BACKGROUND The effect of perioperative blood transfusion(PBT)on the prognosis of ampullary carcinoma(AC)is still debated.AIM To explore the impact of PBT on short-term safety and long-term survival in AC patients who ...BACKGROUND The effect of perioperative blood transfusion(PBT)on the prognosis of ampullary carcinoma(AC)is still debated.AIM To explore the impact of PBT on short-term safety and long-term survival in AC patients who underwent pancreaticoduodenectomy.METHODS A total of 257 patients with AC who underwent pancreaticoduodenectomy between 1998 and 2020 in the Cancer Hospital,Chinese Academy of Medical Sciences,were retrospectively analyzed.We used Cox proportional hazard regression to identify prognostic factors of overall survival(OS)and recurrencefree survival(RFS)and the Kaplan-Meier method to analyze survival information.RESULTS A total of 144(56%)of 257 patients received PBT.The PBT group and nonperioperative blood transfusion group showed no significant differences in demographics.Patients who received transfusion had a comparable incidence of postoperative complications with patients who did not.Univariable and multivariable Cox proportional hazard regression analyses indicated that transfusion was not an independent predictor of OS or RFS.We performed Kaplan-Meier analysis according to subgroups of T stage,and subgroup analysis indicated that PBT might be associated with worse OS(P<0.05)but not RFS in AC of stage T1.CONCLUSION We found that PBT might be associated with decreased OS in early AC,but more validation is needed.The reasonable use of transfusion might be helpful to improve OS.展开更多
Background The age, creatinine levels, and the ejection fraction Ⅱ score(ACEF Ⅱ score) are significant indicators for assessing inflammation and predicting adverse outcomes following cardiac surgery. Our objective w...Background The age, creatinine levels, and the ejection fraction Ⅱ score(ACEF Ⅱ score) are significant indicators for assessing inflammation and predicting adverse outcomes following cardiac surgery. Our objective was to investigate the predictive value of the recently updated ACEF Ⅱ score concerning perioprative blood transfusion in adult patients undergoing cardiac surgery. Methods A retrospective review was conducted involving adults(≥18 years) who underwent cardiac surgery for heart disease between January 2019 and June 2019. The primary outcome measure was perioperative blood transfusion among adult patients. Multivariable logistic regression and receiver operation characteristic(ROC) analysis were applied to analyze the link between the ACEF Ⅱ score and perioperative blood transfusion. Results A total of 415 patients were included, participants were stratified into three groups based on their ACEF Ⅱ scores level: ACEF Ⅱ <0.666, 0.666 ≤ ACEF Ⅱ <0.950, and 0.950 ≤ ACEF II ≤4.781. Multivariable Logistic regression analysis indicated that a high ACEF Ⅱ score(OR: 3.59, 95% CI: 1.68-7.67, P<0.001) was independently associated with an increased risk of perioperative blood transfusion among adults undergoing cardiac surgery. Furthermore, the area under the receiver operating characteristic curve for predicting perioperative blood transfusion risk using the ACEF Ⅱ score was found to be 0.607. The Pearson correlation coefficient showed a direct and statistically significant positive correlation between ACEF Ⅱ score and perioperative blood transfusion(r=0.17, P<0.001). Conclusions In conclusion, our findings suggested that the ACEF Ⅱ score possessed significant predictive value regarding related to perioperative blood transfusions during cardiac surgical procedures in adult patients. The higher the ACEF Ⅱ score, the higher incidence of perioperative blood transfusions.展开更多
文摘BACKGROUND The effect of perioperative blood transfusion(PBT)on the prognosis of ampullary carcinoma(AC)is still debated.AIM To explore the impact of PBT on short-term safety and long-term survival in AC patients who underwent pancreaticoduodenectomy.METHODS A total of 257 patients with AC who underwent pancreaticoduodenectomy between 1998 and 2020 in the Cancer Hospital,Chinese Academy of Medical Sciences,were retrospectively analyzed.We used Cox proportional hazard regression to identify prognostic factors of overall survival(OS)and recurrencefree survival(RFS)and the Kaplan-Meier method to analyze survival information.RESULTS A total of 144(56%)of 257 patients received PBT.The PBT group and nonperioperative blood transfusion group showed no significant differences in demographics.Patients who received transfusion had a comparable incidence of postoperative complications with patients who did not.Univariable and multivariable Cox proportional hazard regression analyses indicated that transfusion was not an independent predictor of OS or RFS.We performed Kaplan-Meier analysis according to subgroups of T stage,and subgroup analysis indicated that PBT might be associated with worse OS(P<0.05)but not RFS in AC of stage T1.CONCLUSION We found that PBT might be associated with decreased OS in early AC,but more validation is needed.The reasonable use of transfusion might be helpful to improve OS.
文摘Background The age, creatinine levels, and the ejection fraction Ⅱ score(ACEF Ⅱ score) are significant indicators for assessing inflammation and predicting adverse outcomes following cardiac surgery. Our objective was to investigate the predictive value of the recently updated ACEF Ⅱ score concerning perioprative blood transfusion in adult patients undergoing cardiac surgery. Methods A retrospective review was conducted involving adults(≥18 years) who underwent cardiac surgery for heart disease between January 2019 and June 2019. The primary outcome measure was perioperative blood transfusion among adult patients. Multivariable logistic regression and receiver operation characteristic(ROC) analysis were applied to analyze the link between the ACEF Ⅱ score and perioperative blood transfusion. Results A total of 415 patients were included, participants were stratified into three groups based on their ACEF Ⅱ scores level: ACEF Ⅱ <0.666, 0.666 ≤ ACEF Ⅱ <0.950, and 0.950 ≤ ACEF II ≤4.781. Multivariable Logistic regression analysis indicated that a high ACEF Ⅱ score(OR: 3.59, 95% CI: 1.68-7.67, P<0.001) was independently associated with an increased risk of perioperative blood transfusion among adults undergoing cardiac surgery. Furthermore, the area under the receiver operating characteristic curve for predicting perioperative blood transfusion risk using the ACEF Ⅱ score was found to be 0.607. The Pearson correlation coefficient showed a direct and statistically significant positive correlation between ACEF Ⅱ score and perioperative blood transfusion(r=0.17, P<0.001). Conclusions In conclusion, our findings suggested that the ACEF Ⅱ score possessed significant predictive value regarding related to perioperative blood transfusions during cardiac surgical procedures in adult patients. The higher the ACEF Ⅱ score, the higher incidence of perioperative blood transfusions.
