AIM:To investigate time trends in myopia and high myopia prevalence over 6y among young university adults in China.METHODS:This is a 6-year series cross-sectional study from 2016 to 2021.Totally 4910 freshmen were enr...AIM:To investigate time trends in myopia and high myopia prevalence over 6y among young university adults in China.METHODS:This is a 6-year series cross-sectional study from 2016 to 2021.Totally 4910 freshmen were enrolled and completed a questionnaire concerning age,gender,and disease history.Students with eye diseases were excluded after a detailed eye examination.The refractive status was measured by non-cycloplegic objective refraction and ocular parameters were measured by Lenstar 900.The examination followed the same protocol each year.Trends over time in myopia and high myopia prevalence,as well as ocular biometry parameters,were analyzed.RESULTS:From 2016 to 2021,the axial length(AL)and corneal radius(CR)increased significantly(P=0.002 for AL;P=0.04 for CR).However,the spherical equivalent(SE)and the ratio of axial length to the corneal radius(AL/CR)did not change significantly(P=0.59 for SE;P=0.24 for AL/CR).The frequency of AL≥26.0 mm increased from 26.6%in 2016 to 29.3%in 2021(P=0.05 for trend).The prevalence of myopia and high myopia did not change significantly in our study(P≥0.18).Compared to a similar cross-sectional study conducted 10 years ago,the prevalence of myopia decreased significantly(94.9%vs 91.8%,P<0.001).Whereas the prevalence of high myopia increased largely(18.12%vs 27.6%,P<0.001).CONCLUSION:The prevalence of high myopia increases in young university adults during 10y period.Myopia control should begin earlier in childhood.However,these interventions are still needed for high myopia even in young adulthood.展开更多
Background: Currently, surgical resection represents the only curative treatment for pancreatic cancer(PC), however, the majority of tumors are no longer resectable by the time of diagnosis. The aim of this study was ...Background: Currently, surgical resection represents the only curative treatment for pancreatic cancer(PC), however, the majority of tumors are no longer resectable by the time of diagnosis. The aim of this study was to describe time trends and distribution of pancreaticoduodenectomies(PDs) performed for treating PC in Brazil in recent years. Methods: Data were retrospectively obtained from Brazilian Health Public System(namely DATASUS) regarding hospitalizations for PC and PD in Brazil from January 2008 to December 2015. PC and PD rates and their mortalities were estimated from DATASUS hospitalizations and analyzed for age, gender and demographic characteristics. Results: A total of 2364 PDs were retrieved. Albeit PC incidence more than doubled, the number of PDs increased only 37%. Most PDs were performed in men(52.2%) and patients between 50 and 69 years old(59.5%). Patients not surgically treated and those 70 years or older had the highest in-hospital mortality rates. The most developed regions(Southeast and South) as well as large metropolitan integrated municipalities registered 76.2% and 54.8% of the procedures, respectively. LMIM PD mortality fluctuated, ranging from 13.6% in 2008 to 11.8% in 2015. Conclusions: This study suggests a trend towards regionalization and volume-outcome relationships for PD due to PC, as large metropolitan integrated municipalities registered most of the PDs and more stable mortality rates. The substantial differences between PD and PC increasing rates reveals a limiting step on the health system resoluteness. Reduction in the number of hospital beds and late access to hospitalization, despite improvement in diagnostic methods, could at least in part explain these findings.展开更多
The trends and periodicities in the annual and seasonal temperature time series at fifteen weather stations within Ontario Great Lakes Basins have been analyzed, for the period 1941-2005, using the statistical analyse...The trends and periodicities in the annual and seasonal temperature time series at fifteen weather stations within Ontario Great Lakes Basins have been analyzed, for the period 1941-2005, using the statistical analyses (Fourier series analysis, t-test, and Mann-Kendall test). The stations were spatially divided into three regions: northwest (NW), southwest (SW), and southeast (SE) to evaluate spatial variability in temperature. The results of the study reveal that the annual maximum mean temperature showed increasing trend for NW, and mixed trends for SW and SE regions. The variability was found to be more for northern stations as compared to southern stations for annual extreme