Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to p...Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.展开更多
After brain damage,regenerative angiogenesis and neurogenesis have been shown to occur simultaneously in mammals,suggesting a close link between these processes.However,the mechanisms by which these processes interact...After brain damage,regenerative angiogenesis and neurogenesis have been shown to occur simultaneously in mammals,suggesting a close link between these processes.However,the mechanisms by which these processes interact are not well understood.In this work,we aimed to study the correlation between angiogenesis and neurogenesis after a telencephalic stab wound injury.To this end,we used zebrafish as a relevant model of neuroplasticity and brain repair mechanisms.First,using the Tg(fli1:EGFP×mpeg1.1:mCherry)zebrafish line,which enables visualization of blood vessels and microglia respectively,we analyzed regenerative angiogenesis from 1 to 21 days post-lesion.In parallel,we monitored brain cell proliferation in neurogenic niches localized in the ventricular zone by using immunohistochemistry.We found that after brain damage,the blood vessel area and width as well as expression of the fli1 transgene and vascular endothelial growth factor(vegfaa and vegfbb)were increased.At the same time,neural stem cell proliferation was also increased,peaking between 3 and 5 days post-lesion in a manner similar to angiogenesis,along with the recruitment of microglia.Then,through pharmacological manipulation by injecting an anti-angiogenic drug(Tivozanib)or Vegf at the lesion site,we demonstrated that blocking or activating Vegf signaling modulated both angiogenic and neurogenic processes,as well as microglial recruitment.Finally,we showed that inhibition of microglia by clodronate-containing liposome injection or dexamethasone treatment impairs regenerative neurogenesis,as previously described,as well as injury-induced angiogenesis.In conclusion,we have described regenerative angiogenesis in zebrafish for the first time and have highlighted the role of inflammation in this process.In addition,we have shown that both angiogenesis and neurogenesis are involved in brain repair and that microglia and inflammation-dependent mechanisms activated by Vegf signaling are important contributors to these processes.This study paves the way for a better understanding of the effect of Vegf on microglia and for studies aimed at promoting angiogenesis to improve brain plasticity after brain injury.展开更多
This study was conducted at Fafan Research Center, Golajo research site to evaluate the effect of Moringa stenopetala and pigeon pea leaf supplementation on growth performance of short-eared Somali goat breed. A total...This study was conducted at Fafan Research Center, Golajo research site to evaluate the effect of Moringa stenopetala and pigeon pea leaf supplementation on growth performance of short-eared Somali goat breed. A total of fifteen yearling indigenous short-eared Somali goat breeds with an initial weight of 15.2 ± 0.30 kg were assigned to three treatment groups using completely randomized design. Pigeon pea (Pp) and Moringa stenopetala (MS) feeds were formulated using 0%, 5%, and 10% inclusion levels of MSLM and PPLM as experimental diets, respectively. The feed of the experiment was prepared in two levels (2 kg of Moringa stenopetala and 2 kg of pigeon pea) and was supplemented to experimental animals in treatments one and two, respectively. The average e initial body weight of selected male goats was 18.82 ± 0.37, 18.8 ± 0.37 and 17.8 ± 0.37 kg under treatment groups T1, T2 and control respectively. Data was analyzed using general linear model (GLM) procedure of SAS computer package Version 9.0 (SAS, 2002). The final weights gain (FWG) of goats on T1 and T2 of experimental group was significantly (P 0.05) the final weight gain of goat supplemented on Moringa stenopetala (T1) and pigeon pea levels (T2). The mean average weight gains (AWG) obtained from the supplemented group in this study were 7.50 ± 0.37 and 7.82 ± 0.37 kg for T1 and T2, whereas mean weight gains for un-supplemented goats were found to be 6.26 ± 0.37 kg. Feeding of dried Moringa stenopetala and pigeon pea leaves mixture improved body weights and average daily body weight gain without affecting feed intake and overall health of Somali goat breed. As Moringa stenopetala and pigeon pea leaves are rich nitrogen/protein source, they can be used effectively as substitute for conventional concentrate in the diet of growing goats at small holder farmer’s level where they can be grown in abundance. Therefore, for higher quality of forage and higher total DM yield for animal feeding, moringa should be harvested at wider harvesting intervals of at least 6th- to 8th-week intervals. Similarly, for pigeon peas, 4- to 6-week harvesting interval can result in optimum forage as well as feed quality and resulted in better growth performances for Somali short-eared goat breeds.展开更多
One of the main obstacles to the development of aquaculture in Senegal is the availability of fry and juveniles in sufficient quantities. The objective of our study is to evaluate the effects of treatment with the hor...One of the main obstacles to the development of aquaculture in Senegal is the availability of fry and juveniles in sufficient quantities. The objective of our study is to evaluate the effects of treatment with the hormone 17 alpha methyl testosterone (17-&-MT) and different doses of Nauclea latifolia root powder on the masculinization rates of tilapia Oreochromis niloticus larvae in Senegal. A total of 450 larvae of Oreochromis niloticus, with an average size of 0.012 g, were placed in 15 aquariums, each containing 30 individuals and fed one of the 5 diets in triplicate. These individuals were fed either a diet containing a plant extract at a dose of 180 mg (T180), 200 mg (T200) and 250 mg (T250) per kg of food, or a diet containing 60 mg/kg of the hormone 17-&-MT (TMT), or a diet without either the plant extract or the hormone (T0). Individuals were fed for 30 days with the treatment diets, and then with the industrial feed for the rest of the experiment. At the end of the study, the results of the masculinization rate were: 80.49%, 73.13%, 69.23%, 66.67% and 45.95% for T250;T200, TMT, T180 and T0 respectively. In summary, we can say that the 250 mg/kg dose provides better masculinization, followed by 200mg/kg and then 17 α MT. For the plant, the increase in the percentage of males is dose-dependent. These results also translate into better growth of individuals in this order. However, the relatively lower survival rates observed in batches treated with Nauclea latifolia extract indicate that these treatments could have a deleterious effect on the survival of Oreochromis niloticus larvae. These results suggest the use of N. latifolia extract at a dose of 250 mg/kg feed for better production of male O. niloticus larvae without compromising their growth.展开更多
Objective: To study the effects of starting antiretroviral treatment (ART) prior the age of two years on the growth (height and weight) of HIV-infected children. Methodology: This was a retrospective cohort study. HIV...Objective: To study the effects of starting antiretroviral treatment (ART) prior the age of two years on the growth (height and weight) of HIV-infected children. Methodology: This was a retrospective cohort study. HIV-infected children on ART aged less than 15 years were divided into two groups Group 1 (G1) comprising children who started ART prior 2 years and Group (G2) those put on treatment thereafter. Main Measures: Percentage of children with growth retardation measured by Height for Age (H/A) and Weight for Age (W/A) Results: In total, we included 90 subjects. The median age was 10 years with a slight female predominance (51.2%). Most children were asymptomatic at the time of the study (96.6%), compliant with treatment (81%), 54.8% of children were on cotrimoxazole, 33% knew their status. At initiation, underweight was predominant in group 1 compared to group 2 (52% versus 29.5%;p = 0.015). Conversely, stunted growth predominated in G2 compared to G1 but without significant difference (38% versus 50%;p = 0.147). At the time of our study (median age of 10 years), catch-up height and weight predominated in G1 compared to G2;only a small proportion remained below −2SD (4% versus 18.2%;p = 0.015 and 9% versus 29.5%;p = 0.006 respectively for underweight and stunted growth). Conclusion and Global Health Implications: Growth retardation was common at ART initiation. Catch-up in height was more evident in the early treatment group. Initiation of ART before the age of 2 years rather influences children’s height than weight. The result of this study further emphasizes the need of early ART and closed clinical monitoring to better assess the impact of ART in areas with high rates of undernutrition.展开更多
