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Relationship between parenting stress and behavioral and emotional problems in preschool children: A mediation effect analysis
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作者 Zhi-Wei Fu Yue-Jing Li +3 位作者 Ran Yu Rui-Qing Guo Li-Xia Gao Sheng-Xia Zhao 《World Journal of Psychiatry》 SCIE 2025年第1期128-136,共9页
BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age children.AIM To investigate the current statu... BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age children.AIM To investigate the current status of family rearing,parental stress,and behavioral and emotional problems of preschool children and to analyze the mediating effect of the current status of family rearing on parental stress and behavioral/emo-tional problems.METHODS We use convenience sampling to select 258 preschool children in the physical examination center of our hospital from October 2021 to September 2023.The children and their parents were evaluated using a questionnaire survey.Pearson's correlation was used to analyze the correlation between child behavioral and emotional problems and parental stress and family rearing,and the structural equation model was constructed to test the mediating effect.RESULTS The score for behavioral/emotional problems of 258 preschool children was(27.54±3.63),the score for parental stress was(87.64±11.34),and the score for parental family rearing was(31.54±5.24).There was a positive correlation between the behavioral and emotional problems of the children and the“hostile/mandatory”parenting style;meanwhile,showed a negative correlation with the“support/participation”parenting style(all P<0.05).The intermediary effect value between the family upbringing of parents in parental stress and children's behavior problems was 29.89%.CONCLUSION Parental family upbringing has a mediating effect between parental stress and behavioral and emotional problems of children.Despite paying attention to the behavioral and emotional problems of preschool-age children,clinical medical staff should provide correct and reasonable parenting advice to their parents to promote the mental health of preschool-age children. 展开更多
关键词 Preschool children Parenting stress Children's behavioral and emotional problems Family rearing Mediating effect
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Efficacy of School-Based Interventions to Manage Psychosocial Problems of an Adolescent: A Clinical Case Study
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作者 Dua Fatima Afzaal Farhan Hashmi 《Open Journal of Medical Psychology》 2025年第1期19-31,共13页
This case study explores the efficacy of school-based intervention to address psychosocial challenges faced by an 11-year-old adolescent. The case study aimed to decrease the agression and acting out behavior as resul... This case study explores the efficacy of school-based intervention to address psychosocial challenges faced by an 11-year-old adolescent. The case study aimed to decrease the agression and acting out behavior as result of being victimized at school by the peers. The aim was to assess and manage the child’s aggressive behavior and academic underperformance which played a significant role in the child’s low self-esteem and emotional regulation. A comprehensive assessment was conducted to rule out the difficulties and a multi-faceted intervention strategy was utilized including anger management and structured activity scheduling that helped that child to improve his academic performance as well as to learn to manage his emotional expression. Throughout 16 sessions, the intervention targeted key behavioural indicators such as emotional expression, and aggression;post-assessment results demonstrated a 22% improvement in the child’s behavioral and academic challenges. The findings suggest that a multi-faceted therapeutic approach can be effective in addressing complex issues of aggression and academic underperformance in children, highlighting the importance of integrated psychological and educational interventions. 展开更多