minimum temperature. In addition, the trend slope per 100 years for the average annual extreme minimum temperature increased within the range of -0.8°C (Stratford) to 15°C (Porcupine). The seasonal analysis demonstrated that extreme maximum temperature has an increasing trend and maximum mean temperature has a decreasing trend during summer and winter. The extreme minimum temperature for winter illustrated an increasing trend (90%) with 22% statistically significant for NW region. For the SW region, the trend is also increasing (80%) for most of the temperature variables and 25% of temperature data were significantly increased in the SW region. The SE region stations showed overall very clear increasing trends (95%) for all the temperature variables. The data also showed that 47% of data were statistically significant in the SE region. The analysis of variance accounted for by trend, significant periodicities, and random component show that the pattern is similar for the percent of variance accounted for periodicities, and random component contribute dominantly for the four temperature variables and frost free days (FFD) for all three regions. Overall, the study reveals that the extreme minimum temperature is increasing annually and seasonally, with statistically significant at many stations.展开更多
During his state visit to Kazakhstan this September,President Xi Jinping made a concrete proposal to build a Silk Road Economic Belt(SREB for short in the following paragraphs)from the aspects of policy communication,...During his state visit to Kazakhstan this September,President Xi Jinping made a concrete proposal to build a Silk Road Economic Belt(SREB for short in the following paragraphs)from the aspects of policy communication,road connectivity,展开更多
Based on the annual sample data on food production in China since the reform and opening up,we select 8 main factors influencing the total food production( growing area,application rate of chemical fertilizer,effectiv...Based on the annual sample data on food production in China since the reform and opening up,we select 8 main factors influencing the total food production( growing area,application rate of chemical fertilizer,effective irrigation area,the affected area,total machinery power,food production cost index,food production price index,financial funds for supporting agriculture,farmers and countryside),and put them into categories of material input,resources and environment,and policy factors. Using the factor analysis,we carry out the multi-angle analysis of these typical influencing factors one by one through the time series trend chart. It is found that application rate of chemical fertilizer,the growing area of food crops and drought-affected area become the key factors affecting food production. On this basis,we set forth the corresponding recommendations for improving the comprehensive food production capacity.展开更多
Seismic data show some important characteristics, such as big volume and strong timeliness. Specific to the time series data of earthquake precursory observations, a piecewise linear representation based on the slidin...Seismic data show some important characteristics, such as big volume and strong timeliness. Specific to the time series data of earthquake precursory observations, a piecewise linear representation based on the sliding window mean value （PLR_MTSW） algorithm is proposed. With this algorithm, the mutation points can be identified accurately according to the rate Of mean value change, while the main features of time series are maintained well. This algorithm can also smooth the noise and improve the compression accuracy with sliding window. Meanwhile the local extreme points can be identified effectively according to the change of mean value trend within window.展开更多
The 10thNortheast Asia Youth Forum,with the theme of China-ROK-Japan Youth Employment Guidance,sponsored by Moral Re-Armament/Initiatives of Change(MRA/IC)-Korea was held in Seoul and Cheonan from August 12 to 17.Seve...The 10thNortheast Asia Youth Forum,with the theme of China-ROK-Japan Youth Employment Guidance,sponsored by Moral Re-Armament/Initiatives of Change(MRA/IC)-Korea was held in Seoul and Cheonan from August 12 to 17.Seventy five college students from 37 universities sent by China International Youth Exchange Center,Moral Re-Armament/Initiatives of Change(MRA/IC)-Korea and Japan Society attended the Forum.Lee Boksil,Vice-Minister of Ministry of展开更多
