BACKGROUND Kidney transplantation is the most effective means to treat patients with renal failure,but its postoperative problems such as rejection reactions,immunosuppressant poisoning,chronic transplant kidney nephr...BACKGROUND Kidney transplantation is the most effective means to treat patients with renal failure,but its postoperative problems such as rejection reactions,immunosuppressant poisoning,chronic transplant kidney nephropathy,etc.still have not been effectively solved.This study searched for literature on traditional Chinese medicine(TCM)syndromes after kidney transplantation in China,conducted statistical analysis of the results,and sought to identify the underlying patterns.AIM To understand the TCM syndromes after renal transplantation and associated rules and provide a theoretical basis for further clinical research.METHODS The literature pertaining to TCM syndromes in renal transplantation,published in the China National Knowledge Infrastructure,Wanfang database,and WIP database from 1970 to 2021,was meticulously searched and comprehensively and statistically analyzed.RESULTS Following the established inclusion and exclusion criteria,13 studies were selected for analysis.Post-renal transplantation,no significant discrepancy was noted among the groups based on the location of TCM viscera.However,when categorized according to TCM pathogenic factors,the groups with spleen and kidney yang deficiency,as well as liver and kidney yin deficiency,exhibited a statistically significant difference in the frequency.CONCLUSION Currently,the research on TCM syndromes pertaining to renal transplantation is in its nascent phase.It is imperative to conduct a multicentric,large-scale survey of TCM syndromes subsequent to renal transplantation in the ensuing years.展开更多
In recent years,diabetes has posed a serious threat to human health.Traditional Chinese medicine for lowering blood sugar has attracted much attention due to its unique advantages in the treatment of diabetes.This pap...In recent years,diabetes has posed a serious threat to human health.Traditional Chinese medicine for lowering blood sugar has attracted much attention due to its unique advantages in the treatment of diabetes.This paper summarizes the research results on common traditional Chinese medicines for lowering blood sugar in recent years.These results lay a theoretical foundation for the future clinical development and use of hypoglycemic Chinese medicine,the improvement of the quality standards of hypoglycemic Chinese medicine,and the in-depth research on the mechanisms.展开更多
Chinese medicine prevention and treatment of gouty nephropathy often uses single drugs and compound formulae to regulate uric acid,which has the effect of lowering uric acid,protecting the kidneys and improving clinic...Chinese medicine prevention and treatment of gouty nephropathy often uses single drugs and compound formulae to regulate uric acid,which has the effect of lowering uric acid,protecting the kidneys and improving clinical symptoms.In conclusion,the mechanism of action of Chinese medicine against gouty nephropathy mainly involves oxidative stress,inflammatory response,etc.,with a view to providing new ideas and methods for the prevention and treatment of gouty nephropathy by Chinese medicine.展开更多
Autoimmune hepatitis is an inflammatory liver disease primarily mediated by T cell.It has not been fully elucidated about the pathogenesis,and it is presently thought to be related to genetic susceptibility,infection ...Autoimmune hepatitis is an inflammatory liver disease primarily mediated by T cell.It has not been fully elucidated about the pathogenesis,and it is presently thought to be related to genetic susceptibility,infection and environmental triggers,and abnormal autoimmune regulation.Recent studies have found that traditional Chinese medicine can improve the biochemical indicators and clinical symptoms of patients with autoimmune hepatitis.This article reviews the specific mechanism of traditional Chinese medicine on treating autoimmune hepatitis in order to propose new ideas for its clinical diagnosis and treatment.展开更多
Knee osteoarthritis(KOA)is a degenerative disease characterized by pathological changes in the cartilage and subchondral bone of the knee joint.Initially,knee joint pain is the main symptom,and in the later stages,def...Knee osteoarthritis(KOA)is a degenerative disease characterized by pathological changes in the cartilage and subchondral bone of the knee joint.Initially,knee joint pain is the main symptom,and in the later stages,deformities and mobility disorders may occur.Modern medicine lacks effective treatment methods for early and mid stage KOA,and has drawbacks such as significant side effects and high costs.A large number of stud‐ies have confirmed that traditional Chinese medicine has unique advantages in treating KOA,and has obvious advantages such as small trauma,low cost,and definite therapeu‐tic effect,which are gradually being accepted by a large number of KOA patients.The commonly used methods for preventing and treating KOA with traditional Chinese medicine in clinical practice include:oral administration of traditional Chinese medi‐cine,external application of traditional Chinese medicine,fumigation,acupuncture therapy,massage therapy for regulating tendons,and targeted penetration therapy of tra‐ditional Chinese medicine.According to relevant literature,traditional Chinese medicine can significantly alleviate knee joint symptoms and improve knee joint function in patients with knee osteoarthritis,which is of great significance for the prevention and treatment of knee osteoarthritis.This article provides a review of the research progress in the prevention and treatment of KOA using traditional Chinese medicine in recent years.展开更多
With the continuous development of medical technology,combined treatment of Chinese and Western medicine has gradually become a research hotspot.As a common disease in pediatrics,the treatment of Mycoplasma pneumoniae...With the continuous development of medical technology,combined treatment of Chinese and Western medicine has gradually become a research hotspot.As a common disease in pediatrics,the treatment of Mycoplasma pneumoniae pneumonia(MPP)in children is also being explored and improved.This article summarizes the research progress of combined Chinese and Western medicine treatment of MPP in children in recent years,aiming to provide a useful reference for the combined treatment of MPP in children.The article firstly introduces the etiology and pathogenesis of MPP in children,thereafter briefly introduces the Western anti-infective treatment and traditional Chinese medicine(TCM)diagnosis and treatment of MPP in children,and lastly introduces the methods of combined treatment of TCM and Western medicine in detail.The article points out that the combination of Chinese and Western medicine can give full play to the overall regulation of Chinese medicine and the precise treatment advantages of Western medicine,improve the therapeutic effect,reduce the use of antibiotics,and lower the recurrence rate of the disease,which is worthy of further research and promotion.展开更多
