期刊文献+
共找到425篇文章
< 1 2 22 >
每页显示 20 50 100
Reliability-based design optimization for flexible mechanism with particle swarm optimization and advanced extremum response surface method 被引量:1
1
作者 张春宜 宋鲁凯 +2 位作者 费成巍 郝广平 刘令君 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第8期2001-2007,共7页
To improve the computational efficiency of the reliability-based design optimization(RBDO) of flexible mechanism, particle swarm optimization-advanced extremum response surface method(PSO-AERSM) was proposed by integr... To improve the computational efficiency of the reliability-based design optimization(RBDO) of flexible mechanism, particle swarm optimization-advanced extremum response surface method(PSO-AERSM) was proposed by integrating particle swarm optimization(PSO) algorithm and advanced extremum response surface method(AERSM). Firstly, the AERSM was developed and its mathematical model was established based on artificial neural network, and the PSO algorithm was investigated. And then the RBDO model of flexible mechanism was presented based on AERSM and PSO. Finally, regarding cross-sectional area as design variable, the reliability optimization of flexible mechanism was implemented subject to reliability degree and uncertainties based on the proposed approach. The optimization results show that the cross-section sizes obviously reduce by 22.96 mm^2 while keeping reliability degree. Through the comparison of methods, it is demonstrated that the AERSM holds high computational efficiency while keeping computational precision for the RBDO of flexible mechanism, and PSO algorithm minimizes the response of the objective function. The efforts of this work provide a useful sight for the reliability optimization of flexible mechanism, and enrich and develop the reliability theory as well. 展开更多
关键词 reliability-based design optimization flexible robot manipulator artificial neural network particle swarm optimization advanced extremum response surface method
在线阅读 下载PDF
Optimal design of butterfly-shaped linear ultrasonic motor using finite element method and response surface methodology 被引量:9
2
作者 时运来 陈超 赵淳生 《Journal of Central South University》 SCIE EI CAS 2013年第2期393-404,共12页
A new method for optimizing a butterfly-shaped linear ultrasonic motor was proposed to maximize its mechanical output. The finite element analysis technology and response surface methodology were combined together to ... A new method for optimizing a butterfly-shaped linear ultrasonic motor was proposed to maximize its mechanical output. The finite element analysis technology and response surface methodology were combined together to realize the optimal design of the butterfly-shaped linear ultrasonic motor. First, the operation principle of the motor was introduced. Second, the finite element parameterized model of the stator of the motor was built using ANSYS parametric design language and some structure parameters of the stator were selected as design variables. Third, the sample points were selected in design variable space using latin