A new manufactured soil product (Turba) was produced using acidified bauxite residue into which 10% green waste compost had been incorporated. A laboratory/greenhouse experiment was carried out to determine if sand co...A new manufactured soil product (Turba) was produced using acidified bauxite residue into which 10% green waste compost had been incorporated. A laboratory/greenhouse experiment was carried out to determine if sand could be used as an ingredient or an amendment for Turba. Sand was added at rates of 0%, 5%, 10%, 25, 50% and 75% (w/w) in two different ways 1) by incorporating it into the Turba during its manufacture (IN) or 2) by mixing it with Turba aggregates after their manufacture (OUT). Incorporation of sand into Turba aggregates (IN) decreased the percentage of sample present as large aggregates (2 - 4 mm dia.) after crushing and sieving (<4 mm) and also reduced the stability of 2 - 4 mm dia. formed aggregates (to dry/wet sieving) and are therefore not recommended. In a 16-week greenhouse study, ryegrass shoot yields were greater in Turba than in sand [and decreased with increasing sand additions (OUT)] while root dry matter showed the opposite trend. The greater grass growth in Turba than sand was attributed to incipit water stress in plants grown in sand and this may have promoted greater allocation of assimilates to roots resulting in a greater root-to-top mass ratio. The much lower macroporosity in Turba coupled with the solid cemented nature of Turba aggregates resulted in production of thinner roots and therefore greater root length than in sand. Turba (manufactured from bauxite residue and compost added at 10% w/w) is a suitable medium for plant growth and there is no advantage in incorporating sand into, or with, the Turba aggregates.展开更多
The study of the morphometric parameters of the three most abundant species in the lower course of the Kouilou River (Chrysichthys auratus, Liza falcipinnis and Pellonula vorax) was carried out. The standard length of...The study of the morphometric parameters of the three most abundant species in the lower course of the Kouilou River (Chrysichthys auratus, Liza falcipinnis and Pellonula vorax) was carried out. The standard length of Chrysichthys auratus varies between 43.57 and 210 mm, for an average of 96.70 ± 28.63 mm;the weight varies between 2.92 and 140.83 mg, an average of 73.03 ± 21.62 mg. The condition coefficient is equal to 4.42 ± 1.52. Liza falcipinnis has a standard length which varies between 59.9 mm and 158.08 mm for an average of 88.15 ± 29.74 mm;its weight varies between 4.77 and 76.21 mg, an average of 18.61 ± 11.82 mg. The condition coefficient is equal to 2.47 ± 1.57. Pellonula vorax has a standard length which varies between 60.33 mm and 117.72 mm;for an average of 80.48 ± 17.75 mm;the weight varies between 3.61 and 25.17 mg, an average of 9.03 ± 3.61 mg. The condition coefficient is equal to 2.17 ± 0.57. These three species have a minor allometric growth.展开更多
A morphology-based growth stage system should describe the growth and development of a crop and thereby help farmers and agronomists in formulating reasonable managementmeasures conducive to the development of marketa...A morphology-based growth stage system should describe the growth and development of a crop and thereby help farmers and agronomists in formulating reasonable managementmeasures conducive to the development of marketable products.However,existing growth stage systems for soybean are either based on plant growth or covered particular phases of flower or pod development,making it difficult to use for tracking the entire growth period of individual flowers and pods.Therefore,the first flower and pod,located at the base of the primary raceme in the eighth trifoliate node of the main stem,were chosen to illustrate growth dynamics during the full reproductive period.The size and fresh weight of the primary raceme in the eighth trifoliate leaf axil,the first flower and pod,the pistils in the first flower,and seeds in the first pod were examined,and the growth of these organs was depicted.Integrating the morphological characteristics and growth features of flowers and pods,as well as existing growth stage systems,the growth and development were delineated in 13 stages.In detail,we classified the flower phase based on the relative positions of floral components,inspired by the ratio of bract to flower used for staging,refined the lag phase proposed previously,retained the use of pod length to define the early pod phase,and innovatively described the late pod phase by the seed appearance.The developmental events in each stage of flower and pod were distinctive and closely connected to the corresponding morphology.Taken together,a more detailed growth stage system for describing individual flowers and pods in soybean was established.This system will serve as a valuable research tool for describing the development,gene expression,and cellular metabolism associated with the formation of flowers,pods,and seeds.展开更多
Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system diseases.The neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may de...Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system diseases.The neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types involved.Voltage-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related diseases.However,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain unclear.In this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from mice.We found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 expression.Increased VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical neurons.These findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological conditions.Thus,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.展开更多
The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after injury.However,whether it is possible to stimulate ne...The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after injury.However,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains unknown.In this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic injury.Our findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated neurons.Importantly,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain function.These findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.展开更多
Greenhouse planting is a key method for increasing the yield of agricultural products in China.The Academy of Agricultural Sciences has conducted extensive research on the water requirements of greenhouse crops during...Greenhouse planting is a key method for increasing the yield of agricultural products in China.The Academy of Agricultural Sciences has conducted extensive research on the water requirements of greenhouse crops during various growth stages.Studies indicate that crops in the germination stage,seedling stage,and other stages of their growth cycle have different water needs.Proper irrigation can significantly enhance both crop quality and yield.To apply the Academy of Agricultural Sciences’expertise on irrigation during different growth stages to practical farming,and to avoid improper irrigation at specific stages that could reduce crop production and quality,our team has designed an intelligent irrigation system for agricultural greenhouses.This system adapts to the growth patterns of crops by establishing an irrigation model based on characteristic images of each growth stage and irrigation data provided by the Academy.Using image recognition technology,the system accurately identifies the growth stage of crops.It then employs a pre-set irrigation curve and data from humidity sensors to execute precise irrigation through a closed-loop Proportion-Integral-Differential(PID)control system.This ensures optimal water management,leading to improved crop quality and yield.展开更多
