Purpose: To clarify the effectiveness of 3-D delivery animation software for the mother’s and husband’s satisfaction with delivery. Subjects and Method: We independently developed a software application used to disp...Purpose: To clarify the effectiveness of 3-D delivery animation software for the mother’s and husband’s satisfaction with delivery. Subjects and Method: We independently developed a software application used to display the pelvic region and explain the labor process. The study involved a collaboration with hospital staff who recruited 18 primiparous and 18 multiparous mothers who were hospitalized for delivery at Facility A. The midwife explained the process of delivery using the “Delivery Animation Software”. A self-administered, anonymous questionnaire was distributed and analyzed separately for primiparous and multiparous mothers and their husbands. Results: 1) For both primiparous and multiparous couples, both mothers and their husbands gained a significantly higher level of understanding after delivery than during pregnancy. 2) The Self-Evaluation Scale for Experience of Delivery results were as follows: “I did my best for the baby even if it was painful” was selected more often for “birth coping skills”;“reliable medical staff” was selected more often for “physiological birth process”;“the birth progressed as I expected” was selected frequently by primiparous mothers;and “the birth progressed smoothly” was selected often by multiparous mothers. 3) In terms of husbands’ satisfaction with the delivery, “I was satisfied with the delivery”, “I was given an easy-to-understand explanation”, and “They explained the process to me” was selected of primiparous and multiparous fathers. 4) All primiparous and multiparous mothers positively evaluated whether the delivery animation was helpful in understanding the process of delivery. Conclusion: The delivery animation was effective in improving the understanding and satisfaction of both the mothers and their husbands.展开更多
Background Face image animation generates a synthetic human face video that harmoniously integrates the identity derived from the source image and facial motion obtained from the driving video.This technology could be...Background Face image animation generates a synthetic human face video that harmoniously integrates the identity derived from the source image and facial motion obtained from the driving video.This technology could be beneficial in multiple medical fields,such as diagnosis and privacy protection.Previous studies on face animation often relied on a single source image to generate an output video.With a significant pose difference between the source image and the driving frame,the quality of the generated video is likely to be suboptimal because the source image may not provide sufficient features for the warped feature map.Methods In this study,we propose a novel face-animation scheme based on multiple sources and perspective alignment to address these issues.We first introduce a multiple-source sampling and selection module to screen the optimal source image set from the provided driving video.We then propose an inter-frame interpolation and alignment module to further eliminate the misalignment between the selected source image and the driving frame.Conclusions The proposed method exhibits superior performance in terms of objective metrics and visual quality in large-angle animation scenes compared to other state-of-the-art face animation methods.It indicates the effectiveness of the proposed method in addressing the distortion issues in large-angle animation.展开更多
Background Considerable research has been conducted in the areas of audio-driven virtual character gestures and facial animation with some degree of success.However,few methods exist for generating full-body animation...Background Considerable research has been conducted in the areas of audio-driven virtual character gestures and facial animation with some degree of success.However,few methods exist for generating full-body animations,and the portability of virtual character gestures and facial animations has not received sufficient attention.Methods Therefore,we propose a deep-learning-based audio-to-animation-and-blendshape(Audio2AB)network that generates gesture animations and ARK it's 52 facial expression parameter blendshape weights based on audio,audio-corresponding text,emotion labels,and semantic relevance labels to generate parametric data for full-body animations.This parameterization method can be used to drive full-body animations of virtual characters and improve their portability.In the experiment,we first downsampled the gesture and facial data to achieve the same temporal resolution for the input,output,and facial data.The Audio2AB network then encoded the audio,audio-corresponding text,emotion labels,and semantic relevance labels,and then fused the text,emotion labels,and semantic relevance labels into the audio to obtain better audio features.Finally,we established links between the body,gestures,and facial decoders and generated the corresponding animation sequences through our proposed GAN-GF loss function.Results By using audio,audio-corresponding text,and emotional and semantic relevance labels as input,the trained Audio2AB network could generate gesture animation data containing blendshape weights.Therefore,different 3D virtual character animations could be created through parameterization.Conclusions The experimental results showed that the proposed method could generate significant gestures and facial animations.展开更多
Background:This study aimed to evaluate the effectiveness of using animation as education material for family empowerment program on perioperative care for caregivers whose children were to undergo neurosurgery.Method...Background:This study aimed to evaluate the effectiveness of using animation as education material for family empowerment program on perioperative care for caregivers whose children were to undergo neurosurgery.Methods:A total of 204 caregivers were randomly assigned to either the face‐to‐face oral nursing educated group(Oral Group)or the animation‐assisted nursing educated group(Animated Group).The nursing education primarily focused on instructing caregivers about the manual vibration method.The primary outcome of interest in this study was participants'knowledge level,collected by a 10‐item questionnaire.Secondary outcomes included child patients'clinical data,including hospitalization days,treatments,and signs of pneumonia.Results:Participants in the Animated Group exhibited significantly higher accuracy in perioperative care knowledge assessment,and patients in this group had a lower chance of requiring atomization therapy compared to the Oral Group.Conclusions:The animation‐assisted nursing education program effectively enhances pediatric caregivers'knowledge,reduces respiratory complications after surgery,and offers valuable insights for future studies on the use of such programs to instruct caregivers.展开更多
The Twangiza mine is located in the Mitumba mountain range, in the western part of the Albertine Rift Valley, just 20 km East of Itombwe Nature Reserve. A biological inventory was carried out within the mine’s decade...The Twangiza mine is located in the Mitumba mountain range, in the western part of the Albertine Rift Valley, just 20 km East of Itombwe Nature Reserve. A biological inventory was carried out within the mine’s decade-old progressive ecological rehabilitation sites. This inventory covered insects, amphibians, reptiles, birds and small mammals. The main objective of the inventory was to assess the level of animal recolonization in the 100-hectares’ restored areas. A total of 22 insect genera, 4 amphibian species, 11 reptile species, 43 bird species and 11 small mammal species were found. All of them were strongly settled in the core area within the afforested sites. Prior to the start of the Twangiza mine activities and 4 years before the ecological rehabilitation in the area, the avifauna was depauperate, both in number of species and their abundance. By then, no mammals or reptiles were recorded within the footprint area. The environmental and social baseline assessment identified 38 bird species in 2008, mainly grassland and mobile species, which were using scrub along valley streams as a refuge, outside the current mine footprint. Our results clearly demonstrate the positive impact of the afforestation on insect, amphibian, reptile, bird and small mammal’s diversity in this area.展开更多
A jungle is full of life.You can sometimes see exhibits of jungle animals and learn about them.Monkeys play in jungle trees.Colorful parrots fly and call to one another.Black and orange tigers hunt under the trees.