hypercube Design. Through modal analysis and harmonic response analysis of the stator based on these sample points, the target responses were obtained. These sample points and response values were combined together to build a response surface model. Finally, the simplex method was used to find the optimal solution. The experimental results showed that many aspects of the design requirements of the butterfly-shaped linear ultrasonic motor have been fulfilled. The prototype motor fabricated based on the optimal design result exhibited considerably high dynamic performance, such as no-load speed of 873 ram/s, maximal thrust of 27.5 N, maximal efficiency of 43%, and thrust-weight ratio of 45.8. 展开更多
关键词 linear ultrasonic motor PIEZOELECTRIC optimal design response surface methodology finite element method
在线阅读 下载PDF
Global Optimization Method Using SLE and Adaptive RBF Based on Fuzzy Clustering 被引量:8
3
作者 ZHU Huaguang LIU Li LONG Teng ZHAO Junfeng 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2012年第4期768-775,共8页
High fidelity analysis models,which are beneficial to improving the design quality,have been more and more widely utilized in the modern engineering design optimization problems.However,the high fidelity analysis mode... High fidelity analysis models,which are beneficial to improving the design quality,have been more and more widely utilized in the modern engineering design optimization problems.However,the high fidelity analysis models are so computationally expensive that the time required in design optimization is usually unacceptable.In order to improve the efficiency of optimization involving high fidelity analysis models,the optimization efficiency can be upgraded through applying surrogates to approximate the computationally expensive models,which can greately reduce the computation time.An efficient heuristic global optimization method using adaptive radial basis function(RBF) based on fuzzy clustering(ARFC) is proposed.In this method,a novel algorithm of maximin Latin hypercube design using successive local enumeration(SLE) is employed to obtain sample points with good performance in both space-filling and projective uniformity properties,which does a great deal of good to metamodels accuracy.RBF method is adopted for constructing the metamodels,and with the increasing the number of sample points the approximation accuracy of RBF is gradually enhanced.The fuzzy c-means clustering method is applied to identify the reduced attractive regions in the original design space.The numerical benchmark examples are used for validating the performance of ARFC.The results demonstrates that for most application examples the global optima are effectively obtained and comparison with adaptive response surface method(ARSM) proves that the proposed method can intuitively capture promising design regions and can efficiently identify the global or near-global design optimum.This method improves the efficiency and global convergence of the optimization problems,and gives a new optimization strategy for engineering design optimization problems involving computationally expensive models. 展开更多