关键词 AGGRESSION School-Related problems BULLYING VICTIMIZATION Cognitive-Behavioral Therapy
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基于ViP设计法则的文创包装设计研究
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作者 刘湘钰 徐师 《造纸装备及材料》 2025年第1期144-146,共3页
在设计文创包装时应融入文化元素和创意表达,巧妙地将传统文化的精神传递给大众。文章将ViP设计法则理论运用于文创包装设计之中,依据ViP设计法则中愿景级、交互级、产品级三大基本层级,结合文创包装设计的优秀案例,为文创包装行业的设... 在设计文创包装时应融入文化元素和创意表达,巧妙地将传统文化的精神传递给大众。文章将ViP设计法则理论运用于文创包装设计之中,依据ViP设计法则中愿景级、交互级、产品级三大基本层级,结合文创包装设计的优秀案例,为文创包装行业的设计实践提供了新的思路和参考。 展开更多
关键词 vip设计法则 文创包装 包装设计
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健胃止泻合剂对脾虚型功能性腹泻大鼠脑肠肽VIP、CCK表达的影响
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作者 武正权 杨红娟 +1 位作者 姚柳伊 郭军 《中医药信息》 2024年第12期23-26,31,共5页
目的:观察不同剂量健胃止泻合剂对脾虚型功能性腹泻大鼠脑肠肽VIP、CCK表达的影响。方法:50只SPF级Wistar大鼠随机分为空白对照组、模型组、妈咪爱组、健胃止泻合剂低剂量组、健胃止泻合剂高剂量组各10只。除空白对照组外,其余各组大鼠... 目的:观察不同剂量健胃止泻合剂对脾虚型功能性腹泻大鼠脑肠肽VIP、CCK表达的影响。方法:50只SPF级Wistar大鼠随机分为空白对照组、模型组、妈咪爱组、健胃止泻合剂低剂量组、健胃止泻合剂高剂量组各10只。除空白对照组外,其余各组大鼠采用灌胃大黄水煎液7.5 g/(kg·d),并每日负重游泳,以力竭为度的方法建立脾虚型功能性腹泻模型。在造模的同时,模型组和空白对照组每天给予大鼠自由饮用0.9%NaCl溶液,健胃止泻合剂高、低剂量组分别灌胃健胃止泻合剂18、4.5 g/(kg·d),妈咪爱组灌胃妈咪爱0.2 g/(kg·d),连续14 d。给药结束后,脱颈处死大鼠,免疫组化法测定大鼠血清中VIP、CCK的表达。结果:与空白对照组比较,模型组脑肠肽VIP、CCK表达显著增加(P<0.05)。与模型组比较,妈咪爱组脑肠肽VIP、CCK表达降低,健胃止泻合剂低、高剂量组脑肠肽VIP表达显著降低(P<0.05),健胃止泻合剂低、高剂量组脑肠肽CCK表达显著降低(P<0.05)。结论:健胃止泻合剂可通过降低脾虚型功能性腹泻大鼠脑肠肽VIP、CCK的表达,调节肠道运动和水液代谢,从而改善功能性腹泻。 展开更多
关键词 健胃止泻合剂 脾虚型功能性腹泻 vip CCK
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ViP设计法则指导下的洗鼻器设计研究 被引量:1
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作者 周瑄 何佳新 《创意设计源》 2024年第2期28-33,共6页
以ViP设计法则为指导,以洗鼻器设计为切入点,依据ViP设计法则中的理论模型,解构洗鼻器设计的产品层、交互层与情境层,预设未来变应性鼻炎患者的鼻腔护理情境,并提出构建未来变应性鼻炎患者洗鼻器护理产品的设计策略框架,展开健康干预设... 以ViP设计法则为指导,以洗鼻器设计为切入点,依据ViP设计法则中的理论模型,解构洗鼻器设计的产品层、交互层与情境层,预设未来变应性鼻炎患者的鼻腔护理情境,并提出构建未来变应性鼻炎患者洗鼻器护理产品的设计策略框架,展开健康干预设计,完成洗鼻器设计实践。该设计能够为未来医疗健康产品的研究提供新的设计思路。 展开更多
关键词 vip设计法则 洗鼻器设计 变应性鼻炎
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基于“脑肠轴理论”探讨龟羚帕安丸对PD大鼠纹状体DA及血清CCK、VIP水平影响的研究
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作者 常学辉 张良芝 +2 位作者 陈帅杰 王冬莲 张创业 《四川中医》 2024年第1期80-83,共4页
目的:基于“脑肠轴理论”探讨龟羚帕安丸对PD大鼠纹状体裂解液多巴胺(Dopamine,DA)、血清胆囊收缩素(cholecystokinin,CCK)及血管活性肠肽(vasoactive intestinal peptide,VIP)水平的影响。方法:采用6-羟基多巴胺注射法制作PD大鼠模型,... 目的:基于“脑肠轴理论”探讨龟羚帕安丸对PD大鼠纹状体裂解液多巴胺(Dopamine,DA)、血清胆囊收缩素(cholecystokinin,CCK)及血管活性肠肽(vasoactive intestinal peptide,VIP)水平的影响。方法:采用6-羟基多巴胺注射法制作PD大鼠模型,随机分为模型组、西药组、中药高、中、低剂量组,每组15只,另设15只假手术组。模型组及假手术组给予等容积生理盐水灌胃,其余组给予相应药物灌胃,连续给药4周。酶联免疫吸附测定法(ELISA)检测纹状体裂解液DA及血清CCK、VIP水平。结果:模型组大鼠纹状体DA、血清CCK及VIP水平显著降低;中药各剂量组、西药组大鼠纹状体DA、血清CCK及VIP水平明显均增加(P<0.01)。结论:龟羚帕安丸具有明显神经保护作用,作用机制与激活脑肠轴、增加血清CCK及VIP水平、增加中脑黑质纹状体DA的水平、发挥改善肠道功能作用有关。 展开更多
关键词 帕金森病 龟羚帕安丸 多巴胺 胆囊收缩素 血管活性肠肽
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基于VIP与SystemVerilog的硬件加速器仿真模型设计
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作者 杜越 吴益然 郑杰良 《计算机与网络》 2024年第4期307-313,共7页
随着片上系统(System on Chip,SoC)芯片规模与功能复杂度的膨胀,硬件加速器已成为大规模SoC的重要组成部分。为了缩短产品交付时间,有必要开发硬件加速器仿真模型,以在SoC设计初期支撑架构的探索与评估。在对硬件加速器的特点与建模需... 随着片上系统(System on Chip,SoC)芯片规模与功能复杂度的膨胀,硬件加速器已成为大规模SoC的重要组成部分。为了缩短产品交付时间,有必要开发硬件加速器仿真模型,以在SoC设计初期支撑架构的探索与评估。在对硬件加速器的特点与建模需求进行分析的基础上,提出一种基于AXI验证IP(Verification IP,VIP)、SystemVerilog信箱和旗语的硬件加速器建模方法。该方法支持完备的总线协议特性,同时支持多个处理引擎的并行处理与乱序输出。以实际SoC项目中的通信基带加速器为例,对提出的建模方法进行介绍,并进行相应的系统级仿真与分析。所提出的建模方法可实现对硬件加速器总线行为的高效建模,能够有力支撑SoC验证以及系统架构评估,缩短项目的开发周期。 展开更多
关键词 硬件加速器 仿真模型 片上系统 信箱 旗语 SYSTEMVERILOG 验证IP
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养荣润肠舒合剂对慢性传输型便秘SD大鼠结肠5-HT、VIP的影响 被引量:1
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作者 邹跃 张虹玺 《辽宁中医杂志》 CAS 北大核心 2024年第3期183-187,共5页
