期刊文献+
共找到97,810篇文章
< 1 2 250 >
每页显示 20 50 100
二味杜仲汤调控Rhoa/Rock通路防治绝经后骨质疏松症作用机制研究
1
作者 吴佳宝 师建平 +6 位作者 刘钰 党赢 海日 王璐 李月炜 姚文智 张慧 《辽宁中医药大学学报》 2025年第2期24-30,共7页
目的 探讨二味杜仲汤调控Rhoa/Rock通路防治绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)的机制,探讨“补肾清热”中医理论在绝经后骨质疏松症中的应用。方法 选取6月龄SPF级健康雌性未孕SD大鼠60只,设置为假手术组、模型组、... 目的 探讨二味杜仲汤调控Rhoa/Rock通路防治绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)的机制,探讨“补肾清热”中医理论在绝经后骨质疏松症中的应用。方法 选取6月龄SPF级健康雌性未孕SD大鼠60只,设置为假手术组、模型组、二味杜仲汤低剂量组、二味杜仲汤中剂量组、二味杜仲汤高剂量组、雌激素组。术后12周,使用双能骨密度仪(DXA)检测大鼠骨密度,假手术组和模型组给予0.9%氯化钠溶液灌胃,二味杜仲汤低、中、高剂量组分别给予二味杜仲汤低、中、高剂量药液,雌激素组给予雌激素。指标检测:DXA检测大鼠骨密度;全自动生化分析仪检测大鼠血清中钙、磷含量的变化;HE染色观察股骨的病理变化;ELISA法测定碱性磷酸酶(ALP)、血清骨钙素(BGP)、骨保护素(OPG);Western Blot法检测骨组织中Rhoa、Rock1、Rock2的蛋白表达;Q-PCR法测定大鼠骨组织Rhoa、Rock1、Rock2 mRNA的表达。结果 与假手术组相比,模型组大鼠体质量增加明显(P<0.01),子宫系数降低显著(P<0.01);与模型组相比,二味杜仲汤低、中、高剂量组及雌激素组体质量明显下降(P<0.01),子宫系数明显上升(P<0.05)。HE染色结果显示:与模型组相比,二味杜仲汤各剂量组和雌激素组骨微结构明显改善,骨小梁排列较为紧密,脂肪细胞减少,骨髓腔内粒细胞数量明显增多。骨密度结果显示:与模型组相比,二味杜仲汤低、中、高剂量组及雌激素组骨密度显著上升(P<0.01);生化结果表明:与模型组相比,二味杜仲汤低、中、高剂量组及雌激素组血清钙磷含量明显升高(P<0.01)。ELISA结果显示:与模型组相比,二味杜仲汤低、中、高剂量组及雌激素组均有效降低了血清中的ALP、BGP含量(P<0.01),提高了OPG含量(P<0.01);Western Blot结果显示:与模型组相比,二味杜仲汤低、中、高剂量组及雌激素组Rhoa、Rock1、Rock2表达明显升高(P<0.01)。Q-PCR结果显示:与模型组相比,二味杜仲汤低、中、高剂量组及雌激素组Rhoa、Rock1、Rock2表达明显升高(P<0.01)。结论 二味杜仲汤可以改善骨组织的微结构,从而改善骨密度,以改善骨质疏松。其机制可能是通过调控Rhoa/Rock信号通路,提高成骨因子Rhoa、Rock1、Rock2的表达来实现的。 展开更多
关键词 二味杜仲汤 绝经后骨质疏松症 Rhoa/rock信号通路
在线阅读 下载PDF
Characterizing large deformation of soft rock tunnel using microseismic monitoring and numerical simulation 被引量:1
2
作者 Yuepeng Sun Nuwen Xu +4 位作者 Peiwei Xiao Zhiqiang Sun Huailiang Li Jun Liu Biao Li 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第1期309-322,共14页
Surrounding rock deterioration and large deformation have always been a significant difficulty in designing and constructing tunnels in soft rock.The key lies in real-time perception and quantitative assessment of the... Surrounding rock deterioration and large deformation have always been a significant difficulty in designing and constructing tunnels in soft rock.The key lies in real-time perception and quantitative assessment of the damaged area around the tunnel.An in situ microseismic(MS)monitoring system is established in the plateau soft tock tunnel.This technique facilitates spatiotemporal monitoring of the rock mass's fracturing expansion and squeezing deformation,which agree well with field convergence deformation results.The formation mechanisms of progressive failure evolution of soft rock tunnels were discussed and analyzed with MS data and numerical results.The results demonstrate that:(1)Localized stress concentration and layered rock result in significant asymmetry in micro-fractures propagation in the tunnel radial section.As excavation continues,the fracture extension area extends into the deep surrounding rockmass on the east side affected by the weak bedding;(2)Tunnel excavation and long-term deformation can induce tensile shear action on the rock mass,vertical tension fractures(account for 45%)exist in deep rockmass,which play a crucial role in controlling the macroscopic failure of surrounding rock;and(3)Based on the radiated MS energy,a three-dimensional model was created to visualize the damage zone of the tunnel surrounding rock.The model depicted varying degrees of damage,and three high damage zones were identified.Generally,the depth of high damage zone ranged from 4 m to 12 m.This study may be a valuable reference for the warning and controlling of large deformations in similar projects. 展开更多
关键词 Soft rock tunnel MS monitoring Progressive failure characteristic Excavation damage zone Failure mechanism
在线阅读 下载PDF
电针内关穴通过抑制RhoA/ROCK信号通路活化减轻脂多糖诱导脓毒症小鼠心功能障碍
3
作者 卢颖琼 陈惠娟 +1 位作者 郑佳铃 郑晓燕 《广州中医药大学学报》 2025年第1期170-175,共6页
【目的】观察电针内关穴减轻脂多糖(LPS)诱导的脓毒症模型小鼠心功能障碍的作用机制。【方法】将48只雄性C57BL/6小鼠随机分为4组,即正常对照组、生理盐水+电针组、脓毒症模型组、脓毒症+电针组。脓毒症模型组及脓毒症+电针组小鼠给予... 【目的】观察电针内关穴减轻脂多糖(LPS)诱导的脓毒症模型小鼠心功能障碍的作用机制。【方法】将48只雄性C57BL/6小鼠随机分为4组,即正常对照组、生理盐水+电针组、脓毒症模型组、脓毒症+电针组。脓毒症模型组及脓毒症+电针组小鼠给予腹腔注射LPS(5 mg/kg)诱导脓毒症心肌损伤模型。LPS注射后立即对小鼠实施电针治疗。于LPS处理后6 h,采用彩色超声心动图监测小鼠左心室短轴收缩末期内径(LVIDs)和短轴缩短率(FS)。酶联免疫吸附分析(ELISA)检测血清炎症因子肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)水平,蛋白免疫印迹(Western Blot)法检测心脏组织中Rho激酶(ROCK)1、ROCK2蛋白表达水平及肌球蛋白磷酸酶底物1(MYPT1)、肌球蛋白轻链2(MLC2)磷酸化水平。【结果】与正常对照组比较,脓毒症模型组小鼠LVIDs增加(P<0.05),FS下降(P<0.05),血清中TNF-α、IL-6含量均升高(P<0.001),心脏组织MYPT1磷酸化水平显著升高(P<0.05);与脓毒症模型组比较,脓毒症+电针组LVIDs降低(P<0.05),FS升高(P<0.05),血清中TNF-α、IL-6含量下降(P<0.05或P<0.01),MYPT1磷酸化水平显著降低(P<0.05)。各组ROCK1、ROCK2蛋白表达水平以及MLC2的磷酸化水平无显著性差异(P>0.05)。【结论】电针内关穴可能通过抑制心脏组织RhoA/ROCK信号通路活化,减轻脓毒症模型小鼠全身和局部炎性反应水平,改善心功能,产生心肌保护效应。 展开更多
关键词 电针 脓毒症 内关穴 心功能障碍 RhoA/rock信号通路 小鼠
原文传递
Correlation between the rock mass properties and maximum horizontal stress:A case study of overcoring stress measurements
4
作者 Peng Li Meifeng Cai +2 位作者 Shengjun Miao Yuan Li Yu Wang 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS 2025年第1期39-48,共10页