The main purpose of this study is to assess the climate variability and change through statistical processing tools that able to highlight annual and monthly rainfall behavior between 1970 and 2010 in six strategical ...The main purpose of this study is to assess the climate variability and change through statistical processing tools that able to highlight annual and monthly rainfall behavior between 1970 and 2010 in six strategical raingauges located in northern (Saint-Louis, Bakel), central (Dakar, Kaolack), and southern (Ziguinchor, Tambacounda) part of Senegal. Further, differences in sensitivity of statistical tests are also exhibited by applying several tests rather than a single one to check for one behavior. Dependency of results from statistical tests on studied sequence in time series is also shown comparing results of tests applied on two different periods (1970-2010 and 1960-2010). Therefore, between 1970 and 2010, exploratory data analysis is made to give in a visible manner a first idea on rainfall behavior. Then, Statistical characteristics such as the mean, variance, standard deviation, coefficient of variation, skewness and kurtosis are calculated. Subsequently, statistical tests are applied to all retained time series. Kendall and Spearman rank correlation tests allow verifying whether or not annual rainfall observations are independent. Hubert’s procedures of segmentation, Pettitt, Lee Heghinian and Buishand tests allow checking rainfall homogeneity. Trend is undertaken by first employing the annual and seasonal Mann-Kendall trend test, and in case of significance, magnitude of trend is calculated by Sen’s slope estimator tests. All statistical tests are applied in the period of 1960-2010. Explanatory analysis data indicates upwards trends for records in northern and central and trend free for southern records. Application of multiple tests shows that the Kendall and spearman ranks correlation tests lead to same conclusion. The difference in tests sensitivity was shown by outcomes of homogeneity tests giving different results either in dates of the shift occurrence or in the significance of an eventual shift. A synthesis analysis of results of tests was carried out to conclude about rainfall behaviors. Tests for homogeneity show that southern rainfall is homogeneous, while northern and central ones are not. According to trend test, upwards trends in Northern and central rainfall trend free in southern assumption in exploratory data analysis have been confirmed. The Sen’s slop estimator shows that all retained trend can be assumed to linear type. The same test over the period 1960-2010 shows independence of observations in all raingauges and exhibits neither trends nor breaks. This seems to show a return to a wet period.展开更多
The aim of this study is to establish the prevailing conditions of changing climatic trends and change point dates in four selected meteorological stations of Uyo, Benin, Port Harcourt, and Warri in the Niger Delta re...The aim of this study is to establish the prevailing conditions of changing climatic trends and change point dates in four selected meteorological stations of Uyo, Benin, Port Harcourt, and Warri in the Niger Delta region of Nigeria. Using daily or 24-hourly annual maximum series (AMS) data with the Indian Meteorological Department (IMD) and the modified Chowdury Indian Meteorological Department (MCIMD) models were adopted to downscale the time series data. Mann-Kendall (MK) trend and Sen’s Slope Estimator (SSE) test showed a statistically significant trend for Uyo and Benin, while Port Harcourt and Warri showed mild trends. The Sen’s Slope magnitude and variation rate were 21.6, 10.8, 6.00 and 4.4 mm/decade, respectively. The trend change-point analysis showed the initial rainfall change-point dates as 2002, 2005, 1988, and 2000 for Uyo, Benin, Port Harcourt, and Warri, respectively. These prove positive changing climatic conditions for rainfall in the study area. Erosion and flood control facilities analysis and design in the Niger Delta will require the application of Non-stationary IDF modelling.展开更多
As the most populous country in the world,China has made strides in health promotion in the past few decades.With the aging population,the burden of cancer in China continues to grow.Changes in risk factors for cancer...As the most populous country in the world,China has made strides in health promotion in the past few decades.With the aging population,the burden of cancer in China continues to grow.Changes in risk factors for cancer,especially diet,obesity,diabetes,and air pollution,continue to fuel the shift of cancer transition in China.The burden of upper gastrointestinal cancer in China is decreasing,but still heavy.The rising burden of colorectal,prostate,and breast cancers is also