Influenced by complex external factors,the displacement-time curve of reservoir landslides demonstrates both short-term and long-term diversity and dynamic complexity.It is difficult for existing methods,including Reg...Influenced by complex external factors,the displacement-time curve of reservoir landslides demonstrates both short-term and long-term diversity and dynamic complexity.It is difficult for existing methods,including Regression models and Neural network models,to perform multi-characteristic coupled displacement prediction because they fail to consider landslide creep characteristics.This paper integrates the creep characteristics of landslides with non-linear intelligent algorithms and proposes a dynamic intelligent landslide displacement prediction method based on a combination of the Biological Growth model(BG),Convolutional Neural Network(CNN),and Long ShortTerm Memory Network(LSTM).This prediction approach improves three different biological growth models,thereby effectively extracting landslide creep characteristic parameters.Simultaneously,it integrates external factors(rainfall and reservoir water level)to construct an internal and external comprehensive dataset for data augmentation,which is input into the improved CNN-LSTM model.Thereafter,harnessing the robust feature extraction capabilities and spatial translation invariance of CNN,the model autonomously captures short-term local fluctuation characteristics of landslide displacement,and combines LSTM's efficient handling of long-term nonlinear temporal data to improve prediction performance.An evaluation of the Liangshuijing landslide in the Three Gorges Reservoir Area indicates that BG-CNN-LSTM exhibits high prediction accuracy,excellent generalization capabilities when dealing with various types of landslides.The research provides an innovative approach to achieving the whole-process,realtime,high-precision displacement predictions for multicharacteristic coupled landslides.展开更多
Rapid growth is an innovative trait of woody bamboos that has been widely studied.However,the genetic basis and evolution of this trait are poorly understood.Taking advantage of genomic resources of 11 representative ...Rapid growth is an innovative trait of woody bamboos that has been widely studied.However,the genetic basis and evolution of this trait are poorly understood.Taking advantage of genomic resources of 11 representative bamboos at different ploidal levels,we integrated morphological,physiological,and transcriptomic datasets to investigate rapid growth.In particular,these bamboos include two large-sized and a small-sized woody species,compared with a diploid herbaceous species.Our results showed that gibberellin A1 was important for the rapid shoot growth of the world's largest bamboo,Dendrocalamus sinicus,and indicated that two gibberellins(GAs)-related genes,KAO and SLRL1,were key to the rapid shoot growth and culm size in woody bamboos.The expression of GAs-related genes exhibited significant subgenome asymmetry with subgenomes A and C demonstrating expression dominance in the large-sized woody bamboos while the generally submissive subgenomes B and D dominating in the small-sized species.The subgenome asymmetry was found to be correlated with the subgenome-specific gene structure,particularly UTRs and core promoters.Our study provides novel insights into the molecular mechanism and evolution of rapid shoot growth following allopolyploidization in woody bamboos,particularly via subgenome asymmetry.These findings are helpful for understanding of how polyploidization in general and subgenome asymmetry in particular contributed to the origin of innovative traits in plants.展开更多
Under current climate warming, the growth resilience of plantation forests after extreme droughts has garnered increasing attention. Platycladus orientalis Linn. is an evergreen tree species commonly used for afforest...Under current climate warming, the growth resilience of plantation forests after extreme droughts has garnered increasing attention. Platycladus orientalis Linn. is an evergreen tree species commonly used for afforestation, and the stability of P. orientalis plantation forests in the Loess Hilly region directly affects the ecological and environmental security of the entire Loess Plateau of China.However, systematic analyses of the growth resilience of P. orientalis plantation forests after extreme droughts along precipitation gradients remain scarce. In this study, we collected tree ring samples of P.orientalis along a precipitation gradient(255, 400, and 517 mm) from 2021 to 2023 and used dendroecological methods to explore the growth resilience of P. orientalis to drought stress on the Loess Plateau. Our findings revealed that the growth resilience of P. orientalis increased with increasing precipitation, enabling the trees to recover to the pre-drought growth levels. In regions with low precipitation(255 mm), the plantation forests were more sensitive to extreme droughts, struggling to recover to previous growth levels, necessitating conditional artificial irrigation. In regions with medium precipitation(400 mm), the growth of P. orientalis was significantly limited by drought stress and exhibited some recovery ability after extreme droughts, therefore warranting management through rainwater harvesting and conservation measures. Conversely, in regions with high precipitation(517 mm), the impacts of extreme droughts on P. orientalis plantation forests were relatively minor. This study underscored the need for targeted strategies tailored to different precipitation conditions rather than a "one-size-fits-all" approach to utilize precipitation resources effectively and maximize the ecological benefits of plantation forests. The findings will help maintain the stability of plantation forests and improve their ecosystem service functions in arid and semi-arid areas.展开更多
Localized rock failures,like cracks or shear bands,demand specific attention in modeling for solids and structures.This is due to the uncertainty of conventional continuum-based mechanical models when localized inelas...Localized rock failures,like cracks or shear bands,demand specific attention in modeling for solids and structures.This is due to the uncertainty of conventional continuum-based mechanical models when localized inelastic deformation has emerged.In such scenarios,as macroscopic inelastic reactions are primarily influenced by deformation and microstructural alterations within the localized area,internal variables that signify these microstructural changes should be established within this zone.Thus,localized deformation characteristics of rocks are studied here by the preset angle shear experiment.A method based on shear displacement and shear stress differences is proposed to identify the compaction,yielding,and residual points for enhancing the model's effectiveness and minimizing subjective influences.Next,a mechanical model for the localized shear band is depicted as an elasto-plastic model outlining the stress-displacement relation across both sides of the shear band.Incorporating damage theory and an elasto-plastic model,a proposed damage model is introduced to replicate shear stressdisplacement responses and localized damage evolution in intact rocks experiencing shear failure.Subsequently,a novel nonlinear mathematical model based on modified logistic growth theory is proposed for depicting the shear band's damage evolution pattern.Thereafter,an innovative damage model is proposed to effectively encompass diverse rock material behaviors,including elasticity,plasticity,and softening behaviors.Ultimately,the effects of the preset angles,temperature,normal stresses and the residual shear strength are carefully discussed.This discovery enhances rock research in the proposed damage model,particularly regarding shear failure mode.展开更多
