目的通过知识图谱可视化探究近20年来中医药抗肿瘤血管生成的研究现状、研究热点以及研究成果,为该领域的进一步研究提供参考。方法以“中医药”“肿瘤血管生成”等为主题词,以2002年1月1日至2021年12月31日为时间段,检索中国知网数据库...目的通过知识图谱可视化探究近20年来中医药抗肿瘤血管生成的研究现状、研究热点以及研究成果,为该领域的进一步研究提供参考。方法以“中医药”“肿瘤血管生成”等为主题词,以2002年1月1日至2021年12月31日为时间段,检索中国知网数据库(Chinese National Knowledge Infrastructure,CNKI)所收录的相关文献,应用CiteSpace.6.1.R1软件对文献进行计量学分析,并绘制、分析相关的知识图谱。结果总共纳入分析文献608篇。2002年至2021年,国内中医药抗肿瘤血管生成的文献数量总体呈上升趋势,其中2010年达到发文量高峰,为47篇;核心作者发文量总计437篇,占总发文量的71.87%(>50%);共形成3个合作紧密的作者机构;中医药抗肿瘤血管生成的高频关键词为:血管生成、肿瘤、中药等;聚类图谱可见所有关键词被聚类成11类;共11个关键词参与突现,其中近两年研究热点包括机制、裸鼠、卵巢癌及免疫功能。结论针对中医药抑制肿瘤血管生成的机制研究既是国内研究现状也是长期的研究方向;抗血管生成药物与免疫疗法相结合是国内中医药抗肿瘤血管生成的研究热点;中西医结合治疗应用于临床抗肿瘤血管生成是未来的研究趋势。展开更多
乙型肝炎病毒(hepatitis B virus,HBV)是肝癌(primary liver cancer,PLC)最常见的治病因素,HBV持续感染易激活肝细胞从静止状态转变为持续复制活跃状态,标志着“炎-癌”转变的开始,如若病毒感染不能得到及时有效的控制,逐渐向“肝炎-肝...乙型肝炎病毒(hepatitis B virus,HBV)是肝癌(primary liver cancer,PLC)最常见的治病因素,HBV持续感染易激活肝细胞从静止状态转变为持续复制活跃状态,标志着“炎-癌”转变的开始,如若病毒感染不能得到及时有效的控制,逐渐向“肝炎-肝硬化-肝癌”转变,因此认为HBV感染为PLC的伏邪。最虚之处,便是容邪之处,核心病机为正虚毒结,正气亏虚为发病之因,癌毒内伏是发病的关键,扶正祛邪、抗癌解毒为肝癌主要治法,治疗上强调中药内服、外治及针灸法尽早截断病变进程,以防恶变、坏证。展开更多
目的:以数据挖掘为基础,分析总结中医辨证论治慢性支气管炎合并肺气肿的用药规律。方法:以中国知网CNKI、维普中文期刊服务平台以及万方医学网数据库平台为基础,检索2024年2月1日前已发表的,有关慢性支气管炎合并肺气肿的中医临床治疗文...目的:以数据挖掘为基础,分析总结中医辨证论治慢性支气管炎合并肺气肿的用药规律。方法:以中国知网CNKI、维普中文期刊服务平台以及万方医学网数据库平台为基础,检索2024年2月1日前已发表的,有关慢性支气管炎合并肺气肿的中医临床治疗文献,筛选出处方明确,且经过随机对照实验证明有效的期刊文献;使用SPSS Statistics、SPSS Modeler、古今医案云平台,分别对纳入的处方进行药物频次分析、性味归经分析、关联分析、聚类分析等。结果:数据库总计录入文献245篇,筛查出符合条件的处方46首,涉及中药123味;其中,中药药性以寒性药物为主;药味以甘、苦、辛味为主;药物多归入肺、脾、肾、心、胃经;高频中药有杏仁、半夏、甘草、麻黄、茯苓等。结论:中医临床治疗慢性支气管炎合并肺气肿多以宣肺平喘,理气化痰为原则;处方以三拗汤为基本方进行加减,根据证型进一步配伍清热、滋阴、温阳、利水渗湿等药物。Objective: Based on data mining, to analyze and summarize the rule of medicine in TCM dialectical treatment of chronic bronchitis complicated with emphysema. Methods: Based on CNKI, VIP Chinese journal service platform and Wanfang Medical network database platform, literature on TCM clinical treatment of chronic bronchitis complicated with emphysema published before February 1, 2024 was searched, and periodical literature with clear prescription and proven effective by randomized controlled experiments was selected. SPSS Statistics, SPSS Modeler and the cloud platform of ancient and modern medical records were used to analyze the drug frequency, sex and taste classification, association analysis and cluster analysis of the included prescriptions. Results: A total of 245 literatures were recorded in the database, 46 eligible prescriptions were screened, involving 123 flavors of traditional Chinese medicine. Among them, the medicinal properties of traditional Chinese medicine are mainly cold drugs. The main taste of medicine is sweet, bitter and sinuous. Drugs are classified into lung, spleen, kidney, heart, stomach channels. The high frequency Chinese medicine has almond, pinellia, licorice, ephedra, tuckahoe and so on. Conclusion: The clinical treatment of chronic bronchitis combined with emphysema is mainly based on the principle of relieving lung asthma, regulating qi and eliminating phlegm. According to the type of syndrome, the prescription was further combined with drugs such as clearing heat, nourishing Yin, warming Yang, removing water and expelling dampness.展开更多
