Fuzzy ontologics are efficient tools to handle fuzzy and uncertain knowledge on the semantic web; but there are heterogeneity problems when gaining interoperability among different fuzzy ontologies. This paper uses co...Fuzzy ontologics are efficient tools to handle fuzzy and uncertain knowledge on the semantic web; but there are heterogeneity problems when gaining interoperability among different fuzzy ontologies. This paper uses concept approximation between fuzzy ontologies based on instances to solve the heterogeneity problems. It firstly proposes an instance selection technology based on instance clustering and weighting to unify the fuzzy interpretation of different ontologies and reduce the number of instances to increase the efficiency. Then the paper resolves the problem of computing the approximations of concepts into the problem of computing the least upper approximations of atom concepts. It optimizes the search strategies by extending atom concept sets and defining the least upper bounds of concepts to reduce the searching space of the problem. An efficient algorithm for searching the least upper bounds of concept is given.展开更多
目的:研究影响脑卒中发病的危险因素,构建及应用脑卒中发病概率预测模型,为临床防治脑卒中提供依据。方法:采用病例对照研究法,收集辖区内收治的脑卒中病例162例,以内科同期收治的非脑卒中慢性病住院患者184例为对照,以多因素非条件Logi...目的:研究影响脑卒中发病的危险因素,构建及应用脑卒中发病概率预测模型,为临床防治脑卒中提供依据。方法:采用病例对照研究法,收集辖区内收治的脑卒中病例162例,以内科同期收治的非脑卒中慢性病住院患者184例为对照,以多因素非条件Logi st i c回归模型为基本依据,通过Logi st i c回归建立脑卒中发病概率预测模型,然后采用ROC曲线法对概率预测模型进行评价。本研究倾向评分法将6个因素指标融为一个综合指标-倾向评分。结果:有意义的变量数仅有6个,从变量数来看适合Logi st i c回归模型和倾向评分法,发现影响脑卒中发病的危险因素包括年龄、高血压、CHOL、TG、HDL-C、LDL-C等,预测准确率能达到90.2%。结论:Logi st i c回归模型能较为准确地预测脑卒中发病概率,而倾向评分表能较好地反映出研究对象的发病危险程度、对脑卒中进行危险评分分层,所构建的Excel脑卒中发病概率预测模型,具有较好的推广应用价值。展开更多
In equipment integrated logistics support(ILS), the supply capability of spare parts is a significant factor. There are lots of depots in the traditional support system, which makes too many redundant spare parts and ...In equipment integrated logistics support(ILS), the supply capability of spare parts is a significant factor. There are lots of depots in the traditional support system, which makes too many redundant spare parts and causes high cost of support. Meanwhile,the inconsistency among depots makes it difficult to manage spare parts. With the development of information technology and transportation, the supply network has become more efficient. In order to further improve the efficiency of supply-support work and the availability of the equipment system, building a system of one centralized depot with multiple depots becomes an appropriate way.In this case, location selection of the depots including centralized depots and multiple depots becomes a top priority in the support system. This paper will focus on the location selection problem of centralized depots considering ILS factors. Unlike the common location selection problem, depots in ILS require a higher service level. Therefore, it becomes desperately necessary to take the high requirement of the mission into account while determining location of depots. Based on this, we raise an optimal depot location model. First, the expected transportation cost is calculated.Next, factors in ILS such as response time, availability and fill rate are analyzed for evaluating positions of open depots. Then, an optimization model of depot location is developed with the minimum expected cost of transportation as objective and ILS factors as constraints. Finally, a numerical case is studied to prove the validity of the model by using the genetic algorithm. Results show that depot location obtained by this model can guarantee the effectiveness and capability of ILS well.展开更多
With the evolution of application system, there are t wo different system architectures. One is the traditional application system suc h as MIS and Business Software. Along with its extension, the traditional applic a...With the evolution of application system, there are t wo different system architectures. One is the traditional application system suc h as MIS and Business Software. Along with its extension, the traditional applic ation system transforms from file-based structure to C/S and then CSS model. At the same time, following the prevalence of Internet/Intranet, Web application s ystem based on browser comes into being. In early time, Web application only pro vided functions of looking over or querying static data on browser. But with the development of Internet/Intranet widely, it’s expected that more and more trad itional applications can be performed on browser, or even E-Business trades and other complicated application systems such as MIS, ERP and CRM and so on. In or der to satisfy both traditional application and Web application, reduce the cost of developing system repeatedly, increase the repeated use of application syste m and take advantage of the functions of OOA/OOD sufficiently, a new distributed architecture structure (system solution based on repeated components) comes for th. In this article, this distributed architecture structure will be discuss ed in detail. Firstly, the evolution of traditional application system and Web application sys tem will be talked over, especially the advantages and disadvantages of these tw o architectures. Secondly, the distributed architecture (system solution based o n repeated components) will be described particular. Several prevalent technolog y of component, such as COM+, CORBA and EJB, will also be illustrate d in this part. Thirdly, the practice of the technology of repeated component wi ll be discussed by analysing and designing the management system of Science & Te chnology Articles. Lastly, the latest distributed techonlogy of E-business(Web service based on xml/soap) will be discussed. In the end, Based on summing-up o f the distributed technology of E-Business, the future distributed tenchnology of E-Business will be expected.展开更多