The epidermal growth factor receptor(EGFR)is a transmembrane glycoprotein that plays a crucial role in signal transduction and cellular responses.This review explores the function of EGFR in kidney physiology and its ...The epidermal growth factor receptor(EGFR)is a transmembrane glycoprotein that plays a crucial role in signal transduction and cellular responses.This review explores the function of EGFR in kidney physiology and its implications for various kidney diseases.EGFR signaling is essential for kidney function and repair mechanisms,and its dysregulation significantly impacts both acute and chronic kidney conditions.The review discusses the normal distribution of EGFR in kidney tubular segments,the mechanism of its activation and inhibition,and the therapeutic potential of EGFR-targeting antagonists and ligands.Additionally,it explores the pathophysiological characteristics observed in rodent models of kidney diseases through pharmacological and genetic inhibition of EGFR,highlighting therapeutic challenges and limitations such as species differences,variability in disease models,and potential adverse effects.Overall,the findings underscore the multifaceted role of EGFR in kidney diseases,influencing inflammation,fibrosis,and tissue injury.This complex involvement suggests that targeting EGFR may be a beneficial therapeutic strategy for managing these conditions,potentially mitigating inflammation and fibrosis while promoting tissue repair.展开更多
[Objectives]To provide a reference for the promotion of appropriate row spacing configuration modes for cotton planting in the Bortala Mongol Autonomous Prefecture of Xinjiang.[Methods]Xinluzao 63 was employed as the ...[Objectives]To provide a reference for the promotion of appropriate row spacing configuration modes for cotton planting in the Bortala Mongol Autonomous Prefecture of Xinjiang.[Methods]Xinluzao 63 was employed as the research subject to examine the effects of three different configuration modes:three rows with one film,four rows with one film,and six rows with one film,on the growth and development of cotton,as well as on yield and the amount of residual film in the field.[Results]In comparison to the configuration modes of four rows with one film and six rows with one film,the development process in the row spacing configuration mode of three rows with one film was accelerated by 1-4 d.This configuration mode exhibited variability in several agronomic traits,particularly in plant height,the number of fruiting branches per plant,and the number of leaves per plant,with the observed trend indicating T3>T2>T1.Conversely,the height of the first fruiting branch node displayed an inverse trend.In terms of yield composition,no significant differences were observed in boll weight and yield among various configuration modes.However,T3 exhibited the highest boll weight at 5.68 g and a yield of 462.67 kg/667 m 2.Additionally,significant differences were noted in harvesting density and the number of bolls per plant.T3 demonstrated the lowest harvesting density at 1.11×104 plants/666.7 m 2,the highest number of bolls per plant at 8.63,and the highest boll opening rate at 97.48%.Furthermore,T3 also resulted in the least amount of agricultural film residue during the current season.[Conclusions]Among the three planting configuration modes examined,the low-density planting configuration mode consisting of three rows and one film demonstrated a significant advantage at the individual plant level.This approach yielded results comparable to those of the high density planting configuration mode while also reducing costs.Furthermore,low density planting positively influenced the cotton boll opening rate,leading to a decreased amount of residual film and promoting ecological health within the agricultural land.展开更多
In this paper,we study high energy normalized solutions for the following Schr?dinger equation{-Δu+V(x)u+λu=f(u),in R^(2),∫_(R^(2))|u|^(2)dx=c,where c>0,λ∈R will appear as a Lagrange multiplier,V(x)=ω|x|2 rep...In this paper,we study high energy normalized solutions for the following Schr?dinger equation{-Δu+V(x)u+λu=f(u),in R^(2),∫_(R^(2))|u|^(2)dx=c,where c>0,λ∈R will appear as a Lagrange multiplier,V(x)=ω|x|2 represents a trapping potential,and f has an exponential critical growth.Under the appropriate assumptions of f,we have obtained the existence of normalized solutions to the above Schr?dinger equation by introducing a variational method.And these solutions are also high energy solutions with positive energy.展开更多
The exopolysaccharide matrix of diazotrophic cyanobacteria was used to integrate phosphorus(P)and potassium(K)solubilizing bacteria,enhancing the survival of plant growth-promoting rhizobacteria,and ultimately the sur...The exopolysaccharide matrix of diazotrophic cyanobacteria was used to integrate phosphorus(P)and potassium(K)solubilizing bacteria,enhancing the survival of plant growth-promoting rhizobacteria,and ultimately the survival of bacteria in the rhizosphere for better plant growth.A new biofilm-based formulation comprising the diazotrophic cyanobacteria Anabaena AMP2,P-solubilizing Bacillus megaterium var.phosphaticum PB1,and K-solubilizing Rhizobium pusense KRBKKM1 was tested for efficacy in rice.The growth medium with half-strength BG-11 medium supplemented with 3%glucose showed best for biofilm formation under in vitro conditions.Analysis of the methanolic extract of the cyanobacterial-bacterial biofilm(CBB)showed the activity of antioxidants,such as 2-methoxy phenol and pentadecane,which are proven to improve plant-microbe interactions and plant growth,respectively.Treatment of rice seeds with CBB extract at 100 mL/kg or 200 mL/kg showed significant enhancement in germination rate and seedling length.Therefore,a pot culture experiment with the CBB formulations was carried out,and different growth and yield parameters were recorded.Principal component analysis showed that plant growth,yield,soil dehydrogenase activity,and soil chlorophyll content were positively correlated with rice plants amended with vermiculite-based CBB at 2 kg/hm^(2) followed by a spray with aqueous CBB formulation at 5 mL/L at 15 and 30 d after rice transplanting grown with a 25%reduced level of nitrogen/phosphorus/potassium chemical fertilizers than the recommended dose.Further,Pearson correlation analysis showed that yield was positively correlated with soil dehydrogenase(r=0.92**)and soil chlorophyll content(r=0.96**).We concluded that CBB could be used as a novel biofilm-based bio-inoculant to increase rice productivity and crop fitness as a component in integrated nutrient management and sustainable organic farming strategies with reduced chemical fertilizers.展开更多
Pulmonary arterial hypertension(PAH)is a progressive disease marked by degeneration of the lung’s blood vessels.As the disease progresses,the resistance to blood flow in the pulmonary arteries increases,putting a str...Pulmonary arterial hypertension(PAH)is a progressive disease marked by degeneration of the lung’s blood vessels.As the disease progresses,the resistance to blood flow in the pulmonary arteries increases,putting a strain on the right side of the heart as it pumps blood through the lungs.PAH is characterized by changes in the structure of blood vessels and excessive cell growth.Untreated PAH leads to irreversible right-sided heart failure,often despite medical intervention.Patients experience a gradual decline in function until they are unable to perform daily activities.Advances in treatment have improved the prognosis for many PAH patients.Currently approved therapies target the prostacyclin,endothelin,nitric oxide,or phosphodiesterase pathways to slow the progression of the disease.To address the unmet need for effective PAH therapies,research efforts are focused on identifying new targets and developing therapies that specifically address the underlying disease mechanisms and restore vascular wall homeostasis.Among these,sotatercept,a fusion protein that targets the transforming growth factor-βsuperfamily signaling pathway,has emerged as a promising therapeutic option.In this review,we examine the available evidence from clinical trials to assess the potential of sotatercept as a treatment for PAH.展开更多
基金supported by the Natio`nal Natural Science Foundation of China,No. 81801241a grant from Sichuan Science and Technology Program,No. 2023NSFSC1578Scientific Research Projects of Southwest Medical University,No. 2022ZD002 (all to JX)。
文摘Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.