关键词 global optimization Latin hypercube design radial basis function fuzzy clustering adaptive response surface method
在线阅读 下载PDF
Effect of Variable Selection on Multidisciplinary Design Optimization:a Flight Vehicle Example 被引量:7
4
作者 J.Roshanian Z.Keshavarz 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2007年第1期86-96,共11页
Different multidisciplinary design optimization (MDO) problems are formulated and compared. Two MDO formulations are applied to a sounding rocket in order to optimize the performance of the rocket. In the MDO of the... Different multidisciplinary design optimization (MDO) problems are formulated and compared. Two MDO formulations are applied to a sounding rocket in order to optimize the performance of the rocket. In the MDO of the referred vehicle, three disciplines have been considered, which are trajectory, propulsion and aerodynamics. A special design structure matrix is developed to assist data exchange between disciplines. This design process uses response surface method (RSM) for multidisciplinary optimization of the rocket. The RSM is applied to the design in two categories: the propulsion model and the system level. In the propulsion model, RSM determines an approximate mathematical model of the engine output parameters as a function of design variables. In the system level, RSM fits a surface of objective function versus design variables. In the first MDO problem formulation, two design variables are selected to form propulsion discipline. In the second one, three new design variables from geometry are added and finally, an optimization method is applied to the response surface in the system level in order to find the best result. Application of the first developed multidisciplinary design optimization procedure increased accessible altitude (performance index) of the referred sounding rocket by twenty five percents and the second one twenty nine. 展开更多
关键词 multidisciplinary design optimization sounding rocket central composite design response surface method equation of motion of a rocket
在线阅读 下载PDF
Robust optimization design on impeller of mixed-flow pump 被引量:1
5
作者 ZHAO Binjuan LIAO Wenyan +3 位作者 XIE Yuntong HAN Luyao FU Yanxia HUANG Zhongfu 《排灌机械工程学报》 CSCD 北大核心 2021年第7期671-677,共7页
To increase the robustness of the optimization solutions of the mixed-flow pump,the impeller was firstly indirectly parameterized based on the 2D blade design theory.Secondly,the robustness of the optimization solutio... To increase the robustness of the optimization solutions of the mixed-flow pump,the impeller was firstly indirectly parameterized based on the 2D blade design theory.Secondly,the robustness of the optimization solution was mathematically defined,and then calculated by Monte Carlo sampling method.Thirdly,the optimization on the mixed-flow pump′s impeller was decomposed into the optimal and robust sub-optimization problems,to maximize the pump head and efficiency and minimize the