目的探讨慢性传输型便秘大鼠结肠黏膜5-羟色(5-hydroxytryptophan,5-HT)、血管活性肠多肽(vasoactive intestinal polypeptide,VIP)的含量,以明确中药制剂养荣润肠舒合剂对大鼠结肠5-HT、VIP表达的调节作用。方法将60只健康的SD大鼠随... 目的探讨慢性传输型便秘大鼠结肠黏膜5-羟色(5-hydroxytryptophan,5-HT)、血管活性肠多肽(vasoactive intestinal polypeptide,VIP)的含量,以明确中药制剂养荣润肠舒合剂对大鼠结肠5-HT、VIP表达的调节作用。方法将60只健康的SD大鼠随机分为空白组10只,造模组50只(模型组10只、莫沙必利组10只、养荣润肠舒合剂高、中、低剂量组各10只)。应用复方地芬诺酯灌胃(2 mL/200 g体质量)以复制慢性传输型便秘大鼠模型(每天1次,连续10 d)。期间记录大鼠首次排便时间,并收集粪便、测量粪便剂量、含水量以判断造模是否成功。复制模型成功后进行药物治疗,每天1次,连续10 d。然后采用间接酶联免疫吸附试验(Enzyme Linked Immunosorbent Assay,ELISA)观测大鼠结肠5-HT、VIP的光密度(optical density,OD)值。结果①与空白组比较,模型组SD大鼠的首次排便时间延后,且新鲜粪便的剂量、含水量减少,差异有显著统计学意义(P<0.01)。②与模型组比较,莫沙必利组和养荣润肠合剂低、中、高剂量组治疗后大鼠的首次排便时间均提前,且粪便的含水率、重量除使用养荣润肠低组外均有所增长(P<0.01)。③与莫沙必利组比较,养荣润肠舒合剂中组剂量组大鼠的一般状况最好,首次排便时间最接近莫沙必利组且较短于莫沙必利组,差异无统计学意义(P>0.05),新鲜粪便剂量最接近莫沙必利组且较重于莫沙必利组,差异无统计学意义(P>0.05),含水量明显优于莫沙必利组,差异有统计学意义(P<0.05);养荣润肠舒合剂高剂量组大鼠排便状况与莫沙必利组相差不大,差异无统计学意义(P>0.05);莫沙必利组大鼠排便状况明显优于养荣润肠舒合剂低剂量组,差异有显著统计学意义(P<0.01)。④养荣润肠舒合剂中剂量组的大鼠一般状况更佳,而低剂量组的大鼠状况较差,新鲜粪便的剂量、含水量较小。⑤与空白组比较,模型组大鼠近端结肠组织5-HT、VIP的含量显著降低,OD值缩小(P<0.01)。⑥治疗后与模型组比较,莫沙必利组及养荣润肠舒合剂低、中、高剂量SD大鼠结肠5-HT、VIP含量显著升高,OD值增加,差异有明显统计学意义(P<0.01)。⑦治疗后与莫沙必利组比较,养荣润肠舒合剂中剂量大鼠结肠的5-HT、VIP含量及OD值增加,最接近莫沙必利组且较高于莫沙必利组,差异无统计学意义(P>0.05);养荣润肠舒合剂高剂量组大鼠状况及大鼠结肠5-HT、VIP含量与莫沙必利组相差不大,差异无统计学意义(P>0.05)。⑧与养荣润肠舒合剂高剂量组比较,养荣润肠舒合剂中剂量组大鼠结肠5-HT、VIP含量更高,OD值差异无统计学意义(P>0.05),而养荣润肠舒合剂低剂量组大鼠结肠的5-HT、VIP含量相对较低,与养荣润肠舒合剂中剂量组相比OD值也较低,具有统计学意义(P<0.01)。结论5-HT作为脑—肠轴的关键神经递质,VIP作为存在于中枢神经和肠神经系统中的神经递质,在慢性传输型便秘的发病中起着重要的作用;中药方剂养荣润肠舒合剂能有效提高慢性传输型便秘大鼠结肠5-HT、VIP含量,增强5-HT、VIP的表达有关;因此,作者认为养荣润肠舒合剂可能是通过这一机制改善慢性传输型便秘的临床症状,从而达到“以补治秘”的目的。 展开更多
关键词 慢性传输型便秘 养荣润肠舒合剂 5-羟色胺(5-HT) 血管活性肠肽(vip) 酶联免疫吸附法
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基于VIP信号改变的清热化湿调枢方对预防结肠炎小鼠肠黏膜屏障损伤的作用
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作者 钟卓泰 杨晨 +6 位作者 张涛 赵润元 王倩影 卿香丽 王琳 姚梦茜 苏晓兰 《时珍国医国药》 CAS CSCD 北大核心 2024年第6期1289-1294,共6页
目的基于VIP及其受体变化,观察清热化湿调枢方对于预防DSS诱导的结肠炎小鼠模型肠黏膜屏障的损伤作用及其机制。方法选用24只C57BL/6雄性小鼠,正常组6只予纯水自由饮用,其余18只分为模型组、美沙拉秦对照组、清热化湿调枢方组,予2.5%葡... 目的基于VIP及其受体变化,观察清热化湿调枢方对于预防DSS诱导的结肠炎小鼠模型肠黏膜屏障的损伤作用及其机制。方法选用24只C57BL/6雄性小鼠,正常组6只予纯水自由饮用,其余18只分为模型组、美沙拉秦对照组、清热化湿调枢方组,予2.5%葡聚糖硫酸钠(DSS)水溶液自由饮用,并分别予灌胃等量纯水、美沙拉秦混悬液(0.52g·kg^(-1)·d^(-1))、清热化湿调枢方(1.69g·kg^(-1)·d^(-1)),连续干预7d。观察各组小鼠的体质量、疾病活动指数(DAI)评分、结肠长度;结肠组织HE染色病理切片;ELISA法检测血清IL-2、IL-4水平;q-PCR法检测结肠组织IL-10 mRNA水平;Western Blot法检测sIgA、Claudin2、MUC2、VIP、VPAC1、VPAC2水平。结果与正常组小鼠比较,模型组小鼠体重下降,DAI分数升高,结肠长度缩短,差异有统计学意义(P<0.05),病理切片显示肠黏膜上皮结构损伤,炎症浸润;血清IL-2、IL-4差异不显著;结肠组织IL-10 mRNA、sIgA、Claudin2、MUC2、VIP、VPAC2水平降低,差异有统计学意义(P<0.05),结肠组织VPAC1水平升高,差异有统计学意义(P<0.05)。与模型组比较,清热化湿调枢方和美沙拉秦对照组都能降低小鼠DAI分数、恢复结肠长度,差异有统计学意义,另外,清热化湿调枢方比美沙拉秦更能恢复小鼠的体质量;清热化湿调枢方和美沙拉秦组小鼠有更紧致的肠黏膜上皮结构及更少的炎性细胞浸润;血清IL-2差异不显著,仅有清热化湿调枢方能提高小鼠血清IL-4水平;清热化湿调枢方和美沙拉秦对照组能恢复结肠组织中IL-10 mRNA、SIgA、Claudin2、MUC2、VIP、VPAC2水平,降低VPAC1水平,差异均有统计学意义(P<0.05)。相关性分析显示,VIP的改变与体重、Cladudin2和VPAC2存在相关性;VPAC1与SIgA存在相关性;VPAC2与DAI分数、IL-10 mRNA、MUC2、VIP存在相关性。结论清热化湿调枢方在一定程度上对于DSS诱导的结肠炎具有预防作用,并能恢复损伤的肠黏膜机械、化学、免疫屏障,且能调节免疫。其中,机械屏障的修复作用可能由VIP-VPAC2驱动;化学屏障的修复与VPAC2相关;免疫屏障的修复与VPAC1相关。 展开更多
关键词 溃疡性结肠炎 清热化湿调枢方 预防 肠黏膜屏障 DSS vip
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Association of preschool children behavior and emotional problems with the parenting behavior of both parents 被引量:3
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作者 Su-Mei Wang Shuang-Qin Yan +4 位作者 Fang-Fang Xie Zhi-Ling Cai Guo-Peng Gao Ting-Ting Weng Fang-Biao Tao 《World Journal of Clinical Cases》 SCIE 2024年第6期1084-1093,共10页
BACKGROUND Parental behaviors are key in shaping children’s psychological and behavioral development,crucial for early identification and prevention of mental health issues,reducing psychological trauma in childhood.... BACKGROUND Parental behaviors are key in shaping children’s psychological and behavioral development,crucial for early identification and prevention of mental health issues,reducing psychological trauma in childhood.AIM To investigate the relationship between parenting behaviors and behavioral and emotional issues in preschool children.METHODS From October 2017 to May 2018,7 kindergartens in Ma’anshan City were selected to conduct a parent self-filled questionnaire-Health Development Survey of Preschool Children.Children’s Strength and Difficulties Questionnaire(Parent Version)was applied to measures the children’s behavioral and emotional