Sub-health,characterized by an imbalance of yin and yang within the organism.Traditional Chinese medicine(TCM)demonstrates distinct advantages and potential in the prevention and treatment of suboptimal health.This st...Sub-health,characterized by an imbalance of yin and yang within the organism.Traditional Chinese medicine(TCM)demonstrates distinct advantages and potential in the prevention and treatment of suboptimal health.This study innovatively focuses on common symptoms within five domains of the“Suboptimal Health Status Questionnaire-25”through a systematic review of relevant literature,it delves into the clinical research status and mechanistic advances of TCM interventions for suboptimal health-related symptoms.Document analysis demonstrates that TCM interventions have shown efficacy in ameliorating diverse symptoms in individuals with suboptimal health,can achieve the effect of bolstering immunity,maintaining metabolic equilibrium,and regulating the operations of internal organs to promote overall physical and mental well-being.Its mechanism of action is closely related to immune regulation,metabolic control,inflammation management,oxidative stress inhibition,hypothalamic-pituitary-adrenal axis and brain-gut axis.In summary,this paper offers a systematical review of clinical and preclinical studies on TCM interventions for sub-health symptom clusters,outlining the current research landscape and affording a more scientific and effective theoretical basis and clinical evidence for the application of TCM in the field of sub-health intervention.This is expected to promote the further application and development of TCM in the prevention and treatment of sub-health,offering new ideas and methods for addressing sub-health issues.展开更多
In recent years,the incidence rate of stroke has increased year by year.Post stroke depres‐sion is one of its main complications,which seriously affects the recovery of physiological functions and quality of life of ...In recent years,the incidence rate of stroke has increased year by year.Post stroke depres‐sion is one of its main complications,which seriously affects the recovery of physiological functions and quality of life of stroke patients.Traditional Chinese medicine has signifi‐cant therapeutic effects in treating this disease.This article provides a classification and review of traditional Chinese medicine treatment methods for post-stroke depression,and looks forward to the current problems.展开更多
Cancer pain,as a common complication in patients with malignant tumors,is regarded as the fifth vital sign.The involvement of traditional Chinese medicine(TCM)in the treatment of malignant tumors has become a distinct...Cancer pain,as a common complication in patients with malignant tumors,is regarded as the fifth vital sign.The involvement of traditional Chinese medicine(TCM)in the treatment of malignant tumors has become a distinctive feature of oncology treatment in China.It is also an important component of cancer pain management.TCM analgesic treatments include various methods,such as internal medicine and external therapies.External analgesic therapies,in particular,are significant methods in TCM pain management and offer both local treatment and systemic regulation.These methods are simple,easy to perform,and non-invasive.They can enhance pain relief effects while reducing the difficulty of oral medication intake and avoiding adverse gastrointestinal reactions,providing new perspectives and approaches for cancer pain treatment with broad development prospects.This article provides a review of the external TCM therapies for cancer pain to share with peers in the field.展开更多
AIM:To analyze the literature on the use of Chinese herbal medicines for the treatment of cholecystitis.METHODS:The literature on treatment of cholecystitis with traditional Chinese medicines(TCM) was analyzed based o...AIM:To analyze the literature on the use of Chinese herbal medicines for the treatment of cholecystitis.METHODS:The literature on treatment of cholecystitis with traditional Chinese medicines(TCM) was analyzed based on the principles and methods described by evidence-based medicine(EBM).Eight databases including MEDLINE,EMbase,Cochrane Central(CCTR),four Chinese databases(China Biological MedicineDatabase,Chinese National Knowledge Infrastructure Database,Database of Chinese Science and Technology Periodicals,Database of Chinese Ministry of Science and Technology) and Chinese Clinical Registry Center,were searched.Full text articles or abstracts concerning TCM treatment of cholecystitis were selected,categorized according to study design,the strength of evidence,the first author's hospital type,and analyzed statistically.RESULTS:A search of the literature published from 1977 through 2009 yielded 1468 articles in Chinese and 9 in other languages;and 93.92% of the articles focused on clinical studies.No article was of levelⅠevidence,and 9.26% were of level Ⅱ evidence.The literature cited by Science Citation Index(SCI),MEDLINE and core Chinese medical journals accounted for 0.41%,0.68% and 7.29%,respectively.Typically,the articles featured in case reports of illness,examined from the perspective of EBM,were weak in both quality and evidence level,which inconsistently conflicted with the fact that most of the papers were by authors from Level-3 hospitals,the highest possible level evaluated based on their comprehensive quality and academic authenticity in China.CONCLUSION:The published literature on TCM treatment of cholecystitis is of low quality and based on low evidence,and cognitive medicine may functions as a useful supplementary framework for the evaluation.展开更多
CLINICAL STUDIES Clinical studies on Chinese herbal medicine(CHM)in lung cancer(LC)have largely been on anumber of basic formulae selected by syndrome(Zheng)differentiation,or specific formula basedon clinical experie...CLINICAL STUDIES Clinical studies on Chinese herbal medicine(CHM)in lung cancer(LC)have largely been on anumber of basic formulae selected by syndrome(Zheng)differentiation,or specific formula basedon clinical experience.There have also been anumber of studies comparing combination ofCHMs with either chemotherapy or radiotherapywith chemotherapy or radiotherapy alone,to as-sess any additional benefits or synergistic outcomesof the combination.展开更多
At present, unified and effective treatment for hypertension with insomnia is still lacking, traditional Chinese medicine (TCM) nursing technology can improve insomnia symptoms, reduce blood pressure, alleviate fatigu...At present, unified and effective treatment for hypertension with insomnia is still lacking, traditional Chinese medicine (TCM) nursing technology can improve insomnia symptoms, reduce blood pressure, alleviate fatigue, improve anxiety, depression, improve the quality of life for patients with hypertension and insomnia. There is not only the application of the single TCM nursing technology, such as acupoint massage, acupoint application, ear acupoint pressure beans and so on, but also the application of two or a variety of TCM nursing techniques in hypertension with insomnia. In this article, the results of TCM nursing technology on hypertension with insomnia in recent years are reviewed in order to provide reference for the treatment of hypertensive with insomnia.展开更多