Understanding the mechanical properties of the lithologies is crucial to accurately determine the horizontal stress magnitude.To investigate the correlation between the rock mass properties and maximum horizontal stre... Understanding the mechanical properties of the lithologies is crucial to accurately determine the horizontal stress magnitude.To investigate the correlation between the rock mass properties and maximum horizontal stress,the three-dimensional(3D)stress tensors at 89 measuring points determined using an improved overcoring technique in nine mines in China were adopted,a newly defined characteristic parameter C_(ERP)was proposed as an indicator for evaluating the structural properties of rock masses,and a fuzzy relation matrix was established using the information distribution method.The results indicate that both the vertical stress and horizontal stress exhibit a good linear growth relationship with depth.There is no remarkable correlation between the elastic modulus,Poisson's ratio and depth,and the distribution of data points is scattered and messy.Moreover,there is no obvious relationship between the rock quality designation(RQD)and depth.The maximum horizontal stress σ_(H) is a function of rock properties,showing a certain linear relationship with the C_(ERP)at the same depth.In addition,the overall change trend of σ_(H) determined by the established fuzzy identification method is to increase with the increase of C_(ERP).The fuzzy identification method also demonstrates a relatively detailed local relationship betweenσ_H and C_(ERP),and the predicted curve rises in a fluctuating way,which is in accord well with the measured stress data. 展开更多
关键词 overcoring stress measurements elastic modulus Poisson's ratio rock quality designation maximum horizontal stress fuzzy identification
在线阅读 下载PDF
化瘀通络灸对血管性痴呆大鼠RhoA/ROCK轴突生长抑制性信号通路相关蛋白表达的影响
5
作者 邱市生 王珊 唐友斌 《中医研究》 2025年第1期72-76,共5页
目的:观察化瘀通络灸对血管性痴呆大鼠Ras同源物基因组成员A(Ras homolog gene family member A,RhoA)/Rho激酶(Rho associated protein kinase, ROCK)轴突生长抑制性信号通路相关蛋白的影响,探讨其治疗血管性痴呆的机制。方法:使用Mor... 目的:观察化瘀通络灸对血管性痴呆大鼠Ras同源物基因组成员A(Ras homolog gene family member A,RhoA)/Rho激酶(Rho associated protein kinase, ROCK)轴突生长抑制性信号通路相关蛋白的影响,探讨其治疗血管性痴呆的机制。方法:使用Morris水迷宫筛除贴壁、原地旋转或溺水的Wistar大鼠,将符合条件大鼠分为假手术组、造模组。假手术组暴露大鼠颈总动脉;造模组用改良的双侧颈总动脉永久结扎术制备血管性痴呆大鼠模型,术后3 d用水迷宫对大鼠进行模型鉴定,将合格者随机分为模型组、艾灸组和西药组。于鉴定次日对大鼠进行治疗,艾灸组悬灸百会、大椎、神庭,20 min/次,1次/d, 1周为1疗程,2个疗程间休息1 d,共3个疗程;西药组用吡拉西坦溶液灌胃,2次/d;假手术组、模型组行灸架固定。治疗结束,取大鼠脑组织,用免疫荧光单染法、蛋白免疫印迹法检测其脑内目的蛋白RhoA、Rho相关螺旋卷曲蛋白激酶Ⅱ(Rho protein-related curl spiral kinase-Ⅱ,ROCKⅡ)、肌球蛋白轻链磷酸化(Phosphorylation of myosin light chain, P-MLC)的阳性表达。结果:模型组大鼠海马、皮质RhoA、ROCKⅡ、P-MLC蛋白表达高于假手术组(P<0.01);艾灸组、西药组海马和皮质RhoA、ROCKⅡ、P-MLC蛋白表达较模型组低(P<0.05);艾灸组皮质ROCKⅡ蛋白表达较西药组稍低(P<0.05);艾灸组与西药组海马ROCKⅡ、海马与皮质RhoA、P-MLC蛋白表达差异无统计学意义(P>0.05)。结论:化瘀通络灸可能是通过下调RhoA/ROCK轴突生长抑制性信号通路相关蛋白的表达提高血管性痴呆大鼠的记忆力,从而发挥治疗血管性痴呆的作用。 展开更多
关键词 血管性痴呆 化瘀通络灸 动物模型 大鼠 RhoA/rock信号通路 海马 皮质
在线阅读 下载PDF
Erratum to “Rock Fragmentation Classification Applying Machine Learning Approaches” [Engineering, 15 (2023) 378-395]*
6
作者 Samaneh Liaghat Nadhir Al Ansari 《Engineering(科研)》 2025年第1期1-18,共18页
The nature of rock fragmentation affects the downstream mining processes like loading, hauling, and crushing the blasted rock. Therefore, it is important to evaluate rock fragmentation after blasting for choosing or d... The nature of rock fragmentation affects the downstream mining processes like loading, hauling, and crushing the blasted rock. Therefore, it is important to evaluate rock fragmentation after blasting for choosing or designing optimal strategies for these processes. However, current techniques of rock fragmentation analysis such as sieving, image-based analysis, empirical methods or artificial intelligence-based methods entail different practical challenges, for example, excessive processing time, higher costs, applicability issues in underground environments, user-biasness, accuracy issues, etc. A classification model has been developed by utilizing image analysis techniques to overcome these challenges. The model was tested on about 7500 videos of load-haul-dump (LHD) buckets with blasted material from Malmberget iron ore mine in Sweden. A Kernel-based support vector machine (SVM) method was utilized to extract frames comprising loaded LHD buckets. Then, the blasted rock in the buckets was classified into five distinct categories using the bagging k-nearest neighbor (KNN) technique. The results showed 99.8% and 89.8% accuracy for kernel-based SVM and bagging KNN classifiers, respectively. The developed framework is efficient in terms of the operation time, cost and practicability for different mines and variate amounts of rock masses. 展开更多
关键词 rock Blasting Load Dump Haul Image Analysis Artificial Intelligence Mine Productivity
在线阅读 下载PDF
Conductivity characteristics of magmatic rock intrusions contained in metamorphic rock strata in Mupi Highway Tunnel
7
作者 Li Bin Xu Qiang +5 位作者 Yu Jianhua Cheng Qiang Feng Chongde Zhao Hu Liu Tianxiang Yang Xubo 《Applied Geophysics》 2025年第1期146-160,234,235,共17页