performance.Parenting behavior was evaluated using the Parental Behavior Inventory.Binomial logistic regression model was used to analyze the association between the detection rate of preschool children’s behavior and emotional problems and their parenting behaviors.RESULTS High level of parental support/participation was negatively correlated with conduct problems,abnormal hyperactivity,abnormal total difficulty scores and abnormal prosocial behavior problems.High level of maternal support/participation was negatively correlated with abnormal emotional symptoms and abnormal peer interaction in children.High level of parental hostility/coercion was positively correlated with abnormal emotional symptoms,abnormal conduct problems,abnormal hyperactivity,abnormal peer interaction,and abnormal total difficulty scores in children(all P<0.05).Moreover,paternal parenting behaviors had similarly effects on behavior and emotional problems of preschool children compared with maternal parenting behaviors(all P>0.05),after calculating ratio of odds ratio values.CONCLUSION Our study found that parenting behaviors are associated with behavioral and emotional issues in preschool children.Overall,the more supportive or involved the parents are,the fewer behavioral and emotional problems the children experience;conversely,the more hostile or controlling the parents are,the more behavioral and emotional problems the children face.Moreover,the impact of fathers’parenting behaviors on preschool children’s behavior and emotions is no less significant than that of mothers’parenting behaviors. 展开更多
关键词 CHILDREN Preschool age PARENTING BEHAVIORAL Parenting problems
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基于ViP设计方法的街道家具系统设计研究——以上海文华村街道家具设计为例 被引量:1
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作者 赫心滢 陈烈胜 《天工》 2024年第33期51-53,共3页
以上海文华村公共家具设计为例,基于VisioninProductDesign(简称ViP设计方法),通过产品、交互、情景三层设计研究,深入分析现有不足与新需求。经过准备、探索、预见、设计阶段,提出融合城乡公共功能与艺术元素的创新设计方案,既能满足... 以上海文华村公共家具设计为例,基于VisioninProductDesign(简称ViP设计方法),通过产品、交互、情景三层设计研究,深入分析现有不足与新需求。经过准备、探索、预见、设计阶段,提出融合城乡公共功能与艺术元素的创新设计方案,既能满足功能需求,又能提升城乡景观风貌。研究结果表明,ViP设计方法能有效指导城乡街道家具系统设计,为促进乡村振兴和提升城市居民生活品质提供了新思路和有益探索。 展开更多
关键词 vip设计方法 家具设计 三层模型 设计流程 乡村街道
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Quafu-Qcover:Explore combinatorial optimization problems on cloud-based quantum computers 被引量:1
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作者 许宏泽 庄伟峰 +29 位作者 王正安 黄凯旋 时运豪 马卫国 李天铭 陈驰通 许凯 冯玉龙 刘培 陈墨 李尚书 杨智鹏 钱辰 靳羽欣 马运恒 肖骁 钱鹏 顾炎武 柴绪丹 普亚南 张翼鹏 魏世杰 增进峰 李行 龙桂鲁 金贻荣 于海峰 范桁 刘东 胡孟军 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第5期104-115,共12页
We introduce Quafu-Qcover,an open-source cloud-based software package developed for solving combinatorial optimization problems using quantum simulators and hardware backends.Quafu-Qcover provides a standardized and c... We introduce Quafu-Qcover,an open-source cloud-based software package developed for solving combinatorial optimization problems using quantum simulators and hardware backends.Quafu-Qcover provides a standardized and comprehensive workflow that utilizes the quantum approximate optimization algorithm(QAOA).It facilitates the automatic conversion of the original problem into a quadratic unconstrained binary optimization(QUBO)model and its corresponding Ising model,which can be subsequently transformed into a weight graph.The core of Qcover relies on a graph decomposition-based classical algorithm,which efficiently derives the optimal parameters for the shallow QAOA circuit.Quafu-Qcover incorporates a dedicated compiler capable of translating QAOA circuits into physical quantum circuits that can be executed on Quafu cloud quantum computers.Compared to a general-purpose compiler,our compiler demonstrates the ability to generate shorter circuit depths,while also exhibiting superior speed performance.Additionally,the Qcover compiler has the capability to dynamically create a library of qubits coupling substructures