significant.Lung cancer became the top cause of cancer-related deaths,together with smoking as the most important contributor to cancer deaths.The Chinese government has taken several approaches to control cancer and cancer-related risk factors.Many achievements have been made,but some challenges remain.Health China 2030 is ambitious and depicts a bright vision of the future for cancer control in China.The decrease in the cancer burden in China will require cross-sector collaboration and coordinated efforts on primary and secondary preventions by governments,public health organizations,and individuals.In this review,we describe the trends of cancer burden and discuss cancer-related risk factors in China,identifying strategies to reduce the burden of cancer in China.展开更多
BACKGROUND Through analyzing the data from a single institution in Northeast China,this study revealed the possible clinicopathologic characteristics that influence the prognosis of patients with gastric cancer(GC).AI...BACKGROUND Through analyzing the data from a single institution in Northeast China,this study revealed the possible clinicopathologic characteristics that influence the prognosis of patients with gastric cancer(GC).AIM To evaluate the changing trends of clinicopathologic features and survival duration after surgery in patients with GC in Northeast China,which is a highprevalence area of GC.METHODS The study analyzed the difference in clinicopathologic features and survival duration after surgery of 5887 patients who were histologically diagnosed with GC at the Harbin Medical University Cancer Hospital.The study mainly analyzed the data in three periods,2000 to 2004(Phase 1),2005 to 2009(Phase 2),and 2010 to 2014(Phase 3).RESULTS Over time,the postoperative survival rate significantly increased from 2000 to 2014.In the past 15 years,compared with Phases 1 and 2,the tumor size was smaller in Phase 3(P<0.001),but the proportion of high-medium differentiated tumors increased(P<0.001).The proportion of early GC gradually increased from 3.9%to 14.4%(P<0.001).A surprising improvement was observed in the mean number of retrieved lymph nodes,ranging from 11.4 to 27.5(P<0.001).The overall 5-year survival rate increased from 24%in Phase 1 to 43.8%in Phase 3.Through multivariate analysis,it was found that age,tumor size,histologic type,tumor-node-metastasis stage,depth of invasion,lymph node metastasis,surgical approach,local infiltration,radical extent,number of retrieved lymph nodes,and age group were independent risk factors that influenced the prognosis of patients with GC.CONCLUSION The clinical features of GC in Northeast China changed during the observation period.The increasing detection of early GC and more standardized surgical treatment effectively prolonged lifetimes.展开更多
基金Supported by China Scholarship Council(CSC,No.202006945002)Chunhui Project of China Education Ministry(No.HZKY20220587)+1 种基金Tianjin Health Technology Research Project(No.TJWJ2022MS014)Tianjin Municipal Education Commission Scientific Research Program(Mental Health Education,No.2022ZDGX20).
文摘AIM:To investigate time trends in myopia and high myopia prevalence over 6y among young university adults in China.METHODS:This is a 6-year series cross-sectional study from 2016 to 2021.Totally 4910 freshmen were enrolled and completed a questionnaire concerning age,gender,and disease history.Students with eye diseases were excluded after a detailed eye examination.The refractive status was measured by non-cycloplegic objective refraction and ocular parameters were measured by Lenstar 900.The examination followed the same protocol each year.Trends over time in myopia and high myopia prevalence,as well as ocular biometry parameters,were analyzed.RESULTS:From 2016 to 2021,the axial length(AL)and corneal radius(CR)increased significantly(P=0.002 for AL;P=0.04 for CR).However,the spherical equivalent(SE)and the ratio of axial length to the corneal radius(AL/CR)did not change significantly(P=0.59 for SE;P=0.24 for AL/CR).The frequency of AL≥26.0 mm increased from 26.6%in 2016 to 29.3%in 2021(P=0.05 for trend).The prevalence of myopia and high myopia did not change significantly in our study(P≥0.18).Compared to a similar cross-sectional study conducted 10 years ago,the prevalence of myopia decreased significantly(94.9%vs 91.8%,P<0.001).Whereas the prevalence of high myopia increased largely(18.12%vs 27.6%,P<0.001).CONCLUSION:The prevalence of high myopia increases in young university adults during 10y period.Myopia control should begin earlier in childhood.However,these interventions are still needed for high myopia even in young adulthood.