Background:Baitouweng decoction is a classic prescription for treating chronic dysentery and mainly used to treat heat-toxic dysentery and is widely used in damp-heat ulcerative colitis(UC)in China.Methods:Meta-analys...Background:Baitouweng decoction is a classic prescription for treating chronic dysentery and mainly used to treat heat-toxic dysentery and is widely used in damp-heat ulcerative colitis(UC)in China.Methods:Meta-analysis and network pharmacology were used to examine the pharmacological properties of Baitouweng decoction in the treatment of UC.Additionally,the potential mechanisms of action were investigated.In the meta-analysis,studies were searched from databases up to March 2024.Data from the included studies were extracted.The results were quantified by calculating the standardized mean difference(SMD).Additionally,95%confidence intervals(CI)were used to assess the precision of the estimates.Results:It was found that 201 components of Baitouweng decoction,including Pulsatillae Radix(Baitouweng),Coptidis Rhizoma(Huanglian),Phellodendri Chinensis Cortex(Huangbo),Fraxini Cortex(Qinpi),and 106 intersecting targets of UC,were obtained from INPUT.PPI and enrichment analyses showed Baitouweng decoction might regulate inflammatory response to improve UC injury.Seventeen included studies were published between 2004 and 2024.The meta-analysis results suggested that Baitouweng decoction may help increase body weight,decrease DAI and CMDI,reduce colon length shortening associated with UC,lower the spleen index,and alleviate tissue damage in colitis.In addition,Baitouweng decoction could inhibit inflammatory response and repair intestinal barrier in UC model.The protective mechanism of Baitouweng decoction was consistent with the predicted targets of network pharmacology,which suggested the results were accurate.Conclusion:Baitouweng decoction could improve UC injury by regulating the inflammatory response,cell apoptosis,and body metabolism through the integration of network pharmacology and meta-analysis.Its protective mechanisms are related to anti-inflammation,regulation of intestinal flora,brain-gut peptides,and protection of the intestinal mucosal barrier,along with modulation of body metabolism,including SCFA,bile acids,and tryptophan metabolism.展开更多
Severe combined immunodeficiency disease(SCID),characterized by profound immune system dysfunction,can lead to life-threatening infections and death.Animal models play a pivotal role in elucidating biological processe...Severe combined immunodeficiency disease(SCID),characterized by profound immune system dysfunction,can lead to life-threatening infections and death.Animal models play a pivotal role in elucidating biological processes and advancing therapeutic strategies.Recent advances in gene-editing technologies,including zincfinger nucleases(ZFNs),transcription activator-like effector nucleases(TALENs),CRISPR/Cas9,and base editing,have significantly enhanced the generation of SCID models.These models have not only deepened our understanding of disease pathophysiology but have also driven progress in cancer therapy,stem cell transplantation,organ transplantation,and infectious diseasemanagement.Thisreviewprovidesa comprehensive overview of current SCID models generated using novel gene-editing approaches,highlighting their potential applications in translational medicine and their role in advancing biomedical research.展开更多
The purpose of this article is to discuss the proper method for Chinese digital animation character design on the foundation of certain cultural elements. The method used in this study is known as comparative analysis...The purpose of this article is to discuss the proper method for Chinese digital animation character design on the foundation of certain cultural elements. The method used in this study is known as comparative analysis of Disney and Japanese animation styles in action, appearance, facial expression and voice design. These dynamic factors are the best carrier of the animation spirit and native culture, so it is important to take the dynamic factors into account when producing the digital animation, and it will be an excellent starting point to innovate Chinese digital animation.展开更多
The super-maneuver flight performance has a very high tactical value, and the development of this tactical value has great significance. A discussion is devoted to the study of intelligent control methods and technolo...The super-maneuver flight performance has a very high tactical value, and the development of this tactical value has great significance. A discussion is devoted to the study of intelligent control methods and technologies of real-time distributed 3-dimensional animation simulation for the super-maneuverable attack of new generational fighter in this paper. A flight control system of super-maneuver is reconstructed by adopting three layers BP neural networks of number 3, and the fire/flight coupler is designed by introducing a fuzzy control rule whose universe of discourse and gain are regulated adaptively on the line. Furthermore, a new method of real-time distributed 3-dimensional animation simulation is put forward, and a real-time distributed 3-dimensional animation simulation tool platform is constructed in this paper. The simulation result is lifelike, perceivable directly and useful.展开更多