in real-time,utilizing the most recent calibration data from the superconducting quantum devices.This ensures that computational tasks can be assigned to connected physical qubits with the highest fidelity.The Quafu-Qcover allows us to retrieve quantum computing sampling results using a task ID at any time,enabling asynchronous processing.Moreover,it incorporates modules for results preprocessing and visualization,facilitating an intuitive display of solutions for combinatorial optimization problems.We hope that Quafu-Qcover can serve as an instructive illustration for how to explore application problems on the Quafu cloud quantum computers. 展开更多
关键词 quantum cloud platform combinatorial optimization problems quantum software
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Data-Driven Learning Control Algorithms for Unachievable Tracking Problems 被引量:1
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作者 Zeyi Zhang Hao Jiang +1 位作者 Dong Shen Samer S.Saab 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第1期205-218,共14页
For unachievable tracking problems, where the system output cannot precisely track a given reference, achieving the best possible approximation for the reference trajectory becomes the objective. This study aims to in... For unachievable tracking problems, where the system output cannot precisely track a given reference, achieving the best possible approximation for the reference trajectory becomes the objective. This study aims to investigate solutions using the Ptype learning control scheme. Initially, we demonstrate the necessity of gradient information for achieving the best approximation.Subsequently, we propose an input-output-driven learning gain design to handle the imprecise gradients of a class of uncertain systems. However, it is discovered that the desired performance may not be attainable when faced with incomplete information.To address this issue, an extended iterative learning control scheme is introduced. In this scheme, the tracking errors are modified through output data sampling, which incorporates lowmemory footprints and offers flexibility in learning gain design.The input sequence is shown to converge towards the desired input, resulting in an output that is closest to the given reference in the least square sense. Numerical simulations are provided to validate the theoretical findings. 展开更多
关键词 Data-driven algorithms incomplete information iterative learning control gradient information unachievable problems
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枳术丸调控VIP、cAMP、PKA、AQP1对慢传输型便秘小鼠肠道水液代谢的影响
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作者 朱哲琴 魏堰翀 +4 位作者 施敏 廖陈敏 朱斌 夏旭婷 刘富林 《时珍国医国药》 CAS CSCD 北大核心 2024年第10期2374-2380,共7页
目的探讨枳术丸对慢传输型便秘脾虚证小鼠肠道水液代谢的影响。方法用番泻叶灌胃+饥饱失常法建立慢传输型便秘脾虚证小鼠模型并随机分为模型组(蒸馏水)、莫沙必利组(2.5mg·kg^(-1))、枳术丸组(11.7g·kg^(-1)),另设空白组(蒸馏... 目的探讨枳术丸对慢传输型便秘脾虚证小鼠肠道水液代谢的影响。方法用番泻叶灌胃+饥饱失常法建立慢传输型便秘脾虚证小鼠模型并随机分为模型组(蒸馏水)、莫沙必利组(2.5mg·kg^(-1))、枳术丸组(11.7g·kg^(-1)),另设空白组(蒸馏水),每组10只。分组治疗7d后,观察各组小鼠的一般行为学特征,检测各组小鼠肠道推进率、粪便含水量,采用HE染色观察各组小鼠结肠组织病理形态改变,Elisa法检测小鼠结肠血管活性肠肽(VIP)、环磷腺苷(cAMP)、蛋白激酶A(PKA)含量,Western-Blot检测结肠cAMP、PKA、水通道蛋白1(AQP1)蛋白表达。结果与空白组相比,模型组肠道推进率、粪便含水量均减少(P<0.05),Elisa法检测示结肠组织VIP、cAMP、PKA含量均降低(P<0.05或P<0.01),Western-Blot结果示结肠组织cAMP、PKA蛋白表达减少(P>0.05,P<0.01),AQP1蛋白表达增加(P<0.05)。与模型组比较,莫沙必利组和枳术丸组肠道推进率呈增加趋势(P>0.05),粪便含水量增加(P<0.05)。Elisa法检测示结肠组织VIP呈上升趋势(P>0.05),cAMP、PKA含量均明显增加(P<0.01),Western-Blot结果示结肠组织cAMP、PKA蛋白表达增加(P>0.05,P<0.01),AQP1蛋白表达减少(P<0.05)。结论枳术丸可以改善慢传输型脾虚证便秘小鼠的便秘症状,其机制可能与上调VIP-cAMP-PKA通路从而降低结肠AQP1表达,减少肠道水分重吸收,软化大便有关。 展开更多
关键词 枳术丸 慢传输型便秘 血管活性肠肽 环磷腺苷 蛋白激酶A 水通道蛋白1
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An Improved Artificial Rabbits Optimization Algorithm with Chaotic Local Search and Opposition-Based Learning for Engineering Problems and Its Applications in Breast Cancer Problem 被引量:1
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作者 Feyza AltunbeyÖzbay ErdalÖzbay Farhad Soleimanian Gharehchopogh 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第11期1067-1110,共44页