The stratum lithology and geological structure of the highway tunnel in the mountainous areas of western China are complex,and the engineering geological conditions are complicated.When the highway tunnel passes throu... The stratum lithology and geological structure of the highway tunnel in the mountainous areas of western China are complex,and the engineering geological conditions are complicated.When the highway tunnel passes through different lithological strata,its structural design and construction technology are completely diff erent.Therefore,in order to support the tunnel design and construction,the tunnel survey Among them,the identifi cation of the contact boundary between magmatic rock and metamorphic rock and the grade of surrounding rock is very important.Through magnetotelluric survey of the Mupi tunnel of Jiuzhaigou-Mianyang highway on G8513 line,2D forward numerical simulation,1D,2D,3D inversion,and engineering geological analysis,it is revealed that the electrical characteristics of each layer,focusing on the identifi cation of the contact boundary between magmatic rock and metamorphic rock.This study provides the electrical characteristics of the magmatic rock and metamorphic rock contact boundary of the Mupi Tunnel.It is speculated that the boundary is revealed by the tunnel construction excavation,which verifies the correctness of the geophysical inversion model and provides a more detailed design basis for the tunnel design.I believe that taking the Mupi Tunnel survey as an example,through this research,it can provide detailed geophysical evidence for highway tunnels to distinguish between magmatic rock and metamorphic rock. 展开更多
关键词 Highway tunnel magnetotelluric method engineering geology magmatic rock metamorphic rock
在线阅读 下载PDF
Quantitative principles of dynamic interaction between rock support and surrounding rock in rockburst roadways
8
作者 Lianpeng Dai Dingjie Feng +4 位作者 Yishan Pan Aiwen Wang Ying Ma Yonghui Xiao Jianzhuo Zhang 《International Journal of Mining Science and Technology》 2025年第1期41-55,共15页
Rockbursts, which mainly affect mining roadways, are dynamic disasters arising from the surrounding rock under high stress. Understanding the interaction between supports and the surrounding rock is necessary for effe... Rockbursts, which mainly affect mining roadways, are dynamic disasters arising from the surrounding rock under high stress. Understanding the interaction between supports and the surrounding rock is necessary for effective rockburst control. In this study, the squeezing behavior of the surrounding rock is analyzed in rockburst roadways, and a mechanical model of rockbursts is established considering the dynamic support stress, thus deriving formulas and providing characteristic curves for describing the interaction between the support and surrounding rock. Design principles and parameters of supports for rockburst control are proposed. The results show that only when the geostress magnitude exceeds a critical value can it drive the formation of rockburst conditions. The main factors influencing the convergence response and rockburst occurrence around roadways are geostress, rock brittleness, uniaxial compressive strength, and roadway excavation size. Roadway support devices can play a role in controlling rockburst by suppressing the squeezing evolution of the surrounding rock towards instability points of rockburst. Further, the higher the strength and the longer the impact stroke of support devices with constant resistance, the more easily multiple balance points can be formed with the surrounding rock to control rockburst occurrence. Supports with long impact stroke allow adaptation to varying geostress levels around the roadway, aiding in rockburst control. The results offer a quantitative method for designing support systems for rockburst-prone roadways. The design criterion of supports is determined by the intersection between the convergence curve of the surrounding rock and the squeezing deformation curve of the support devices. 展开更多
关键词 Deep roadway rockBURST Dynamic interaction rock support Surrounding rock rockburst control
在线阅读 下载PDF
Microstructure effect of mechanical and cracking behaviors on brittle rocks using image-based fast Fourier transform method
9
作者 Mingyao Li Lei Peng +1 位作者 Dejun Liu Jianping Zuo 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第1期399-413,共15页