fluctuation degree of them under varying working conditions at the same time.Fourthly,using response surface model,a surrogate model was established between the optimization objectives and control variables of the shape of the impeller.Finally,based on a multi-objective genetic optimization algorithm,a two-loop iterative optimization process was designed to find the optimal solution with good robustness.Comparing the original and optimized pump,it is found that the internal flow field of the optimized pump has been improved under various operating conditions,the hydraulic performance has been improved consequently,and the range of high efficient zone has also been widened.Besides,with the changing of working conditions,the change trend of the hydraulic performance of the optimized pump becomes gentler,the flow field distribution is more uniform,and the influence degree of the varia-tion of working conditions decreases,and the operating stability of the pump is improved.It is concluded that the robust optimization method proposed in this paper is a reasonable way to optimize the mixed-flow pump,and provides references for optimization problems of other fluid machinery. 展开更多
关键词 mixed-flow pump multi-objective genetic optimization robust optimization response surface method 2D blade design theory
在线阅读 下载PDF
Optimal Designs Technique for Locating the Optimum of a Second Order Response Function
6
作者 Idorenyin Etukudo 《American Journal of Operations Research》 2017年第5期263-271,共9页
A more efficient method of locating the optimum of a second order response function was of interest in this work. In order to do this, the principles of optimal designs of experiment is invoked and used for this purpo... A more efficient method of locating the optimum of a second order response function was of interest in this work. In order to do this, the principles of optimal designs of experiment is invoked and used for this purpose. At the end, it was discovered that the noticeable pitfall in response surface methodology (RSM) was circumvented by this method as the step length was obtained by taking the derivative of the response function rather than doing so by intuition or trial and error as is the case in RSM. A numerical illustration shows that this method is suitable for obtaining the desired optimizer in just one move which compares favourably with other known methods such as Newton-Raphson method which requires more than one iteration to reach the optimizer. 展开更多
关键词 Optimal designS of Experiment UNCONSTRAINED optimization response surface methodology Modified Super CONVERGENT Line Series Algorithm NEWTON-RAPHSON method
在线阅读 下载PDF
基于响应面法与MOPSO算法的水轮机叶轮优化设计
7
作者 刘铭滨 成思源 +1 位作者 李永健 杨雪荣 《中国农村水利水电》 北大核心 2025年第2期160-165,172,共7页
为进一步提高阻力型水轮机的效率并降低其对管道液体输送能力的影响,通过单因素试验法分析了叶轮参数对其性能的影响,筛选出了四个关键参数及其取值范围。接着采用响应面法设计试验方案,利用最小二乘法拟合关键参数与效率和水头损失的... 为进一步提高阻力型水轮机的效率并降低其对管道液体输送能力的影响,通过单因素试验法分析了叶轮参数对其性能的影响,筛选出了四个关键参数及其取值范围。接着采用响应面法设计试验方案,利用最小二乘法拟合关键参数与效率和水头损失的函数关系,得到了回归模型。最后运用MOPSO算法对回归模型进行寻优,获得了叶轮最佳参数组合。结果表明,优化后的阻力型水轮机效率平均提高4.053%,水头损失平均降低0.679%。 展开更多