基金supported by European Regional Development Funds RE0022527 ZEBRATOX(EU-Région Réunion-French State national counterpart,to Nicolas Diotel and Jean-Loup Bascands).
文摘After brain damage,regenerative angiogenesis and neurogenesis have been shown to occur simultaneously in mammals,suggesting a close link between these processes.However,the mechanisms by which these processes interact are not well understood.In this work,we aimed to study the correlation between angiogenesis and neurogenesis after a telencephalic stab wound injury.To this end,we used zebrafish as a relevant model of neuroplasticity and brain repair mechanisms.First,using the Tg(fli1:EGFP×mpeg1.1:mCherry)zebrafish line,which enables visualization of blood vessels and microglia respectively,we analyzed regenerative angiogenesis from 1 to 21 days post-lesion.In parallel,we monitored brain cell proliferation in neurogenic niches localized in the ventricular zone by using immunohistochemistry.We found that after brain damage,the blood vessel area and width as well as expression of the fli1 transgene and vascular endothelial growth factor(vegfaa and vegfbb)were increased.At the same time,neural stem cell proliferation was also increased,peaking between 3 and 5 days post-lesion in a manner similar to angiogenesis,along with the recruitment of microglia.Then,through pharmacological manipulation by injecting an anti-angiogenic drug(Tivozanib)or Vegf at the lesion site,we demonstrated that blocking or activating Vegf signaling modulated both angiogenic and neurogenic processes,as well as microglial recruitment.Finally,we showed that inhibition of microglia by clodronate-containing liposome injection or dexamethasone treatment impairs regenerative neurogenesis,as previously described,as well as injury-induced angiogenesis.In conclusion,we have described regenerative angiogenesis in zebrafish for the first time and have highlighted the role of inflammation in this process.In addition,we have shown that both angiogenesis and neurogenesis are involved in brain repair and that microglia and inflammation-dependent mechanisms activated by Vegf signaling are important contributors to these processes.This study paves the way for a better understanding of the effect of Vegf on microglia and for studies aimed at promoting angiogenesis to improve brain plasticity after brain injury.
文摘This study was conducted at Fafan Research Center, Golajo research site to evaluate the effect of Moringa stenopetala and pigeon pea leaf supplementation on growth performance of short-eared Somali goat breed. A total of fifteen yearling indigenous short-eared Somali goat breeds with an initial weight of 15.2 ± 0.30 kg were assigned to three treatment groups using completely randomized design. Pigeon pea (Pp) and Moringa stenopetala (MS) feeds were formulated using 0%, 5%, and 10% inclusion levels of MSLM and PPLM as experimental diets, respectively. The feed of the experiment was prepared in two levels (2 kg of Moringa stenopetala and 2 kg of pigeon pea) and was supplemented to experimental animals in treatments one and two, respectively. The average e initial body weight of selected male goats was 18.82 ± 0.37, 18.8 ± 0.37 and 17.8 ± 0.37 kg under treatment groups T1, T2 and control respectively. Data was analyzed using general linear model (GLM) procedure of SAS computer package Version 9.0 (SAS, 2002). The final weights gain (FWG) of goats on T1 and T2 of experimental group was significantly (P 0.05) the final weight gain of goat supplemented on Moringa stenopetala (T1) and pigeon pea levels (T2). The mean average weight gains (AWG) obtained from the supplemented group in this study were 7.50 ± 0.37 and 7.82 ± 0.37 kg for T1 and T2, whereas mean weight gains for un-supplemented goats were found to be 6.26 ± 0.37 kg. Feeding of dried Moringa stenopetala and pigeon pea leaves mixture improved body weights and average daily body weight gain without affecting feed intake and overall health of Somali goat breed. As Moringa stenopetala and pigeon pea leaves are rich nitrogen/protein source, they can be used effectively as substitute for conventional concentrate in the diet of growing goats at small holder farmer’s level where they can be grown in abundance. Therefore, for higher quality of forage and higher total DM yield for animal feeding, moringa should be harvested at wider harvesting intervals of at least 6th- to 8th-week intervals. Similarly, for pigeon peas, 4- to 6-week harvesting interval can result in optimum forage as well as feed quality and resulted in better growth performances for Somali short-eared goat breeds.
文摘One of the main obstacles to the development of aquaculture in Senegal is the availability of fry and juveniles in sufficient quantities. The objective of our study is to evaluate the effects of treatment with the hormone 17 alpha methyl testosterone (17-&-MT) and different doses of Nauclea latifolia root powder on the masculinization rates of tilapia Oreochromis niloticus larvae in Senegal. A total of 450 larvae of Oreochromis niloticus, with an average size of 0.012 g, were placed in 15 aquariums, each containing 30 individuals and fed one of the 5 diets in triplicate. These individuals were fed either a diet containing a plant extract at a dose of 180 mg (T180), 200 mg (T200) and 250 mg (T250) per kg of food, or a diet containing 60 mg/kg of the hormone 17-&-MT (TMT), or a diet without either the plant extract or the hormone (T0). Individuals were fed for 30 days with the treatment diets, and then with the industrial feed for the rest of the experiment. At the end of the study, the results of the masculinization rate were: 80.49%, 73.13%, 69.23%, 66.67% and 45.95% for T250;T200, TMT, T180 and T0 respectively. In summary, we can say that the 250 mg/kg dose provides better masculinization, followed by 200mg/kg and then 17 α MT. For the plant, the increase in the percentage of males is dose-dependent. These results also translate into better growth of individuals in this order. However, the relatively lower survival rates observed in batches treated with Nauclea latifolia extract indicate that these treatments could have a deleterious effect on the survival of Oreochromis niloticus larvae. These results suggest the use of N. latifolia extract at a dose of 250 mg/kg feed for better production of male O. niloticus larvae without compromising their growth.