Recurrent miscarriage （RM） as a gynecological disorder was recognized by traditional Chinese medicine （TCM）practitioners long before the age of modern medicine. TCM physicians reported and recorded RM in the canon...Recurrent miscarriage （RM） as a gynecological disorder was recognized by traditional Chinese medicine （TCM）practitioners long before the age of modern medicine. TCM physicians reported and recorded RM in the canonical TCMliterature, which dates back more than 1500 years. The first cases of RM as a fertility abnormality were reported inChanjing, which was written during the Nanbei Dynasty of China （420 A.D. – 589 A.D.）. Some prescriptions for thetreatment of RM are still actively used by modern TCM practitioners. In addition, many recent pharmacological andclinical studies have focused on the TCM therapy for RM. To identify the new therapeutic targets for RM and furtherpromote the interest in treating RM with TCM, we reviewed the etiology, pathogenesis, treatment, and prevention of RMdiscussed both in the TCM literature and in contemporary pharmacological and clinical studies.展开更多
At present, unified and effective treatment for diabetic peripheral neuropathy （DPN） is still lacking, however Chinese medicine techniques characterized by syndrome differentiation and treatment, for example traditi...At present, unified and effective treatment for diabetic peripheral neuropathy （DPN） is still lacking, however Chinese medicine techniques characterized by syndrome differentiation and treatment, for example traditional Chinese medicine preparations, acupuncture, and fumigation, have been considered the promising alternative for DPN. Traditional Chinese medicine nursing, which is development on the basis of traditional Chinese medicine （TCM） theory, uses not only acupuncture, acupoint application and other treatments but also cares for the patient＇s diet and emotions in order to promote the recovery of skin and nerve endings in patients with DPN. Vast amounts of studies have explored the efficacies of various TCM nursing techniques in managing DPN, however, the article, which comprehensively documented these TCM nursing techniques in DNP patients, cannot be cap- tured. In the present article, we summarized the latest findings of TCM research on DPN in recent years in order to provide a reference for DPN.展开更多
Objective:To systematically analyze the basic information,research contents and related problems in the design of literature in the research field of traditional Chinese medicine(TCM) for irritable bowel syndrome,as w...Objective:To systematically analyze the basic information,research contents and related problems in the design of literature in the research field of traditional Chinese medicine(TCM) for irritable bowel syndrome,as well as to provide reliable evidence for improving clinical efficacy of IBS.Methods:Clinical observational literatures on the treatment of irritable bowel syndrome by TCM in 2009-2019 were searched in following Chinese databases:Chinese National Knowledge Infrastructure(CNKI),Wan Fang Database,China Science and Technology Journal Database(VIP).After selection,included studies were categorized by items as publication time,author regional distribution,treatment of TCM and control group,etc..Then we analyzed and evaluated the clinical effects of TCM treatment of irritable bowel syndrome.Results:1.Of the 986 literatures retrieved,318 met the inclusion criteria,and the number of relative literatures increased year by year.2.There were 224 literatures related to syndrome differentiation,in which 20 types of TCM syndromes were involved.The top three were the syndrome of disharmony between liver and spleen,deficiency of spleen Yang and kidney Yang and deficiency of spleen with damp retention,accounting for 53.12%、15.17% and 8.48%.3.There were 90 literatures on non-dialectical medication,among which Self-made Prescriptions(自拟方) were the most commonly used,accounting for 34.44%.4.There were 39.13% of the control group using antispasmodic.Among the antispasmodic,57.58% was Pinaverium bromide.5.Only 57 literatures were related to the recurrence rate,among which 54 showed a statistically significant difference between the two groups(P<0.05).6.There were 142 literatures involved in the observation of adverse reactions of patients,and the adverse reactions mainly included dryness in the mouth,constipation,abdominal pain,diarrhea,nausea,etc..7.After the evaluation of the quality of the included literature,it was found that among the types of randomized controlled trials(RCTs),5 was class Ⅰ,27 were class Ⅱ,and 273 were class Ⅲ;In non-randomized controlled trials,13 were all class Ⅲ.Conclusion:The number of literatures on TCM treatment for irritable bowel syndrome was increasing year by year,showing that more and more attention had been paid to the clinical application and research of TCM by clinical workers and researchers.While In the clinical research of TCM treatment of irritable bowel syndrome,there were some deficiencies,such as non-standard TCM syndrome type,the main subjects of this study were irritable bowel syndrome-D and the international scale for evaluation of irritable bowel syndrome was not used in most of the experiments.Therefore,it is an urgent need for more high-quality clinical research in attempts to provide enough and reliable evidence to guide the medical care.展开更多
Chinese medicine has been used for centuries to treat a range of health conditions.This history has produced a wealth of classical literature,case studies and clinical research data detailing its use and effectiveness...Chinese medicine has been used for centuries to treat a range of health conditions.This history has produced a wealth of classical literature,case studies and clinical research data detailing its use and effectiveness.However,high-quality and conclusive evidence that meets modern requirements for clinical decision support is lacking.This evidence gap limits the integration of Chinese medicine with contemporary medicine,which in turn limits global access and acceptance of Chinese medicine as a form of safe and effective health care.Over the past 20 years,researchers and organisations around the world,including the World Health Organization(WHO)and United Nations,have worked to support the integration of traditional medicines,such as Chinese medicine,with conventional medicines to improve global health care.This paper provides an overview of Chinese medicine studies published in the top four general medical journals(BMJ,JAMA,Lancet and New England Journal of Medicine)from February 2005 to February 2024 in the past 20 years to highlight the progress in the