关键词 阻力型水轮机 多目标优化 响应面法 MOPSO算法 优化设计
在线阅读 下载PDF
响应面法优化UV/O_(3)催化氧化RO浓水处理工艺参数
8
作者 朱晓岩 《净水技术》 2025年第2期139-147,165,共10页
【目的】该研究将紫外(UV)与臭氧(O_(3))催化氧化工艺相耦合,以上海某化工厂生产废水处理工艺产生的二级反渗透(RO)浓水为研究对象进行研究,探究不同温度、初始pH和O_(3)投加量对二级RO浓水COD_(Cr)、UV_(254)去除率的影响,并进一步优... 【目的】该研究将紫外(UV)与臭氧(O_(3))催化氧化工艺相耦合,以上海某化工厂生产废水处理工艺产生的二级反渗透(RO)浓水为研究对象进行研究,探究不同温度、初始pH和O_(3)投加量对二级RO浓水COD_(Cr)、UV_(254)去除率的影响,并进一步优化工艺参数,得到最佳的处理效果。【方法】在单因素试验的基础上,采用响应面优化法(RSM)分析温度、初始pH和O_(3)投加量3种主要因素及其交互作用对二级RO浓水COD_(Cr)、UV_(254)去除率的影响,并对该工艺参数进行优化。【结果】试验结果表明,温度、初始pH和O_(3)投加量这3种因素对UV/O_(3)催化氧化耦合工艺的影响程度为:温度>初始pH>O_(3)投加量。对于COD_(Cr)去除率,各因素两两之间交互作用的显著强弱顺序为:温度与O_(3)投加量>初始pH与O_(3)投加量>温度与初始pH。对于UV_(254)去除率,各因素两两之间交互作用的显著强弱顺序为:温度与O_(3)投加量>温度与初始pH>初始pH与O_(3)投加量。在O_(3)催化剂为20mg/L,UV光照强度为50μW/cm^(2),反应时间为60min的反应条件下,温度为23.2℃、初始pH值为10.6、O_(3)投加量为14g/h时RO浓水处理效果最佳,COD_(Cr)、UV_(254)去除率分别能达到63.27%、73.01%。【结论】通过模型验证,证实了box-behnken设计(BBD)响应面模型可有效优化UV/O_(3)催化氧化工艺参数。 展开更多
关键词 反渗透(RO)浓水 响应面法 紫外(UV)/臭氧(O_(3)) 催化氧化 box-behnken设计(BBD)优化法
在线阅读 下载PDF
基于Design-Expert软件对原子吸收光谱仪工作参数优化 被引量:1
9
作者 廖伟 谢亨旺 +2 位作者 刘永林 才硕 苏甜 《分析测试技术与仪器》 CAS 2018年第3期143-150,共8页
将响应表面试验设计方法(RSM)应用于原子吸收光谱仪工作参数优化,以铜元素为目标化合物,结合Design-Expert软件进行数据处理.结果表明,单因素试验最佳工作条件:仪器灯电流15 m A,仪器吸喷速率7 m L/min,仪器乙炔气流量3.00 L/min.中心... 将响应表面试验设计方法(RSM)应用于原子吸收光谱仪工作参数优化,以铜元素为目标化合物,结合Design-Expert软件进行数据处理.结果表明,单因素试验最佳工作条件:仪器灯电流15 m A,仪器吸喷速率7 m L/min,仪器乙炔气流量3.00 L/min.中心组合试验结果表明:当吸喷速率为7 m L/min、乙炔气流量为2.25 L/min、灯电流为10 m A时,仪器灵敏度最好. 展开更多
关键词 design-Expert 原子吸收光谱仪 响应曲面设计法 参数优化
在线阅读 下载PDF
Combined Size and Shape Optimization of Structures with DOE,RSM and GA 被引量:1
10
作者 Jie Song Hongliang Hua +2 位作者 Zhenqiang Liao Tao Wang Ming Qiu 《Journal of Beijing Institute of Technology》 EI CAS 2018年第2期267-275,共9页
In this paper,size and shape optimization problem of a machine gun system is addressed with an efficient hybrid method,in which a novel and flexible mesh morphing technique is employed to achieve fast parameterization... In this paper,size and shape optimization problem of a machine gun system is addressed with an efficient hybrid method,in which a novel and flexible mesh morphing technique is employed to achieve fast parameterization and modification of complexity structure without going back to CAD for reconstruction of geometric models or to finite element analysis( FEA) for remodeling. Design of experiments( DOE) and response surface method( RSM) are applied to approximate the constitutive parameters of a machine gun system based on experimental tests. Further FEA,secondary development technique and genetic algorithm( GA) are introduced to find all the optimal solutions in one go and the optimal design of the demonstrated machine gun system is obtained. Results of the rigid-flexible coupling dynamic analysis and exterior ballistics calculation validate the proposed methodology,which is relatively time-saving,reliable and has the potential to solve similar problems. 展开更多
关键词 finite element method(FEA) shape optimization mesh morphing response surface method(RSM) design of experiments(DOE) rigid-flexible coupling machine gun system