Artificial rabbits optimization(ARO)is a recently proposed biology-based optimization algorithm inspired by the detour foraging and random hiding behavior of rabbits in nature.However,for solving optimization problems... Artificial rabbits optimization(ARO)is a recently proposed biology-based optimization algorithm inspired by the detour foraging and random hiding behavior of rabbits in nature.However,for solving optimization problems,the ARO algorithm shows slow convergence speed and can fall into local minima.To overcome these drawbacks,this paper proposes chaotic opposition-based learning ARO(COARO),an improved version of the ARO algorithm that incorporates opposition-based learning(OBL)and chaotic local search(CLS)techniques.By adding OBL to ARO,the convergence speed of the algorithm increases and it explores the search space better.Chaotic maps in CLS provide rapid convergence by scanning the search space efficiently,since their ergodicity and non-repetitive properties.The proposed COARO algorithm has been tested using thirty-three distinct benchmark functions.The outcomes have been compared with the most recent optimization algorithms.Additionally,the COARO algorithm’s problem-solving capabilities have been evaluated using six different engineering design problems and compared with various other algorithms.This study also introduces a binary variant of the continuous COARO algorithm,named BCOARO.The performance of BCOARO was evaluated on the breast cancer dataset.The effectiveness of BCOARO has been compared with different feature selection algorithms.The proposed BCOARO outperforms alternative algorithms,according to the findings obtained for real applications in terms of accuracy performance,and fitness value.Extensive experiments show that the COARO and BCOARO algorithms achieve promising results compared to other metaheuristic algorithms. 展开更多
关键词 Artificial rabbit optimization binary optimization breast cancer chaotic local search engineering design problem opposition-based learning
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基于UVM和AXI VIP的SoC外设组件仿真模型设计
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作者 吴益然 杜越 郑杰良 《计算机与网络》 2024年第4期359-365,共7页
随着片上系统(System on Chip,SoC)复杂度和集成度的提高,其对验证效率的要求也不断提高。传统的瀑布形式的系统设计流程中,各个开发子过程顺序执行。为了将功能模块开发与系统架构验证并行开展以缩短项目的交付时间,提出了一种利用通... 随着片上系统(System on Chip,SoC)复杂度和集成度的提高,其对验证效率的要求也不断提高。传统的瀑布形式的系统设计流程中,各个开发子过程顺序执行。为了将功能模块开发与系统架构验证并行开展以缩短项目的交付时间,提出了一种利用通用验证方法学(Universal Verification Methodology,UVM)验证IP(Verification IP,VIP)进行SoC外设组件快速建模的方法。使用事务级建模(Transaction-Level Modeling,TLM)模型模拟硬件行为代替未开发完成的功能模块产生数据流,使得在设计早期系统架构搭建完成后能更早地开展系统级测试,帮助评估总线架构性能和功能,提高验证效率。以网络处理器芯片中的数据转发模块为例,对SoC外设组件的建模方法进行了介绍,在系统级测试中进行了仿真验证。 展开更多
关键词 通用验证方法学 事务级建模 数据转发 片上系统外设 验证IP
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A Comparative Study of Metaheuristic Optimization Algorithms for Solving Real-World Engineering Design Problems
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作者 Elif Varol Altay Osman Altay Yusuf Ovik 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第4期1039-1094,共56页
Real-world engineering design problems with complex objective functions under some constraints are relatively difficult problems to solve.Such design problems are widely experienced in many engineering fields,such as ... Real-world engineering design problems with complex objective functions under some constraints are relatively difficult problems to solve.Such design problems are widely experienced in many engineering fields,such as industry,automotive,construction,machinery,and interdisciplinary research.However,there are established optimization techniques that have shown effectiveness in addressing these types of issues.This research paper gives a comparative study of the implementation of seventeen new metaheuristic methods in order to optimize twelve distinct engineering design issues.The algorithms used in the study are