The internal microstructures of rock materials, including mineral heterogeneity and intrinsic microdefects, exert a significant influence on their nonlinear mechanical and cracking behaviors. It is of great significan... The internal microstructures of rock materials, including mineral heterogeneity and intrinsic microdefects, exert a significant influence on their nonlinear mechanical and cracking behaviors. It is of great significance to accurately characterize the actual microstructures and their influence on stress and damage evolution inside the rocks. In this study, an image-based fast Fourier transform (FFT) method is developed for reconstructing the actual rock microstructures by combining it with the digital image processing (DIP) technique. A series of experimental investigations were conducted to acquire information regarding the actual microstructure and the mechanical properties. Based on these experimental evidences, the processed microstructure information, in conjunction with the proposed micromechanical model, is incorporated into the numerical calculation. The proposed image-based FFT method was firstly validated through uniaxial compression tests. Subsequently, it was employed to predict and analyze the influence of microstructure on macroscopic mechanical behaviors, local stress distribution and the internal crack evolution process in brittle rocks. The distribution of feldspar is considerably more heterogeneous and scattered than that of quartz, which results in a greater propensity for the formation of cracks in feldspar. It is observed that initial cracks and new cracks, including intragranular and boundary ones, ultimately coalesce and connect as the primary through cracks, which are predominantly distributed along the boundary of the feldspar. This phenomenon is also predicted by the proposed numerical method. The results indicate that the proposed numerical method provides an effective approach for analyzing, understanding and predicting the nonlinear mechanical and cracking behaviors of brittle rocks by taking into account the actual microstructure characteristics. 展开更多
关键词 rock microstructure Cracking process Brittle rocks Fast Fourier transform(FFT) Digital image processing(DIP)
在线阅读 下载PDF
参附注射液通过NgR1/Lingo-1/p75NTR复合物及RhoA/ROCKⅡ信号通路减轻心肺复苏脑损伤机制的研究
10
作者 肖佳佳 邓海霞 吴鑫宇 《中国中医急症》 2025年第1期33-36,50,共5页
目的观察参附注射液对心脏骤停后脑缺血再灌注损伤大鼠的神经保护作用,研究其是否通过调控NgR1/RhoA/ROCKⅡ信号通路及其上游因子Nogo受体相互作用蛋白1(Lingo-1)和p75神经营养因子受体(p75NTR),减轻脑损伤并促进神经轴突再生。方法制... 目的观察参附注射液对心脏骤停后脑缺血再灌注损伤大鼠的神经保护作用,研究其是否通过调控NgR1/RhoA/ROCKⅡ信号通路及其上游因子Nogo受体相互作用蛋白1(Lingo-1)和p75神经营养因子受体(p75NTR),减轻脑损伤并促进神经轴突再生。方法制备心脏骤停/心肺复苏大鼠模型,将大鼠分为模型组、参附组、拮抗剂组及参拮组。通过ELISA检测各组脑组织中NgR1、p75NTR、Lingo-1、RhoA和RockⅡ的表达水平,并通过HE染色观察脑组织损伤情况。结果ELISA结果显示,心脏骤停后大鼠脑皮层中,模型组的各指标表达在特定时间点显著升高,尤其在3 d时NgR1、p75NTR、RhoA和ROCKⅡ达到峰值,显著高于空白组(P<0.01);参附组、拮抗剂组及参拮组的各指标表达水平均显著低于模型组(P<0.01),其中参拮组在所有时间点均表现出较低的NgR1、p75NTR、Lingo-1、RhoA及ROCKⅡ水平,尤其在3 d和7 d的ROCKⅡ和RhoA表达方面,显著低于模型组(P<0.01),RhoA在7 d时显著低于空白组(P<0.01)。HE染色结果表明,参附组和参拮组在各时间点的脑组织结构恢复效果优于模型组,细胞排列改善,水肿减轻。结论参附注射液通过调控NgR1/RhoA/ROCKⅡ信号通路及其上游因子,减轻了心脏骤停后脑缺血再灌注损伤,促进了神经轴突再生与功能恢复。 展开更多
关键词 心肺复苏 脑损伤 参附注射液 NgR1/p75NTR/Lingo-1复合物 RhoA/rockⅡ信号通路 神经轴突再生
在线阅读 下载PDF
Performance evaluation of rock fragmentation prediction based on RF-BOA,AdaBoost-BOA,GBoost-BOA,and ERT-BOA hybrid models
11
作者 Junjie Zhao Diyuan Li +2 位作者 Jian Zhou Danial JArmaghani Aohui Zhou 《Deep Underground Science and Engineering》 2025年第1期3-17,共15页
Rock fragmentation is an important indicator for assessing the quality of blasting operations.However,accurate prediction of rock fragmentation after blasting is challenging due to the complicated blasting parameters ... Rock fragmentation is an important indicator for assessing the quality of blasting operations.However,accurate prediction of rock fragmentation after blasting is challenging due to the complicated blasting parameters and rock properties.For this reason,optimized by the Bayesian optimization algorithm(BOA),four hybrid machine learning models,including random forest,adaptive boosting,gradient boosting,and extremely randomized trees,were developed in this study.A total of 102 data sets with seven input parameters(spacing-to-burden ratio,hole depth-to-burden ratio,burden-to-hole diameter ratio,stemming length-to-burden ratio,powder factor,in situ block size,and elastic modulus)and one output parameter(rock fragment mean size,X_(50))were adopted to train and validate the predictive models.The root mean square error(RMSE),the mean absolute error(MAE),and the coefficient of determination(R^(2))were used as the evaluation metrics.The evaluation results demonstrated that the hybrid models showed superior performance than the standalone models.The hybrid model consisting of gradient boosting and BOA(GBoost-BOA)achieved the best prediction results compared with the other hybrid models,with the highest R^(2)value of 0.96 and the smallest values of RMSE and MAE of 0.03 and 0.02,respectively.Furthermore,sensitivity analysis was carried out to study the effects of input variables on rock fragmentation.In situ block size(XB),elastic modulus(E),and stemming length-to-burden ratio(T/B)were set as the main influencing factors.The proposed hybrid model provided a reliable prediction result and thus could be considered an alternative approach for rock fragment prediction in mining engineering. 展开更多
关键词 Bayesian optimization BLASTING machine learning rock fragmentation
在线阅读 下载PDF
An adjustable bio-sealing method for rock fracture leakage mitigation
12
作者 Zhihao Dong Xiaohua Pan +2 位作者 Chaosheng Tang Chao Lv Bin Shi 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第1期220-232,共13页