文摘Objective: To study the effects of starting antiretroviral treatment (ART) prior the age of two years on the growth (height and weight) of HIV-infected children. Methodology: This was a retrospective cohort study. HIV-infected children on ART aged less than 15 years were divided into two groups Group 1 (G1) comprising children who started ART prior 2 years and Group (G2) those put on treatment thereafter. Main Measures: Percentage of children with growth retardation measured by Height for Age (H/A) and Weight for Age (W/A) Results: In total, we included 90 subjects. The median age was 10 years with a slight female predominance (51.2%). Most children were asymptomatic at the time of the study (96.6%), compliant with treatment (81%), 54.8% of children were on cotrimoxazole, 33% knew their status. At initiation, underweight was predominant in group 1 compared to group 2 (52% versus 29.5%;p = 0.015). Conversely, stunted growth predominated in G2 compared to G1 but without significant difference (38% versus 50%;p = 0.147). At the time of our study (median age of 10 years), catch-up height and weight predominated in G1 compared to G2;only a small proportion remained below −2SD (4% versus 18.2%;p = 0.015 and 9% versus 29.5%;p = 0.006 respectively for underweight and stunted growth). Conclusion and Global Health Implications: Growth retardation was common at ART initiation. Catch-up in height was more evident in the early treatment group. Initiation of ART before the age of 2 years rather influences children’s height than weight. The result of this study further emphasizes the need of early ART and closed clinical monitoring to better assess the impact of ART in areas with high rates of undernutrition.
文摘A new manufactured soil product (Turba) was produced using acidified bauxite residue into which 10% green waste compost had been incorporated. A laboratory/greenhouse experiment was carried out to determine if sand could be used as an ingredient or an amendment for Turba. Sand was added at rates of 0%, 5%, 10%, 25, 50% and 75% (w/w) in two different ways 1) by incorporating it into the Turba during its manufacture (IN) or 2) by mixing it with Turba aggregates after their manufacture (OUT). Incorporation of sand into Turba aggregates (IN) decreased the percentage of sample present as large aggregates (2 - 4 mm dia.) after crushing and sieving (<4 mm) and also reduced the stability of 2 - 4 mm dia. formed aggregates (to dry/wet sieving) and are therefore not recommended. In a 16-week greenhouse study, ryegrass shoot yields were greater in Turba than in sand [and decreased with increasing sand additions (OUT)] while root dry matter showed the opposite trend. The greater grass growth in Turba than sand was attributed to incipit water stress in plants grown in sand and this may have promoted greater allocation of assimilates to roots resulting in a greater root-to-top mass ratio. The much lower macroporosity in Turba coupled with the solid cemented nature of Turba aggregates resulted in production of thinner roots and therefore greater root length than in sand. Turba (manufactured from bauxite residue and compost added at 10% w/w) is a suitable medium for plant growth and there is no advantage in incorporating sand into, or with, the Turba aggregates.
文摘The study of the morphometric parameters of the three most abundant species in the lower course of the Kouilou River (Chrysichthys auratus, Liza falcipinnis and Pellonula vorax) was carried out. The standard length of Chrysichthys auratus varies between 43.57 and 210 mm, for an average of 96.70 ± 28.63 mm;the weight varies between 2.92 and 140.83 mg, an average of 73.03 ± 21.62 mg. The condition coefficient is equal to 4.42 ± 1.52. Liza falcipinnis has a standard length which varies between 59.9 mm and 158.08 mm for an average of 88.15 ± 29.74 mm;its weight varies between 4.77 and 76.21 mg, an average of 18.61 ± 11.82 mg. The condition coefficient is equal to 2.47 ± 1.57. Pellonula vorax has a standard length which varies between 60.33 mm and 117.72 mm;for an average of 80.48 ± 17.75 mm;the weight varies between 3.61 and 25.17 mg, an average of 9.03 ± 3.61 mg. The condition coefficient is equal to 2.17 ± 0.57. These three species have a minor allometric growth.
基金supported by the National Key Research and Development Program of China(2023YFD2301500).
文摘A morphology-based growth stage system should describe the growth and development of a crop and thereby help farmers and agronomists in formulating reasonable managementmeasures conducive to the development of marketable products.However,existing growth stage systems for soybean are either based on plant growth or covered particular phases of flower or pod development,making it difficult to use for tracking the entire growth period of individual flowers and pods.Therefore,the first flower and pod,located at the base of the primary raceme in the eighth trifoliate node of the main stem,were chosen to illustrate growth dynamics during the full reproductive period.The size and fresh weight of the primary raceme in the eighth trifoliate leaf axil,the first flower and pod,the pistils in the first flower,and seeds in the first pod were examined,and the growth of these organs was depicted.Integrating the morphological characteristics and growth features of flowers and pods,as well as existing growth stage systems,the growth and development were delineated in 13 stages.In detail,we classified the flower phase based on the relative positions of floral components,inspired by the ratio of bract to flower used for staging,refined the lag phase proposed previously,retained the use of pod length to define the early pod phase,and innovatively described the late pod phase by the seed appearance.The developmental events in each stage of flower and pod were distinctive and closely connected to the corresponding morphology.Taken together,a more detailed growth stage system for describing individual flowers and pods in soybean was established.This system will serve as a valuable research tool for describing the development,gene expression,and cellular metabolism associated with the formation of flowers,pods,and seeds.
基金supported by the Natural Science Foundation of Guangdong Province,Nos.2019A1515010649(to WC),2022A1515012044(to JS)the China Postdoctoral Science Foundation,No.2018M633091(to JS).
文摘Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system diseases.The neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types involved.Voltage-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related diseases.However,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain unclear.In this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from mice.We found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 expression.Increased VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical neurons.These findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological conditions.Thus,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.
基金supported by the National Natural Science Foundation of China,Nos.82272171(to ZY),82271403(to XL),81941011(to XL),31971279(to ZY),31730030(to XL)the Natural Science Foundation of Beijing,No.7222004(to HD).
文摘The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after injury.However,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains unknown.In this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic injury.Our findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated neurons.Importantly,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain function.These findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.
文摘Greenhouse planting is a key method for increasing the yield of agricultural products in China.The Academy of Agricultural Sciences has conducted extensive research on the water requirements of greenhouse crops during various growth stages.Studies indicate that crops in the germination stage,seedling stage,and other stages of their growth cycle have different water needs.Proper irrigation can significantly enhance both crop quality and yield.To apply the Academy of Agricultural Sciences’expertise on irrigation during different growth stages to practical farming,and to avoid improper irrigation at specific stages that could reduce crop production and quality,our team has designed an intelligent irrigation system for agricultural greenhouses.This system adapts to the growth patterns of crops by establishing an irrigation model based on characteristic images of each growth stage and irrigation data provided by the Academy.Using image recognition technology,the system accurately identifies the growth stage of crops.It then employs a pre-set irrigation curve and data from humidity sensors to execute precise irrigation through a closed-loop Proportion-Integral-Differential(PID)control system.This ensures optimal water management,leading to improved crop quality and yield.