目的:探讨阳虚质、气虚质、血瘀质与慢性肾脏病及其水肿症状发病的相关性以及基于中医体质理论运用中药对慢性肾脏病的临床研究进展,探讨该疾病易感体质的相关性,以期通过中医体质为切入点运用中西医联合治疗的诊疗模式,能够全面有效控...目的:探讨阳虚质、气虚质、血瘀质与慢性肾脏病及其水肿症状发病的相关性以及基于中医体质理论运用中药对慢性肾脏病的临床研究进展,探讨该疾病易感体质的相关性,以期通过中医体质为切入点运用中西医联合治疗的诊疗模式,能够全面有效控制慢性肾脏病的发生发展。方法:采用回顾性分析法,通过查阅文献、图书、指南等相关文献,分析、总结近年来中西医对慢性肾脏病及相关中医体质的研究,探讨中医体质与慢性肾脏病水肿症状之间的因果关系。结果:目前慢性肾脏病发病的机制仍不明确,中医药治疗对慢性肾脏病患者的恢复有一定改善,同时阳虚、气虚、血瘀质在慢性肾脏病中医体质类型中分布占有较高比例。结论:基于体病相关、体质可调理论,辨体论治已经成为防治慢性肾脏病水肿症状的研究热点,并且也为治疗该疾病提供新的思路。Objective: This paper aims to explore the correlations between the Yang-deficiency constitution, Qi-deficiency constitution, Blood-stasis constitution and the onset of chronic kidney disease (CKD) and its edema symptoms, as well as the clinical research progress of applying traditional Chinese medicine (TCM) based on the TCM constitution theory to treat CKD, and to investigate the correlation of the susceptible constitution for this disease, with the aim of adopting a combined treatment model of Chinese and Western medicine by taking TCM constitution as the entry point, so as to comprehensively and effectively control the occurrence and development of CKD. Methods: A retrospective analysis method was employed. By consulting relevant literatures such as papers, books, and guidelines, the research on CKD and related TCM constitutions in recent years was analyzed and summarized to explore the causal relationship between TCM constitution and edema symptoms of CKD. Results: Currently, the pathogenesis of CKD remains unclear. TCM treatment has shown certain improvements in the recovery of CKD patients. Meanwhile, Yang-deficiency, Qi-deficiency, and Blood-stasis constitutions account for a relatively high proportion among the TCM constitution types of CKD. Conclusion: Based on the theories of body-disease correlation and constitution adjustability, diagnosis and treatment based on constitution have become a research hotspot in preventing and treating edema symptoms of CKD, and have also provided new ideas for the treatment of this disease.展开更多
文摘目的通过知识图谱可视化探究近20年来中医药抗肿瘤血管生成的研究现状、研究热点以及研究成果,为该领域的进一步研究提供参考。方法以“中医药”“肿瘤血管生成”等为主题词,以2002年1月1日至2021年12月31日为时间段,检索中国知网数据库(Chinese National Knowledge Infrastructure,CNKI)所收录的相关文献,应用CiteSpace.6.1.R1软件对文献进行计量学分析,并绘制、分析相关的知识图谱。结果总共纳入分析文献608篇。2002年至2021年,国内中医药抗肿瘤血管生成的文献数量总体呈上升趋势,其中2010年达到发文量高峰,为47篇;核心作者发文量总计437篇,占总发文量的71.87%(>50%);共形成3个合作紧密的作者机构;中医药抗肿瘤血管生成的高频关键词为:血管生成、肿瘤、中药等;聚类图谱可见所有关键词被聚类成11类;共11个关键词参与突现,其中近两年研究热点包括机制、裸鼠、卵巢癌及免疫功能。结论针对中医药抑制肿瘤血管生成的机制研究既是国内研究现状也是长期的研究方向;抗血管生成药物与免疫疗法相结合是国内中医药抗肿瘤血管生成的研究热点;中西医结合治疗应用于临床抗肿瘤血管生成是未来的研究趋势。
文摘乙型肝炎病毒(hepatitis B virus,HBV)是肝癌(primary liver cancer,PLC)最常见的治病因素,HBV持续感染易激活肝细胞从静止状态转变为持续复制活跃状态,标志着“炎-癌”转变的开始,如若病毒感染不能得到及时有效的控制,逐渐向“肝炎-肝硬化-肝癌”转变,因此认为HBV感染为PLC的伏邪。最虚之处,便是容邪之处,核心病机为正虚毒结,正气亏虚为发病之因,癌毒内伏是发病的关键,扶正祛邪、抗癌解毒为肝癌主要治法,治疗上强调中药内服、外治及针灸法尽早截断病变进程,以防恶变、坏证。
文摘目的:以数据挖掘为基础,分析总结中医辨证论治慢性支气管炎合并肺气肿的用药规律。方法:以中国知网CNKI、维普中文期刊服务平台以及万方医学网数据库平台为基础,检索2024年2月1日前已发表的,有关慢性支气管炎合并肺气肿的中医临床治疗文献,筛选出处方明确,且经过随机对照实验证明有效的期刊文献;使用SPSS Statistics、SPSS Modeler、古今医案云平台,分别对纳入的处方进行药物频次分析、性味归经分析、关联分析、聚类分析等。结果:数据库总计录入文献245篇,筛查出符合条件的处方46首,涉及中药123味;其中,中药药性以寒性药物为主;药味以甘、苦、辛味为主;药物多归入肺、脾、肾、心、胃经;高频中药有杏仁、半夏、甘草、麻黄、茯苓等。结论:中医临床治疗慢性支气管炎合并肺气肿多以宣肺平喘,理气化痰为原则;处方以三拗汤为基本方进行加减,根据证型进一步配伍清热、滋阴、温阳、利水渗湿等药物。