Background: The successful treatment of military combat casualties with penetrating injuries is significantly dependent on the time needed to get the patient to an adequate treatment facility. Profound hypothermia ind...Background: The successful treatment of military combat casualties with penetrating injuries is significantly dependent on the time needed to get the patient to an adequate treatment facility. Profound hypothermia induced suspended animation for delayed resuscitation(SADR) is a novel approach for inducing cardiac arrest and buying additional time for such injuries. However, the time used to safely administer circulatory arrest(CA) is controversial. The goal of this study was to evaluate the safety of hypothermia-induced SADR over 90 and 120 min time intervals.Methods: Sixteen male BAMA minipigs were randomized into two groups: CA90 group(90 min, n =8) and CA120 group(120 min, n =8). Cannulation of the right common carotid arteries and internal jugular veins was performed to establish cardiopulmonary bypass for each animal. Through the perfusion of cold organ preservation solution(OPS), cardioplegia and profound hypothermia(15℃) were induced. After CA, cardiopumonary bypass(CPB) was restarted, and the animals were gradually re-warmed and resuscitated. The animals were assisted with ventilators until spontaneous breathing was achieved. The index of hemodynamic perioperative serum chemistry values [alanine transaminase(ALT), aspartate aminotransferase(AST), creatinine(CR), lactic dehydrogenase(LDH) and troponin T(TnT)] and survival were observed from pre-operation to 7 days post-operation.Results: Fifteen animals were enrolled in the experiment, while 1 animal in CA120 group died from surgical error. All 8 animals in CA90 group recovered, with only 1 animal displaying mild disability. However, in CA120 group, only 2 animals survived with severe disability, and the other 5 animals died after 2 days post-operation. In CA90 group, the perioperative serum chemistry values increased at 1 day post-operation(ALT 84.43±18.65 U/L; AST 88.99±23.19 U/L; Cr 87.90±24.49μmol/L; LDH 1894.13±322.26 U/L; TnT 0.849±0.135 ng/ml) but decreased to normal or almost normal levels at 7 days post-operation(ALT 52.48±9.04 U/L; AST 75.23±21.46 U/L; Cr 82.69±18.41μmol/L; LDH 944.67±834.32 U/L; TnT 0.336±0.076 ng/ml).Conclusion: Profound hypothermia-induced SADR is an effective method for inducing cardiac arrest. Our results indicate that inducing CA for 90 min(at 15℃) is safer than doing so for 120 min. Our results indicate that 120 min of CA at 15℃ is dangerous and can result in high mortality and severe neurological complications. Further experimentation is needed to determine whether 120 min of CA at temperatures lower than 15℃ can lead to safe recovery.展开更多
Driving facial animation based on tens of tracked markers is a challenging task due to the complex topology and to the non-rigid nature of human faces. We propose a solution named manifold Bayesian regression. First a...Driving facial animation based on tens of tracked markers is a challenging task due to the complex topology and to the non-rigid nature of human faces. We propose a solution named manifold Bayesian regression. First a novel distance metric, the geodesic manifold distance, is introduced to replace the Euclidean distance. The problem of facial animation can be formulated as a sparse warping kernels regression problem, in which the geodesic manifold distance is used for modelling the topology and discontinuities of the face models. The geodesic manifold distance can be adopted in traditional regression methods, e.g. radial basis functions without much tuning. We put facial animation into the framework of Bayesian regression. Bayesian approaches provide an elegant way of dealing with noise and uncertainty. After the covariance matrix is properly modulated, Hybrid Monte Carlo is used to approximate the integration of probabilities and get deformation results. The experimental results showed that our algorithm can robustly produce facial animation with large motions and complex face models.展开更多
In Chinese ancient costume animation movies, there are problems of unreasonable cultural expression in many architectural scenes, such as not meticulous scene design and weak understanding of the relationship between ...In Chinese ancient costume animation movies, there are problems of unreasonable cultural expression in many architectural scenes, such as not meticulous scene design and weak understanding of the relationship between artistic design and image cultural expression. This is greatly different from the spirit of passing on national ethnic culture. In order to transform such situation, it is recommended to set up the concept of passing on the ethnic culture, follow the principle of creation of national art and practice of story creation, improve the style of domestic animation movies, and raise the concept of cultural creation.展开更多
<strong>Objectives:</strong> To clarify the effects on the delivery experience of midwives giving parturient females individual explanations about how the course of delivery, using 3D animation software (D...<strong>Objectives:</strong> To clarify the effects on the delivery experience of midwives giving parturient females individual explanations about how the course of delivery, using 3D animation software (Delivery Animation). <strong>Method:</strong> 1) Subjects: Women admitted to Institution A for delivery;70 in the intervention group (34 primipara, 36 multipara), and 79 (41 primipara, 38 multipara) in the control group. 2) Data collection method: Intervention group;3) During phases 1 and 2 of delivery, after internal examinations, collaborative-researcher midwives gave parturient women explanations about the course of delivery, using tablets with the Delivery Animation software installed. This software was independently developed by the researchers. On postpartum day 1, the collaborative-researcher midwives distributed anonymous, self-administered questionnaires to the postpartum women. 4) During phases 1 and 2 of delivery, the course of delivery was explained using existing methods, and anonymous, self-administered questionnaires were distributed on postpartum day 1. 5) The intervention group and control group were compared using descriptive and inferential statistics, organized into primipara and multipara. <strong>Results:</strong> In the Understanding the Delivery Process category, primipara in the intervention group had significantly higher scores for “understood baby’s rotation” (p < 0.01) and “understood progress through delivery” (p < 0.05). In multipara, the intervention group scored significantly higher for “understood baby’s rotation” (p < 0.01). In the anonymous self-evaluation, primipara in the intervention group scored significantly higher in “midwife I could trust was by my side” (p < 0.01). Opinions on the Delivery Animation were classified into 7 categories. In their evaluations of the Delivery Animation, 89.0% of primipara and 92.0% of multipara said it helped them understand the course of labor, and 85.0% of primipara and 86.0% of multipara said it helped them communicate with the doctor/midwife. <strong>Conclusion:</strong> The significant differences in understanding of the course of delivery seen between the intervention and control groups, the satisfaction scores on the “Self-evaluation scale for experience of delivery (abridged version)” questionnaire, opinions about and evaluation of the Delivery Animation all show that a personal explanation of the course of childbirth has a positive effect on the understanding and satisfaction of parturient women.展开更多