基金supported by grants from Fundacao de Amparo à Pesquisa do Estado do Rio de Janeiro-FAPERJ [E-26/2014-202.008]Conselho Nacional de Desenvolvimento Científico e Tecnológico–CNPq [302401/2016-4]
文摘Background: Currently, surgical resection represents the only curative treatment for pancreatic cancer(PC), however, the majority of tumors are no longer resectable by the time of diagnosis. The aim of this study was to describe time trends and distribution of pancreaticoduodenectomies(PDs) performed for treating PC in Brazil in recent years. Methods: Data were retrospectively obtained from Brazilian Health Public System(namely DATASUS) regarding hospitalizations for PC and PD in Brazil from January 2008 to December 2015. PC and PD rates and their mortalities were estimated from DATASUS hospitalizations and analyzed for age, gender and demographic characteristics. Results: A total of 2364 PDs were retrieved. Albeit PC incidence more than doubled, the number of PDs increased only 37%. Most PDs were performed in men(52.2%) and patients between 50 and 69 years old(59.5%). Patients not surgically treated and those 70 years or older had the highest in-hospital mortality rates. The most developed regions(Southeast and South) as well as large metropolitan integrated municipalities registered 76.2% and 54.8% of the procedures, respectively. LMIM PD mortality fluctuated, ranging from 13.6% in 2008 to 11.8% in 2015. Conclusions: This study suggests a trend towards regionalization and volume-outcome relationships for PD due to PC, as large metropolitan integrated municipalities registered most of the PDs and more stable mortality rates. The substantial differences between PD and PC increasing rates reveals a limiting step on the health system resoluteness. Reduction in the number of hospital beds and late access to hospitalization, despite improvement in diagnostic methods, could at least in part explain these findings.
文摘The trends and periodicities in the annual and seasonal temperature time series at fifteen weather stations within Ontario Great Lakes Basins have been analyzed, for the period 1941-2005, using the statistical analyses (Fourier series analysis, t-test, and Mann-Kendall test). The stations were spatially divided into three regions: northwest (NW), southwest (SW), and southeast (SE) to evaluate spatial variability in temperature. The results of the study reveal that the annual maximum mean temperature showed increasing trend for NW, and mixed trends for SW and SE regions. The variability was found to be more for northern stations as compared to southern stations for annual extreme minimum temperature. In addition, the trend slope per 100 years for the average annual extreme minimum temperature increased within the range of -0.8°C (Stratford) to 15°C (Porcupine). The seasonal analysis demonstrated that extreme maximum temperature has an increasing trend and maximum mean temperature has a decreasing trend during summer and winter. The extreme minimum temperature for winter illustrated an increasing trend (90%) with 22% statistically significant for NW region. For the SW region, the trend is also increasing (80%) for most of the temperature variables and 25% of temperature data were significantly increased in the SW region. The SE region stations showed overall very clear increasing trends (95%) for all the temperature variables. The data also showed that 47% of data were statistically significant in the SE region. The analysis of variance accounted for by trend, significant periodicities, and random component show that the pattern is similar for the percent of variance accounted for periodicities, and random component contribute dominantly for the four temperature variables and frost free days (FFD) for all three regions. Overall, the study reveals that the extreme minimum temperature is increasing annually and seasonally, with statistically significant at many stations.