在线阅读 下载PDF
Transient reliability optimization for turbine disk radial deformation
11
作者 费成巍 白广忱 +2 位作者 唐文忠 蔡逸思 高海峰 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第2期344-352,共9页
The radial deformation design of turbine disk seriously influences the control of gas turbine high pressure turbine(HPT) blade-tip radial running clearance(BTRRC). To improve the design of BTRRC under continuous opera... The radial deformation design of turbine disk seriously influences the control of gas turbine high pressure turbine(HPT) blade-tip radial running clearance(BTRRC). To improve the design of BTRRC under continuous operation, the nonlinear dynamic reliability optimization of disk radial deformation was implemented based on extremum response surface method(ERSM), including ERSM-based quadratic function(QF-ERSM) and ERSM-based support vector machine of regression(SR-ERSM). The mathematical models of the two methods were established and the framework of reliability-based dynamic design optimization was developed. The numerical experiments demonstrate that the proposed optimization methods have the promising potential in reducing additional design samples and improving computational efficiency with acceptable precision, in which the SR-ERSM emerges more obviously. Through the case study, we find that disk radial deformation is reduced by about 6.5×10–5 m; δ=1.31×10–3 m is optimal for turbine disk radial deformation design and the proposed methods are verified again. The presented efforts provide an effective optimization method for the nonlinear transient design of motion structures for further research, and enrich mechanical reliability design theory. 展开更多
关键词 turbine disk radial deformation reliability-based transient design optimization extremum response surface method support vector machine regression
在线阅读 下载PDF
Practical Aspects for Designing Statistically Optimal Experiments
12
作者 Mark J. Anderson Patrick J. Whitcomb 《Journal of Statistical Science and Application》 2014年第3期85-92,共8页
Due to operational or physical considerations, standard factorial and response surface method (RSM) design of experiments (DOE) often prove to be unsuitable. In such cases a computer-generated statistically-optima... Due to operational or physical considerations, standard factorial and response surface method (RSM) design of experiments (DOE) often prove to be unsuitable. In such cases a computer-generated statistically-optimal design fills the breech. This article explores vital mathematical properties for evaluating alternative designs with a focus on what is really important for industrial experimenters. To assess "goodness of design" such evaluations must consider the model choice, specific optimality criteria (in particular D and I), precision of estimation based on the fraction of design space (FDS), the number of runs to achieve required precision, lack-of-fit testing, and so forth. With a focus on RSM, all these issues are considered at a practical level, keeping engineers and scientists in mind. This brings to the forefront such considerations as subject-matter knowledge from first principles and experience, factor choice and the feasibility of the experiment design. 展开更多