A discrete-event system simulation and animation program was developed to enhance the efficiency of a truck-excavator operation and reduce the environmental impact of haulage in an open-cut coal mine with multiple-pit...A discrete-event system simulation and animation program was developed to enhance the efficiency of a truck-excavator operation and reduce the environmental impact of haulage in an open-cut coal mine with multiple-pit operations. In any mine, a key objective is to have sufficient equipment for production and not to have excess to where it becomes counterproductive. Due to the advent of responsible mining,environmental regulations, and eco-friendly practices, these factors must also be considered in the analysis. Simulation studies can be financially advantageous for both the optimization of existing mine operations and new development phases in a mine. This study is a new approach to use discrete-event system simulation for mine systems, in order to investigate and possibly reduce environmental impact considering mining haulage performance and production target. A hypothetical layout of a surface coal mine with two pit operations was used for the simulation and animation model. The simulation model includes the animation of the operation. Animation is helpful to enhance the benefit of a mine simulation model. GPSS/Hòand Proof Professionalòwere the software used for the investigation.展开更多
Homogeneous matrices are widely used to represent geometric transformations in computer graphics, with interpo- lation between those matrices being of high interest for computer animation. Many approaches have been pr...Homogeneous matrices are widely used to represent geometric transformations in computer graphics, with interpo- lation between those matrices being of high interest for computer animation. Many approaches have been proposed to address this problem, including computing matrix curves from curves in Euclidean space by registration, representing one-parameter curves on manifold by rational representations, changing subdivisional methods generating curves in Euclidean space to corresponding methods working for matrix curve generation, and variational methods. In this paper, we propose a scheme to generate rational one-parameter matrix curves based on exponential map for interpolation, and demonstrate how to obtain higher smoothness from existing curves. We also give an iterative technique for rapid computing of these curves. We take the computation as solving an ordinary differential equation on manifold numerically by a generalized Euler method. Furthermore, we give this algorithm’s bound of the error and prove that the bound is proportional to the shift length when the shift length is sufficiently small. Compared to direct computation of the matrix functions, our Euler solution is faster.展开更多
VRML offers powerful tool for generating 3D scene and realizing real time interactive animation on Web. This paper briefly introduces the related techniques of implementing interactive animation in Web 3D, focusing on...VRML offers powerful tool for generating 3D scene and realizing real time interactive animation on Web. This paper briefly introduces the related techniques of implementing interactive animation in Web 3D, focusing on how to use JavaScript to create Script node for extending VRML functions. This is very useful for virtual product design, product performance simulation, virtual assembly and remote education.展开更多
Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse ...Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease itself.Stem cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s disease.Mesenchymal stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of teratogenicity.We performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal model.We searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,2023.The study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control groups.We use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the meta-analysis.Treatment with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational test.Among the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a protective effect on dopaminergic neurons.Subgroup analysis of the amphetamine-induced rotation test showed a significant reduction only in the intracranial-striatum route(SMD[95%CI]=-2.59[-3.25 to-1.94],P=0.0001,I^(2)=74.4%).The memory test showed significant improvement only in the intravenous route(SMD[95%CI]=4.80[1.84 to 7.76],P=0.027,I^(2)=79.6%).Mesenchymal stem cells have been shown to positively impact motor function and memory function and protect dopaminergic neurons in preclinical models of Parkinson’s disease.Further research is required to determine the optimal stem cell types,modifications,transplanted cell numbe rs,and delivery methods for these protocols.展开更多
为了Java三维图形程序能在不同的移动设备和平台上运行,JCP(Java Community Process)制定了J2ME M3G(Mobile 3D Graphics API),规范了移动设备上Java三维图形程序的API和框架。而M3G中由于动画部分的独特性以及它在设计和实现中的复杂性...为了Java三维图形程序能在不同的移动设备和平台上运行,JCP(Java Community Process)制定了J2ME M3G(Mobile 3D Graphics API),规范了移动设备上Java三维图形程序的API和框架。而M3G中由于动画部分的独特性以及它在设计和实现中的复杂性,我们结合在XORP上开发M3G类库经验的基础,总结并给出了其设计和实现的参考模型和理论基础,也适用于其它3D类库的设计和开发。展开更多