This study proposed a repeated adjustable mixture injection strategy(RAM)based microbial induced carbonate precipitation(MICP)for efficient mitigation of rock fracture leakage.Granite fractures with small apertures we... This study proposed a repeated adjustable mixture injection strategy(RAM)based microbial induced carbonate precipitation(MICP)for efficient mitigation of rock fracture leakage.Granite fractures with small apertures were investigated,and bio-sealing experiments were conducted using five different cementation solution(CS)concentrations(0.25−2 M).The results showed that the RAM-based bio-sealing method can seal and bond the small aperture rock fractures with high efficiency and uniform precipitation by adjusting the CS concentration.The RAM-based bio-sealing mechanism is attributed to the following four stages:(1)fixation of bacterial flocs onto the fracture surfaces,(2)precipitation of CaCO3 onto the fracture surfaces,(3)growth of pre-precipitated CaCO3 and adhesion of new-suspended CaCO3,and(4)bridging and clogging processes.The optimal CS concentration of 1 M resulted in a fracture filling rate up to 85%,a transmissivity reduction of 4 orders of magnitude,and a shear strength ranging from 512 kPa to 688 kPa.The bio-sealing effect was found to be influenced by the CS concentration on bacterial attachment,calcium carbonate yield and calcium carbonate bulk density.The CS concentration of 1 M promoted bacterial attachment,and increased calcium carbonate yield as well as calcium carbonate bulk density,while concentrations above 1 M had the opposite effect.The bulk density of calcium carbonate played a crucial role in the sealing and bonding performance of bio-sealed fractures,particularly at comparable filling ratios and bridging areas.The bulk density was regulated by the size of calcium carbonate crystals and was determined by Ca2+concentration in the CS.This study provides valuable insights into the RAM-based bio-sealing method,highlighting its potential for efficient rock fracture leakage mitigation through precise control of CS concentration and understanding the underlying mechanisms. 展开更多
关键词 MICP rock fracture Hydraulic and mechanical performance Bio-sealing
在线阅读 下载PDF
Assessing ground stability of a vertical backfilled stope considering creep behaviors of surrounding rocks
13
作者 Ruofan Wang Lang Liu +4 位作者 Mengbo Zhu Huafu Qiu Bingbing Tu Huisheng Qu Hao Cui 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第1期187-199,共13页
Backfill is often employed in mining operations for ground support,with its positive impact on ground stability acknowledged in many underground mines.However,existing studies have predominantly focused only on the st... Backfill is often employed in mining operations for ground support,with its positive impact on ground stability acknowledged in many underground mines.However,existing studies have predominantly focused only on the stress development within the backfill material,leaving the influence of stope backfilling on stress distribution in surrounding rock mass and ground stability largely unexplored.Therefore,this paper presents numerical models in FLAC3D to investigate,for the first time,the time-dependent stress redistribution around a vertical backfilled stope and its implications on ground stability,considering the creep of surrounding rock mass.Using the Soft Soil constitutive model,the compressibility of backfill under large pressure was captured.It is found that the creep deformation of rock mass exercises compression on backfill and results in a less void ratio and increased modulus for fill material.The compacted backfill conversely influenced the stress distribution and ground stability of rock mass which was a combined effect of wall creep and compressibility of backfill.With the increase of time or/and creep deformation,the minimum principal stress in the rocks surrounding the backfilled stope increased towards the pre-mining stress state,while the deviatoric stress reduces leading to an increased factor of safety and improved ground stability.This improvement effect of backfill on ground stability increased with the increase of mine depth and stope height,while it is also more pronounced for the narrow stope,the backfill with a smaller compression index,and the soft rocks with a smaller viscosity coefficient.Furthermore,the results emphasize the importance of minimizing empty time and backfilling extracted stope as soon as possible for ground control.Reduction of filling gap height enhances the local stability around the roof of stope. 展开更多
关键词 Ground stability Time dependency CREEP Surrounding rocks Backfilled stope
在线阅读 下载PDF
Can laser irradiation improve the strength of weak rock mass?
14
作者 Xiaowei Feng Peng Huang +3 位作者 Valter Carvelli Gongshun Lin Chuankai Zhu Fengzhen He 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第1期139-153,共15页
