目的:探讨玫瑰痤疮患者采用低能量Pixel调Q像束激光与米诺环素联合治疗后红斑情况及面部功能改善情况。方法:研究对象选自于2020年3月-2023年7月在上海交通大学医学院苏州九龙医院接受治疗的玫瑰痤疮患者110例,并分为对照组和观察组,每...目的:探讨玫瑰痤疮患者采用低能量Pixel调Q像束激光与米诺环素联合治疗后红斑情况及面部功能改善情况。方法:研究对象选自于2020年3月-2023年7月在上海交通大学医学院苏州九龙医院接受治疗的玫瑰痤疮患者110例,并分为对照组和观察组,每组例数均为55例,分组方法为随机数字表法。对照组给予盐酸米诺环素片,在对照组患者治疗的基础上,采用低能量Pixel调Q像束激光对观察组患者进行治疗。两组治疗时间均为6周。比较两组临床疗效(治疗6周后),玫瑰痤疮情况、整体病情、p38丝裂原活化蛋白激酶(p38 mitogen activated protein kinase,p38MAPK)通路蛋白、生活质量、红斑情况、面部功能、炎性因子(治疗前、治疗6周后),不良反应(治疗期间)。结果:治疗6周后,观察组总有效率高于对照组(76.36%vs.54.55%,P<0.05)。与治疗前比较,两组治疗6周后的玫瑰痤疮医师全球评分(Patient's global assessment,PGA)、整体病情评估(Investigator global assessment,IGA)、皮肤病生活质量量表(Dermatology life quality index,DLQI)评分、红斑评估量表(Clinician′s erythema assessment,CEA)评分、皮损区红斑指数(Erythema index,EI)、经皮水分丢失(Trans epidermal water loss,TEWL)、皮肤酸碱度(Pondus Hydrogenii,pH)值、炎性因子及p38MAPK通路蛋白相关因子水平均降低,且相比于对照组,观察组更低;两组角质层含水量均升高,且相比于对照组,观察组更高(P<0.05)。观察组和对照组治疗期间的不良反应发生率比较差异无统计学意义(P>0.05)。结论:玫瑰痤疮患者经低能量Pixel调Q像束激光联合米诺环素治疗后,其相关临床症状可得到有效缓解,炎症反应得以减轻,并可调节p38MAPK信号通路蛋白的表达,进一步可促进患者红斑情况及面部功能的改善,进而促使患者生活质量及临床疗效得以提高,且具有良好的安全性。展开更多
In the research and development of new silicon pixel detectors,a collimated monoenergetic charged-particle test beam equipped with a high-resolution pixel-beam telescope is crucial for prototype verification and perfo...In the research and development of new silicon pixel detectors,a collimated monoenergetic charged-particle test beam equipped with a high-resolution pixel-beam telescope is crucial for prototype verification and performance evaluation.When the beam energy is low,the effect of multiple Coulomb scattering on the measured resolution of the Device Under Test(DUT)must be considered to accurately evaluate the performance of the pixel chips and detectors.This study aimed to investigate the effect of multiple Coulomb scattering on the measured resolution,particularly at low beam energies.Simulations were conducted using Allpix^(2) to study the effects of multiple Coulomb scattering under different beam energies,material budgets,and telescope layouts.The simulations also provided the minimum energy at which the effect of multiple Coulomb scattering could be ignored.Compared with the results of a five-layer detector system tested with an electron beam at DESY,the simulation results were consistent with the beam test results,confirming the reliability of the simulations.展开更多
A three-transistor active pixel sensor and its double sampling readout circuit implemented by a switch capacitor amplifier are designed. The circuit is embedded in a 64 × 64 pixel array CMOS image sensor and succ...A three-transistor active pixel sensor and its double sampling readout circuit implemented by a switch capacitor amplifier are designed. The circuit is embedded in a 64 × 64 pixel array CMOS image sensor and success-fully taped out with a Chartered 0.35μm process. The pixel pitch is 8μm × 8μm with a fill factor of 57%, the photo-sensitivity is 0.8V/（lux · s） ,and the dynamic range is 50dB. Theoretical analysis and test results indicate that as the process is scaled down, a smaller pixel pitch reduces the sensitivity. A deep junction n-well/p-substrate photodiode with a reasonable fill factor and high sensitivity are more appropriate for submicron processes.展开更多
We present a novel scheme for embedding secret data into a binary image without introducing noticeable artifacts. Unlike some block-based methods, the proposed scheme encodes the secret bits directly into boundary pix...We present a novel scheme for embedding secret data into a binary image without introducing noticeable artifacts. Unlike some block-based methods, the proposed scheme encodes the secret bits directly into boundary pixels by checking each pixel of the cover image in a pseudo-random order for embedding eligibility. A set of rules ensures correct identification of data-carrying pixels in blind extraction. The proposed scheme does not generate isolated dots, and can incorporate various coding methods such as matrix encoding to further improve the embedding performance. It is shown that up to one fourth of the boundary pixels may be used to carry secret data. Experimental results indicate that the method can achieve good visual quality with fairly large data capacity.展开更多
A detailed principle and a rigorous analysis of a new noise,the gate-induced noise,in pixel MOSFET of CMOS imagers are provided.The gate-induced noise of the MOSFET is more notable in the strong reversion region than...A detailed principle and a rigorous analysis of a new noise,the gate-induced noise,in pixel MOSFET of CMOS imagers are provided.The gate-induced noise of the MOSFET is more notable in the strong reversion region than that in the subthreshold region when the applied gate voltage is low.However,the applied gate voltage being up to 3V,the gate-induced noise is more notable with the ω/ω T increasing when the MOSFET operates in the subthreshold region than that in the strong reversion region.Between the photocurrent I D and the root mean square value of the gated-induced noise,current i 2 d presents the relation of i 2 d∝I D in the saturation region of the strong reversion and approximately i 2 d∝I D in the subthreshold region.A deta iled and rigorous study of the gate-induced noise in the reset MOSFET for the p hotodiode APS and improved photodiode APS are provided.The improvement of logari thmic response APS is analyzed and the simulation results show that the gate-in duced noise can be reduced.展开更多