development of this evidence base.It also highlights key actions taken to promote evidence-based clinical Chinese medicine,including product and practitioner regulation,formalising education standards,and international collaborations.Research conducted at the China-Australia International Research Centre for Chinese Medicine demonstrates the benefits of such a collaboration.Through development of its unique and inclusive‘whole-evidence’approach,plus clinical studies and systematic reviews,the Centre has significantly contributed to the evidence base for clinical Chinese medicine.In addition,its high-impact papers and groundbreaking monographs have been cited in international conventional medicine guidelines.While progress has certainly been made during the past 20 years to build a stronger evidence base for clinical Chinese medicine,there is still a considerable gap that limits its integration with conventional medicine.Future funding and research are needed to continue this work and achieve to safe,effective and accessible traditional medicine as part of the WHO’s Universal Health Coverage strategy.展开更多
Objective To cater to the demands for personalized health services from a deep learning per-spective by investigating the characteristics of traditional Chinese medicine(TCM)constitu-tion data and constructing models ...Objective To cater to the demands for personalized health services from a deep learning per-spective by investigating the characteristics of traditional Chinese medicine(TCM)constitu-tion data and constructing models to explore new prediction methods.Methods Data from students at Chengdu University of Traditional Chinese Medicine were collected and organized according to the 24 solar terms from January 21,2020,to April 6,2022.The data were used to identify nine TCM constitutions,including balanced constitution,Qi deficiency constitution,Yang deficiency constitution,Yin deficiency constitution,phlegm dampness constitution,damp heat constitution,stagnant blood constitution,Qi stagnation constitution,and specific-inherited predisposition constitution.Deep learning algorithms were employed to construct multi-layer perceptron(MLP),long short-term memory(LSTM),and deep belief network(DBN)models for the prediction of TCM constitutions based on the nine constitution types.To optimize these TCM constitution prediction models,this study in-troduced the attention mechanism(AM),grey wolf optimizer(GWO),and particle swarm op-timization(PSO).The models’performance was evaluated before and after optimization us-ing the F1-score,accuracy,precision,and recall.Results The research analyzed a total of 31655 pieces of data.(i)Before optimization,the MLP model achieved more than 90%prediction accuracy for all constitution types except the balanced and Qi deficiency constitutions.The LSTM model's prediction accuracies exceeded 60%,indicating that their potential in TCM constitutional prediction may not have been fully realized due to the absence of pronounced temporal features in the data.Regarding the DBN model,the binary classification analysis showed that,apart from slightly underperforming in predicting the Qi deficiency constitution and damp heat constitution,with accuracies of 65%and 60%,respectively.The DBN model demonstrated considerable discriminative power for other constitution types,achieving prediction accuracy rates and area under the receiver op-erating characteristic(ROC)curve(AUC)values exceeding 70%and 0.78,respectively.This indicates that while the model possesses a certain level of constitutional differentiation abili-ty,it encounters limitations in processing specific constitutional features,leaving room for further improvement in its performance.For multi-class classification problem,the DBN model’s prediction accuracy rate fell short of 50%.(ii)After optimization,the LSTM model,enhanced with the AM,typically achieved a prediction accuracy rate above 75%,with lower performance for the Qi deficiency constitution,stagnant blood constitution,and Qi stagna-tion constitution.The GWO-optimized DBN model for multi-class classification showed an increased prediction accuracy rate of 56%,while the PSO-optimized model had a decreased accuracy rate to 37%.The GWO-PSO-DBN model,optimized with both algorithms,demon-strated an improved prediction accuracy rate of 54%.Conclusion This study constructed MLP,LSTM,and DBN models for predicting TCM consti-tution and improved them based on different optimisation algorithms.The results showed that the MLP model performs well,the LSTM and DBN models were effective in prediction but with certain limitations.This study also provided a new technology reference for the es-tablishment and optimisation strategies of TCM constitution prediction models,and a novel idea for the treatment of non-disease.展开更多
Traditional Chinese medicine(TCM)has an exemplary role in the treatment and prevention of diseases.However,the advancement of TCM has been constrained by several factors,including its intricate structure,low active in...Traditional Chinese medicine(TCM)has an exemplary role in the treatment and prevention of diseases.However,the advancement of TCM has been constrained by several factors,including its intricate structure,low active ingredient concentration,prolonged growth cycle,and the dfficulty in artificial cultivation.In recent years,research on the fermentation technology of TCM has increased.This paper provides an overview of the advantages of TCM fermentation technology,including efficiency enhancement and toxicity reduction,the development of new drugs,and the secondary utilization of dregs.Additionally,it discusses the progress of research on the application of fermented TCM in animal husbandry and disease treatment.The aim is to provide theoretical guidance for TCM fermentation technology research and the development of fermented TCM.展开更多
Due to increasing safety concerns regarding human consumption of fish products, an increasing number of medicinal chemicals are prohibited from use in aquaculture. As a result, Chinese herbal medicines are being incre...Due to increasing safety concerns regarding human consumption of fish products, an increasing number of medicinal chemicals are prohibited from use in aquaculture. As a result, Chinese herbal medicines are being increasingly used, coining the use of the term ＂green medicine.＂ Research shows that Chinese herbal medicines have many beneficial effects on fish, including growth promotion, enhancement of disease resistance, and improvement in meat quality. Many effective ingredients have been discovered in Chinese herbal medicines, which function to promote feed intake, improve meat flavor, and increase digestive enzyme activity. They also regulate and participate in processes that improve the specific and non-specific immunity of fish; however, the composition of Chinese herbal medicines is very complex and it is often difficult to identify the effective ingredients. This article reviews the latest research and application progress in Chinese herbal medicines regarding growth and feed utilization, immunity and disease resistance, and the meat quality of cultured fish. It also discusses research on the chemical constituents of classical Chinese medicinal herbs and problems with the application of Chinese herbal medicines in fish culture. This article concludes by proposing that future studies on Chinese herbal medicines should focus on how to cheaply refine and extract the effective ingredients in classical Chinese medicinal herbs, as well as how to use them efficiently in aquaculture.展开更多
