目的:观察食管癌患者血清可溶性内皮糖蛋白(Soluble endoglin,sEndoglin)、SiSo细胞表达的受体结合肿瘤抗原(Receptor binding cancer antigen expressed on siso cells,RCAS1)、细胞角化素蛋白19片段(Cytokeratin19fragmentantigen21-1...目的:观察食管癌患者血清可溶性内皮糖蛋白(Soluble endoglin,sEndoglin)、SiSo细胞表达的受体结合肿瘤抗原(Receptor binding cancer antigen expressed on siso cells,RCAS1)、细胞角化素蛋白19片段(Cytokeratin19fragmentantigen21-1,Cyfra21-1)水平,并探究其与临床病理特征相关性及其临床应用价值。方法:选取2020年2月~2023年2月本院108例食管癌患者为研究组,另选取同期健康志愿者54例作为对照组。比较两组血清sEndoglin、RCAS1、CYFRA21-1水平。分析研究组不同临床病理特征者血清sEndoglin、RCAS1、CYFRA21-1水平,并分析其与临床病理特征相关性。评价血清sEndoglin、RCAS1、CYFRA21-1对食管癌的诊断价值。COX回归分析食管癌患者1年内预后的影响因素。结果:研究组血清sEndoglin、RCAS1、CYFRA21-1水平高于对照组(P<0.05);血清sEndoglin、RCAS1、CYFRA21-1与分化程度呈负相关,与淋巴结转移、TNM分期呈正相关(P<0.05);血清sEndoglin、RCAS1、CYFRA21-1联合诊断食管癌的AUC大于单项指标诊断(P<0.05);淋巴结转移、TNM分期及血清sEndoglin、RCAS1、CYFRA21-1水平为预后的影响因素(P<0.05)。结论:血清sEndoglin、RCAS1、CYFRA21-1水平与食管癌患者分化程度呈负相关,与淋巴结转移、TNM分期呈正相关,其对食管癌具有一定诊断价值,且为预后的影响因素,可能作为评估患者预后的潜在指标。展开更多
Objective: To compare the levels of p38 mitogen-activated protein kinase (MAPK), soluble endoglin and endothelin-1 in the serum of patients with severe preeclampsia, hemolysis, elevated liver enzymes, and low platelet...Objective: To compare the levels of p38 mitogen-activated protein kinase (MAPK), soluble endoglin and endothelin-1 in the serum of patients with severe preeclampsia, hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome and normal pregnancies. Methods: This study was an observational analytic cross-sectional study performed at Wahidin Sudirohusodo Hospital, Makassar, Indonesia, in the period of 5th February 2016 to 20th January 2017. P38 MAPK, soluble endoglin and endothelin-1 levels of patients with normal pregnancies, severe preeclampsia and HELLP syndrome were measured by enzyme-linked immunoabsorbentassay technique, using kits of human soluble endoglin, endothelin-1 and p38 MAPK, Quantikine immunoassay: R&D System Inc. Results: Level of serum p38 MAPK in HELLP syndrome group was higher than in severe preeclampsia and normal pregnancy groups. Soluble endoglin and endothelin-1 levels in pregnancies with severe preeclampsia and HELLP syndrome were higher than normal pregnancy but there was no significant difference between these two groups (P>0.05). Levels of p38 MAPK, soluble endoglin and endothelin-1 also had a positive linear correlation with systolic and diastolic blood pressures (P<0.05). Conclusions: P38 MAPK in serum may be a marker for evidence of the severe hypoxia and its application may be considered for the diagnosis of HELLP syndrome.展开更多
文摘目的:观察食管癌患者血清可溶性内皮糖蛋白(Soluble endoglin,sEndoglin)、SiSo细胞表达的受体结合肿瘤抗原(Receptor binding cancer antigen expressed on siso cells,RCAS1)、细胞角化素蛋白19片段(Cytokeratin19fragmentantigen21-1,Cyfra21-1)水平,并探究其与临床病理特征相关性及其临床应用价值。方法:选取2020年2月~2023年2月本院108例食管癌患者为研究组,另选取同期健康志愿者54例作为对照组。比较两组血清sEndoglin、RCAS1、CYFRA21-1水平。分析研究组不同临床病理特征者血清sEndoglin、RCAS1、CYFRA21-1水平,并分析其与临床病理特征相关性。评价血清sEndoglin、RCAS1、CYFRA21-1对食管癌的诊断价值。COX回归分析食管癌患者1年内预后的影响因素。结果:研究组血清sEndoglin、RCAS1、CYFRA21-1水平高于对照组(P<0.05);血清sEndoglin、RCAS1、CYFRA21-1与分化程度呈负相关,与淋巴结转移、TNM分期呈正相关(P<0.05);血清sEndoglin、RCAS1、CYFRA21-1联合诊断食管癌的AUC大于单项指标诊断(P<0.05);淋巴结转移、TNM分期及血清sEndoglin、RCAS1、CYFRA21-1水平为预后的影响因素(P<0.05)。结论:血清sEndoglin、RCAS1、CYFRA21-1水平与食管癌患者分化程度呈负相关,与淋巴结转移、TNM分期呈正相关,其对食管癌具有一定诊断价值,且为预后的影响因素,可能作为评估患者预后的潜在指标。
文摘Objective: To compare the levels of p38 mitogen-activated protein kinase (MAPK), soluble endoglin and endothelin-1 in the serum of patients with severe preeclampsia, hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome and normal pregnancies. Methods: This study was an observational analytic cross-sectional study performed at Wahidin Sudirohusodo Hospital, Makassar, Indonesia, in the period of 5th February 2016 to 20th January 2017. P38 MAPK, soluble endoglin and endothelin-1 levels of patients with normal pregnancies, severe preeclampsia and HELLP syndrome were measured by enzyme-linked immunoabsorbentassay technique, using kits of human soluble endoglin, endothelin-1 and p38 MAPK, Quantikine immunoassay: R&D System Inc. Results: Level of serum p38 MAPK in HELLP syndrome group was higher than in severe preeclampsia and normal pregnancy groups. Soluble endoglin and endothelin-1 levels in pregnancies with severe preeclampsia and HELLP syndrome were higher than normal pregnancy but there was no significant difference between these two groups (P>0.05). Levels of p38 MAPK, soluble endoglin and endothelin-1 also had a positive linear correlation with systolic and diastolic blood pressures (P<0.05). Conclusions: P38 MAPK in serum may be a marker for evidence of the severe hypoxia and its application may be considered for the diagnosis of HELLP syndrome.