关键词 design of experiments optimal design response surface methods fraction of design space.
在线阅读 下载PDF
Application of Improved RSM in the Optimization of Automotive Frontal Crashworthiness
13
作者 Chunke Liu Jianxing Li Xiaojun Xu 《Journal of Transportation Technologies》 2016年第3期155-161,共7页
Based on the vehicle front crash finite element analysis, it shows that there is a large acceleration, so it needs further optimization. In order to improve the performance of vehicle collision, eight parts were selec... Based on the vehicle front crash finite element analysis, it shows that there is a large acceleration, so it needs further optimization. In order to improve the performance of vehicle collision, eight parts were selected which have large impact for the result, its thickness as design variables to the right of the B-pillar acceleration peak of optimization goal;17 sample points were selected by Latin hypercube sampling method. Many structure parameters are optimized using sequential quadratic program (SQP) based on the surrogate model. The results show that the improved RSM has high accuracy;the right B-pillar acceleration reduced approximately 22.8%, reached the expected objective and was more conducive to the occupant safety. 展开更多
关键词 Automobile Safety Frontal Crash Finite Element Analysis response surface method (RSM) optimization design
在线阅读 下载PDF
基于响应面法的血管支架拉伸、扭转性能优化及考虑加工精度影响的强度可靠性分析 被引量:1
14
作者 马宗民 李淑娴 白猛威 《机械设计》 CSCD 北大核心 2024年第S01期78-82,共5页
为分析设计变量对血管支架拉伸性能、扭转性能的精准影响,进行血管支架拉伸性能、扭转性能优化,考虑加工精度的影响,进行血管支架的强度可靠性分析。方法:取血管支架支撑筋宽度、支撑筋长度、连接筋宽度和支架厚度为设计变量,应用斯皮... 为分析设计变量对血管支架拉伸性能、扭转性能的精准影响,进行血管支架拉伸性能、扭转性能优化,考虑加工精度的影响,进行血管支架的强度可靠性分析。方法:取血管支架支撑筋宽度、支撑筋长度、连接筋宽度和支架厚度为设计变量,应用斯皮尔曼等级相关系数法分析设计变量对血管支架拉伸刚度、扭转刚度等响应变量的精准影响;采用响应面方法进行以拉伸刚度、扭转刚度为目标进行血管支架的优化设计;对优化后的血管支架,考虑加工精度所致设计变量的随机性,利用六西格玛工具分析应力的概率分布。结果:对于血管支架拉伸刚度,支撑筋宽度和连接筋宽度灵敏度系数大,且均为正值;对于血管支架扭转刚度,支撑筋宽度灵敏度系数较大,且为负值;优化后的血管支架相比原始血管支架,拉伸刚度降低了11.5%;扭转刚度减小了50.6%;考虑加工精度所致设计变量的随机性进行可靠性分析,在可靠度为99.8%时,虽然血管支架的拉伸刚度和扭转刚度最大值高于优化值,但血管支架的最大应力满足强度条件。结论:支撑筋宽度对血管支架的拉伸性能影响最大,连接筋宽度次之,支撑筋长度和支架厚度影响较小;支撑筋宽度对血管支架的扭转性能影响最大,连接筋宽度、支撑筋长度和支架厚度影响较小;随机因素加工精度对血管支架优化目标有一定的影响,但优化结果仍是可靠的。本文提供了一种血管支架优化的思路:首先是进行基于目标的优化,然后考虑随机因素的影响进行基于概率的强度可靠性分析。 展开更多
关键词 血管支架 响应面法 优化设计 强度可靠性
在线阅读 下载PDF
旋风分离器内置导流叶片结构参数优化研究
15
作者 曾云 陈宓 +4 位作者 魏轲 李美求 李银银 李伟伟 董吉宁 《石油机械》 北大核心 2024年第8期92-100,共9页
为研究旋风分离器内置导流叶片各个结构参数之间的相互作用,基于CFD数值模拟方法和BBD试验设计,采用二阶多项式基函数建立了Stairmand旋风分离器的叶片轴向位置、叶片长度及叶片偏转角度与分离效率及压降间的数学模型。拟合结果表明:响... 为研究旋风分离器内置导流叶片各个结构参数之间的相互作用,基于CFD数值模拟方法和BBD试验设计,采用二阶多项式基函数建立了Stairmand旋风分离器的叶片轴向位置、叶片长度及叶片偏转角度与分离效率及压降间的数学模型。拟合结果表明:响应目标的决定系数均在0.99以上,表明相关性和回归模型效果较好。使用Design Expert软件处理数据后选择了最佳推荐点,对分离器结构进行了优化。优化后的模型与原结构对比结果如下:优化模型的压降略有上升;颗粒直径在1~20μm范围内时,优化前后分离器的分离效率变化明显,尤其在1~15μm范围内时,优化前分离效率为6.8%~31.0%,优化后则达到了17.0%~54.0%,提升约20个百分点;而当粒径在15~40μm区间时,优化前后的分离效率变化不明显,尤其是在粒径20~40μm时,优化前的分离效率为71.0%~98.0%,而优化后的分离效率只有77%~99%,提升约10个百分点;优化后的模型性能符合“高效低阻”的设计目标。所得结论可为旋风分离器内置叶片的改进提供设计指导。 展开更多