文摘Purpose: To clarify the effectiveness of 3-D delivery animation software for the mother’s and husband’s satisfaction with delivery. Subjects and Method: We independently developed a software application used to display the pelvic region and explain the labor process. The study involved a collaboration with hospital staff who recruited 18 primiparous and 18 multiparous mothers who were hospitalized for delivery at Facility A. The midwife explained the process of delivery using the “Delivery Animation Software”. A self-administered, anonymous questionnaire was distributed and analyzed separately for primiparous and multiparous mothers and their husbands. Results: 1) For both primiparous and multiparous couples, both mothers and their husbands gained a significantly higher level of understanding after delivery than during pregnancy. 2) The Self-Evaluation Scale for Experience of Delivery results were as follows: “I did my best for the baby even if it was painful” was selected more often for “birth coping skills”;“reliable medical staff” was selected more often for “physiological birth process”;“the birth progressed as I expected” was selected frequently by primiparous mothers;and “the birth progressed smoothly” was selected often by multiparous mothers. 3) In terms of husbands’ satisfaction with the delivery, “I was satisfied with the delivery”, “I was given an easy-to-understand explanation”, and “They explained the process to me” was selected of primiparous and multiparous fathers. 4) All primiparous and multiparous mothers positively evaluated whether the delivery animation was helpful in understanding the process of delivery. Conclusion: The delivery animation was effective in improving the understanding and satisfaction of both the mothers and their husbands.
基金the Fund from Sichuan Provincial Key Laboratory of Intelligent Terminals(SCITLAB-20016).
文摘Background Face image animation generates a synthetic human face video that harmoniously integrates the identity derived from the source image and facial motion obtained from the driving video.This technology could be beneficial in multiple medical fields,such as diagnosis and privacy protection.Previous studies on face animation often relied on a single source image to generate an output video.With a significant pose difference between the source image and the driving frame,the quality of the generated video is likely to be suboptimal because the source image may not provide sufficient features for the warped feature map.Methods In this study,we propose a novel face-animation scheme based on multiple sources and perspective alignment to address these issues.We first introduce a multiple-source sampling and selection module to screen the optimal source image set from the provided driving video.We then propose an inter-frame interpolation and alignment module to further eliminate the misalignment between the selected source image and the driving frame.Conclusions The proposed method exhibits superior performance in terms of objective metrics and visual quality in large-angle animation scenes compared to other state-of-the-art face animation methods.It indicates the effectiveness of the proposed method in addressing the distortion issues in large-angle animation.
基金Supported by the National Natural Science Foundation of China (62277014)the National Key Research and Development Program of China (2020YFC1523100)the Fundamental Research Funds for the Central Universities of China (PA2023GDSK0047)。
文摘Background Considerable research has been conducted in the areas of audio-driven virtual character gestures and facial animation with some degree of success.However,few methods exist for generating full-body animations,and the portability of virtual character gestures and facial animations has not received sufficient attention.Methods Therefore,we propose a deep-learning-based audio-to-animation-and-blendshape(Audio2AB)network that generates gesture animations and ARK it's 52 facial expression parameter blendshape weights based on audio,audio-corresponding text,emotion labels,and semantic relevance labels to generate parametric data for full-body animations.This parameterization method can be used to drive full-body animations of virtual characters and improve their portability.In the experiment,we first downsampled the gesture and facial data to achieve the same temporal resolution for the input,output,and facial data.The Audio2AB network then encoded the audio,audio-corresponding text,emotion labels,and semantic relevance labels,and then fused the text,emotion labels,and semantic relevance labels into the audio to obtain better audio features.Finally,we established links between the body,gestures,and facial decoders and generated the corresponding animation sequences through our proposed GAN-GF loss function.Results By using audio,audio-corresponding text,and emotional and semantic relevance labels as input,the trained Audio2AB network could generate gesture animation data containing blendshape weights.Therefore,different 3D virtual character animations could be created through parameterization.Conclusions The experimental results showed that the proposed method could generate significant gestures and facial animations.
基金Technology Foundation Project of Shanghai Jiaotong University School of Medicine,Grant/Award Number:Jyhz2015。
文摘Background:This study aimed to evaluate the effectiveness of using animation as education material for family empowerment program on perioperative care for caregivers whose children were to undergo neurosurgery.Methods:A total of 204 caregivers were randomly assigned to either the face‐to‐face oral nursing educated group(Oral Group)or the animation‐assisted nursing educated group(Animated Group).The nursing education primarily focused on instructing caregivers about the manual vibration method.The primary outcome of interest in this study was participants'knowledge level,collected by a 10‐item questionnaire.Secondary outcomes included child patients'clinical data,including hospitalization days,treatments,and signs of pneumonia.Results:Participants in the Animated Group exhibited significantly higher accuracy in perioperative care knowledge assessment,and patients in this group had a lower chance of requiring atomization therapy compared to the Oral Group.Conclusions:The animation‐assisted nursing education program effectively enhances pediatric caregivers'knowledge,reduces respiratory complications after surgery,and offers valuable insights for future studies on the use of such programs to instruct caregivers.
