The mechanism underlying the pathogenesis of severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection in humans is poorly understood,although the cellular receptors which facilitate the virus fusion have b...The mechanism underlying the pathogenesis of severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection in humans is poorly understood,although the cellular receptors which facilitate the virus fusion have been identified.Although the major symptoms of the infection have been identified as acute respiratory distress,pneumonia,and fever,recently,symptoms involving nervous system dysfunctions,including encephalopathy and stroke,have been detected.Herein,we comprehensively review the evidence that SARS-CoV-2 infection involves a neurotropic mechanism including a nose-brain-lung axis suggesting implications in therapy development.展开更多
基金(This work is partly supported by a University of South Florida Pandemic Response Research Network funding for COVID-19 and Veterans Affairs Merit Review grant)(and Research Career Scientist Awards to Dr.Subhra Mohapatra)+4 种基金in partby the Department of Veterans AffairsVeterans Health AdministrationOffice of Research and Developmentthe contents of this report do not represent the views of the Department of Veterans Affairs or the United States Government
文摘The mechanism underlying the pathogenesis of severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection in humans is poorly understood,although the cellular receptors which facilitate the virus fusion have been identified.Although the major symptoms of the infection have been identified as acute respiratory distress,pneumonia,and fever,recently,symptoms involving nervous system dysfunctions,including encephalopathy and stroke,have been detected.Herein,we comprehensively review the evidence that SARS-CoV-2 infection involves a neurotropic mechanism including a nose-brain-lung axis suggesting implications in therapy development.