Gastric cancer(GC)is a malignant tumor originating from the gastric epithelium,and its incidence and mortality rates rank third among all malignant tumors worldwide.It is also one of the most common cancers in China a...Gastric cancer(GC)is a malignant tumor originating from the gastric epithelium,and its incidence and mortality rates rank third among all malignant tumors worldwide.It is also one of the most common cancers in China and is treated predominantly by Western medicine in clinical practice.However,with the advancements in medical technology and informatics,the values of traditional Chinese medicine(TCM)in preventing and treating GC and improving prognosis have increasingly been recognized.According to TCM,clinical manifestations of GC can be divided into Yege(dysphagia),regurgitation,stomach pain,and Zhengxia(abdominal mass).Due to the unbalanced distribution of health care resources in China,most GC patients already have progressive or advanced-stage disease at the first diagnosis.As a result,most GC patients have poor physical function,and surgery or chemotherapy alone will aggravate the impairment to the immune function and seriously affect the quality of life.In contrast,TCM therapies have shown promising efficacy in the management of these patients.Here we review the role of the integrated TCM and Western medicine in treating advanced GC.展开更多
文摘BACKGROUND Kidney transplantation is the most effective means to treat patients with renal failure,but its postoperative problems such as rejection reactions,immunosuppressant poisoning,chronic transplant kidney nephropathy,etc.still have not been effectively solved.This study searched for literature on traditional Chinese medicine(TCM)syndromes after kidney transplantation in China,conducted statistical analysis of the results,and sought to identify the underlying patterns.AIM To understand the TCM syndromes after renal transplantation and associated rules and provide a theoretical basis for further clinical research.METHODS The literature pertaining to TCM syndromes in renal transplantation,published in the China National Knowledge Infrastructure,Wanfang database,and WIP database from 1970 to 2021,was meticulously searched and comprehensively and statistically analyzed.RESULTS Following the established inclusion and exclusion criteria,13 studies were selected for analysis.Post-renal transplantation,no significant discrepancy was noted among the groups based on the location of TCM viscera.However,when categorized according to TCM pathogenic factors,the groups with spleen and kidney yang deficiency,as well as liver and kidney yin deficiency,exhibited a statistically significant difference in the frequency.CONCLUSION Currently,the research on TCM syndromes pertaining to renal transplantation is in its nascent phase.It is imperative to conduct a multicentric,large-scale survey of TCM syndromes subsequent to renal transplantation in the ensuing years.
文摘In recent years,diabetes has posed a serious threat to human health.Traditional Chinese medicine for lowering blood sugar has attracted much attention due to its unique advantages in the treatment of diabetes.This paper summarizes the research results on common traditional Chinese medicines for lowering blood sugar in recent years.These results lay a theoretical foundation for the future clinical development and use of hypoglycemic Chinese medicine,the improvement of the quality standards of hypoglycemic Chinese medicine,and the in-depth research on the mechanisms.
基金National Natural Science Foundation of China(82360895)Yunnan Provincial Science and Technology Department Basic Research Program of Traditional Chinese Medicine Joint Special(2019FF002-028)+2 种基金Yunnan Key Laboratory of Formulated Granules(202105AG070014)Yunnan Provincial Department of Education Science Research Fund Project(2024Y371)National Administration of Traditional Chinese Medicine High-level Key Discipline Construction Project‘Dai Pharmacy’(ZYYZDXK-2023192).
文摘Chinese medicine prevention and treatment of gouty nephropathy often uses single drugs and compound formulae to regulate uric acid,which has the effect of lowering uric acid,protecting the kidneys and improving clinical symptoms.In conclusion,the mechanism of action of Chinese medicine against gouty nephropathy mainly involves oxidative stress,inflammatory response,etc.,with a view to providing new ideas and methods for the prevention and treatment of gouty nephropathy by Chinese medicine.
文摘Autoimmune hepatitis is an inflammatory liver disease primarily mediated by T cell.It has not been fully elucidated about the pathogenesis,and it is presently thought to be related to genetic susceptibility,infection and environmental triggers,and abnormal autoimmune regulation.Recent studies have found that traditional Chinese medicine can improve the biochemical indicators and clinical symptoms of patients with autoimmune hepatitis.This article reviews the specific mechanism of traditional Chinese medicine on treating autoimmune hepatitis in order to propose new ideas for its clinical diagnosis and treatment.
文摘Knee osteoarthritis(KOA)is a degenerative disease characterized by pathological changes in the cartilage and subchondral bone of the knee joint.Initially,knee joint pain is the main symptom,and in the later stages,deformities and mobility disorders may occur.Modern medicine lacks effective treatment methods for early and mid stage KOA,and has drawbacks such as significant side effects and high costs.A large number of stud‐ies have confirmed that traditional Chinese medicine has unique advantages in treating KOA,and has obvious advantages such as small trauma,low cost,and definite therapeu‐tic effect,which are gradually being accepted by a large number of KOA patients.The commonly used methods for preventing and treating KOA with traditional Chinese medicine in clinical practice include:oral administration of traditional Chinese medi‐cine,external application of traditional Chinese medicine,fumigation,acupuncture therapy,massage therapy for regulating tendons,and targeted penetration therapy of tra‐ditional Chinese medicine.According to relevant literature,traditional Chinese medicine can significantly alleviate knee joint symptoms and improve knee joint function in patients with knee osteoarthritis,which is of great significance for the prevention and treatment of knee osteoarthritis.This article provides a review of the research progress in the prevention and treatment of KOA using traditional Chinese medicine in recent years.