文摘The Twangiza mine is located in the Mitumba mountain range, in the western part of the Albertine Rift Valley, just 20 km East of Itombwe Nature Reserve. A biological inventory was carried out within the mine’s decade-old progressive ecological rehabilitation sites. This inventory covered insects, amphibians, reptiles, birds and small mammals. The main objective of the inventory was to assess the level of animal recolonization in the 100-hectares’ restored areas. A total of 22 insect genera, 4 amphibian species, 11 reptile species, 43 bird species and 11 small mammal species were found. All of them were strongly settled in the core area within the afforested sites. Prior to the start of the Twangiza mine activities and 4 years before the ecological rehabilitation in the area, the avifauna was depauperate, both in number of species and their abundance. By then, no mammals or reptiles were recorded within the footprint area. The environmental and social baseline assessment identified 38 bird species in 2008, mainly grassland and mobile species, which were using scrub along valley streams as a refuge, outside the current mine footprint. Our results clearly demonstrate the positive impact of the afforestation on insect, amphibian, reptile, bird and small mammal’s diversity in this area.
文摘A jungle is full of life.You can sometimes see exhibits of jungle animals and learn about them.Monkeys play in jungle trees.Colorful parrots fly and call to one another.Black and orange tigers hunt under the trees.
基金supported by the National Natural Science Foundation of China(No.82405237,82373835,82173781)Guangdong Basic and Applied Basic Research Foundation(No.2023A1515110768,2019A1515010806)+3 种基金Foshan Science and Technology Bureau’s self funded project(No.2320001007283)Key Field Projects(Intelligent Manufacturing)of General Universities in Guangdong Province(No.2020ZDZX2057)the Scientific Research Projects(Characteristic Innovation)of General Universities in Guangdong Province(No.2019KTSCX195)Guangdong Provincial Medical Research Foundation(No.A2022061).
文摘Background:Baitouweng decoction is a classic prescription for treating chronic dysentery and mainly used to treat heat-toxic dysentery and is widely used in damp-heat ulcerative colitis(UC)in China.Methods:Meta-analysis and network pharmacology were used to examine the pharmacological properties of Baitouweng decoction in the treatment of UC.Additionally,the potential mechanisms of action were investigated.In the meta-analysis,studies were searched from databases up to March 2024.Data from the included studies were extracted.The results were quantified by calculating the standardized mean difference(SMD).Additionally,95%confidence intervals(CI)were used to assess the precision of the estimates.Results:It was found that 201 components of Baitouweng decoction,including Pulsatillae Radix(Baitouweng),Coptidis Rhizoma(Huanglian),Phellodendri Chinensis Cortex(Huangbo),Fraxini Cortex(Qinpi),and 106 intersecting targets of UC,were obtained from INPUT.PPI and enrichment analyses showed Baitouweng decoction might regulate inflammatory response to improve UC injury.Seventeen included studies were published between 2004 and 2024.The meta-analysis results suggested that Baitouweng decoction may help increase body weight,decrease DAI and CMDI,reduce colon length shortening associated with UC,lower the spleen index,and alleviate tissue damage in colitis.In addition,Baitouweng decoction could inhibit inflammatory response and repair intestinal barrier in UC model.The protective mechanism of Baitouweng decoction was consistent with the predicted targets of network pharmacology,which suggested the results were accurate.Conclusion:Baitouweng decoction could improve UC injury by regulating the inflammatory response,cell apoptosis,and body metabolism through the integration of network pharmacology and meta-analysis.Its protective mechanisms are related to anti-inflammation,regulation of intestinal flora,brain-gut peptides,and protection of the intestinal mucosal barrier,along with modulation of body metabolism,including SCFA,bile acids,and tryptophan metabolism.
基金supported by the Postdoctoral Fellowship Program of CPSF (GZC20231064)China Postdoctoral Science Foundation (2024M761345)+3 种基金Guangzhou Basic and Applied Basic Research Foundation (2024A04J6615)Scientific Research Project of Southern Medical University Stomatological Hospital (PY2023004)National Key Research and Development Program of China (2021YFA0805300)National Natural Science Foundation of China (82171244,32470564)。
文摘Severe combined immunodeficiency disease(SCID),characterized by profound immune system dysfunction,can lead to life-threatening infections and death.Animal models play a pivotal role in elucidating biological processes and advancing therapeutic strategies.Recent advances in gene-editing technologies,including zincfinger nucleases(ZFNs),transcription activator-like effector nucleases(TALENs),CRISPR/Cas9,and base editing,have significantly enhanced the generation of SCID models.These models have not only deepened our understanding of disease pathophysiology but have also driven progress in cancer therapy,stem cell transplantation,organ transplantation,and infectious diseasemanagement.Thisreviewprovidesa comprehensive overview of current SCID models generated using novel gene-editing approaches,highlighting their potential applications in translational medicine and their role in advancing biomedical research.
文摘The purpose of this article is to discuss the proper method for Chinese digital animation character design on the foundation of certain cultural elements. The method used in this study is known as comparative analysis of Disney and Japanese animation styles in action, appearance, facial expression and voice design. These dynamic factors are the best carrier of the animation spirit and native culture, so it is important to take the dynamic factors into account when producing the digital animation, and it will be an excellent starting point to innovate Chinese digital animation.