The third in ter nati onal sta ndardizati on excha nge meeting themed on urban sustainability and high-quality development recently took place in Beijing, attracting nearly 140 representatives from ISO/TC 268 (sustain...The third in ter nati onal sta ndardizati on excha nge meeting themed on urban sustainability and high-quality development recently took place in Beijing, attracting nearly 140 representatives from ISO/TC 268 (sustainable cities and comm uni ties), CNIS, Nati onal En ergy Conservation Center, China Academy of Information and Communication Tech no logy, etc.展开更多
基于农户调查数据,采用条件价值评估法(CVM)和排序Logi st i c模型,对鄱阳湖湿地农户生态补偿受偿意愿及其影响因素进行分析。研究结果表明:研究区内具有生态补偿受偿意愿的农户占被调查农户总数的89.49%,农户户均年受偿意愿值为5531.08...基于农户调查数据,采用条件价值评估法(CVM)和排序Logi st i c模型,对鄱阳湖湿地农户生态补偿受偿意愿及其影响因素进行分析。研究结果表明:研究区内具有生态补偿受偿意愿的农户占被调查农户总数的89.49%,农户户均年受偿意愿值为5531.08元;被调查农户的受教育年数、家庭人口数、家庭主要收入来源、家庭居住位置、是否重视对湿地环境的改善、耕地面积和承包水域面积与农户受偿意愿呈现显著相关性。展开更多
In 2011,Hanahan and Weinberg added“Deregulating Cellular Energetics”and“Avoiding Immune Destruction”to the six previous hallmarks of cancer.Since this seminal paper,there has been a growing consensus that these ne...In 2011,Hanahan and Weinberg added“Deregulating Cellular Energetics”and“Avoiding Immune Destruction”to the six previous hallmarks of cancer.Since this seminal paper,there has been a growing consensus that these new hallmarks are not mutually exclusive but rather interdependent.The following review summarizes how founding genetic events for tumorigenesis ultimately increase tumor cell glycolysis,which not only supports the metabolic demands of malignancy but also provides an immunoprotective niche,promoting malignant cell proliferation,maintenance and progression.The mechanisms by which altered metabolism contributes to immune impairment are multifactorial:(1)the metabolic demands of proliferating tumor cells and activated immune cells are similar,thus creating a situation where immune cells may be in competition for key nutrients;(2)the metabolic byproducts of aerobic glycolysis directly inhibit antitumor immunity while promoting a regulatory immune phenotype;and(3)the gene programs associated with the upregulation of glycolysis also result in the generation of immunosuppressive cytokines and metabolites.From this perspective,we shed light on important considerations for the development of new classes of agents targeting cancer metabolism.These types of therapies can impair tumor growth but also pose a significant risk of stifling antitumor immunity.展开更多
Doubled haploid(DH) technology is used to obtain homozygous lines in a single generation, a technique that significantly accelerates the crop breeding trajectory. Traditionally, in vitro culture is used to generate DH...Doubled haploid(DH) technology is used to obtain homozygous lines in a single generation, a technique that significantly accelerates the crop breeding trajectory. Traditionally, in vitro culture is used to generate DHs, but this technique is limited by species and genotype recalcitrance. In vivo haploid induction(HI) through seed is widely and efficiently used in maize and was recently extended to several other crops. Here we show that in vivo HI can be triggered by mutation of DMP maternal haploid inducer genes in allopolyploid(allotetraploid) Brassica napus and Nicotiana tabacum. We developed a pipeline for selection of DMP orthologs for clustered regularly interspaced palindromic repeats mutagenesis and demonstrated average amphihaploid induction rates of2.4% and 1.2% in multiple B. napus and N. tabacum genotypes, respectively. These results further confirmed the HI ability of DMP gene in polyploid dicot crops. The DMP-HI system offers a novel DH technology to facilitate breeding in these crops. The success of this approach and the conservation of DMP genes in dicots suggest the broad applicability of this technique in other dicot crops.展开更多
基金Supported by the National Natural Science Foundation of China(60373066 , 60425206 , 90412003) , National Grand Fundamental Research 973Programof China(2002CB312000) , National Research Foundationfor the DoctoralProgramof Higher Education of China (20020286004)
文摘Fuzzy ontologics are efficient tools to handle fuzzy and uncertain knowledge on the semantic web; but there are heterogeneity problems when gaining interoperability among different fuzzy ontologies. This paper uses concept approximation between fuzzy ontologies based on instances to solve the heterogeneity problems. It firstly proposes an instance selection technology based on instance clustering and weighting to unify the fuzzy interpretation of different ontologies and reduce the number of instances to increase the efficiency. Then the paper resolves the problem of computing the approximations of concepts into the problem of computing the least upper approximations of atom concepts. It optimizes the search strategies by extending atom concept sets and defining the least upper bounds of concepts to reduce the searching space of the problem. An efficient algorithm for searching the least upper bounds of concept is given.