Controllable rock cracking technology is crucial for the exploration and exploitation of deep underground resources.Many existing studies have been dedicated to the laser-assisted rock-weakening technology.It has been... Controllable rock cracking technology is crucial for the exploration and exploitation of deep underground resources.Many existing studies have been dedicated to the laser-assisted rock-weakening technology.It has been proved that laser irradiation can improve drilling and blasting efficiency when combined with mechanical rock fracturing methods,which are irrelevant for borehole stabilization.To improve the latter,this study used laser ablation for borehole reinforcement.The high-power laser was applied to typical rock samples(sandstone,mudstone and coal)in both dry and saturated conditions.Multi-technique observations and measurements were used to fully understand the peculiar modifications of the specimens under laser treatment,i.e.mechanical loading,acoustic emission(AE)monitoring,digital image correlation(DIC)strain field evaluation,infrared thermography(IRT)monitoring and X-ray computed tomography(CT)scanning.The results showed that,in addition to the effects already demonstrated,laser irradiation can improve the strength of the soft rock,especially in the saturated state.The process involved a complicated phase change including melting and evaporation of the matrix under high-temperature and high-pressure to form a glassy high strength silicate material.This process is similar to the reaction between molten lava and water,or the impact of an asteroid on the earth.Inspired by the results,a conceptual path for a new borehole stabilization technology using laser ablation was outlined. 展开更多
关键词 Laser irradiation rock CRACKING Ablation Borehole stability Mechanical characteristics
在线阅读 下载PDF
Fluid evolution and fragmentation characteristics under high pressure water jet impact on thermal rock
15
作者 Jianming Shangguan Zhaolong Ge +2 位作者 Qinglin Deng Yuhuai Cui Zhi Yao 《International Journal of Mining Science and Technology》 2025年第3期483-497,共15页
In the application of high-pressure water jet assisted breaking of deep underground rock engineering,the influence mechanism of rock temperature on the rock fragmentation process under jet action is still unclear.Ther... In the application of high-pressure water jet assisted breaking of deep underground rock engineering,the influence mechanism of rock temperature on the rock fragmentation process under jet action is still unclear.Therefore,the fluid evolution characteristics and rock fracture behavior during jet impingement were studied.The results indicate that the breaking process of high-temperature rock by jet impact can be divided into four stages:initial fluid-solid contact stage,intense thermal exchange stage,perforation and fracturing stage,and crack propagation and penetration stage.With the increase of rock temperature,the jet reflection angles and the time required for complete cooling of the impact surface significantly decrease,while the number of cracks and crack propagation rate significantly increase,and the rock breaking critical time is shortened by up to 34.5%.Based on numerical simulation results,it was found that the center temperature of granite at 400℃ rapidly decreased from 390 to 260℃ within 0.7 s under jet impact.In addition,a critical temperature and critical heat flux prediction model considering the staged breaking of hot rocks was established.These findings provide valuable insights to guide the water jet technology assisted deep ground hot rock excavation project. 展开更多
关键词 Fluid evolution Fragmentation characteristics Fracture process Water jet Thermal rock
在线阅读 下载PDF
Experiments on image data augmentation techniques for geological rock type classification with convolutional neural networks
16
作者 Afshin Tatar Manouchehr Haghighi Abbas Zeinijahromi 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第1期106-125,共20页
The integration of image analysis through deep learning(DL)into rock classification represents a significant leap forward in geological research.While traditional methods remain invaluable for their expertise and hist... The integration of image analysis through deep learning(DL)into rock classification represents a significant leap forward in geological research.While traditional methods remain invaluable for their expertise and historical context,DL offers a powerful complement by enhancing the speed,objectivity,and precision of the classification process.This research explores the significance of image data augmentation techniques in optimizing the performance of convolutional neural networks(CNNs)for geological image analysis,particularly in the classification of igneous,metamorphic,and sedimentary rock types from rock thin section(RTS)images.This study primarily focuses on classic image augmentation techniques and evaluates their impact on model accuracy and precision.Results demonstrate that augmentation techniques like Equalize significantly enhance the model's classification capabilities,achieving an F1-Score of 0.9869 for igneous rocks,0.9884 for metamorphic rocks,and 0.9929 for sedimentary