文摘With the continuous development of medical technology,combined treatment of Chinese and Western medicine has gradually become a research hotspot.As a common disease in pediatrics,the treatment of Mycoplasma pneumoniae pneumonia(MPP)in children is also being explored and improved.This article summarizes the research progress of combined Chinese and Western medicine treatment of MPP in children in recent years,aiming to provide a useful reference for the combined treatment of MPP in children.The article firstly introduces the etiology and pathogenesis of MPP in children,thereafter briefly introduces the Western anti-infective treatment and traditional Chinese medicine(TCM)diagnosis and treatment of MPP in children,and lastly introduces the methods of combined treatment of TCM and Western medicine in detail.The article points out that the combination of Chinese and Western medicine can give full play to the overall regulation of Chinese medicine and the precise treatment advantages of Western medicine,improve the therapeutic effect,reduce the use of antibiotics,and lower the recurrence rate of the disease,which is worthy of further research and promotion.
基金supported by the Innovation Team Project of the Clinical Basic Discipline of Traditional Chinese Medicine in the Science and Technology Innovation Project of the Chinese Academy of Chinese Medical Sciences(CI2021B003)the commissioned project of the China Association of Chinese Medicine“Review and Prospect of the 20-year Research on Sub-health Conditions”(202451-003)the scientific research project on integrated traditional Chinese and Western medicine of the Tianjin Municipal Health Commission(2023147).
文摘Sub-health,characterized by an imbalance of yin and yang within the organism.Traditional Chinese medicine(TCM)demonstrates distinct advantages and potential in the prevention and treatment of suboptimal health.This study innovatively focuses on common symptoms within five domains of the“Suboptimal Health Status Questionnaire-25”through a systematic review of relevant literature,it delves into the clinical research status and mechanistic advances of TCM interventions for suboptimal health-related symptoms.Document analysis demonstrates that TCM interventions have shown efficacy in ameliorating diverse symptoms in individuals with suboptimal health,can achieve the effect of bolstering immunity,maintaining metabolic equilibrium,and regulating the operations of internal organs to promote overall physical and mental well-being.Its mechanism of action is closely related to immune regulation,metabolic control,inflammation management,oxidative stress inhibition,hypothalamic-pituitary-adrenal axis and brain-gut axis.In summary,this paper offers a systematical review of clinical and preclinical studies on TCM interventions for sub-health symptom clusters,outlining the current research landscape and affording a more scientific and effective theoretical basis and clinical evidence for the application of TCM in the field of sub-health intervention.This is expected to promote the further application and development of TCM in the prevention and treatment of sub-health,offering new ideas and methods for addressing sub-health issues.
文摘In recent years,the incidence rate of stroke has increased year by year.Post stroke depres‐sion is one of its main complications,which seriously affects the recovery of physiological functions and quality of life of stroke patients.Traditional Chinese medicine has signifi‐cant therapeutic effects in treating this disease.This article provides a classification and review of traditional Chinese medicine treatment methods for post-stroke depression,and looks forward to the current problems.
基金National Natural Science Foundation of China(Project No.82104553)。
文摘Cancer pain,as a common complication in patients with malignant tumors,is regarded as the fifth vital sign.The involvement of traditional Chinese medicine(TCM)in the treatment of malignant tumors has become a distinctive feature of oncology treatment in China.It is also an important component of cancer pain management.TCM analgesic treatments include various methods,such as internal medicine and external therapies.External analgesic therapies,in particular,are significant methods in TCM pain management and offer both local treatment and systemic regulation.These methods are simple,easy to perform,and non-invasive.They can enhance pain relief effects while reducing the difficulty of oral medication intake and avoiding adverse gastrointestinal reactions,providing new perspectives and approaches for cancer pain treatment with broad development prospects.This article provides a review of the external TCM therapies for cancer pain to share with peers in the field.
文摘AIM:To analyze the literature on the use of Chinese herbal medicines for the treatment of cholecystitis.METHODS:The literature on treatment of cholecystitis with traditional Chinese medicines(TCM) was analyzed based on the principles and methods described by evidence-based medicine(EBM).Eight databases including MEDLINE,EMbase,Cochrane Central(CCTR),four Chinese databases(China Biological MedicineDatabase,Chinese National Knowledge Infrastructure Database,Database of Chinese Science and Technology Periodicals,Database of Chinese Ministry of Science and Technology) and Chinese Clinical Registry Center,were searched.Full text articles or abstracts concerning TCM treatment of cholecystitis were selected,categorized according to study design,the strength of evidence,the first author's hospital type,and analyzed statistically.RESULTS:A search of the literature published from 1977 through 2009 yielded 1468 articles in Chinese and 9 in other languages;and 93.92% of the articles focused on clinical studies.No article was of levelⅠevidence,and 9.26% were of level Ⅱ evidence.The literature cited by Science Citation Index(SCI),MEDLINE and core Chinese medical journals accounted for 0.41%,0.68% and 7.29%,respectively.Typically,the articles featured in case reports of illness,examined from the perspective of EBM,were weak in both quality and evidence level,which inconsistently conflicted with the fact that most of the papers were by authors from Level-3 hospitals,the highest possible level evaluated based on their comprehensive quality and academic authenticity in China.CONCLUSION:The published literature on TCM treatment of cholecystitis is of low quality and based on low evidence,and cognitive medicine may functions as a useful supplementary framework for the evaluation.
文摘CLINICAL STUDIES Clinical studies on Chinese herbal medicine(CHM)in lung cancer(LC)have largely been on anumber of basic formulae selected by syndrome(Zheng)differentiation,or specific formula basedon clinical experience.There have also been anumber of studies comparing combination ofCHMs with either chemotherapy or radiotherapywith chemotherapy or radiotherapy alone,to as-sess any additional benefits or synergistic outcomesof the combination.
文摘At present, unified and effective treatment for hypertension with insomnia is still lacking, traditional Chinese medicine (TCM) nursing technology can improve insomnia symptoms, reduce blood pressure, alleviate fatigue, improve anxiety, depression, improve the quality of life for patients with hypertension and insomnia. There is not only the application of the single TCM nursing technology, such as acupoint massage, acupoint application, ear acupoint pressure beans and so on, but also the application of two or a variety of TCM nursing techniques in hypertension with insomnia. In this article, the results of TCM nursing technology on hypertension with insomnia in recent years are reviewed in order to provide reference for the treatment of hypertensive with insomnia.