基金the funding support from the National Natural Science Foundation of China(Grant No.52308340)Chongqing Talent Innovation and Entrepreneurship Demonstration Team Project(Grant No.cstc2024ycjh-bgzxm0012)the Science and Technology Projects supported by China Coal Technology and Engineering Chongqing Design and Research Institute(Group)Co.,Ltd..(Grant No.H20230317)。
文摘Influenced by complex external factors,the displacement-time curve of reservoir landslides demonstrates both short-term and long-term diversity and dynamic complexity.It is difficult for existing methods,including Regression models and Neural network models,to perform multi-characteristic coupled displacement prediction because they fail to consider landslide creep characteristics.This paper integrates the creep characteristics of landslides with non-linear intelligent algorithms and proposes a dynamic intelligent landslide displacement prediction method based on a combination of the Biological Growth model(BG),Convolutional Neural Network(CNN),and Long ShortTerm Memory Network(LSTM).This prediction approach improves three different biological growth models,thereby effectively extracting landslide creep characteristic parameters.Simultaneously,it integrates external factors(rainfall and reservoir water level)to construct an internal and external comprehensive dataset for data augmentation,which is input into the improved CNN-LSTM model.Thereafter,harnessing the robust feature extraction capabilities and spatial translation invariance of CNN,the model autonomously captures short-term local fluctuation characteristics of landslide displacement,and combines LSTM's efficient handling of long-term nonlinear temporal data to improve prediction performance.An evaluation of the Liangshuijing landslide in the Three Gorges Reservoir Area indicates that BG-CNN-LSTM exhibits high prediction accuracy,excellent generalization capabilities when dealing with various types of landslides.The research provides an innovative approach to achieving the whole-process,realtime,high-precision displacement predictions for multicharacteristic coupled landslides.
基金supported by the Key Project of Natural Science Foundation of Yunnan Province (202401AS070082)the National Natural Science Foundation of China (grants 32120103003 and 31970355)
文摘Rapid growth is an innovative trait of woody bamboos that has been widely studied.However,the genetic basis and evolution of this trait are poorly understood.Taking advantage of genomic resources of 11 representative bamboos at different ploidal levels,we integrated morphological,physiological,and transcriptomic datasets to investigate rapid growth.In particular,these bamboos include two large-sized and a small-sized woody species,compared with a diploid herbaceous species.Our results showed that gibberellin A1 was important for the rapid shoot growth of the world's largest bamboo,Dendrocalamus sinicus,and indicated that two gibberellins(GAs)-related genes,KAO and SLRL1,were key to the rapid shoot growth and culm size in woody bamboos.The expression of GAs-related genes exhibited significant subgenome asymmetry with subgenomes A and C demonstrating expression dominance in the large-sized woody bamboos while the generally submissive subgenomes B and D dominating in the small-sized species.The subgenome asymmetry was found to be correlated with the subgenome-specific gene structure,particularly UTRs and core promoters.Our study provides novel insights into the molecular mechanism and evolution of rapid shoot growth following allopolyploidization in woody bamboos,particularly via subgenome asymmetry.These findings are helpful for understanding of how polyploidization in general and subgenome asymmetry in particular contributed to the origin of innovative traits in plants.
基金funded by the National Natural Science Foundation of China (42071047)Innovation Fund Project for College Teachers in Gansu Province (2025A-008)+1 种基金Research Capability Enhancement Plan for Young Teachers at Northwest Normal University (NWNU-LKQN2024-19)Basic Research Innovation Group Project of Gansu Province (22JR5RA129)。
文摘Under current climate warming, the growth resilience of plantation forests after extreme droughts has garnered increasing attention. Platycladus orientalis Linn. is an evergreen tree species commonly used for afforestation, and the stability of P. orientalis plantation forests in the Loess Hilly region directly affects the ecological and environmental security of the entire Loess Plateau of China.However, systematic analyses of the growth resilience of P. orientalis plantation forests after extreme droughts along precipitation gradients remain scarce. In this study, we collected tree ring samples of P.orientalis along a precipitation gradient(255, 400, and 517 mm) from 2021 to 2023 and used dendroecological methods to explore the growth resilience of P. orientalis to drought stress on the Loess Plateau. Our findings revealed that the growth resilience of P. orientalis increased with increasing precipitation, enabling the trees to recover to the pre-drought growth levels. In regions with low precipitation(255 mm), the plantation forests were more sensitive to extreme droughts, struggling to recover to previous growth levels, necessitating conditional artificial irrigation. In regions with medium precipitation(400 mm), the growth of P. orientalis was significantly limited by drought stress and exhibited some recovery ability after extreme droughts, therefore warranting management through rainwater harvesting and conservation measures. Conversely, in regions with high precipitation(517 mm), the impacts of extreme droughts on P. orientalis plantation forests were relatively minor. This study underscored the need for targeted strategies tailored to different precipitation conditions rather than a "one-size-fits-all" approach to utilize precipitation resources effectively and maximize the ecological benefits of plantation forests. The findings will help maintain the stability of plantation forests and improve their ecosystem service functions in arid and semi-arid areas.
基金supported by the China Scholarship Council Program(Grant No.202008320274)it is also supported by Technical University of Munich.
文摘Localized rock failures,like cracks or shear bands,demand specific attention in modeling for solids and structures.This is due to the uncertainty of conventional continuum-based mechanical models when localized inelastic deformation has emerged.In such scenarios,as macroscopic inelastic reactions are primarily influenced by deformation and microstructural alterations within the localized area,internal variables that signify these microstructural changes should be established within this zone.Thus,localized deformation characteristics of rocks are studied here by the preset angle shear experiment.A method based on shear displacement and shear stress differences is proposed to identify the compaction,yielding,and residual points for enhancing the model's effectiveness and minimizing subjective influences.Next,a mechanical model for the localized shear band is depicted as an elasto-plastic model outlining the stress-displacement relation across both sides of the shear band.Incorporating damage theory and an elasto-plastic model,a proposed damage model is introduced to replicate shear stressdisplacement responses and localized damage evolution in intact rocks experiencing shear failure.Subsequently,a novel nonlinear mathematical model based on modified logistic growth theory is proposed for depicting the shear band's damage evolution pattern.Thereafter,an innovative damage model is proposed to effectively encompass diverse rock material behaviors,including elasticity,plasticity,and softening behaviors.Ultimately,the effects of the preset angles,temperature,normal stresses and the residual shear strength are carefully discussed.This discovery enhances rock research in the proposed damage model,particularly regarding shear failure mode.
基金supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)and funded by the Ministry of Education(2021R1I1A3056002,to Jinu Kim,RS-2023-00274853,to Daeun MOON).
