The Air Transport Research Society(ATRS)World Conference is one of the major venues for air transport research.The conference covers a wide range of research talks,practice/industrial sessions,and research workshop ac...The Air Transport Research Society(ATRS)World Conference is one of the major venues for air transport research.The conference covers a wide range of research talks,practice/industrial sessions,and research workshop activities.In this paper,we perform a data-driven analysis of the research abstracts that have been accepted and presented at the conference since 2014.We have grouped the abstracts from the ten annual conferences using t-distributed stochastic neighbor embedding to map high-dimensional keyword vectors into a two-dimensional plane for clustering,analysis,and visualization.The major focus of our study concerns three directions.First,we provide a formal description of the actual research presented at the ATRS World Conference series by using methods from natural language processing and machine learning,leading to a data-driven classification consisting of 35 major subject categories.Second,we analyze the origin of main authors/presenters and their background,including their institutions and countries of origin.Third,we perform a network-driven analysis of co-authorships across abstracts to identify the role and importance of key researchers in the community.Finally,we provide an analysis of popular research topics indicated by authors when submitting their abstracts,and a set of major recommendations for future work,based on the insights obtained from our study.展开更多
As an important branch of human geography, transportation geography has experienced three periods of evolution: foundation, systematization, and rapid development of the discipline. It has gradually become a relativel...As an important branch of human geography, transportation geography has experienced three periods of evolution: foundation, systematization, and rapid development of the discipline. It has gradually become a relatively mature discipline. During the period 1930– 1980, the development of transportation geography consisted mainly of the publication of theoretical texts. During 1980–2000, it gradually became a systematic discipline. Since the start of the 21 st century, transportation geography has focused mainly on exploring the impacts of transportation on socio-economic development. Currently, studies on transportation geography have led to significant developments in a number of areas, including transportation theory, facility distribution and planning, transportation flows and network analysis, evaluation of transport modes, transportation planning, and simulation and assessment of urban transportation. Such studies have also enriched human geography research, provided a wider geographical overview and elucidated the development mechanism of transportation, as well as helped to understand the impacts of transport development on socio-economic systems. Some findings obtained by geographers have been widely used in transportation geography and related fields, including the four basic laws of transportation generation, the hub–spoke mode of transport organization, the subordinating and guiding functions of transportation on socio-economic development, regional transport dominance measures, accessibility measures, and spatial organization of port systems.展开更多
Rail systems are gradually becoming the most desirable form of transit infrastructure around the world, partly because they are becoming more environmentally friendly compared with airplanes and automobiles. This pape...Rail systems are gradually becoming the most desirable form of transit infrastructure around the world, partly because they are becoming more environmentally friendly compared with airplanes and automobiles. This paper examines the place of emerging countries in this move of implementing modern rail system that will eventually enhance the realization of a low-carbon society. Network model, transportation model and linear programming algorithms are used to model the present urban rail transport system in Nigeria, as an emerging country, in order to optimize it. Operational research methods, including simplex method and MODI, with the aids of computer software (excel solver and LIP solver) were adopted to solve the resulting models. The results showed that optimization of rail transport system will not only reduce carbon emission but also bring about economic development which is required for the eradication of prevalent poverty in these emerging countries.展开更多
为了解航空运输优化研究领域的研究现状、研究热点及前沿趋势,本文采用文献计量法,以中国知网(CNKI)和Web of Science核心数据库2006—2023年国内外关于航空运输优化研究领域的出版物为分析数据,借助CiteSpace 6.2 R4(Advance)对该领域...为了解航空运输优化研究领域的研究现状、研究热点及前沿趋势,本文采用文献计量法,以中国知网(CNKI)和Web of Science核心数据库2006—2023年国内外关于航空运输优化研究领域的出版物为分析数据,借助CiteSpace 6.2 R4(Advance)对该领域研究进行可视化分析。结果表明:该领域国内研究成果随时间变化呈波动上升趋势且波动较小,国外研究成果总体呈逐步增长趋势且于2019年后迅速增加;研究机构数量较多但未形成核心作者群,缺乏合作;航线网络、机队规划、算法等是国内外该领域的主要研究内容。展开更多
Metabolic reprogramming and altered energetics have become an emerging hallmark of cancer and an active area of basic, translational, and clinical cancer research in the recent decade. Development of effective antican...Metabolic reprogramming and altered energetics have become an emerging hallmark of cancer and an active area of basic, translational, and clinical cancer research in the recent decade. Development of effective anticancer therapeutics may depend on improved understanding of the altered cancer metabolism compared to that of normal cells. Changes in glucose transport and glycolysis, which are drastically upregulated in most can-cers and termed the Warburg effect, are one of major focuses of this new research area. By taking advantage of the new knowledge and understanding of cancer's mechanisms, numerous therapeutic agents have been developed to target proteins and enzymes involved in glucose transport and metabolism, with promising results in cancer cells, animal tumor models and even clinical trials. It has also been hypothesized that targeting a pathway or a process, such as glucose transport or glucose metabolism, rather than a specific protein or enzyme in a signaling pathway may be more effective. This is based on the observation that cancer somehow can always bypass the inhibition of a target drug by switching to a redundant or compensatory pathway. In addition, cancer cells have higher dependence on glucose. This review will provide background information on glucose transport and metabolism in cancer, and summarize new therapeutic developments in basic and translational research in these areas, with a focus on glucose transporter inhibitors and glycolysis inhibitors. The daunting challenges facing both basic and clinical researchers of the field are also presented and discussed.展开更多
文摘The Air Transport Research Society(ATRS)World Conference is one of the major venues for air transport research.The conference covers a wide range of research talks,practice/industrial sessions,and research workshop activities.In this paper,we perform a data-driven analysis of the research abstracts that have been accepted and presented at the conference since 2014.We have grouped the abstracts from the ten annual conferences using t-distributed stochastic neighbor embedding to map high-dimensional keyword vectors into a two-dimensional plane for clustering,analysis,and visualization.The major focus of our study concerns three directions.First,we provide a formal description of the actual research presented at the ATRS World Conference series by using methods from natural language processing and machine learning,leading to a data-driven classification consisting of 35 major subject categories.Second,we analyze the origin of main authors/presenters and their background,including their institutions and countries of origin.Third,we perform a network-driven analysis of co-authorships across abstracts to identify the role and importance of key researchers in the community.Finally,we provide an analysis of popular research topics indicated by authors when submitting their abstracts,and a set of major recommendations for future work,based on the insights obtained from our study.