Objective: Based on data mining, to analyze and summarize the rule of medicine in TCM dialectical treatment of chronic bronchitis complicated with emphysema. Methods: Based on CNKI, VIP Chinese journal service platform and Wanfang Medical network database platform, literature on TCM clinical treatment of chronic bronchitis complicated with emphysema published before February 1, 2024 was searched, and periodical literature with clear prescription and proven effective by randomized controlled experiments was selected. SPSS Statistics, SPSS Modeler and the cloud platform of ancient and modern medical records were used to analyze the drug frequency, sex and taste classification, association analysis and cluster analysis of the included prescriptions. Results: A total of 245 literatures were recorded in the database, 46 eligible prescriptions were screened, involving 123 flavors of traditional Chinese medicine. Among them, the medicinal properties of traditional Chinese medicine are mainly cold drugs. The main taste of medicine is sweet, bitter and sinuous. Drugs are classified into lung, spleen, kidney, heart, stomach channels. The high frequency Chinese medicine has almond, pinellia, licorice, ephedra, tuckahoe and so on. Conclusion: The clinical treatment of chronic bronchitis combined with emphysema is mainly based on the principle of relieving lung asthma, regulating qi and eliminating phlegm. According to the type of syndrome, the prescription was further combined with drugs such as clearing heat, nourishing Yin, warming Yang, removing water and expelling dampness.
文摘目的:探讨阳虚质、气虚质、血瘀质与慢性肾脏病及其水肿症状发病的相关性以及基于中医体质理论运用中药对慢性肾脏病的临床研究进展,探讨该疾病易感体质的相关性,以期通过中医体质为切入点运用中西医联合治疗的诊疗模式,能够全面有效控制慢性肾脏病的发生发展。方法:采用回顾性分析法,通过查阅文献、图书、指南等相关文献,分析、总结近年来中西医对慢性肾脏病及相关中医体质的研究,探讨中医体质与慢性肾脏病水肿症状之间的因果关系。结果:目前慢性肾脏病发病的机制仍不明确,中医药治疗对慢性肾脏病患者的恢复有一定改善,同时阳虚、气虚、血瘀质在慢性肾脏病中医体质类型中分布占有较高比例。结论:基于体病相关、体质可调理论,辨体论治已经成为防治慢性肾脏病水肿症状的研究热点,并且也为治疗该疾病提供新的思路。Objective: This paper aims to explore the correlations between the Yang-deficiency constitution, Qi-deficiency constitution, Blood-stasis constitution and the onset of chronic kidney disease (CKD) and its edema symptoms, as well as the clinical research progress of applying traditional Chinese medicine (TCM) based on the TCM constitution theory to treat CKD, and to investigate the correlation of the susceptible constitution for this disease, with the aim of adopting a combined treatment model of Chinese and Western medicine by taking TCM constitution as the entry point, so as to comprehensively and effectively control the occurrence and development of CKD. Methods: A retrospective analysis method was employed. By consulting relevant literatures such as papers, books, and guidelines, the research on CKD and related TCM constitutions in recent years was analyzed and summarized to explore the causal relationship between TCM constitution and edema symptoms of CKD. Results: Currently, the pathogenesis of CKD remains unclear. TCM treatment has shown certain improvements in the recovery of CKD patients. Meanwhile, Yang-deficiency, Qi-deficiency, and Blood-stasis constitutions account for a relatively high proportion among the TCM constitution types of CKD. Conclusion: Based on the theories of body-disease correlation and constitution adjustability, diagnosis and treatment based on constitution have become a research hotspot in preventing and treating edema symptoms of CKD, and have also provided new ideas for the treatment of this disease.