文摘目的:探讨玫瑰痤疮患者采用低能量Pixel调Q像束激光与米诺环素联合治疗后红斑情况及面部功能改善情况。方法:研究对象选自于2020年3月-2023年7月在上海交通大学医学院苏州九龙医院接受治疗的玫瑰痤疮患者110例,并分为对照组和观察组,每组例数均为55例,分组方法为随机数字表法。对照组给予盐酸米诺环素片,在对照组患者治疗的基础上,采用低能量Pixel调Q像束激光对观察组患者进行治疗。两组治疗时间均为6周。比较两组临床疗效(治疗6周后),玫瑰痤疮情况、整体病情、p38丝裂原活化蛋白激酶(p38 mitogen activated protein kinase,p38MAPK)通路蛋白、生活质量、红斑情况、面部功能、炎性因子(治疗前、治疗6周后),不良反应(治疗期间)。结果:治疗6周后,观察组总有效率高于对照组(76.36%vs.54.55%,P<0.05)。与治疗前比较,两组治疗6周后的玫瑰痤疮医师全球评分(Patient's global assessment,PGA)、整体病情评估(Investigator global assessment,IGA)、皮肤病生活质量量表(Dermatology life quality index,DLQI)评分、红斑评估量表(Clinician′s erythema assessment,CEA)评分、皮损区红斑指数(Erythema index,EI)、经皮水分丢失(Trans epidermal water loss,TEWL)、皮肤酸碱度(Pondus Hydrogenii,pH)值、炎性因子及p38MAPK通路蛋白相关因子水平均降低,且相比于对照组,观察组更低;两组角质层含水量均升高,且相比于对照组,观察组更高(P<0.05)。观察组和对照组治疗期间的不良反应发生率比较差异无统计学意义(P>0.05)。结论:玫瑰痤疮患者经低能量Pixel调Q像束激光联合米诺环素治疗后,其相关临床症状可得到有效缓解,炎症反应得以减轻,并可调节p38MAPK信号通路蛋白的表达,进一步可促进患者红斑情况及面部功能的改善,进而促使患者生活质量及临床疗效得以提高,且具有良好的安全性。
基金supported by the National Natural Science Foundation of China(Nos.11875274 and U1232202)。
文摘In the research and development of new silicon pixel detectors,a collimated monoenergetic charged-particle test beam equipped with a high-resolution pixel-beam telescope is crucial for prototype verification and performance evaluation.When the beam energy is low,the effect of multiple Coulomb scattering on the measured resolution of the Device Under Test(DUT)must be considered to accurately evaluate the performance of the pixel chips and detectors.This study aimed to investigate the effect of multiple Coulomb scattering on the measured resolution,particularly at low beam energies.Simulations were conducted using Allpix^(2) to study the effects of multiple Coulomb scattering under different beam energies,material budgets,and telescope layouts.The simulations also provided the minimum energy at which the effect of multiple Coulomb scattering could be ignored.Compared with the results of a five-layer detector system tested with an electron beam at DESY,the simulation results were consistent with the beam test results,confirming the reliability of the simulations.
文摘A three-transistor active pixel sensor and its double sampling readout circuit implemented by a switch capacitor amplifier are designed. The circuit is embedded in a 64 × 64 pixel array CMOS image sensor and success-fully taped out with a Chartered 0.35μm process. The pixel pitch is 8μm × 8μm with a fill factor of 57%, the photo-sensitivity is 0.8V/（lux · s） ,and the dynamic range is 50dB. Theoretical analysis and test results indicate that as the process is scaled down, a smaller pixel pitch reduces the sensitivity. A deep junction n-well/p-substrate photodiode with a reasonable fill factor and high sensitivity are more appropriate for submicron processes.
基金Project supported by the National Natural Science Foundation of China （Grant Nos.60372090, 60502039）, and the Key Project of Shanghai Municipality for Basic Research （Grant No.04JC14037）
文摘We present a novel scheme for embedding secret data into a binary image without introducing noticeable artifacts. Unlike some block-based methods, the proposed scheme encodes the secret bits directly into boundary pixels by checking each pixel of the cover image in a pseudo-random order for embedding eligibility. A set of rules ensures correct identification of data-carrying pixels in blind extraction. The proposed scheme does not generate isolated dots, and can incorporate various coding methods such as matrix encoding to further improve the embedding performance. It is shown that up to one fourth of the boundary pixels may be used to carry secret data. Experimental results indicate that the method can achieve good visual quality with fairly large data capacity.
文摘A detailed principle and a rigorous analysis of a new noise,the gate-induced noise,in pixel MOSFET of CMOS imagers are provided.The gate-induced noise of the MOSFET is more notable in the strong reversion region than that in the subthreshold region when the applied gate voltage is low.However,the applied gate voltage being up to 3V,the gate-induced noise is more notable with the ω/ω T increasing when the MOSFET operates in the subthreshold region than that in the strong reversion region.Between the photocurrent I D and the root mean square value of the gated-induced noise,current i 2 d presents the relation of i 2 d∝I D in the saturation region of the strong reversion and approximately i 2 d∝I D in the subthreshold region.A deta iled and rigorous study of the gate-induced noise in the reset MOSFET for the p hotodiode APS and improved photodiode APS are provided.The improvement of logari thmic response APS is analyzed and the simulation results show that the gate-in duced noise can be reduced.