文摘The super-maneuver flight performance has a very high tactical value, and the development of this tactical value has great significance. A discussion is devoted to the study of intelligent control methods and technologies of real-time distributed 3-dimensional animation simulation for the super-maneuverable attack of new generational fighter in this paper. A flight control system of super-maneuver is reconstructed by adopting three layers BP neural networks of number 3, and the fire/flight coupler is designed by introducing a fuzzy control rule whose universe of discourse and gain are regulated adaptively on the line. Furthermore, a new method of real-time distributed 3-dimensional animation simulation is put forward, and a real-time distributed 3-dimensional animation simulation tool platform is constructed in this paper. The simulation result is lifelike, perceivable directly and useful.
基金supported by the Major Project for Equipment Development of PLA in 2013(ASY135001)the National High Technology Research and Development Program of China(2015AA020312)
文摘Background: The successful treatment of military combat casualties with penetrating injuries is significantly dependent on the time needed to get the patient to an adequate treatment facility. Profound hypothermia induced suspended animation for delayed resuscitation(SADR) is a novel approach for inducing cardiac arrest and buying additional time for such injuries. However, the time used to safely administer circulatory arrest(CA) is controversial. The goal of this study was to evaluate the safety of hypothermia-induced SADR over 90 and 120 min time intervals.Methods: Sixteen male BAMA minipigs were randomized into two groups: CA90 group(90 min, n =8) and CA120 group(120 min, n =8). Cannulation of the right common carotid arteries and internal jugular veins was performed to establish cardiopulmonary bypass for each animal. Through the perfusion of cold organ preservation solution(OPS), cardioplegia and profound hypothermia(15℃) were induced. After CA, cardiopumonary bypass(CPB) was restarted, and the animals were gradually re-warmed and resuscitated. The animals were assisted with ventilators until spontaneous breathing was achieved. The index of hemodynamic perioperative serum chemistry values [alanine transaminase(ALT), aspartate aminotransferase(AST), creatinine(CR), lactic dehydrogenase(LDH) and troponin T(TnT)] and survival were observed from pre-operation to 7 days post-operation.Results: Fifteen animals were enrolled in the experiment, while 1 animal in CA120 group died from surgical error. All 8 animals in CA90 group recovered, with only 1 animal displaying mild disability. However, in CA120 group, only 2 animals survived with severe disability, and the other 5 animals died after 2 days post-operation. In CA90 group, the perioperative serum chemistry values increased at 1 day post-operation(ALT 84.43±18.65 U/L; AST 88.99±23.19 U/L; Cr 87.90±24.49μmol/L; LDH 1894.13±322.26 U/L; TnT 0.849±0.135 ng/ml) but decreased to normal or almost normal levels at 7 days post-operation(ALT 52.48±9.04 U/L; AST 75.23±21.46 U/L; Cr 82.69±18.41μmol/L; LDH 944.67±834.32 U/L; TnT 0.336±0.076 ng/ml).Conclusion: Profound hypothermia-induced SADR is an effective method for inducing cardiac arrest. Our results indicate that inducing CA for 90 min(at 15℃) is safer than doing so for 120 min. Our results indicate that 120 min of CA at 15℃ is dangerous and can result in high mortality and severe neurological complications. Further experimentation is needed to determine whether 120 min of CA at temperatures lower than 15℃ can lead to safe recovery.
基金Project supported by the National Natural Science Foundation of China (No. 60272031), the National Basic Research Program (973) of China (No. 2002CB312101) and the Technology Plan Program of Zhejiang Province (No. 2003C21010), China
文摘Driving facial animation based on tens of tracked markers is a challenging task due to the complex topology and to the non-rigid nature of human faces. We propose a solution named manifold Bayesian regression. First a novel distance metric, the geodesic manifold distance, is introduced to replace the Euclidean distance. The problem of facial animation can be formulated as a sparse warping kernels regression problem, in which the geodesic manifold distance is used for modelling the topology and discontinuities of the face models. The geodesic manifold distance can be adopted in traditional regression methods, e.g. radial basis functions without much tuning. We put facial animation into the framework of Bayesian regression. Bayesian approaches provide an elegant way of dealing with noise and uncertainty. After the covariance matrix is properly modulated, Hybrid Monte Carlo is used to approximate the integration of probabilities and get deformation results. The experimental results showed that our algorithm can robustly produce facial animation with large motions and complex face models.
文摘In Chinese ancient costume animation movies, there are problems of unreasonable cultural expression in many architectural scenes, such as not meticulous scene design and weak understanding of the relationship between artistic design and image cultural expression. This is greatly different from the spirit of passing on national ethnic culture. In order to transform such situation, it is recommended to set up the concept of passing on the ethnic culture, follow the principle of creation of national art and practice of story creation, improve the style of domestic animation movies, and raise the concept of cultural creation.