基金National Natural Science Foundation of China,No.41171107No.41371143
文摘As an important branch of human geography, transportation geography has experienced three periods of evolution: foundation, systematization, and rapid development of the discipline. It has gradually become a relatively mature discipline. During the period 1930– 1980, the development of transportation geography consisted mainly of the publication of theoretical texts. During 1980–2000, it gradually became a systematic discipline. Since the start of the 21 st century, transportation geography has focused mainly on exploring the impacts of transportation on socio-economic development. Currently, studies on transportation geography have led to significant developments in a number of areas, including transportation theory, facility distribution and planning, transportation flows and network analysis, evaluation of transport modes, transportation planning, and simulation and assessment of urban transportation. Such studies have also enriched human geography research, provided a wider geographical overview and elucidated the development mechanism of transportation, as well as helped to understand the impacts of transport development on socio-economic systems. Some findings obtained by geographers have been widely used in transportation geography and related fields, including the four basic laws of transportation generation, the hub–spoke mode of transport organization, the subordinating and guiding functions of transportation on socio-economic development, regional transport dominance measures, accessibility measures, and spatial organization of port systems.
文摘Rail systems are gradually becoming the most desirable form of transit infrastructure around the world, partly because they are becoming more environmentally friendly compared with airplanes and automobiles. This paper examines the place of emerging countries in this move of implementing modern rail system that will eventually enhance the realization of a low-carbon society. Network model, transportation model and linear programming algorithms are used to model the present urban rail transport system in Nigeria, as an emerging country, in order to optimize it. Operational research methods, including simplex method and MODI, with the aids of computer software (excel solver and LIP solver) were adopted to solve the resulting models. The results showed that optimization of rail transport system will not only reduce carbon emission but also bring about economic development which is required for the eradication of prevalent poverty in these emerging countries.
文摘为了解航空运输优化研究领域的研究现状、研究热点及前沿趋势,本文采用文献计量法,以中国知网(CNKI)和Web of Science核心数据库2006—2023年国内外关于航空运输优化研究领域的出版物为分析数据,借助CiteSpace 6.2 R4(Advance)对该领域研究进行可视化分析。结果表明:该领域国内研究成果随时间变化呈波动上升趋势且波动较小,国外研究成果总体呈逐步增长趋势且于2019年后迅速增加;研究机构数量较多但未形成核心作者群,缺乏合作;航线网络、机队规划、算法等是国内外该领域的主要研究内容。
基金Supported by Research Awards to Chen X from Heritage College of Osteopathic Medicine of Ohio Universitythe Edison Program of State of OhioStudent Enhancement Award,Graduate Student Senate Original Work Grant,the Donald Clippinger Graduate Fellowship to Qian Y from Ohio University
文摘Metabolic reprogramming and altered energetics have become an emerging hallmark of cancer and an active area of basic, translational, and clinical cancer research in the recent decade. Development of effective anticancer therapeutics may depend on improved understanding of the altered cancer metabolism compared to that of normal cells. Changes in glucose transport and glycolysis, which are drastically upregulated in most can-cers and termed the Warburg effect, are one of major focuses of this new research area. By taking advantage of the new knowledge and understanding of cancer's mechanisms, numerous therapeutic agents have been developed to target proteins and enzymes involved in glucose transport and metabolism, with promising results in cancer cells, animal tumor models and even clinical trials. It has also been hypothesized that targeting a pathway or a process, such as glucose transport or glucose metabolism, rather than a specific protein or enzyme in a signaling pathway may be more effective. This is based on the observation that cancer somehow can always bypass the inhibition of a target drug by switching to a redundant or compensatory pathway. In addition, cancer cells have higher dependence on glucose. This review will provide background information on glucose transport and metabolism in cancer, and summarize new therapeutic developments in basic and translational research in these areas, with a focus on glucose transporter inhibitors and glycolysis inhibitors. The daunting challenges facing both basic and clinical researchers of the field are also presented and discussed.