文摘During his state visit to Kazakhstan this September,President Xi Jinping made a concrete proposal to build a Silk Road Economic Belt(SREB for short in the following paragraphs)from the aspects of policy communication,road connectivity,
基金Supported by Humanities and Social Sciences Fund of the Ministry of Education(12YJC790094)Tianjin Philosophy and Social Science Planning Project(TJYY13-028TJLJ13-011)
文摘Based on the annual sample data on food production in China since the reform and opening up,we select 8 main factors influencing the total food production( growing area,application rate of chemical fertilizer,effective irrigation area,the affected area,total machinery power,food production cost index,food production price index,financial funds for supporting agriculture,farmers and countryside),and put them into categories of material input,resources and environment,and policy factors. Using the factor analysis,we carry out the multi-angle analysis of these typical influencing factors one by one through the time series trend chart. It is found that application rate of chemical fertilizer,the growing area of food crops and drought-affected area become the key factors affecting food production. On this basis,we set forth the corresponding recommendations for improving the comprehensive food production capacity.
基金Project supported by the Shanghai Leading Academic Discipline Project(Grant No.J50103)the Natural Science Foundation of Shanghai Municipality(Grant No.08ZR1408400)
文摘Seismic data show some important characteristics, such as big volume and strong timeliness. Specific to the time series data of earthquake precursory observations, a piecewise linear representation based on the sliding window mean value （PLR_MTSW） algorithm is proposed. With this algorithm, the mutation points can be identified accurately according to the rate Of mean value change, while the main features of time series are maintained well. This algorithm can also smooth the noise and improve the compression accuracy with sliding window. Meanwhile the local extreme points can be identified effectively according to the change of mean value trend within window.
文摘The 10thNortheast Asia Youth Forum,with the theme of China-ROK-Japan Youth Employment Guidance,sponsored by Moral Re-Armament/Initiatives of Change(MRA/IC)-Korea was held in Seoul and Cheonan from August 12 to 17.Seventy five college students from 37 universities sent by China International Youth Exchange Center,Moral Re-Armament/Initiatives of Change(MRA/IC)-Korea and Japan Society attended the Forum.Lee Boksil,Vice-Minister of Ministry of
文摘The main purpose of this study is to assess the climate variability and change through statistical processing tools that able to highlight annual and monthly rainfall behavior between 1970 and 2010 in six strategical raingauges located in northern (Saint-Louis, Bakel), central (Dakar, Kaolack), and southern (Ziguinchor, Tambacounda) part of Senegal. Further, differences in sensitivity of statistical tests are also exhibited by applying several tests rather than a single one to check for one behavior. Dependency of results from statistical tests on studied sequence in time series is also shown comparing results of tests applied on two different periods (1970-2010 and 1960-2010). Therefore, between 1970 and 2010, exploratory data analysis is made to give in a visible manner a first idea on rainfall behavior. Then, Statistical characteristics such as the mean, variance, standard deviation, coefficient of variation, skewness and kurtosis are calculated. Subsequently, statistical tests are applied to all retained time series. Kendall and Spearman rank correlation tests allow verifying whether or not annual rainfall observations are independent. Hubert’s procedures of segmentation, Pettitt, Lee Heghinian and Buishand tests allow checking rainfall homogeneity. Trend is undertaken by first employing the annual and seasonal Mann-Kendall trend test, and in case of significance, magnitude of trend is calculated by Sen’s slope estimator tests. All statistical tests are applied in the period of 1960-2010. Explanatory analysis data indicates upwards trends for records in northern and central and trend free for southern records. Application of multiple tests shows that the Kendall and spearman ranks correlation tests lead to same conclusion. The difference in tests sensitivity was shown by outcomes of homogeneity tests giving different results either in dates of the shift occurrence or in the significance of an eventual shift. A synthesis analysis of results of tests was carried out to conclude about rainfall behaviors. Tests for homogeneity show that southern rainfall is homogeneous, while northern and central ones are not. According to trend test, upwards trends in Northern and central rainfall trend free in southern assumption in exploratory data analysis have been confirmed. The Sen’s slop estimator shows that all retained trend can be assumed to linear type. The same test over the period 1960-2010 shows independence of observations in all raingauges and exhibits neither trends nor breaks. This seems to show a return to a wet period.