关键词 旋风分离器 FLUENT 结构优化 响应面法 BBD试验设计 分离效率
在线阅读 下载PDF
吲哚美辛二元醇质体凝胶剂的制备与质量研究
16
作者 于秋菊 《安徽化工》 CAS 2024年第4期58-64,68,共8页
目的:优化吲哚美辛(IND)二元醇质体凝胶的处方工艺,并进行药效学研究和稳定性考查。方法:以平均粒径Y1和包封率Y2为因变量,磷脂用量X1、混合醇用量X_(2)、丙二醇用量X_(3)为自变量,采用星点设计-效应面法优化IND二元醇质体的制备工艺,... 目的:优化吲哚美辛(IND)二元醇质体凝胶的处方工艺,并进行药效学研究和稳定性考查。方法:以平均粒径Y1和包封率Y2为因变量,磷脂用量X1、混合醇用量X_(2)、丙二醇用量X_(3)为自变量,采用星点设计-效应面法优化IND二元醇质体的制备工艺,并与卡波姆凝胶基质以1∶1比例研和制备IND二元醇质体凝胶,通过改良的Franz扩散池法考查IND凝胶、纳米乳与二元醇质体凝胶的体外透皮性能并进行IND二元醇质体的初步稳定性考查;采用热板法和醋酸扭体法考查IND三种制剂的体内镇痛作用。结果:最优处方工艺为IND0.50g,磷脂0.46g,混合醇8.45mL,丙二醇2.15mL,制备的IND二元醇质体凝胶的平均粒径为(81.80±1.04)nm,包封率为(72.61±1.01)%,与预测值相对误差分别为2.36%、2.29%。IND二元醇质体凝胶的稳态渗透速率常数为(0.646 7±0.007 30)μg·cm^(-2)·h^(-1),是普通凝胶的2.16倍,纳米乳的1.43倍;IND二元醇质体凝胶能明显抑制小鼠的热板添足反应和醋酸扭体反应。结论:制备的IND二元醇质体凝胶剂粒径小,分布较为均匀,具有良好的体外透皮吸收性能和体内镇痛作用,稳定性良好,为IND用于局部炎症治疗的新剂型研究提供依据。 展开更多
关键词 吲哚美辛 二元醇质体凝胶 星点-效应面法 经皮渗透 稳定性
在线阅读 下载PDF
益肾固精暖脐贴制备工艺的研究 被引量:1
17
作者 包晴 高元航 +5 位作者 廖卓 王璐 黄莉 唐林 黄超文 杨磊 《湖南中医药大学学报》 CAS 2024年第6期1018-1026,共9页
目的研究益肾固精暖脐贴的提取工艺及其成型工艺。方法以蛇床子素、羟基-α-山椒素、金丝桃苷以及浸膏得率为考察指标,以提取时间、提取溶媒倍数、乙醇浓度为考察因素,运用Box-Behnken设计-响应面法优选出最佳提取工艺;以凝胶贴膏的初... 目的研究益肾固精暖脐贴的提取工艺及其成型工艺。方法以蛇床子素、羟基-α-山椒素、金丝桃苷以及浸膏得率为考察指标,以提取时间、提取溶媒倍数、乙醇浓度为考察因素,运用Box-Behnken设计-响应面法优选出最佳提取工艺;以凝胶贴膏的初黏力、持黏力、剥离强度、感官评价为指标,采用D-最优混料设计优选益肾固精暖脐贴的最佳成型工艺。结果益肾固精暖脐贴的最佳提取工艺为回流提取120 min,提取溶媒倍数为12,乙醇浓度为57%,同法提取2次;最佳成型工艺的质量比为NP700占6.00%、PVP-k90占0.60%、甘羟铝占0.15%、填充剂5.76%、EDTA-2Na占0.10%、甘油占21.76%、柠檬酸占0.20%、水和药液总量占65.43%。结论该实验优选的益肾固精暖脐贴的提取工艺及其凝胶贴膏的制备工艺稳定可行,可为该产品的进一步开发利用提供参考。 展开更多
关键词 益肾固精暖脐贴 高效液相色谱法 Box-Behnken-设计响应面法 D-最优混料设计 凝胶贴膏
在线阅读 下载PDF
双主轴卧式加工中心横梁结构综合优化设计 被引量:1
18
作者 尹浇钦 高自成 +3 位作者 李立君 刘怀粤 乔志东 胡意波 《机床与液压》 北大核心 2024年第14期94-99,共6页
为了在降低横梁总质量的同时保证其低阶固有频率和刚度,提出一种结合拓扑结构和尺寸优化的设计方法。使用拓扑优化方法确定横梁内部结构,并对它进行修复;根据修复后横梁的有限元分析结果,以横梁内部的厚度、孔尺寸等多个参数为设计变量... 为了在降低横梁总质量的同时保证其低阶固有频率和刚度,提出一种结合拓扑结构和尺寸优化的设计方法。使用拓扑优化方法确定横梁内部结构,并对它进行修复;根据修复后横梁的有限元分析结果,以横梁内部的厚度、孔尺寸等多个参数为设计变量,整体最大变形和1阶固有频率为约束条件,采用总质量最小为目标函数建立数学模型。利用多目标遗传算法(MOGA)进行求解,通过CCD试验设计获得初始样本点,并使用Kriging模型建立响应面。经过多次试验发现,横梁的总质量相比于优化前减少了20.3%。 展开更多
关键词 双主轴卧式加工中心 横梁 拓扑优化 响应面法 轻量化设计
在线阅读 下载PDF
一种艾灸装置的结构设计及支撑座的优化设计 被引量:1
19
作者 徐新 邓斌 刘宁波 《机械设计与制造》 北大核心 2024年第2期332-337,共6页
为了提高艾灸的质量和效率,设计了一种艾灸装置,整个艾灸装置既能实现自动清灰,且艾灸温度能精准控制。为了艾灸装置的使用方便和成本低减,对艾灸装置的关键部件艾灸支撑座进行了优化设计,以艾灸支撑座的三个结构尺寸为设计变量,利用OS... 为了提高艾灸的质量和效率,设计了一种艾灸装置,整个艾灸装置既能实现自动清灰,且艾灸温度能精准控制。为了艾灸装置的使用方便和成本低减,对艾灸装置的关键部件艾灸支撑座进行了优化设计,以艾灸支撑座的三个结构尺寸为设计变量,利用OSF方法选取了设计变量的试验点,建立了径向基神经网络代理模型,并检验了该模型的精度。以艾灸支撑座的质量和最大变形量为多目标优化函数,以最大变形量和最大应力为约束条件,利用多岛遗传算法得到Pareto最优解集。在保证艾灸支撑座力学性能不降低的前提下,质量减轻了15.01%。结果表明,该方法具有较高的精度和较强的工程实用性。 展开更多
关键词 艾灸装置 结构设计 有限元法 响应面 多目标优化
在线阅读 下载PDF
基于星点设计-响应面法研制黄精益智仁复合固体饮料及抗疲劳作用研究 被引量:1
20
作者 张瑞博 闫小娟 张海悦 《中国食品添加剂》 CAS 2024年第11期153-161,共9页
以黄精、益智仁、茯苓、芡实、枸杞、山药、大枣、山楂等8味药食同源地道药材,开发一款具有抗疲劳功能的黄精益智仁固体饮料(PASB)。利用单因素以及星点设计-响应面试验优化其煎煮提取工艺,喷雾干燥制得的固体饮料,并通过小鼠负重游泳... 以黄精、益智仁、茯苓、芡实、枸杞、山药、大枣、山楂等8味药食同源地道药材,开发一款具有抗疲劳功能的黄精益智仁固体饮料(PASB)。利用单因素以及星点设计-响应面试验优化其煎煮提取工艺,喷雾干燥制得的固体饮料,并通过小鼠负重游泳试验考察抗疲劳效果。结果表明最佳煎煮工艺为:料液比1∶13 g/mL,煎煮时间100 min,浸泡60 min,煎煮两次。同时动物实验结果显示,PASB能够延长小鼠负重游泳时间,降低血乳酸、血清尿素氮的堆积,提高肝糖原含量,表明黄精益智仁固体饮料具有较好的抗疲劳活性。 展开更多
关键词 黄精益智仁固体饮料 星点设计-响应面 负重游泳实验 抗疲劳
在线阅读 下载PDF
上一页 1 2 22 下一页 到第
使用帮助 返回顶部