期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
药源性血小板减少症的发生机制及诊断 被引量:6
1
作者 聂晓璐 马静瑶 +1 位作者 孙凤 詹思延 《中国药物警戒》 2024年第7期829-835,共7页
药源性血小板减少症(drug-induced thrombocytopenia,DITP)是临床最常见的一种继发性血小板减少症。根据血小板减少症的发病机制可分为2大类:非免疫介导和药源性免疫性血小板减少症(drug-induced immune thrombocytopenia,DIIT)。后者... 药源性血小板减少症(drug-induced thrombocytopenia,DITP)是临床最常见的一种继发性血小板减少症。根据血小板减少症的发病机制可分为2大类:非免疫介导和药源性免疫性血小板减少症(drug-induced immune thrombocytopenia,DIIT)。后者进一步根据不同的免疫介导作用机制划分为4类。除经典途径由药物依赖性血小板抗体(drug-dependent platelet-reactive antibodies,DDAbs)与血小板结合引起的DIIT、肝素诱导的血小板减少(heparin-induced thrombocytopenia,HIT)、免疫抑制剂诱导的血小板减少(immune checkpoint inhibitors-induced thrombocytopenia,ICI-ITP)以外,随着新型冠状病毒感染(COVID-19)后开展广泛疫苗研发及接种,新近出现的疫苗诱导的血栓性血小板减少(vaccine-induced thrombotic thrombocytopenia,VITT)也属于DITP范畴。本研究结合近年发表的相关文献,全面综述上述各类型DITP的发生机制特点及诊断,梳理DITP相关数据库,并提出未来研究展望。 展开更多
关键词 药源性血小板减少症 免疫性 半抗原 药物依赖性 肝素 疫苗 诱导 药品不良反应
在线阅读 下载PDF
Chronic Immune Thrombocytopenic Purpura in a Young Female with Rheumatoid Arthritis (Unusual Course)
2
作者 Sara Elhadari Asif Hashmi Hani Hussein 《Case Reports in Clinical Medicine》 2018年第11期557-566,共10页
We present a case of a 29-year-old female from Sudan, who was diagnosed with rheumatoid arthritis (RA) in 2005 and with immune thrombocytopenic purpura (ITP) in 2009. The ITP immediately followed using, for four weeks... We present a case of a 29-year-old female from Sudan, who was diagnosed with rheumatoid arthritis (RA) in 2005 and with immune thrombocytopenic purpura (ITP) in 2009. The ITP immediately followed using, for four weeks, a combination of medications that included rifampicin. The platelets count continued to be low thereafter. During the year following her diagnosis with ITP, she reported gradual improvement in her joints symptoms, which continued during her pregnancy in 2011. Following puerperium, her chronic ITP resolved completely;however, her joint disease flared up few months later. To our knowledge, there are no reported cases of chronic ITP, which were drug induced at first in a patient of RA except with gold therapy. Similarly, there are no reports on cases that recovered from chronic ITP after delivery. Finally, this case highlights the impact different coexisting autoimmune diseases may have on each other regarding course and prognosis. 展开更多
关键词 ITP Immune THROMBOCYTOPENIC PURPURA drug-induced thrombocytopenia ditp Pregnancy RHEUMATOID ARTHRITIS
在线阅读 下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部