rocks,representing improvements compared to the baseline original results.Moreover,the weighted average F1-Score across all classes and techniques is 0.9886,indicating an enhancement.Conversely,methods like Distort lead to decreased accuracy and F1-Score,with an F1-Score of 0.949 for igneous rocks,0.954 for metamorphic rocks,and 0.9416 for sedimentary rocks,exacerbating the performance compared to the baseline.The study underscores the practicality of image data augmentation in geological image classification and advocates for the adoption of DL methods in this domain for automation and improved results.The findings of this study can benefit various fields,including remote sensing,mineral exploration,and environmental monitoring,by enhancing the accuracy of geological image analysis both for scientific research and industrial applications. 展开更多
关键词 Deep learning(DL) Image analysis Image data augmentation Convolutional neural networks(CNNs) Geological image analysis rock classification rock thin section(RTS)images
在线阅读 下载PDF
Research status of creep-fatigue characteristics of salt rocks and stability of compressed air storage in salt caverns
17
作者 Marion Fourmeau Wen Liu +4 位作者 Zongze Li Daniel Nelias Jinyang Fan Hao Tian Wei Liu 《Earth Energy Science》 2025年第1期98-116,共19页
Energy is an important resource that supports the development of human society,and energy security is even more relevant to the strength of a country.In order to ensure energy security,countries around the world are t... Energy is an important resource that supports the development of human society,and energy security is even more relevant to the strength of a country.In order to ensure energy security,countries around the world are taking measures to carry out energy transformation and construct new energy systems.As an important part of the new energy system,energy storage technology is highly valued by all countries.Among many large-scale energy storage technologies,salt cavern compressed air energy storage(CAES)technology stands out for its safety and economy,which is recognized and valued by scholars from various countries.For the construction of salt cavern CAES power station,it is very important to ensure the stability of salt cavern.Therefore,scholars have investigated the mechanical properties of salt rocks and the stability of salt caverns for CAES.This paper synthesizes the findings of current research on the creep and fatigue properties of salt rock,highlighting three key points:The factors influencing the creep and fatigue characteristics of salt rock include its composition,stress levels,and temperature.Notably,impurities and surrounding pressure tend to inhibit the deformation of salt rock,whereas elevated temperature and differential stress facilitate its deformation;The mechanisms governing creep and fatigue damage in salt rock are primarily associated with dislocation movement and microcracking;Most existing constitutive models for creep and fatigue are based on viscoelastic-plasticity theory,with fewer models derived from micro-mechanical perspectives.Additionally,this paper reviews studies on the stability of salt cavern CAES reservoirs utilizing numerical simulation methods and offers insights into future research directions concerning the creep and fatigue properties of salt rocks. 展开更多
关键词 Salt rock Creep properties Fatigue properties Stability of energy storage
在线阅读 下载PDF
Pore-scale investigation of forced imbibition in porous rocks through interface curvature and pore topology analysis
18
作者 Jianchao Cai Xiangjie Qin +2 位作者 Han Wang Yuxuan Xia Shuangmei Zou 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第1期245-257,共13页
Forced imbibition,the invasion of a wetting fluid into porous rocks,plays an important role in the effective exploitation of hydrocarbon resources and the geological sequestration of carbon dioxide.However,the interfa... Forced imbibition,the invasion of a wetting fluid into porous rocks,plays an important role in the effective exploitation of hydrocarbon resources and the geological sequestration of carbon dioxide.However,the interface dynamics influenced by complex topology commonly leads to non-wetting fluid trapping.Particularly,the underlying mechanisms under viscously unfavorable conditions remain unclear.This study employs a direct numerical simulation method to simulate forced imbibition through the reconstructed digital rocks of sandstone.The interface dynamics and fluid–fluid interactions are investigated through transient simulations,while the pore topology metrics are introduced to analyze the impact on steady-state residual fluid distribution obtained by a pseudo-transient scheme.The results show that the cooperative pore-filling process promoted by corner flow is dominant at low capillary numbers.This leads to unstable inlet pressure,mass flow,and interface curvature,which correspond to complicated interface dynamics and higher residual fluid saturation.During forced imbibition,the interface curvature gradually increases,with the pore-filling mechanisms involving the cooperation of main terminal meniscus movement and arc menisci filling.Complex topology with small diameter pores may result in the destabilization of interface curvature.The residual fluid saturation is negatively correlated with porosity and pore throat size,and positively correlated with tortuosity and aspect ratio.A large mean coordination number characterizing global connectivity promotes imbibition.However,high connectivity characterized by the standardized Euler number corresponding to small pores is associated with a high probability of non-wetting fluid trapping. 展开更多