文摘目的:研究影响脑卒中发病的危险因素,构建及应用脑卒中发病概率预测模型,为临床防治脑卒中提供依据。方法:采用病例对照研究法,收集辖区内收治的脑卒中病例162例,以内科同期收治的非脑卒中慢性病住院患者184例为对照,以多因素非条件Logi st i c回归模型为基本依据,通过Logi st i c回归建立脑卒中发病概率预测模型,然后采用ROC曲线法对概率预测模型进行评价。本研究倾向评分法将6个因素指标融为一个综合指标-倾向评分。结果:有意义的变量数仅有6个,从变量数来看适合Logi st i c回归模型和倾向评分法,发现影响脑卒中发病的危险因素包括年龄、高血压、CHOL、TG、HDL-C、LDL-C等,预测准确率能达到90.2%。结论:Logi st i c回归模型能较为准确地预测脑卒中发病概率,而倾向评分表能较好地反映出研究对象的发病危险程度、对脑卒中进行危险评分分层,所构建的Excel脑卒中发病概率预测模型,具有较好的推广应用价值。
基金supported by the Science Challenge Project(TZ2018007)the National Natural Science Foundation of China(71671009+2 种基金 61871013 61573041 61573043)
文摘In equipment integrated logistics support(ILS), the supply capability of spare parts is a significant factor. There are lots of depots in the traditional support system, which makes too many redundant spare parts and causes high cost of support. Meanwhile,the inconsistency among depots makes it difficult to manage spare parts. With the development of information technology and transportation, the supply network has become more efficient. In order to further improve the efficiency of supply-support work and the availability of the equipment system, building a system of one centralized depot with multiple depots becomes an appropriate way.In this case, location selection of the depots including centralized depots and multiple depots becomes a top priority in the support system. This paper will focus on the location selection problem of centralized depots considering ILS factors. Unlike the common location selection problem, depots in ILS require a higher service level. Therefore, it becomes desperately necessary to take the high requirement of the mission into account while determining location of depots. Based on this, we raise an optimal depot location model. First, the expected transportation cost is calculated.Next, factors in ILS such as response time, availability and fill rate are analyzed for evaluating positions of open depots. Then, an optimization model of depot location is developed with the minimum expected cost of transportation as objective and ILS factors as constraints. Finally, a numerical case is studied to prove the validity of the model by using the genetic algorithm. Results show that depot location obtained by this model can guarantee the effectiveness and capability of ILS well.