listed as:transient search optimization(TSO),equilibrium optimizer(EO),grey wolf optimizer(GWO),moth-flame optimization(MFO),whale optimization algorithm(WOA),slimemould algorithm(SMA),harris hawks optimization(HHO),chimp optimization algorithm(COA),coot optimization algorithm(COOT),multi-verse optimization(MVO),arithmetic optimization algorithm(AOA),aquila optimizer(AO),sine cosine algorithm(SCA),smell agent optimization(SAO),and seagull optimization algorithm(SOA),pelican optimization algorithm(POA),and coati optimization algorithm(CA).As far as we know,there is no comparative analysis of recent and popular methods against the concrete conditions of real-world engineering problems.Hence,a remarkable research guideline is presented in the study for researchersworking in the fields of engineering and artificial intelligence,especiallywhen applying the optimization methods that have emerged recently.Future research can rely on this work for a literature search on comparisons of metaheuristic optimization methods in real-world problems under similar conditions. 展开更多
关键词 Metaheuristic optimization algorithms real-world engineering design problems multidisciplinary design optimization problems
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An Effective Meshless Approach for Inverse Cauchy Problems in 2D and 3D Electroelastic Piezoelectric Structures
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作者 Ziqiang Bai Wenzhen Qu Guanghua Wu 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第3期2955-2972,共18页
In the past decade,notable progress has been achieved in the development of the generalized finite difference method(GFDM).The underlying principle of GFDM involves dividing the domain into multiple sub-domains.Within... In the past decade,notable progress has been achieved in the development of the generalized finite difference method(GFDM).The underlying principle of GFDM involves dividing the domain into multiple sub-domains.Within each sub-domain,explicit formulas for the necessary partial derivatives of the partial differential equations(PDEs)can be obtained through the application of Taylor series expansion and moving-least square approximation methods.Consequently,the method generates a sparse coefficient matrix,exhibiting a banded structure,making it highly advantageous for large-scale engineering computations.In this study,we present the application of the GFDM to numerically solve inverse Cauchy problems in two-and three-dimensional piezoelectric structures.Through our preliminary numerical experiments,we demonstrate that the proposed GFDMapproach shows great promise for accurately simulating coupled electroelastic equations in inverse problems,even with 3%errors added to the input data. 展开更多
关键词 Generalized finite difference method meshless method inverse Cauchy problems piezoelectric problems electroelastic analysis
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Highly Accurate Golden Section Search Algorithms and Fictitious Time Integration Method for Solving Nonlinear Eigenvalue Problems
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作者 Chein-Shan Liu Jian-Hung Shen +1 位作者 Chung-Lun Kuo Yung-Wei Chen 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第5期1317-1335,共19页
This study sets up two new merit functions,which are minimized for the detection of real eigenvalue and complex eigenvalue to address nonlinear eigenvalue problems.For each eigen-parameter the vector variable is solve... This study sets up two new merit functions,which are minimized for the detection of real eigenvalue and complex eigenvalue to address nonlinear eigenvalue problems.For each eigen-parameter the vector variable is solved from a nonhomogeneous linear system obtained by reducing the number of eigen-equation one less,where one of the nonzero components of the eigenvector is normalized to the unit and moves the column containing that component to the right-hand side as a nonzero input