 90例老年重度心力衰竭合并快速心律失常患者,随机分为对照组和观察组,各45例。对照组予以重症心力衰竭合并快速心律失常常规治疗,观察组在常规治疗基础上静脉注射胺碘酮。观察两组患者的治疗效果、不良反应情况以及治疗前后心脏指数(CI)、平均动脉压(MAP)和心脏射血分数(LVEF)。结果观察组的心力衰竭、心律失常治疗有效率及不良反应发生率分别为93.3%、95.6%、6.7%,对照组的心力衰竭、心律失常的治疗有效率及不良反应发生率分别为77.8%、82.2%、22.2%,观察组治疗总有效率高于对照组,不良反应发生率低于对照组(P<0.05);治疗前观察组的CI为(2.12±0.33)L/(min·m2),MAP为(74.37±5.34)mm Hg(1 mm Hg=0.133 k Pa),LVEF为(32.20±5.45)%,对照组的CI为(2.22±0.45)L/(min·m2),MAP为(75.12±4.29)mm Hg,LVEF为(33.19±6.20)%,治疗前两组比较差异无统计学意义(P>0.05);治疗后观察组的CI为(2.56±0.50)L/(min·m2),MAP为(89.90±5.60)mm Hg,LVEF为(50.20±5.00)%,对照组的CI为(2.27±0.41)L/(min·m2),MAP为(82.01±5.78)mm Hg,LVEF为(41.12±6.07)%,治疗后两组的CI、MAP以及LVEF分数均优于治疗前,且观察组优于对照组(P<0.05)。结论对老年重度心力衰竭合并快速心律失常患者予以胺碘酮治疗,效果显著,不良发应发生率低,可在临床推广。