文摘With the evolution of application system, there are t wo different system architectures. One is the traditional application system suc h as MIS and Business Software. Along with its extension, the traditional applic ation system transforms from file-based structure to C/S and then CSS model. At the same time, following the prevalence of Internet/Intranet, Web application s ystem based on browser comes into being. In early time, Web application only pro vided functions of looking over or querying static data on browser. But with the development of Internet/Intranet widely, it’s expected that more and more trad itional applications can be performed on browser, or even E-Business trades and other complicated application systems such as MIS, ERP and CRM and so on. In or der to satisfy both traditional application and Web application, reduce the cost of developing system repeatedly, increase the repeated use of application syste m and take advantage of the functions of OOA/OOD sufficiently, a new distributed architecture structure (system solution based on repeated components) comes for th. In this article, this distributed architecture structure will be discuss ed in detail. Firstly, the evolution of traditional application system and Web application sys tem will be talked over, especially the advantages and disadvantages of these tw o architectures. Secondly, the distributed architecture (system solution based o n repeated components) will be described particular. Several prevalent technolog y of component, such as COM+, CORBA and EJB, will also be illustrate d in this part. Thirdly, the practice of the technology of repeated component wi ll be discussed by analysing and designing the management system of Science & Te chnology Articles. Lastly, the latest distributed techonlogy of E-business(Web service based on xml/soap) will be discussed. In the end, Based on summing-up o f the distributed technology of E-Business, the future distributed tenchnology of E-Business will be expected.
文摘The third in ter nati onal sta ndardizati on excha nge meeting themed on urban sustainability and high-quality development recently took place in Beijing, attracting nearly 140 representatives from ISO/TC 268 (sustainable cities and comm uni ties), CNIS, Nati onal En ergy Conservation Center, China Academy of Information and Communication Tech no logy, etc.
文摘基于农户调查数据,采用条件价值评估法(CVM)和排序Logi st i c模型,对鄱阳湖湿地农户生态补偿受偿意愿及其影响因素进行分析。研究结果表明:研究区内具有生态补偿受偿意愿的农户占被调查农户总数的89.49%,农户户均年受偿意愿值为5531.08元;被调查农户的受教育年数、家庭人口数、家庭主要收入来源、家庭居住位置、是否重视对湿地环境的改善、耕地面积和承包水域面积与农户受偿意愿呈现显著相关性。
基金This work was supported by R01 CA217987(JCR),the Vanderbilt-Incyte Research Alliance(JCR),F30 CA247202(BIR)the American Association for Cancer Research(BIR and WKR)T32 GM00734742.The figures were made at Biorender.com.
文摘In 2011,Hanahan and Weinberg added“Deregulating Cellular Energetics”and“Avoiding Immune Destruction”to the six previous hallmarks of cancer.Since this seminal paper,there has been a growing consensus that these new hallmarks are not mutually exclusive but rather interdependent.The following review summarizes how founding genetic events for tumorigenesis ultimately increase tumor cell glycolysis,which not only supports the metabolic demands of malignancy but also provides an immunoprotective niche,promoting malignant cell proliferation,maintenance and progression.The mechanisms by which altered metabolism contributes to immune impairment are multifactorial:(1)the metabolic demands of proliferating tumor cells and activated immune cells are similar,thus creating a situation where immune cells may be in competition for key nutrients;(2)the metabolic byproducts of aerobic glycolysis directly inhibit antitumor immunity while promoting a regulatory immune phenotype;and(3)the gene programs associated with the upregulation of glycolysis also result in the generation of immunosuppressive cytokines and metabolites.From this perspective,we shed light on important considerations for the development of new classes of agents targeting cancer metabolism.These types of therapies can impair tumor growth but also pose a significant risk of stifling antitumor immunity.
基金supported by National Key Research and Development Program of China (2016YFD0101200, 2018YFD0100201)China Agriculture Research System of MOF and MARA, National Natural Science Foundation of China (91935303, 32001554)+1 种基金the 2020 Research Program of Sanya Yazhou Bay Science and Technology City (SKJC-2020-02-003)China Postdoctoral Science Foundation (2020TQ0356)
文摘Doubled haploid(DH) technology is used to obtain homozygous lines in a single generation, a technique that significantly accelerates the crop breeding trajectory. Traditionally, in vitro culture is used to generate DHs, but this technique is limited by species and genotype recalcitrance. In vivo haploid induction(HI) through seed is widely and efficiently used in maize and was recently extended to several other crops. Here we show that in vivo HI can be triggered by mutation of DMP maternal haploid inducer genes in allopolyploid(allotetraploid) Brassica napus and Nicotiana tabacum. We developed a pipeline for selection of DMP orthologs for clustered regularly interspaced palindromic repeats mutagenesis and demonstrated average amphihaploid induction rates of2.4% and 1.2% in multiple B. napus and N. tabacum genotypes, respectively. These results further confirmed the HI ability of DMP gene in polyploid dicot crops. The DMP-HI system offers a novel DH technology to facilitate breeding in these crops. The success of this approach and the conservation of DMP genes in dicots suggest the broad applicability of this technique in other dicot crops.