vector.1D and 2D golden section search algorithms are employed to minimize the merit functions to locate real and complex eigenvalues.Simultaneously,the real and complex eigenvectors can be computed very accurately.A simpler approach to the nonlinear eigenvalue problems is proposed,which implements a normalization condition for the uniqueness of the eigenvector into the eigenequation directly.The real eigenvalues can be computed by the fictitious time integration method(FTIM),which saves computational costs compared to the one-dimensional golden section search algorithm(1D GSSA).The simpler method is also combined with the Newton iterationmethod,which is convergent very fast.All the proposed methods are easily programmed to compute the eigenvalue and eigenvector with high accuracy and efficiency. 展开更多
关键词 Nonlinear eigenvalue problem quadratic eigenvalue problem two new merit functions golden section search algorithm fictitious time integration method
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Linking 24-h Movement Behavior Guidelines to Cognitive Difficulties,Internalizing and Externalizing Problems in Preterm Youth
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作者 Zhihui Cheng Ailikute Aikeremu +6 位作者 Yanping Gao Zhihao Zhang Anthony G.Delli Paoli Paolo Marcello Cunha Alyx Taylor Fabian Herold Liye Zou 《International Journal of Mental Health Promotion》 2024年第8期651-662,共12页
Background:Given the heightened risk of developmental challenges associated with preterm birth,it is crucial to explore interventions that may ameliorate potential adverse outcomes.This study aimed to examine whether ... Background:Given the heightened risk of developmental challenges associated with preterm birth,it is crucial to explore interventions that may ameliorate potential adverse outcomes.This study aimed to examine whether meeting the 24-h movement behavior(24-HMB)guidelines,which include recommendations on physical activity(PA),screen time(ST),and sleep(SL),is related to indicators of cognitive difficulties,internalizing problems(e.g.,depression and anxiety),and externalizing problems(e.g.,difficulties in making friends and arguing)in a sample of preterm youth(children and adolescents born preterm).Methods:In this cross-sectional study,data from 3410 preterm youth(aged 6 to 17 years)were included for data analyses.Multivariable logistic regression was used to investigate associations between meeting the 24-HMB guidelines and the above-mentioned health outcomes,while controlling for sociodemographic and health-related factors.Results:The prevalence of meeting 24-HMB guidelines varied across independent and integrated components of the 24-HMB guidelines.Meeting the ST guideline alone(p<0.05)and integrated guidelines(i.e.,ST+SL and ST+SL+PA)were associated with fewer cognitive difficulties and reduced internalizing and externalizing problems(p<0.05).Specifically,meeting the SL guideline alone and integrated guidelines(i.e.,SL+ST)were associated with lower odds of depression and anxiety(p<0.01).Additionally,meeting independent,and integrated(PA and/or ST)guidelines were associated with less pronounced difficulties in making friends and arguing(p<0.05).Meeting 24-HMB guidelines in an isolated and integrated manner are linked to better cognitive performance and fewer internalizing and externalizing problems in preterm youth.Conclusion:Results suggest that advocating for the implementation of the 24-HMB guidelines may reduce cognitive challenges and behavioral issues,which is of high relevance for improving public health.Future longitudinal studies in preterm youth should investigate how modifying specific 24-HMB behaviors,especially ST,influence cognitive difficulties,internalizing and externalizing problems in this vulnerable population. 展开更多
关键词 Cognitive difficulties externalizing problems internalizing problems physical activity preterm youth
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