文摘<strong>Objectives:</strong> To clarify the effects on the delivery experience of midwives giving parturient females individual explanations about how the course of delivery, using 3D animation software (Delivery Animation). <strong>Method:</strong> 1) Subjects: Women admitted to Institution A for delivery;70 in the intervention group (34 primipara, 36 multipara), and 79 (41 primipara, 38 multipara) in the control group. 2) Data collection method: Intervention group;3) During phases 1 and 2 of delivery, after internal examinations, collaborative-researcher midwives gave parturient women explanations about the course of delivery, using tablets with the Delivery Animation software installed. This software was independently developed by the researchers. On postpartum day 1, the collaborative-researcher midwives distributed anonymous, self-administered questionnaires to the postpartum women. 4) During phases 1 and 2 of delivery, the course of delivery was explained using existing methods, and anonymous, self-administered questionnaires were distributed on postpartum day 1. 5) The intervention group and control group were compared using descriptive and inferential statistics, organized into primipara and multipara. <strong>Results:</strong> In the Understanding the Delivery Process category, primipara in the intervention group had significantly higher scores for “understood baby’s rotation” (p < 0.01) and “understood progress through delivery” (p < 0.05). In multipara, the intervention group scored significantly higher for “understood baby’s rotation” (p < 0.01). In the anonymous self-evaluation, primipara in the intervention group scored significantly higher in “midwife I could trust was by my side” (p < 0.01). Opinions on the Delivery Animation were classified into 7 categories. In their evaluations of the Delivery Animation, 89.0% of primipara and 92.0% of multipara said it helped them understand the course of labor, and 85.0% of primipara and 86.0% of multipara said it helped them communicate with the doctor/midwife. <strong>Conclusion:</strong> The significant differences in understanding of the course of delivery seen between the intervention and control groups, the satisfaction scores on the “Self-evaluation scale for experience of delivery (abridged version)” questionnaire, opinions about and evaluation of the Delivery Animation all show that a personal explanation of the course of childbirth has a positive effect on the understanding and satisfaction of parturient women.
文摘A discrete-event system simulation and animation program was developed to enhance the efficiency of a truck-excavator operation and reduce the environmental impact of haulage in an open-cut coal mine with multiple-pit operations. In any mine, a key objective is to have sufficient equipment for production and not to have excess to where it becomes counterproductive. Due to the advent of responsible mining,environmental regulations, and eco-friendly practices, these factors must also be considered in the analysis. Simulation studies can be financially advantageous for both the optimization of existing mine operations and new development phases in a mine. This study is a new approach to use discrete-event system simulation for mine systems, in order to investigate and possibly reduce environmental impact considering mining haulage performance and production target. A hypothetical layout of a surface coal mine with two pit operations was used for the simulation and animation model. The simulation model includes the animation of the operation. Animation is helpful to enhance the benefit of a mine simulation model. GPSS/Hòand Proof Professionalòwere the software used for the investigation.
基金Project (No. 200038) partially supported by FANEDD, China
文摘Homogeneous matrices are widely used to represent geometric transformations in computer graphics, with interpo- lation between those matrices being of high interest for computer animation. Many approaches have been proposed to address this problem, including computing matrix curves from curves in Euclidean space by registration, representing one-parameter curves on manifold by rational representations, changing subdivisional methods generating curves in Euclidean space to corresponding methods working for matrix curve generation, and variational methods. In this paper, we propose a scheme to generate rational one-parameter matrix curves based on exponential map for interpolation, and demonstrate how to obtain higher smoothness from existing curves. We also give an iterative technique for rapid computing of these curves. We take the computation as solving an ordinary differential equation on manifold numerically by a generalized Euler method. Furthermore, we give this algorithm’s bound of the error and prove that the bound is proportional to the shift length when the shift length is sufficiently small. Compared to direct computation of the matrix functions, our Euler solution is faster.
基金This research is sponsored by the project of the Ministry of Science and Technology.
文摘VRML offers powerful tool for generating 3D scene and realizing real time interactive animation on Web. This paper briefly introduces the related techniques of implementing interactive animation in Web 3D, focusing on how to use JavaScript to create Script node for extending VRML functions. This is very useful for virtual product design, product performance simulation, virtual assembly and remote education.
文摘Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease itself.Stem cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s disease.Mesenchymal stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of teratogenicity.We performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal model.We searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,2023.The study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control groups.We use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the meta-analysis.Treatment with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational test.Among the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a protective effect on dopaminergic neurons.Subgroup analysis of the amphetamine-induced rotation test showed a significant reduction only in the intracranial-striatum route(SMD[95%CI]=-2.59[-3.25 to-1.94],P=0.0001,I^(2)=74.4%).The memory test showed significant improvement only in the intravenous route(SMD[95%CI]=4.80[1.84 to 7.76],P=0.027,I^(2)=79.6%).Mesenchymal stem cells have been shown to positively impact motor function and memory function and protect dopaminergic neurons in preclinical models of Parkinson’s disease.Further research is required to determine the optimal stem cell types,modifications,transplanted cell numbe rs,and delivery methods for these protocols.
基金Intel公司基金资助项目"J2ME Claa Libraries with Small FootprintLow Power and High Performance on XScale Processor"
文摘为了Java三维图形程序能在不同的移动设备和平台上运行,JCP(Java Community Process)制定了J2ME M3G(Mobile 3D Graphics API),规范了移动设备上Java三维图形程序的API和框架。而M3G中由于动画部分的独特性以及它在设计和实现中的复杂性,我们结合在XORP上开发M3G类库经验的基础,总结并给出了其设计和实现的参考模型和理论基础,也适用于其它3D类库的设计和开发。