关键词 Forced imbibition Porous rocks Interface dynamics Pore topology Residual fluid distribution
在线阅读 下载PDF
Study on the Correlation Between the Preservation Status of Mountain Ancient Buildings,Wind Environment,and Protection Methods-A Case Study of the Rock Temples on Wudang Mountain
19
作者 Jin Xu Chen Gaonan Wang Yansong Wang 《Journal of Architectural Research and Development》 2025年第1期67-81,共15页
The preservation condition of historical buildings is closely related to their ventilation environment.This study focuses on the rock temples in Wudang Mountain,specifically comparing the ventilation conditions of Yin... The preservation condition of historical buildings is closely related to their ventilation environment.This study focuses on the rock temples in Wudang Mountain,specifically comparing the ventilation conditions of Yinxian Rock and Huayang Rock.The following conclusions are drawn:(1)The main wind direction at Yinxian Rock aligns with its orientation,which is an easterly wind,while Huayang Rock experiences a westerly wind,deviating from its southwestern entrance;(2)Huayang Rock has significantly lower wind speeds compared to Yinxian Rock,with minimal airflow;(3)The surrounding environment of Huayang Rock features steep terrain,dense tree cover,and the presence of railings and other structures that impede wind entry into the cave,whereas Yinxian Rock is surrounded by fewer trees and has a flat terrain;(4)In terms of cave morphology,Yinxian Rock is completely open on the east side,while Huayang Rock's opening accounts for only half of its area and is not directly aligned with the rock temple.In summary,Huayang Rock's ventilation environment is inferior to that of Yinxian Rock,leading to more severe pathologies.It is inferred that Huayang Rock's preservation issues are closely related to its poor ventilation environment.Therefore,improving its ventilation conditions is crucial for preventive conservation.Using environmental simulation,this study compares the ventilation conditions of Huayang Rock under different wind directions and speeds,identifies the two most ideal scenarios,and proposes several feasible solutions. 展开更多
关键词 Wudang Mountain rock temple Architectural issues Natural ventilation Preventive conservation
在线阅读 下载PDF
A model LayerDFN for characterizing the inherent anisotropic rocks with large-scale and dense joints
20
作者 Gang Han Shuling Huang +4 位作者 Chuanqing Zhang Xiuli Ding Yuting Zhang Yang Gao Jun He 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第3期1569-1584,共16页
Large-scale and heavily jointed rocks have inherent planes of anisotropy and secondary structural planes,such as dominant joint sets and random fractures,which result in significant differences in their failure mechan... Large-scale and heavily jointed rocks have inherent planes of anisotropy and secondary structural planes,such as dominant joint sets and random fractures,which result in significant differences in their failure mechanism and deformation behavior compared to other rock types.To address this issue,inherent anisotropic rocks with large-scale and dense joints are considered to be composed of the rock matrix,inherent planes of anisotropy,and secondary structural planes.Then a new implicit continuum model called LayerDFN is developed based on the crack tensor and damage tensor theories to characterize the mechanical properties of inherent anisotropic rocks.Furthermore,the LayerDFN model is implemented in the FLAC3D software,and a series of numerical results for typical example problems is compared with those obtained from the 3DEC,the analytical solutions,similar classical models,laboratory uniaxial compression tests,and field rigid bearing plate tests.The results demonstrate that the LayerDFN model can effectively capture the anisotropic mechanical properties of inherent anisotropic rocks,and can quantitatively characterize the damaging effect of the secondary structural planes.Overall,the numerical method based on the LayerDFN model provides a comprehensive and reliable approach for describing and analyzing the behavior of inherent anisotropic rocks,which will provide valuable insights for engineering design and decision-making processes. 展开更多
关键词 Inherent anisotropic rocks Secondary structural planes Constitutive model Crack tensor Damage tensor
在线阅读 下载PDF
上一页 1 2 250 下一页 到第
使用帮助 返回顶部