目的 观察祛浊清源汤治疗糖尿病肾病患者的临床疗效及对其肾功能指标的影响。方法 选取2019年9月—2021年3月期间衡水市中医医院收治的120例糖尿病肾病患者作为研究对象,按照随机数字表法分为对照组和观察组,每组各60例。两组患者均给...目的 观察祛浊清源汤治疗糖尿病肾病患者的临床疗效及对其肾功能指标的影响。方法 选取2019年9月—2021年3月期间衡水市中医医院收治的120例糖尿病肾病患者作为研究对象,按照随机数字表法分为对照组和观察组,每组各60例。两组患者均给予优质蛋白、降糖、利尿消肿等基础治疗。对照组给予依那普利治疗,观察组在对照组基础上给予祛浊清源汤口服。连续治疗16周后,观察比较两组患者临床疗效,治疗前及治疗16周后中医证候积分,肾功能指标[血清肌酐(Serum creatinine, Scr)、尿素氮(Blood urea nitrogen, BUN)、24 h尿蛋白定量(24 h urine protein quantification, 24 h UPQ)、24 h尿微量白蛋白排泄率(24 h urine microalbumin excretion rate, 24 h UAER)]水平及不良反应发生情况。结果 治疗后观察组临床总有效率93.33%(56/60)明显高于对照组78.33%(47/60),差异有统计学意义(P<0.05)。治疗后两组患者神疲乏力、少气懒言、腰膝酸软、口干咽燥、潮热盗汗、夜尿频多积分均较治疗前降低,差异有统计学意义(P<0.05);且观察组神疲乏力、少气懒言、腰膝酸软、口干咽燥、潮热盗汗、夜尿频多积分均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者肾功能24 h UAER、24 h UPQ、BUN、Scr水平均较治疗前降低,差异有统计学意义(P<0.05);且观察组肾功能24 h UAER、24 h UPQ、BUN、Scr水平均较对照组明显降低,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 祛浊清源汤治疗糖尿病肾病疗效较好,能够明显改善中医症状,同时可以改善肾功能,具有较高安全性,具有临床推广意义。展开更多
OBJECTIVE:To clarify the relationship between helicobacter pylori(Hp)infection,tongue manifestation and gastroscopic manifestation,and explore the mechanism of action of“oral-gastric microecology”in the occurrence a...OBJECTIVE:To clarify the relationship between helicobacter pylori(Hp)infection,tongue manifestation and gastroscopic manifestation,and explore the mechanism of action of“oral-gastric microecology”in the occurrence and development of stomach-related diseases.MEDHODS:A total of 1100 patients were divided into Hp positive group and Hp negative group according to 13 C breath test results.The tongue manifestation materials from patients were collected to make tongue printing slides for morphological observation of exfoliative cells from tongue coating,and electronic gastroscopy was performed on the patients and the data was analyzed.RESULTS:Hp infection rate was about 45.95%;and the greasy coating was mostly observed in Hp positive group(63.14%,P<0.05).The total tongue coating distribution was as follows:yellow greasy coating(56.66%,P<0.05)>yellow coating>white coating>white greasy coating.The gastric mucosal roughness and mucosal hematoplastic plaques in the two groups were more common in the Hp positive group(P<0.05).There was a significant difference in the granular subgroup and in the rough mucosal group(P<0.05).CONCLUSIONS:Hp infection is more commonly observed in yellow greasy coating,and this can be used as a reference for Traditional Chinese Medicine in determining whether it is Hp infection or not.Mucosal granule roughness,hyperemia,and oral Hp showed association with Hp infection in the stomach and interacted with micro-ecological environment that is composed of the oral cavity.展开更多
文摘目的 观察祛浊清源汤治疗糖尿病肾病患者的临床疗效及对其肾功能指标的影响。方法 选取2019年9月—2021年3月期间衡水市中医医院收治的120例糖尿病肾病患者作为研究对象,按照随机数字表法分为对照组和观察组,每组各60例。两组患者均给予优质蛋白、降糖、利尿消肿等基础治疗。对照组给予依那普利治疗,观察组在对照组基础上给予祛浊清源汤口服。连续治疗16周后,观察比较两组患者临床疗效,治疗前及治疗16周后中医证候积分,肾功能指标[血清肌酐(Serum creatinine, Scr)、尿素氮(Blood urea nitrogen, BUN)、24 h尿蛋白定量(24 h urine protein quantification, 24 h UPQ)、24 h尿微量白蛋白排泄率(24 h urine microalbumin excretion rate, 24 h UAER)]水平及不良反应发生情况。结果 治疗后观察组临床总有效率93.33%(56/60)明显高于对照组78.33%(47/60),差异有统计学意义(P<0.05)。治疗后两组患者神疲乏力、少气懒言、腰膝酸软、口干咽燥、潮热盗汗、夜尿频多积分均较治疗前降低,差异有统计学意义(P<0.05);且观察组神疲乏力、少气懒言、腰膝酸软、口干咽燥、潮热盗汗、夜尿频多积分均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者肾功能24 h UAER、24 h UPQ、BUN、Scr水平均较治疗前降低,差异有统计学意义(P<0.05);且观察组肾功能24 h UAER、24 h UPQ、BUN、Scr水平均较对照组明显降低,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 祛浊清源汤治疗糖尿病肾病疗效较好,能够明显改善中医症状,同时可以改善肾功能,具有较高安全性,具有临床推广意义。
基金Supported by the Hebei Province Science and Technology Research and Development Project(No.162777113D)the High-level Talent Development Plan of Hebei Province+1 种基金the Special Scientific Research Projects in Traditional Chinese Medicine Industrythe Traditional Chinese Medicine Identification Database(Zang-fu Syndrome Differentiation,Physical Constitution Identification,Health Risk Early Warning)(No.201507003-05)
文摘OBJECTIVE:To clarify the relationship between helicobacter pylori(Hp)infection,tongue manifestation and gastroscopic manifestation,and explore the mechanism of action of“oral-gastric microecology”in the occurrence and development of stomach-related diseases.MEDHODS:A total of 1100 patients were divided into Hp positive group and Hp negative group according to 13 C breath test results.The tongue manifestation materials from patients were collected to make tongue printing slides for morphological observation of exfoliative cells from tongue coating,and electronic gastroscopy was performed on the patients and the data was analyzed.RESULTS:Hp infection rate was about 45.95%;and the greasy coating was mostly observed in Hp positive group(63.14%,P<0.05).The total tongue coating distribution was as follows:yellow greasy coating(56.66%,P<0.05)>yellow coating>white coating>white greasy coating.The gastric mucosal roughness and mucosal hematoplastic plaques in the two groups were more common in the Hp positive group(P<0.05).There was a significant difference in the granular subgroup and in the rough mucosal group(P<0.05).CONCLUSIONS:Hp infection is more commonly observed in yellow greasy coating,and this can be used as a reference for Traditional Chinese Medicine in determining whether it is Hp infection or not.Mucosal granule roughness,hyperemia,and oral Hp showed association with Hp infection in the stomach and interacted with micro-ecological environment that is composed of the oral cavity.