文摘The aim of this study is to establish the prevailing conditions of changing climatic trends and change point dates in four selected meteorological stations of Uyo, Benin, Port Harcourt, and Warri in the Niger Delta region of Nigeria. Using daily or 24-hourly annual maximum series (AMS) data with the Indian Meteorological Department (IMD) and the modified Chowdury Indian Meteorological Department (MCIMD) models were adopted to downscale the time series data. Mann-Kendall (MK) trend and Sen’s Slope Estimator (SSE) test showed a statistically significant trend for Uyo and Benin, while Port Harcourt and Warri showed mild trends. The Sen’s Slope magnitude and variation rate were 21.6, 10.8, 6.00 and 4.4 mm/decade, respectively. The trend change-point analysis showed the initial rainfall change-point dates as 2002, 2005, 1988, and 2000 for Uyo, Benin, Port Harcourt, and Warri, respectively. These prove positive changing climatic conditions for rainfall in the study area. Erosion and flood control facilities analysis and design in the Niger Delta will require the application of Non-stationary IDF modelling.
基金supported by the National Key Research and Development Program of China(Grant No.2018YFC1313100)the National Natural Science Foundation of China(Grant No.81602931)+1 种基金the CAMS Innovation Fund for Medical Sciences(Grant No.2016-I2M-2-004)the Sanming Project of Medicine in Shenzhen(Grant No.SZSM201911015)。
文摘As the most populous country in the world,China has made strides in health promotion in the past few decades.With the aging population,the burden of cancer in China continues to grow.Changes in risk factors for cancer,especially diet,obesity,diabetes,and air pollution,continue to fuel the shift of cancer transition in China.The burden of upper gastrointestinal cancer in China is decreasing,but still heavy.The rising burden of colorectal,prostate,and breast cancers is also significant.Lung cancer became the top cause of cancer-related deaths,together with smoking as the most important contributor to cancer deaths.The Chinese government has taken several approaches to control cancer and cancer-related risk factors.Many achievements have been made,but some challenges remain.Health China 2030 is ambitious and depicts a bright vision of the future for cancer control in China.The decrease in the cancer burden in China will require cross-sector collaboration and coordinated efforts on primary and secondary preventions by governments,public health organizations,and individuals.In this review,we describe the trends of cancer burden and discuss cancer-related risk factors in China,identifying strategies to reduce the burden of cancer in China.
基金Nn10 Program of Harbin Medical University Cancer Hospital,China,No.Nn10 PY 2017-03.
文摘BACKGROUND Through analyzing the data from a single institution in Northeast China,this study revealed the possible clinicopathologic characteristics that influence the prognosis of patients with gastric cancer(GC).AIM To evaluate the changing trends of clinicopathologic features and survival duration after surgery in patients with GC in Northeast China,which is a highprevalence area of GC.METHODS The study analyzed the difference in clinicopathologic features and survival duration after surgery of 5887 patients who were histologically diagnosed with GC at the Harbin Medical University Cancer Hospital.The study mainly analyzed the data in three periods,2000 to 2004(Phase 1),2005 to 2009(Phase 2),and 2010 to 2014(Phase 3).RESULTS Over time,the postoperative survival rate significantly increased from 2000 to 2014.In the past 15 years,compared with Phases 1 and 2,the tumor size was smaller in Phase 3(P<0.001),but the proportion of high-medium differentiated tumors increased(P<0.001).The proportion of early GC gradually increased from 3.9%to 14.4%(P<0.001).A surprising improvement was observed in the mean number of retrieved lymph nodes,ranging from 11.4 to 27.5(P<0.001).The overall 5-year survival rate increased from 24%in Phase 1 to 43.8%in Phase 3.Through multivariate analysis,it was found that age,tumor size,histologic type,tumor-node-metastasis stage,depth of invasion,lymph node metastasis,surgical approach,local infiltration,radical extent,number of retrieved lymph nodes,and age group were independent risk factors that influenced the prognosis of patients with GC.CONCLUSION The clinical features of GC in Northeast China changed during the observation period.The increasing detection of early GC and more standardized surgical treatment effectively prolonged lifetimes.