文摘Recurrent miscarriage （RM） as a gynecological disorder was recognized by traditional Chinese medicine （TCM）practitioners long before the age of modern medicine. TCM physicians reported and recorded RM in the canonical TCMliterature, which dates back more than 1500 years. The first cases of RM as a fertility abnormality were reported inChanjing, which was written during the Nanbei Dynasty of China （420 A.D. – 589 A.D.）. Some prescriptions for thetreatment of RM are still actively used by modern TCM practitioners. In addition, many recent pharmacological andclinical studies have focused on the TCM therapy for RM. To identify the new therapeutic targets for RM and furtherpromote the interest in treating RM with TCM, we reviewed the etiology, pathogenesis, treatment, and prevention of RMdiscussed both in the TCM literature and in contemporary pharmacological and clinical studies.
文摘At present, unified and effective treatment for diabetic peripheral neuropathy （DPN） is still lacking, however Chinese medicine techniques characterized by syndrome differentiation and treatment, for example traditional Chinese medicine preparations, acupuncture, and fumigation, have been considered the promising alternative for DPN. Traditional Chinese medicine nursing, which is development on the basis of traditional Chinese medicine （TCM） theory, uses not only acupuncture, acupoint application and other treatments but also cares for the patient＇s diet and emotions in order to promote the recovery of skin and nerve endings in patients with DPN. Vast amounts of studies have explored the efficacies of various TCM nursing techniques in managing DPN, however, the article, which comprehensively documented these TCM nursing techniques in DNP patients, cannot be cap- tured. In the present article, we summarized the latest findings of TCM research on DPN in recent years in order to provide a reference for DPN.
基金National Science and Technology Major Project(Major new drug de-velopment,NO.40883770)National Natural Science Foundation of China(NO.81774303)。
文摘Objective:To systematically analyze the basic information,research contents and related problems in the design of literature in the research field of traditional Chinese medicine(TCM) for irritable bowel syndrome,as well as to provide reliable evidence for improving clinical efficacy of IBS.Methods:Clinical observational literatures on the treatment of irritable bowel syndrome by TCM in 2009-2019 were searched in following Chinese databases:Chinese National Knowledge Infrastructure(CNKI),Wan Fang Database,China Science and Technology Journal Database(VIP).After selection,included studies were categorized by items as publication time,author regional distribution,treatment of TCM and control group,etc..Then we analyzed and evaluated the clinical effects of TCM treatment of irritable bowel syndrome.Results:1.Of the 986 literatures retrieved,318 met the inclusion criteria,and the number of relative literatures increased year by year.2.There were 224 literatures related to syndrome differentiation,in which 20 types of TCM syndromes were involved.The top three were the syndrome of disharmony between liver and spleen,deficiency of spleen Yang and kidney Yang and deficiency of spleen with damp retention,accounting for 53.12%、15.17% and 8.48%.3.There were 90 literatures on non-dialectical medication,among which Self-made Prescriptions(自拟方) were the most commonly used,accounting for 34.44%.4.There were 39.13% of the control group using antispasmodic.Among the antispasmodic,57.58% was Pinaverium bromide.5.Only 57 literatures were related to the recurrence rate,among which 54 showed a statistically significant difference between the two groups(P<0.05).6.There were 142 literatures involved in the observation of adverse reactions of patients,and the adverse reactions mainly included dryness in the mouth,constipation,abdominal pain,diarrhea,nausea,etc..7.After the evaluation of the quality of the included literature,it was found that among the types of randomized controlled trials(RCTs),5 was class Ⅰ,27 were class Ⅱ,and 273 were class Ⅲ;In non-randomized controlled trials,13 were all class Ⅲ.Conclusion:The number of literatures on TCM treatment for irritable bowel syndrome was increasing year by year,showing that more and more attention had been paid to the clinical application and research of TCM by clinical workers and researchers.While In the clinical research of TCM treatment of irritable bowel syndrome,there were some deficiencies,such as non-standard TCM syndrome type,the main subjects of this study were irritable bowel syndrome-D and the international scale for evaluation of irritable bowel syndrome was not used in most of the experiments.Therefore,it is an urgent need for more high-quality clinical research in attempts to provide enough and reliable evidence to guide the medical care.
文摘Chinese medicine has been used for centuries to treat a range of health conditions.This history has produced a wealth of classical literature,case studies and clinical research data detailing its use and effectiveness.However,high-quality and conclusive evidence that meets modern requirements for clinical decision support is lacking.This evidence gap limits the integration of Chinese medicine with contemporary medicine,which in turn limits global access and acceptance of Chinese medicine as a form of safe and effective health care.Over the past 20 years,researchers and organisations around the world,including the World Health Organization(WHO)and United Nations,have worked to support the integration of traditional medicines,such as Chinese medicine,with conventional medicines to improve global health care.This paper provides an overview of Chinese medicine studies published in the top four general medical journals(BMJ,JAMA,Lancet and New England Journal of Medicine)from February 2005 to February 2024 in the past 20 years to highlight the progress in the development of this evidence base.It also highlights key actions taken to promote evidence-based clinical Chinese medicine,including product and practitioner regulation,formalising education standards,and international collaborations.Research conducted at the China-Australia International Research Centre for Chinese Medicine demonstrates the benefits of such a collaboration.Through development of its unique and inclusive‘whole-evidence’approach,plus clinical studies and systematic reviews,the Centre has significantly contributed to the evidence base for clinical Chinese medicine.In addition,its high-impact papers and groundbreaking monographs have been cited in international conventional medicine guidelines.While progress has certainly been made during the past 20 years to build a stronger evidence base for clinical Chinese medicine,there is still a considerable gap that limits its integration with conventional medicine.Future funding and research are needed to continue this work and achieve to safe,effective and accessible traditional medicine as part of the WHO’s Universal Health Coverage strategy.