文摘The epidermal growth factor receptor(EGFR)is a transmembrane glycoprotein that plays a crucial role in signal transduction and cellular responses.This review explores the function of EGFR in kidney physiology and its implications for various kidney diseases.EGFR signaling is essential for kidney function and repair mechanisms,and its dysregulation significantly impacts both acute and chronic kidney conditions.The review discusses the normal distribution of EGFR in kidney tubular segments,the mechanism of its activation and inhibition,and the therapeutic potential of EGFR-targeting antagonists and ligands.Additionally,it explores the pathophysiological characteristics observed in rodent models of kidney diseases through pharmacological and genetic inhibition of EGFR,highlighting therapeutic challenges and limitations such as species differences,variability in disease models,and potential adverse effects.Overall,the findings underscore the multifaceted role of EGFR in kidney diseases,influencing inflammation,fibrosis,and tissue injury.This complex involvement suggests that targeting EGFR may be a beneficial therapeutic strategy for managing these conditions,potentially mitigating inflammation and fibrosis while promoting tissue repair.
基金Supported by China Agriculture(Cotton)Research System(CARS-15-46)Intellectual Aid Xinjiang Innovation and Expansion Talent Program of Xinjiang Uygur Autonomous Region(2024500207).
文摘[Objectives]To provide a reference for the promotion of appropriate row spacing configuration modes for cotton planting in the Bortala Mongol Autonomous Prefecture of Xinjiang.[Methods]Xinluzao 63 was employed as the research subject to examine the effects of three different configuration modes:three rows with one film,four rows with one film,and six rows with one film,on the growth and development of cotton,as well as on yield and the amount of residual film in the field.[Results]In comparison to the configuration modes of four rows with one film and six rows with one film,the development process in the row spacing configuration mode of three rows with one film was accelerated by 1-4 d.This configuration mode exhibited variability in several agronomic traits,particularly in plant height,the number of fruiting branches per plant,and the number of leaves per plant,with the observed trend indicating T3>T2>T1.Conversely,the height of the first fruiting branch node displayed an inverse trend.In terms of yield composition,no significant differences were observed in boll weight and yield among various configuration modes.However,T3 exhibited the highest boll weight at 5.68 g and a yield of 462.67 kg/667 m 2.Additionally,significant differences were noted in harvesting density and the number of bolls per plant.T3 demonstrated the lowest harvesting density at 1.11×104 plants/666.7 m 2,the highest number of bolls per plant at 8.63,and the highest boll opening rate at 97.48%.Furthermore,T3 also resulted in the least amount of agricultural film residue during the current season.[Conclusions]Among the three planting configuration modes examined,the low-density planting configuration mode consisting of three rows and one film demonstrated a significant advantage at the individual plant level.This approach yielded results comparable to those of the high density planting configuration mode while also reducing costs.Furthermore,low density planting positively influenced the cotton boll opening rate,leading to a decreased amount of residual film and promoting ecological health within the agricultural land.
基金Supported by National Natural Science Foundation of China(Grant Nos.11671403 and 11671236)Henan Provincial General Natural Science Foundation Project(Grant No.232300420113)。
文摘In this paper,we study high energy normalized solutions for the following Schr?dinger equation{-Δu+V(x)u+λu=f(u),in R^(2),∫_(R^(2))|u|^(2)dx=c,where c>0,λ∈R will appear as a Lagrange multiplier,V(x)=ω|x|2 represents a trapping potential,and f has an exponential critical growth.Under the appropriate assumptions of f,we have obtained the existence of normalized solutions to the above Schr?dinger equation by introducing a variational method.And these solutions are also high energy solutions with positive energy.
基金supported by the Researchers Supporting Project of King Saud University,Riyadh,Saudi Arabia(Grant No.RSP2025R358)Tamil Nadu Agricultural University,Coimbatore,India(Grant No.NRM-MDU-AGM-14-006).
文摘The exopolysaccharide matrix of diazotrophic cyanobacteria was used to integrate phosphorus(P)and potassium(K)solubilizing bacteria,enhancing the survival of plant growth-promoting rhizobacteria,and ultimately the survival of bacteria in the rhizosphere for better plant growth.A new biofilm-based formulation comprising the diazotrophic cyanobacteria Anabaena AMP2,P-solubilizing Bacillus megaterium var.phosphaticum PB1,and K-solubilizing Rhizobium pusense KRBKKM1 was tested for efficacy in rice.The growth medium with half-strength BG-11 medium supplemented with 3%glucose showed best for biofilm formation under in vitro conditions.Analysis of the methanolic extract of the cyanobacterial-bacterial biofilm(CBB)showed the activity of antioxidants,such as 2-methoxy phenol and pentadecane,which are proven to improve plant-microbe interactions and plant growth,respectively.Treatment of rice seeds with CBB extract at 100 mL/kg or 200 mL/kg showed significant enhancement in germination rate and seedling length.Therefore,a pot culture experiment with the CBB formulations was carried out,and different growth and yield parameters were recorded.Principal component analysis showed that plant growth,yield,soil dehydrogenase activity,and soil chlorophyll content were positively correlated with rice plants amended with vermiculite-based CBB at 2 kg/hm^(2) followed by a spray with aqueous CBB formulation at 5 mL/L at 15 and 30 d after rice transplanting grown with a 25%reduced level of nitrogen/phosphorus/potassium chemical fertilizers than the recommended dose.Further,Pearson correlation analysis showed that yield was positively correlated with soil dehydrogenase(r=0.92**)and soil chlorophyll content(r=0.96**).We concluded that CBB could be used as a novel biofilm-based bio-inoculant to increase rice productivity and crop fitness as a component in integrated nutrient management and sustainable organic farming strategies with reduced chemical fertilizers.
文摘Pulmonary arterial hypertension(PAH)is a progressive disease marked by degeneration of the lung’s blood vessels.As the disease progresses,the resistance to blood flow in the pulmonary arteries increases,putting a strain on the right side of the heart as it pumps blood through the lungs.PAH is characterized by changes in the structure of blood vessels and excessive cell growth.Untreated PAH leads to irreversible right-sided heart failure,often despite medical intervention.Patients experience a gradual decline in function until they are unable to perform daily activities.Advances in treatment have improved the prognosis for many PAH patients.Currently approved therapies target the prostacyclin,endothelin,nitric oxide,or phosphodiesterase pathways to slow the progression of the disease.To address the unmet need for effective PAH therapies,research efforts are focused on identifying new targets and developing therapies that specifically address the underlying disease mechanisms and restore vascular wall homeostasis.Among these,sotatercept,a fusion protein that targets the transforming growth factor-βsuperfamily signaling pathway,has emerged as a promising therapeutic option.In this review,we examine the available evidence from clinical trials to assess the potential of sotatercept as a treatment for PAH.