基金National Natural Science Foundation of China(81904324)Sichuan Science and Technology Department Project(2022YFS0194).
文摘Objective To cater to the demands for personalized health services from a deep learning per-spective by investigating the characteristics of traditional Chinese medicine(TCM)constitu-tion data and constructing models to explore new prediction methods.Methods Data from students at Chengdu University of Traditional Chinese Medicine were collected and organized according to the 24 solar terms from January 21,2020,to April 6,2022.The data were used to identify nine TCM constitutions,including balanced constitution,Qi deficiency constitution,Yang deficiency constitution,Yin deficiency constitution,phlegm dampness constitution,damp heat constitution,stagnant blood constitution,Qi stagnation constitution,and specific-inherited predisposition constitution.Deep learning algorithms were employed to construct multi-layer perceptron(MLP),long short-term memory(LSTM),and deep belief network(DBN)models for the prediction of TCM constitutions based on the nine constitution types.To optimize these TCM constitution prediction models,this study in-troduced the attention mechanism(AM),grey wolf optimizer(GWO),and particle swarm op-timization(PSO).The models’performance was evaluated before and after optimization us-ing the F1-score,accuracy,precision,and recall.Results The research analyzed a total of 31655 pieces of data.(i)Before optimization,the MLP model achieved more than 90%prediction accuracy for all constitution types except the balanced and Qi deficiency constitutions.The LSTM model's prediction accuracies exceeded 60%,indicating that their potential in TCM constitutional prediction may not have been fully realized due to the absence of pronounced temporal features in the data.Regarding the DBN model,the binary classification analysis showed that,apart from slightly underperforming in predicting the Qi deficiency constitution and damp heat constitution,with accuracies of 65%and 60%,respectively.The DBN model demonstrated considerable discriminative power for other constitution types,achieving prediction accuracy rates and area under the receiver op-erating characteristic(ROC)curve(AUC)values exceeding 70%and 0.78,respectively.This indicates that while the model possesses a certain level of constitutional differentiation abili-ty,it encounters limitations in processing specific constitutional features,leaving room for further improvement in its performance.For multi-class classification problem,the DBN model’s prediction accuracy rate fell short of 50%.(ii)After optimization,the LSTM model,enhanced with the AM,typically achieved a prediction accuracy rate above 75%,with lower performance for the Qi deficiency constitution,stagnant blood constitution,and Qi stagna-tion constitution.The GWO-optimized DBN model for multi-class classification showed an increased prediction accuracy rate of 56%,while the PSO-optimized model had a decreased accuracy rate to 37%.The GWO-PSO-DBN model,optimized with both algorithms,demon-strated an improved prediction accuracy rate of 54%.Conclusion This study constructed MLP,LSTM,and DBN models for predicting TCM consti-tution and improved them based on different optimisation algorithms.The results showed that the MLP model performs well,the LSTM and DBN models were effective in prediction but with certain limitations.This study also provided a new technology reference for the es-tablishment and optimisation strategies of TCM constitution prediction models,and a novel idea for the treatment of non-disease.
基金Supported by the Key Scientific Research Project of Higher Education Institutions in Henan Province(23A416003).
文摘Traditional Chinese medicine(TCM)has an exemplary role in the treatment and prevention of diseases.However,the advancement of TCM has been constrained by several factors,including its intricate structure,low active ingredient concentration,prolonged growth cycle,and the dfficulty in artificial cultivation.In recent years,research on the fermentation technology of TCM has increased.This paper provides an overview of the advantages of TCM fermentation technology,including efficiency enhancement and toxicity reduction,the development of new drugs,and the secondary utilization of dregs.Additionally,it discusses the progress of research on the application of fermented TCM in animal husbandry and disease treatment.The aim is to provide theoretical guidance for TCM fermentation technology research and the development of fermented TCM.
文摘Due to increasing safety concerns regarding human consumption of fish products, an increasing number of medicinal chemicals are prohibited from use in aquaculture. As a result, Chinese herbal medicines are being increasingly used, coining the use of the term ＂green medicine.＂ Research shows that Chinese herbal medicines have many beneficial effects on fish, including growth promotion, enhancement of disease resistance, and improvement in meat quality. Many effective ingredients have been discovered in Chinese herbal medicines, which function to promote feed intake, improve meat flavor, and increase digestive enzyme activity. They also regulate and participate in processes that improve the specific and non-specific immunity of fish; however, the composition of Chinese herbal medicines is very complex and it is often difficult to identify the effective ingredients. This article reviews the latest research and application progress in Chinese herbal medicines regarding growth and feed utilization, immunity and disease resistance, and the meat quality of cultured fish. It also discusses research on the chemical constituents of classical Chinese medicinal herbs and problems with the application of Chinese herbal medicines in fish culture. This article concludes by proposing that future studies on Chinese herbal medicines should focus on how to cheaply refine and extract the effective ingredients in classical Chinese medicinal herbs, as well as how to use them efficiently in aquaculture.
文摘Gastric cancer(GC)is a malignant tumor originating from the gastric epithelium,and its incidence and mortality rates rank third among all malignant tumors worldwide.It is also one of the most common cancers in China and is treated predominantly by Western medicine in clinical practice.However,with the advancements in medical technology and informatics,the values of traditional Chinese medicine(TCM)in preventing and treating GC and improving prognosis have increasingly been recognized.According to TCM,clinical manifestations of GC can be divided into Yege(dysphagia),regurgitation,stomach pain,and Zhengxia(abdominal mass).Due to the unbalanced distribution of health care resources in China,most GC patients already have progressive or advanced-stage disease at the first diagnosis.As a result,most GC patients have poor physical function,and surgery or chemotherapy alone will aggravate the impairment to the immune function and seriously affect the quality of life.In contrast,TCM therapies have shown promising efficacy in the management of these patients.Here we review the role of the integrated TCM and Western medicine in treating advanced GC.
